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1. 发明授权

US10045844B2 Post-implant accommodating lens modification 有权
公开(公告)号：US10045844B2
公开(公告)日：2018-08-14
申请号：US12178304
申请日：2008-07-23
申请人： Terah Whiting Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
发明人： Terah Whiting Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
IPC分类号： A61F2/16
摘要： Methods of adjusting an intraocular lens after implantation. In some embodiments the methods include positioning an accommodating intraocular lens within an eye, the intraocular lens comprising an optic portion in fluid communication with a peripheral chamber, wherein movement of a fluid between the peripheral chamber and the optic portion in response to ciliary muscle movement changes the optical power of the lens, and reducing a power of the intraocular lens by causing the fluid to move between the optic portion and the peripheral chamber, wherein the reduction in power of the intraocular lens is not in response to ciliary muscle movement, and wherein the positioning step occurs prior to reducing the power.

2. 发明申请

US20090005865A1 Post-Implant Accommodating Lens Modification 有权
标题翻译：植入后适应镜片修改
公开(公告)号：US20090005865A1
公开(公告)日：2009-01-01
申请号：US12178304
申请日：2008-07-23
申请人： Terry W. Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
发明人： Terry W. Smiley , John H. Shadduck , Victor C. Esch , John A. Scholl , Claudio Argento , Barry Cheskin , David John Smith , Denise H. Burns
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1624 , A61F2/1627 , A61F2/1635 , A61F2/1648 , A61F2210/0047 , A61F2250/0003 , A61F2250/0004 , A61F2250/0053
摘要： Post-implant modifications to an intraocular lens. In some embodiments the lens is an accommodating intraocular lens.
摘要翻译：植入后修改眼内透镜。在一些实施例中，透镜是容纳的眼内透镜。

3. 发明授权

US07261737B2 Accommodating intraocular lens system and method 有权
标题翻译：适应眼内透镜系统和方法
公开(公告)号：US07261737B2
公开(公告)日：2007-08-28
申请号：US10971598
申请日：2004-10-22
申请人： Victor C. Esch , Donald Stenger , Barry Cheskin
发明人： Victor C. Esch , Donald Stenger , Barry Cheskin
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1648 , A61F2002/1682 , A61F2250/0053
摘要： An accommodating intraocular lens is provided having optical parameters that are altered in-situ, wherein an optic portion of the lens includes a lens piston that alters the shape of a lens element of the lens to alter the optical power of the lens, responsive to forces applied to a haptic portion to the lens by contraction of the ciliary muscles. Forces applied to the haptic portion are concentrated by the lens piston to provide a greater dynamic range, and may be further augmented by the use of haptic pistons disposed in the haptic portion of the lens.
摘要翻译：提供一种适应性的眼内透镜，其具有原位改变的光学参数，其中透镜的光学部分包括透镜活塞，该透镜活塞改变透镜的透镜元件的形状以响应于力而改变透镜的光焦度通过睫状肌的收缩应用于透镜的触觉部分。施加到触觉部分的力由透镜活塞集中以提供更大的动态范围，并且可以通过使用设置在透镜的触觉部分中的触觉活塞进一步增强。

4. 发明授权

US07068439B2 Lens system and method for power adjustment 有权
标题翻译：镜头系统和功率调节方法
公开(公告)号：US07068439B2
公开(公告)日：2006-06-27
申请号：US11015918
申请日：2004-12-17
申请人： Victor C. Esch , John H. Shadduck
发明人： Victor C. Esch , John H. Shadduck
IPC分类号： G02B1/06
CPC分类号： A61F2/1613 , A61F2/1601 , A61F2/1635 , A61F2/1648 , G02C7/04 , G02C7/085
摘要： A lens is provided that having optical parameters that may be adjusted in-situ, and is particularly useful as an IOL for use in cataract patients that require an adjustment in the optical power of the lens post-implantation. In one embodiment, the lens body carries an array of interior fluid-filled cells in which fluid is controllably moved upon application of energy from an external source to move a fluid media into or out of the cells to thereby alter the lens surface shape.
摘要翻译：提供了具有可以原位调整的光学参数的透镜，并且作为需要调整透镜植入后光学功率的白内障患者的IOL特别有用。在一个实施例中，透镜体携带内部流体填充单元的阵列，其中流体在施加来自外部源的能量时可控地移动，以将流体介质移入或移出单元，从而改变透镜表面形状。

5. 发明授权

US08841104B2 Methods for isolating a target analyte from a heterogeneous sample 有权
标题翻译：从异质样品中分离目标分析物的方法
公开(公告)号：US08841104B2
公开(公告)日：2014-09-23
申请号：US13091510
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C12Q1/24 , G01N33/563 , G01N33/543 , C12Q1/68 , C07K16/12 , C12N13/00 , C07K1/22
CPC分类号： G01N33/5434 , B01L3/502738 , B01L2300/0636 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/68 , C12Q1/6806 , G01N21/64 , G01N33/53 , G01N33/54333 , G01N2446/90 , Y10T436/25 , Y10T436/25375 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
摘要翻译：本发明一般涉及使用组合物的方法，所述组合物包括一组磁性颗粒，每组的成员与特异于病原体的抗体缀合，以及磁体，用于将病原体与体液样品分离。

6. 发明申请

US20110262926A1 EXTRACTING LOW CONCENTRATIONS OF BACTERIA FROM A SAMPLE 有权
标题翻译：从样品中提取细菌的低浓度
公开(公告)号：US20110262926A1
公开(公告)日：2011-10-27
申请号：US13091534
申请日：2011-04-21
申请人： Victor C. Esch , Sergey A. Dryga , Lisa-Jo Ann Clarizia
发明人： Victor C. Esch , Sergey A. Dryga , Lisa-Jo Ann Clarizia
IPC分类号： C12Q1/02 , G01N33/569 , G01N27/00 , C12Q1/04 , C12Q1/68
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample.
摘要翻译：本发明一般涉及对从样品中分离出细菌的样品进行测定，其中测定分离出样品中低至约1CFU / ml的细菌。

7. 发明授权

US5875275A Methods of connecting an optical fiber and methods of providing radiation from an optical fiber 失效
标题翻译：连接光纤的方法和提供来自光纤的辐射的方法
公开(公告)号：US5875275A
公开(公告)日：1999-02-23
申请号：US979387
申请日：1997-11-26
申请人： William James Evans , Thomas Henning , Kelly Cox , Victor C. Esch , Yefim Gelfond , Stephanos Papademetriou , Daren L. Stewart
发明人： William James Evans , Thomas Henning , Kelly Cox , Victor C. Esch , Yefim Gelfond , Stephanos Papademetriou , Daren L. Stewart
IPC分类号： G02B6/36 , G02B6/38 , G02B6/42
CPC分类号： G02B6/4292 , G02B6/3869 , G02B6/4296 , G02B2006/4297
摘要： A fiber optic radiation transmission system is provided in which an optical fiber and a radiation source are connected to establish optical communication therebetween. Additionally, a connecting system is provided for connecting an optical fiber and a radiation source such that optical communication is established therebetween. The systems include a connector which carries the optical fiber therein. The connector is extendable within the system toward the radiation source to bring the optical fiber into optical communication with the radiation source. More particularly, the systems are configured in such a way that when the connector is extended sufficiently within the system, it seats the optical fiber relative to the radiation source under bias, thereby establishing a reliable optical connection. Once the optical connection is thus established, the connector engages a connection port associated with the radiation source to secure the system in a fully connected configuration appropriate for use. Thus, in a method of using such a system, the user simply extends the connector until the connector engages the connection port. The present invention thus provides efficient and reliable systems in which optical communication is established between an optical fiber and a radiation source.
摘要翻译：提供了一种光纤辐射传输系统，其中光纤和辐射源被连接以在它们之间建立光通信。此外，提供连接系统以连接光纤和辐射源，使得它们之间建立光通信。该系统包括在其中承载光纤的连接器。连接器可在系统内朝向辐射源延伸以使光纤与辐射源成光学通信。更具体地，系统被配置成使得当连接器在系统内充分地延伸时，其在偏压下相对于辐射源来放置光纤，从而建立可靠的光学连接。一旦建立了光学连接，则连接器接合与辐射源相关联的连接端口，以将系统固定成适合使用的完全连接的构造。因此，在使用这种系统的方法中，用户简单地延伸连接器，直到连接器接合连接端口。因此，本发明提供了在光纤和辐射源之间建立光通信的有效和可靠的系统。

8. 发明授权

US09671395B2 Analyzing bacteria without culturing 有权
公开(公告)号：US09671395B2
公开(公告)日：2017-06-06
申请号：US13091548
申请日：2011-04-21
申请人： Sergey A. Dryga , Lisa-Jo Ann Clarizia , Eddie W. Adams , Victor C. Esch
发明人： Sergey A. Dryga , Lisa-Jo Ann Clarizia , Eddie W. Adams , Victor C. Esch
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/554 , G01N33/543 , G01N33/569 , C07K1/22 , C07K16/12 , C12N13/00 , G01N24/08 , G01R33/465 , A61B5/055
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.

9. 发明申请

US20110263833A1 COMPOSITIONS FOR ISOLATING A TARGET ANALYTE FROM A HETEROGENEOUS SAMPLE 有权
标题翻译：用于从异味样品中分离目标分析物的组合物
公开(公告)号：US20110263833A1
公开(公告)日：2011-10-27
申请号：US13091506
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C07K16/12
CPC分类号： G01N33/54333 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/6806 , G01N33/56911 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.
摘要翻译：本发明一般涉及包括一组磁性颗粒的组合物，每组的成员与特异于病原体的抗体缀合。

10. 发明申请

US20110262925A1 METHODS FOR ISOLATING A TARGET ANALYTE FROM A HETEROGENEOUS SAMPLE 有权
标题翻译：从异质样品中分离目标分析物的方法
公开(公告)号：US20110262925A1
公开(公告)日：2011-10-27
申请号：US13091510
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C12Q1/68 , G01N33/577 , G01N33/569
CPC分类号： G01N33/5434 , B01L3/502738 , B01L2300/0636 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/68 , C12Q1/6806 , G01N21/64 , G01N33/53 , G01N33/54333 , G01N2446/90 , Y10T436/25 , Y10T436/25375 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
摘要翻译：本发明一般涉及使用组合物的方法，所述组合物包括一组磁性颗粒，每组的成员与特异于病原体的抗体缀合，以及磁体，用于将病原体与体液样品分离。

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