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    • 10. 发明授权
    • Method and apparatus for detecting bio-complexes using rule-based templates
    • 使用基于规则的模板检测生物复合物的方法和装置
    • US07869960B2
    • 2011-01-11
    • US11635553
    • 2006-12-08
    • Jae Hun ChoiJong Min ParkSeon Hee Park
    • Jae Hun ChoiJong Min ParkSeon Hee Park
    • G01N33/48
    • G06F19/12G06F19/24
    • Provided are a method and apparatus for detecting bio-complexes that are important sub protein interaction networks using a rule-based template in large interaction networks present in a single species. The method includes (a) defining a rule-based template corresponding to a bio-complex to be detected by defining a node that consists of at least one protein, a triplet that consists of two defined nodes and a protein interaction relationship therebetween, and single and composite rules using the triplet and an operator; (b) analyzing the rules of the defined rule-based template by analyzing whether the protein corresponding to the node included in the defined rule-based template and the protein interaction relationship corresponding to the triplet are present in a protein interaction network; and (c) detecting a bio-complex in the protein interaction network by assessing the triplet included in the rules analyzed and the node included in the triplet using a protein interaction relationship and protein of the protein interaction networks.
    • 提供了一种用于检测生物复合物的方法和装置,其是在单个物种中存在的大型相互作用网络中使用基于规则的模板的重要的亚蛋白质相互作用网络。 该方法包括(a)通过定义由至少一个蛋白质组成的节点,由两个定义的节点组成的三联体以及它们之间的蛋白质相互作用关系来定义与要检测的生物复合物相对应的基于规则的模板,以及单个 和使用三元组和运算符的复合规则; (b)通过分析蛋白质相互作用网络中是否存在与定义的基于规则的模板中包含的节点相对应的蛋白质和对应于三联体的蛋白质相互作用关系来分析所定义的基于规则的模板的规则; 和(c)通过使用蛋白质相互作用网络的蛋白质相互作用关系和蛋白质评估包含在所分析的规则中的三联体和包含在三联体中的节点来检测蛋白质相互作用网络中的生物复合物。