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1. 发明授权

US08911426B2 Low-permeability, laser-activated drug delivery device 有权
标题翻译：低渗透性，激光激活药物输送装置
公开(公告)号：US08911426B2
公开(公告)日：2014-12-16
申请号：US13023370
申请日：2011-02-08
申请人： Jonathan Robert Coppeta , Kenneth N. Horne , John T. Santini, Jr. , John A. Scholl , Gregory J. R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
发明人： Jonathan Robert Coppeta , Kenneth N. Horne , John T. Santini, Jr. , John A. Scholl , Gregory J. R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
IPC分类号： A61K9/22 , A61K9/00 , A61F9/00 , A61F9/008
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译：一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。第二活性药物成分包含在第二封闭空腔体积中。该装置还包括包含第一和第二壳单元的包络元件。

2. 发明申请

US20120035528A1 LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 有权
标题翻译：低渗透性，激光激活药物递送装置
公开(公告)号：US20120035528A1
公开(公告)日：2012-02-09
申请号：US13023370
申请日：2011-02-08
申请人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
发明人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
IPC分类号： A61M37/00 , B65B1/04
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译：一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。第二活性药物成分包含在第二封闭空腔体积中。该装置还包括包含第一和第二壳单元的包络元件。

3. 发明授权

US08657804B2 Visual indication of rupture of drug reservoir 失效
标题翻译：药库破裂的视觉指示
公开(公告)号：US08657804B2
公开(公告)日：2014-02-25
申请号：US12910572
申请日：2010-10-22
申请人： Kenneth N. Horne , Gregory J. R. Spooner , John A. Scholl , John T. Santini, Jr.
发明人： Kenneth N. Horne , Gregory J. R. Spooner , John A. Scholl , John T. Santini, Jr.
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , A61F2002/30714 , A61F2250/0068 , A61F2250/0089 , A61F2250/0097 , A61K9/0009 , A61K9/0051
摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.
摘要翻译：本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。所述方法包括将药物递送装置植入受试者的解剖结构内。药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

4. 发明申请

US20110098640A1 VISUAL INDICATION OF RUPTURE OF DRUG RESERVOIR 失效
标题翻译：药物残留破裂的可视化指标
公开(公告)号：US20110098640A1
公开(公告)日：2011-04-28
申请号：US12910572
申请日：2010-10-22
申请人： Kenneth N. HORNE , Gregory J.R. Spooner , John A. Scholl , John T. Santini, JR.
发明人： Kenneth N. HORNE , Gregory J.R. Spooner , John A. Scholl , John T. Santini, JR.
IPC分类号： A61M31/00 , A61F9/00 , A61K31/573 , A61P27/02 , A61P9/10 , A61P27/06 , A61P35/00 , A61P27/12
CPC分类号： A61F9/0017 , A61F2002/30714 , A61F2250/0068 , A61F2250/0089 , A61F2250/0097 , A61K9/0009 , A61K9/0051
摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.
摘要翻译：本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。所述方法包括将药物递送装置植入受试者的解剖结构内。药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

5. 发明申请

US20090005865A1 Post-Implant Accommodating Lens Modification 有权
标题翻译：植入后适应镜片修改
公开(公告)号：US20090005865A1
公开(公告)日：2009-01-01
申请号：US12178304
申请日：2008-07-23
申请人： Terry W. Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
发明人： Terry W. Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1624 , A61F2/1627 , A61F2/1635 , A61F2/1648 , A61F2210/0047 , A61F2250/0003 , A61F2250/0004 , A61F2250/0053
摘要： Post-implant modifications to an intraocular lens. In some embodiments the lens is an accommodating intraocular lens.
摘要翻译：植入后修改眼内透镜。在一些实施例中，透镜是容纳的眼内透镜。

6. 发明授权

US6050999A Corneal implant introducer and method of use 失效
标题翻译：角膜植入物导引器及其使用方法
公开(公告)号：US6050999A
公开(公告)日：2000-04-18
申请号：US993594
申请日：1997-12-18
申请人： Joseph F. Paraschac , John A. Scholl , Thomas A. Silvestrini
发明人： Joseph F. Paraschac , John A. Scholl , Thomas A. Silvestrini
IPC分类号： A61F2/14 , A61F9/013 , A61F9/00
CPC分类号： A61F2/148 , A61F9/013 , Y10S623/906
摘要： A device for introducing a corneal implant into a cornea of a human eye. The device includes a body, a member coupled thereto, and a guide portion. The body has a distal end and a proximal end. The guide portion is disposed at the distal end of the body and forms a channel. The guide portion is configured for laterally supporting the implant when positioned in the channel and the member is arranged to axially support the implant when positioned in the channel.
摘要翻译：用于将角膜植入物引入人眼角膜的装置。该装置包括主体，与其连接的构件和引导部。身体具有远端和近端。引导部分设置在身体的远端并形成通道。引导部分构造成在定位在通道中时横向地支撑植入物，并且该构件布置成当定位在通道中时轴向地支撑植入物。

7. 发明授权

US10045844B2 Post-implant accommodating lens modification 有权
公开(公告)号：US10045844B2
公开(公告)日：2018-08-14
申请号：US12178304
申请日：2008-07-23
申请人： Terah Whiting Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
发明人： Terah Whiting Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
IPC分类号： A61F2/16
摘要： Methods of adjusting an intraocular lens after implantation. In some embodiments the methods include positioning an accommodating intraocular lens within an eye, the intraocular lens comprising an optic portion in fluid communication with a peripheral chamber, wherein movement of a fluid between the peripheral chamber and the optic portion in response to ciliary muscle movement changes the optical power of the lens, and reducing a power of the intraocular lens by causing the fluid to move between the optic portion and the peripheral chamber, wherein the reduction in power of the intraocular lens is not in response to ciliary muscle movement, and wherein the positioning step occurs prior to reducing the power.

8. 发明授权

US06251118B1 Radial pocket forming and insert positioning instruments, corneal marker, and method for using same 失效
标题翻译：径向口袋成型和插入定位仪器，角膜标记及其使用方法
公开(公告)号：US06251118B1
公开(公告)日：2001-06-26
申请号：US09060223
申请日：1998-04-14
申请人： Robert A. Proudfoot , John A. Scholl , Thomas A. Silvestrini , Sid Gandionco
发明人： Robert A. Proudfoot , John A. Scholl , Thomas A. Silvestrini , Sid Gandionco
IPC分类号： A61F900
CPC分类号： A61F9/013 , A61F2/147 , A61F9/0017 , A61F9/0133
摘要： Instruments and methods are provided which permit a surgeon to implant multiple radial inserts within a patient's cornea through one or more incisions made into the cornea. Instruments provided by the invention include a corneal marker, a radial pocket-forming instrument, and a positioning instrument. In one method provided by the invention, the surgeon uses the corneal marker to mark the patient's cornea with an incision mark, radial pocket marks, and circumferential channels marks simultaneously. The surgeon forms clockwise and counter-clockwise intrastromal circumferential channels through a single incision into the cornea, and then the surgeon inserts the radial pocket-forming instrument through the incision and into one of the circumferential channels to form radial pockets beneath the radial pocket marks. The surgeon inserts radial intrastromal inserts through the incision and into the circumferential channels and positions them within the radial pockets using the positioning instrument.
摘要翻译：提供的仪器和方法允许外科医生通过制成角膜的一个或多个切口在患者的角膜内植入多个径向插入物。本发明提供的仪器包括角膜标记物，径向口袋形成仪器和定位仪器。在本发明提供的一种方法中，外科医生使用角膜标记物同时用切口标记，径向袋痕迹和圆周通道标记来标记患者的角膜。外科医生通过单个切口进入角膜形成顺时针和逆时针的基底内圆周通道，然后外科医生通过切口将径向口袋形成器械插入到其中一个周向通道中，以在径向穴位下方形成径向穴。外科医生通过切口插入径向的基质内插入物并进入圆周通道，并使用定位仪将它们定位在径向穴内。

9. 发明授权

US06231582B1 Corneal pocketing tool 失效
标题翻译：角膜贴袋工具
公开(公告)号：US06231582B1
公开(公告)日：2001-05-15
申请号：US08993445
申请日：1997-12-18
申请人： Isidro Gandianco , John A. Scholl
发明人： Isidro Gandianco , John A. Scholl
IPC分类号： A61F900
CPC分类号： A61F9/013
摘要： The invention relates to a corneal pocketing tool for separating the lamella of the cornea. The corneal pocketing tool has a dissector portion for insertion into a corneal incision and a reference surface or region adapted to contact the cornea. As the dissector is advanced into the corneal incision the reference region comes into contact with the surface of the cornea and resists further advancement of the dissector. As the reference region is moved in a clockwise or counterclockwise direction, the dissector portion follows in the same direction forming a pocket in the cornea.
摘要翻译：本发明涉及一种用于分离角膜薄片的角膜贴袋工具。角膜包埋工具具有用于插入角膜切口的解剖部分和适于接触角膜的参考表面或区域。当解剖器进入角膜切口时，参考区域与角膜的表面接触并抵抗剥离器的进一步前进。当参考区域沿顺时针或逆时针方向移动时，解剖器部分沿着形成角膜中的口袋的相同方向。

10. 发明授权

US5846256A Device and method for inserting a biocompatible material into the corneal stroma 失效
公开(公告)号：US5846256A
公开(公告)日：1998-12-08
申请号：US462297
申请日：1995-06-05
申请人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
发明人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
IPC分类号： A61F9/007 , A61B17/30 , A61B17/32 , A61F2/14 , A61F9/013 , A61F9/00
CPC分类号： A61F2/147 , A61F9/013 , A61B17/32053 , A61B2017/306 , A61B2017/320052
摘要： This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a biocompatible material. The biocompatible polymer may be an intrastromal corneal ring (ICR). The method involves the use of clockwise and counter-clockwise dissectors, and optionally channel connectors and finish channel connectors. The kit contains clockwise and counter-clockwise dissectors and optionally channel connectors, finish channel connectors and probes.

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