专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09388427B2 In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors 有权
公开(公告)号：US09388427B2
公开(公告)日：2016-07-12
申请号：US12320434
申请日：2009-01-26
申请人： Lakshman R. Sehgal , Jonathan Wong
发明人： Lakshman R. Sehgal , Jonathan Wong
IPC分类号： C12N15/11 , A61K39/235 , C12N15/861 , A61K31/715 , A01N63/00 , C07H21/04 , C12N15/86 , A61K38/44 , A61K39/00 , C07K14/745 , C12N7/00 , A61K48/00 , A61K38/00
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

2. 发明授权

US08420075B2 Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases 有权
公开(公告)号：US08420075B2
公开(公告)日：2013-04-16
申请号：US12750219
申请日：2010-03-30
申请人： Lakshman R. Sehgal , Jonathan Wong
发明人： Lakshman R. Sehgal , Jonathan Wong
IPC分类号： A01N63/00 , A61K31/715 , A61K39/235 , C07H21/04 , C12N15/861
CPC分类号： C07K14/7455 , A61K38/00 , A61K48/00 , A61K48/005 , C12N15/86 , C12N2710/10343 , C12N2799/022 , C12N2830/008
摘要： The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel in vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.

3. 发明授权

US08292878B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权
标题翻译：操作员控制的扫描激光程序设计用于大面积去皮
公开(公告)号：US08292878B2
公开(公告)日：2012-10-23
申请号：US13073747
申请日：2011-03-28
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B2017/00057 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置成增强光学反馈的脉冲序列的扫描允许上皮的大面积被消融，使得操作者可以检测上皮层的穿透。

4. 发明申请

US20110307076A1 IN VIVO AND EX VIVO GENE TRANSFER INTO RENAL TISSUE USING GUTLESS ADENOVIRUS VECTORS 有权
公开(公告)号：US20110307076A1
公开(公告)日：2011-12-15
申请号：US13180378
申请日：2011-07-11
申请人： Lakshman R. SEHGAL , Jonathan Wong
发明人： Lakshman R. SEHGAL , Jonathan Wong
IPC分类号： A61F2/04 , A61M25/10 , A61P9/10 , A61P9/12 , A61K31/711 , A61P13/12
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

5. 发明授权

US07931644B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权
标题翻译：操作员控制的扫描激光程序设计用于大面积去皮
公开(公告)号：US07931644B2
公开(公告)日：2011-04-26
申请号：US11937760
申请日：2007-11-09
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B2017/00057 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置成增强光学反馈的脉冲序列的扫描允许上皮的大面积被消融，使得操作者可以检测上皮层的穿透。

6. 发明申请

US20050102008A1 Variable repetition rate firing scheme for refractive laser systems 有权
$Variable repetition rate firing scheme for refractive laser systems$
标题翻译：屈光激光系统的可重复率发射方案
公开(公告)号：US20050102008A1
公开(公告)日：2005-05-12
申请号：US10447665
申请日：2003-05-28
申请人： Jonathan Wong
发明人： Jonathan Wong
IPC分类号： A61F9/007 , A61B19/00 , A61F9/01 , H01S3/00 , A61N1/00
CPC分类号： A61F9/008 , A61B34/10 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： Systems and methods apply pulsed laser energy to an eye with a pulsed laser system. The laser system includes a pulsed laser, a laser beam delivery system and at least one processor. The laser makes a beam of an ablative light energy. A dimension across the laser beam varies during a treatment of the eye. A firing rate of the laser varies as the dimension across the beam varies during the treatment. The dimension across the beam and the firing rate of the laser can be arranged so as to maintain a power of the beam applied to the eye at a substantially constant level during at least a portion of the treatment. A firing rate of the laser for each pulse may be listed in a treatment table.
摘要翻译：系统和方法使用脉冲激光系统将脉冲激光能量应用于眼睛。激光系统包括脉冲激光器，激光束传送系统和至少一个处理器。激光产生烧蚀光束。在治疗眼睛期间，穿过激光束的尺寸变化。激光的燃烧速率随着治疗期间横梁的尺寸变化而变化。横梁上的尺寸和激光的射出速率可被布置成在治疗的至少一部分期间将施加到眼睛的光束的功率保持在基本恒定的水平。每个脉冲的激光的点火速率可以列在治疗台中。

7. 发明授权

US09353383B2 Vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors 有权
标题翻译：体内和离体基因转移到肾组织使用无胆腺腺病毒载体
公开(公告)号：US09353383B2
公开(公告)日：2016-05-31
申请号：US13180378
申请日：2011-07-11
申请人： Lakshman R. Sehgal , Jonathan Wong
发明人： Lakshman R. Sehgal , Jonathan Wong
IPC分类号： C12N15/11 , A61K48/00 , C12N15/86 , A61K38/44 , A61K39/00 , C07K14/745 , C12N7/00 , A61K38/00
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
摘要翻译：公开了一种治疗受试者的肾脏疾病的方法。该方法包括用有效量的含有编码治疗剂的多核苷酸的无毒腺病毒载体向受试者的肾中施用。无毒腺病毒载体含有SEQ ID NO：13或SEQ ID NO：15的核苷酸序列，并在受试者的肾组织中表达治疗剂。

8. 发明授权

US08242095B2 In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors 有权
公开(公告)号：US08242095B2
公开(公告)日：2012-08-14
申请号：US12778340
申请日：2010-05-12
申请人： Lakshman R. Sehgal , Jonathan Wong
发明人： Lakshman R. Sehgal , Jonathan Wong
IPC分类号： A61K48/00 , C07H21/04
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

9. 发明授权

US08007106B2 Systems for differentiating left and right eye images 有权
标题翻译：用于区分左眼和右眼图像的系统
公开(公告)号：US08007106B2
公开(公告)日：2011-08-30
申请号：US12337956
申请日：2008-12-18
申请人： Jonathan Wong , Dimitri Chernyak
发明人： Jonathan Wong , Dimitri Chernyak
IPC分类号： A61B3/10
CPC分类号： G06K9/00604 , A61B3/10 , A61B3/1015 , A61F9/008 , A61F9/00802 , A61F9/00825 , A61F2009/00846 , A61F2009/00872 , A61F2009/0088 , G06K9/00899
摘要： Methods and systems for determining whether an image is of a left eye or a right eye may be used to enhance laser eye surgery systems and techniques. Methods generally involve locating an iris center and/or pupil center on an image of the eye, locating a corneal vertex and/or at least one reflection on the image, and determining whether the image is of a left eye or a right eye, based on the location of the corneal vertex and/or reflection(s) relative to the iris center and/or pupil center. Systems include a laser emitting a beam of an ablative light energy and a computer processor having a computer program for determining whether the image is of a left eye or a right eye, based on a location of the corneal vertex and/or reflection(s) relative to the iris center and/or pupil center.
摘要翻译：用于确定图像是左眼还是右眼的方法和系统可以用于增强激光眼睛手术系统和技术。方法通常涉及将虹膜中心和/或瞳孔中心定位在眼睛的图像上，将角膜顶点和/或至少一个反射定位在图像上，并基于图像确定是左眼还是右眼在相对于虹膜中心和/或瞳孔中心的角膜顶点和/或反射的位置上。系统包括基于角膜顶点和/或反射的位置发射消融光能量束的激光器和具有用于确定图像是左眼还是右眼的计算机程序的计算机处理器，相对于虹膜中心和/或瞳孔中心。

10. 发明申请

US20100249221A1 IN VIVO AND EX VIVO GENE TRANSFER INTO RENAL TISSUE USING GUTLESS ADENOVIRUS VECTORS 有权
公开(公告)号：US20100249221A1
公开(公告)日：2010-09-30
申请号：US12778360
申请日：2010-05-12
申请人： Lakshman R. SEHGAL , Jonathan Wong
发明人： Lakshman R. SEHGAL , Jonathan Wong
IPC分类号： A61K31/7088 , C12N15/63 , A61P13/12
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式