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    • 3. 发明授权
    • Crack resistant weld
    • 耐破裂焊缝
    • US06410165B1
    • 2002-06-25
    • US09723940
    • 2000-11-28
    • John WarrenPaul NeitzkeCraig Higgins
    • John WarrenPaul NeitzkeCraig Higgins
    • B23K3522
    • B23K31/02H01J35/101H01J2235/1046Y10T428/12937Y10T428/12944
    • A welding method that enables the joining of at least two dissimilar, metallic alloys to form a weld that is free of cracks is disclosed. The method incorporates a pure (99.00% minimum by weight) nickel fill-wire, integrally assembled into the joint between the two alloyed metals to be joined. The alloys joined by this method are an iron-based, low expansivity, gamma-prime strengthened superalloy (i.e., Incoloy®) and a high carbon, powder metallurgical tool steel high in refractory metal alloying agents (i.e., CPM REX 20). Welding of the joint results in the formation of a nickel rich region within the weld, thus “inoculating” the weld against cracks. The weld joint formed by the method of the present invention can be used in the fabrication of a rotating anode bearing shaft assembly for use in an x-ray generating device.
    • 公开了一种焊接方法,其能够连接至少两种不同的金属合金以形成没有裂纹的焊缝。 该方法包含纯(99.00%最小重量)镍填充线,整体组装到要接合的两种合金金属之间的接头中。 通过这种方法接合的合金是一种铁基低膨胀性的γ-强化超级合金(即Incoloy)和一种高耐火金属合金剂(即CPM REX 20)的高碳粉末冶金工具钢, 。 接头的焊接导致在焊缝内形成富镍区域,从而“焊接”焊缝以防止裂缝。 通过本发明的方法形成的焊接接头可用于制造用于x射线产生装置的旋转阳极轴承轴组件。
    • 4. 发明授权
    • Electrical switch
    • 电开关
    • US4187419A
    • 1980-02-05
    • US875925
    • 1978-02-07
    • John Warren
    • John Warren
    • H01H19/62H01H9/16
    • H01H9/16
    • An electrical switch including a fixed contact, a movable contact and means for moving the movable contact into and out of engagement with the fixed contact. A first legend indicative of one of the operative states of the switch is carried by a fixed part of the switch and a second legend indicative of the other operative state of the switch is carried by a part movable relative to the fixed part. The movable part is movable between a position wherein the first legend is revealed and the second legend is obscured and a position wherein the movable part obscures the first legend and the second legend is revealed. A resilient arrangement moves the movable part to one of the positions and there is provided a releasable latch arrangement for retaining the movable part in the other of the positions against the action of the resilient means. The switch incorporates a mechanism for releasing the latch at a predetermined point in the movement of the movable contact relative to the fixed contact and further includes a mechanism for returning the movable part against the action of said resilient means.
    • 一种电开关,包括固定触点,可移动触点和用于使可动触头移动到与固定触点接合的装置。 指示开关的操作状态之一的第一图例由开关的固定部分承载,并且指示开关的另一操作状态的第二图例由相对于固定部件可移动的部件承载。 可移动部分可以在其中露出第一图例并且第二图例被遮蔽的位置和可移动部分遮蔽第一图例和第二图例之间的位置之间移动。 弹性布置将可移动部件移动到其中一个位置,并且设置有可释放的闩锁装置,用于将可移动部件保持在抵抗弹性装置的作用的另一个位置。 开关包括用于在可动触头相对于固定触点的运动中的预定点处释放闩锁的机构,并且还包括抵抗所述弹性装置的作用使可动部分返回的机构。
    • 5. 发明授权
    • Method of treating interstitial cytitis with recombinant heparin-binding epidermal growth factor-like growth factor (HB-EGF)
    • 用重组肝素结合表皮生长因子样生长因子(HB-EGF)治疗间质性膀胱炎的方法
    • US06232289B1
    • 2001-05-15
    • US09293037
    • 1999-04-16
    • Susan KeayJohn WarrenMichael Hise
    • Susan KeayJohn WarrenMichael Hise
    • C07K1400
    • A61K38/1808
    • Interstitial cystitis (IC) is a chronic bladder disease for which the exact etiology is unknown and for which there is no reliably effective treatment. However, it is known that the bladder epithelium is often abnormal in IC. We discovered that human bladder epithelial cells from both normal controls and IC patients are inhibited from proliferating by an anti-proliferative factor (APF) present in IC urine specimens. Inhibited proliferation may cause epithelial abnormalities characteristic of IC such as ulcerations and multiple tears in the bladder epithelium. We further discovered that 1) levels of heparin binding-epidermal growth factor-like growth factor (HB-EGF), a factor known be important for epithelial cell proliferation and wound healing in other tissues, are abnormally low in the urine of patients suffering from IC as compared to asymptomatic controls or patients with acute bacterial cystitis; 2) the APF found in IC urine specimens inhibits HB-EGF production by bladder epithelial cells; and 3) that the administration of rHB-EGF blocks the effects of APF on bladder epithelial cells from either IC patients or controls. The invention herein is directed to the administration of HB-EGF, or a functional derivative or agonist thereof, to bladder epithelial cells to inhibit the effects of APF on bladder cell proliferation, thereby reducing or eliminating the chronic damage to the bladder epithelium. HB-EGF or a functional derivative may be used as a therapy for patients suffering from IC or other diseases characterized by inhibited epithelial cell proliferation.
    • 间质性膀胱炎(IC)是一种慢性膀胱疾病,其确切的病因是未知的,并且没有可靠的有效治疗。 然而,已知膀胱上皮在IC中通常是异常的。 我们发现来自正常对照组和IC患者的人膀胱上皮细胞被IC尿液标本中存在的抗增殖因子(APF)抑制增殖。 抑制性增殖可能导致IC的特征性上皮异常,如膀胱上皮中的溃疡和多发性泪液。 我们进一步发现,1)肝素结合表皮生长因子样生长因子(HB-EGF)水平是已知对其他组织中的上皮细胞增殖和伤口愈合很重要的因素,在患有尿液的患者的尿液中异常低 IC与无症状对照或急性细菌性膀胱炎患者相比; 2)IC尿液标本中发现的APF可抑制膀胱上皮细胞产生HB-EGF; 和3)rHB-EGF的给药阻断APF对来自IC患者或对照的膀胱上皮细胞的影响。 本发明涉及向膀胱上皮细胞施用HB-EGF或其功能性衍生物或激动剂,以抑制APF对膀胱细胞增殖的影响,从而减少或消除膀胱上皮细胞的慢性损伤。 HB-EGF或功能衍生物可用作患有IC或其它以抑制性上皮细胞增殖为特征的疾病的患者的治疗。
    • 7. 发明授权
    • Method for producing a crack resistant weld
    • 裂纹焊缝的制造方法
    • US06610962B1
    • 2003-08-26
    • US09723906
    • 2000-11-28
    • John WarrenPaul NeitzkeCraig Higgins
    • John WarrenPaul NeitzkeCraig Higgins
    • B23K900
    • B23K31/02H01J35/101H01J2235/1046Y10T428/12937Y10T428/12944
    • A welding method that enables the joining of at least two dissimilar, metallic alloys to form a weld that is free of cracks is disclosed. The method incorporates a pure (99.00% minimum by weight) nickel fill-wire, integrally assembled into the joint between the two alloyed metals to be joined. The alloys joined by this method are an iron-based, low expansivity, gamma-prime strengthened superalloy (i.e., Incoloy®) and a high carbon, powder metallurgical tool steel high in refractory metal alloying agents (i.e., CPM REX 20). Welding of the joint results in the formation of a nickel rich region within the weld, thus “inoculating” the weld against cracks. The weld joint formed by the method of the present invention can be used in the fabrication of a rotating anode bearing shaft assembly for use in an x-ray generating device.
    • 公开了一种焊接方法,其能够连接至少两种不同的金属合金以形成没有裂纹的焊缝。 该方法包含纯(99.00%最小重量)镍填充线,整体组装到要接合的两种合金金属之间的接头中。 通过这种方法接合的合金是一种铁基低膨胀性的γ-强化超级合金(即Incoloy)和一种高耐火金属合金剂(即CPM REX 20)的高碳粉末冶金工具钢, 。 接头的焊接导致在焊缝内形成富镍区域,从而“焊接”焊缝以防止裂缝。 通过本发明的方法形成的焊接接头可用于制造用于x射线产生装置的旋转阳极轴承轴组件。
    • 8. 发明授权
    • X-ray device comprising a crack resistant weld
    • X射线装置包括耐裂纹焊缝
    • US06335512B1
    • 2002-01-01
    • US09352393
    • 1999-07-13
    • John WarrenPaul NeitzkeCraig Higgins
    • John WarrenPaul NeitzkeCraig Higgins
    • B23K900
    • B23K31/02H01J35/101H01J2235/1046Y10T428/12937Y10T428/12944
    • A welding method that enables the joining of at least two dissimilar, metallic alloys to form a weld that is free of cracks is disclosed. The method incorporates a pure (99.00% minimum by weight) nickel fill-wire, integrally assembled into the joint between the two alloyed metals to be joined. The alloys joined by this method are an iron-based, low expansivity, gamma-prime strengthened superalloy (i.e., Incoloy®) and a high carbon, powder metallurgical tool steel high in refractory metal alloying agents (i.e., CPM REX 20). Welding of the joint results in the formation of a nickel rich region within the weld, thus “inoculating” the weld against cracks. The weld joint formed by the method of the present invention can be used in the fabrication of a rotating anode bearing shaft assembly for use in an x-ray generating device.
    • 公开了一种焊接方法,其能够连接至少两种不同的金属合金以形成没有裂纹的焊缝。 该方法包含纯(99.00%最小重量)镍填充线,整体组装到要接合的两种合金金属之间的接头中。 通过这种方法接合的合金是一种铁基低膨胀性的γ-强化超级合金(即Incoloy)和一种高耐火金属合金剂(即CPM REX 20)的高碳粉末冶金工具钢, 。 接头的焊接导致在焊缝内形成富镍区域,从而“焊接”焊缝以防止裂缝。 通过本发明的方法形成的焊接接头可用于制造用于x射线产生装置的旋转阳极轴承轴组件。