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1. 发明授权

US06565584B1 Device and method for inserting a biocompatible material into the corneal stroma 失效
标题翻译：将生物相容性材料插入角膜基质的装置和方法
公开(公告)号：US06565584B1
公开(公告)日：2003-05-20
申请号：US08947733
申请日：1997-10-20
申请人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
发明人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
IPC分类号： A61F900
CPC分类号： A61F9/013 , A61B17/32053 , A61B2017/306 , A61B2017/320052 , A61F2/147 , A61F9/0017 , A61L27/34 , A61L2430/16
摘要： This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a biocompatible material. The biocompatible polymer may be an intrastromal corneal ring (ICR). The method involves the use of clockwise and counter-clockwise dissectors, and optionally channel connectors and finish channel connectors. The kit contains clockwise and counter-clockwise dissectors and optionally channel connectors, finish channel connectors and probes.
摘要翻译：本发明是用于在角膜基质的层间空间中产生期望的通道或通路的改进方法和试剂盒，用于插入生物相容性材料。生物相容性聚合物可以是内部角膜环（ICR）。该方法包括使用顺时针和逆时针解剖器，以及可选的通道连接器和完成通道连接器。套件包含顺时针和逆时针分离器，以及可选的通道连接器，完成通道连接器和探头。

2. 发明授权

US5846256A Device and method for inserting a biocompatible material into the corneal stroma 失效
公开(公告)号：US5846256A
公开(公告)日：1998-12-08
申请号：US462297
申请日：1995-06-05
申请人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
发明人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
IPC分类号： A61F9/007 , A61B17/30 , A61B17/32 , A61F2/14 , A61F9/013 , A61F9/00
CPC分类号： A61F2/147 , A61F9/013 , A61B17/32053 , A61B2017/306 , A61B2017/320052
摘要： This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a biocompatible material. The biocompatible polymer may be an intrastromal corneal ring (ICR). The method involves the use of clockwise and counter-clockwise dissectors, and optionally channel connectors and finish channel connectors. The kit contains clockwise and counter-clockwise dissectors and optionally channel connectors, finish channel connectors and probes.

3. 发明授权

US5843105A System for inserting material into corneal stroma 失效
标题翻译：将材料插入角膜基质的系统
公开(公告)号：US5843105A
公开(公告)日：1998-12-01
申请号：US676377
申请日：1996-08-06
申请人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
发明人： Mark L. Mathis , John A. Scholl , Robert A. Proudfoot , Thomas A. Silvestrini
IPC分类号： A61F9/007 , A61B17/30 , A61B17/32 , A61F2/14 , A61F9/013 , A61F9/00
CPC分类号： A61F2/147 , A61F9/013 , A61B17/32053 , A61B2017/306 , A61B2017/320052
摘要： This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a bio-compatible material. The method involves the use of clockwise and counter-clockwise dissectors and optionally channel connectors and finish channel connector.
摘要翻译： PCT No.PCT / US95 / 00063 Sec。 371日期：1996年8月6日 102（e）日期1996年8月6日PCT 1995年1月6日PCT PCT。公开号WO95 / 18569 日期1995年7月13日本发明是用于在角膜基质的层间空间中产生期望的通道或通路的改进方法和试剂盒，用于插入生物相容性材料。该方法包括使用顺时针和逆时针解剖器，以及可选的通道连接器和完成通道连接器。

4. 发明授权

US6143010A Corneal vacuum centering device 失效
标题翻译：角膜真空定心装置
公开(公告)号：US6143010A
公开(公告)日：2000-11-07
申请号：US896754
申请日：1997-07-18
申请人： Thomas A. Silvestrini , Robert A. Proudfoot , John A. Scholl
发明人： Thomas A. Silvestrini , Robert A. Proudfoot , John A. Scholl
IPC分类号： A61F9/007 , A61F9/013 , A61F9/00
CPC分类号： A61F9/013
摘要： This invention is a vacuum centering device which may be used in conjunction with other surgical instruments in opthomological surgery. The device provides an improved interface with the eye by way of features that reduce interference with a patient's eyelids interocular pressure and/or the propensity to rotate. These features may include a flared outer wall portion which may either be curved or straight for a section, providing a low profile vacuum chamber, and/or the use of a non-circular outer sealing region potentially producing a saddle-shaped outer periphery providing for potentially increased vacuum exposure to the eye and a contour resistant to rotation.
摘要翻译：本发明是一种真空定心装置，其可以与光学手术中的其它手术器械结合使用。该装置通过减少对患者眼睑眼压和/或旋转倾向的干扰的特征提供与眼睛的改善的界面。这些特征可以包括扩张的外壁部分，其可以对于部分弯曲或直线，提供薄型真空室，和/或使用非圆形的外密封区域，其可能产生鞍形外周边，潜在地增加对眼睛的真空暴露和耐旋转的轮廓。

5. 发明授权

US06251118B1 Radial pocket forming and insert positioning instruments, corneal marker, and method for using same 失效
标题翻译：径向口袋成型和插入定位仪器，角膜标记及其使用方法
公开(公告)号：US06251118B1
公开(公告)日：2001-06-26
申请号：US09060223
申请日：1998-04-14
申请人： Robert A. Proudfoot , John A. Scholl , Thomas A. Silvestrini , Sid Gandionco
发明人： Robert A. Proudfoot , John A. Scholl , Thomas A. Silvestrini , Sid Gandionco
IPC分类号： A61F900
CPC分类号： A61F9/013 , A61F2/147 , A61F9/0017 , A61F9/0133
摘要： Instruments and methods are provided which permit a surgeon to implant multiple radial inserts within a patient's cornea through one or more incisions made into the cornea. Instruments provided by the invention include a corneal marker, a radial pocket-forming instrument, and a positioning instrument. In one method provided by the invention, the surgeon uses the corneal marker to mark the patient's cornea with an incision mark, radial pocket marks, and circumferential channels marks simultaneously. The surgeon forms clockwise and counter-clockwise intrastromal circumferential channels through a single incision into the cornea, and then the surgeon inserts the radial pocket-forming instrument through the incision and into one of the circumferential channels to form radial pockets beneath the radial pocket marks. The surgeon inserts radial intrastromal inserts through the incision and into the circumferential channels and positions them within the radial pockets using the positioning instrument.
摘要翻译：提供的仪器和方法允许外科医生通过制成角膜的一个或多个切口在患者的角膜内植入多个径向插入物。本发明提供的仪器包括角膜标记物，径向口袋形成仪器和定位仪器。在本发明提供的一种方法中，外科医生使用角膜标记物同时用切口标记，径向袋痕迹和圆周通道标记来标记患者的角膜。外科医生通过单个切口进入角膜形成顺时针和逆时针的基底内圆周通道，然后外科医生通过切口将径向口袋形成器械插入到其中一个周向通道中，以在径向穴位下方形成径向穴。外科医生通过切口插入径向的基质内插入物并进入圆周通道，并使用定位仪将它们定位在径向穴内。

6. 发明授权

US5599341A Laser surgical procedure and device for treatment of the cornea 失效
标题翻译：激光手术和角膜治疗装置
公开(公告)号：US5599341A
公开(公告)日：1997-02-04
申请号：US259886
申请日：1994-06-15
申请人： Mark L. Mathis , Thomas A. Silvestrini
发明人： Mark L. Mathis , Thomas A. Silvestrini
IPC分类号： A61F9/01 , A61F9/011 , A61B17/36
CPC分类号： A61F9/008 , A61F9/00804 , A61F2009/00853 , A61F2009/00872
摘要： This invention is a procedure and system for the correction of optical abnormalities in a hum, a eye. It involves the use of laser radiation to desiccate or ablate tissue in the stromal layer of the cornea. The procedure involved the initial step of forming at least one access site allowing access to the corneal volume behind Bowman's layer. The laser probe is then introduced into the access site and, depending upon the visual abnormality to be corrected, the probe is activated to adjust the volume of the corneal stromal layers. The shape of the volume desiccated or ablated is dependent upon the aberration to be corrected. In certain circumstances, radial or circumferential cuts in Bowman's layer may allow the curvature of the cornea to change following the corneal volume adjustment.
摘要翻译：本发明是用于校正嗡嗡声，眼睛中的光学异常的程序和系统。它涉及使用激光辐射来干燥或消融角膜基质层中的组织。该程序涉及形成至少一个访问站点的初始步骤，允许访问Bowman层后面的角膜体积。然后将激光探针引入进入位置，并且根据要校正的视觉异常，激活探针以调节角膜基质层的体积。干燥或消融的体积的形状取决于要校正的像差。在某些情况下，Bowman层中的径向或周向切割可允许角膜体积调整后角膜的曲率改变。

7. 发明授权

US6050999A Corneal implant introducer and method of use 失效
标题翻译：角膜植入物导引器及其使用方法
公开(公告)号：US6050999A
公开(公告)日：2000-04-18
申请号：US993594
申请日：1997-12-18
申请人： Joseph F. Paraschac , John A. Scholl , Thomas A. Silvestrini
发明人： Joseph F. Paraschac , John A. Scholl , Thomas A. Silvestrini
IPC分类号： A61F2/14 , A61F9/013 , A61F9/00
CPC分类号： A61F2/148 , A61F9/013 , Y10S623/906
摘要： A device for introducing a corneal implant into a cornea of a human eye. The device includes a body, a member coupled thereto, and a guide portion. The body has a distal end and a proximal end. The guide portion is disposed at the distal end of the body and forms a channel. The guide portion is configured for laterally supporting the implant when positioned in the channel and the member is arranged to axially support the implant when positioned in the channel.
摘要翻译：用于将角膜植入物引入人眼角膜的装置。该装置包括主体，与其连接的构件和引导部。身体具有远端和近端。引导部分设置在身体的远端并形成通道。引导部分构造成在定位在通道中时横向地支撑植入物，并且该构件布置成当定位在通道中时轴向地支撑植入物。

8. 发明授权

US08529492B2 Drug delivery devices and methods 有权
公开(公告)号：US08529492B2
公开(公告)日：2013-09-10
申请号：US12973853
申请日：2010-12-20
申请人： Luke Clauson , Thomas A. Silvestrini , Tsontcho Ianchulev , Steven John
发明人： Luke Clauson , Thomas A. Silvestrini , Tsontcho Ianchulev , Steven John
IPC分类号： A61M5/00 , A61M37/00 , A61M31/00 , A61F2/14 , A61F11/00
CPC分类号： A61F9/0017 , A61F9/00781 , A61K9/0024 , A61K9/0048 , A61K31/00 , A61K47/30 , A61M27/002 , A61M2210/0606 , Y02A50/491
摘要： This disclosure relates generally to methods and devices for use in treating eye conditions with implantable drug delivery devices. One method includes introducing an implant into the suprachoroidal space, wherein the interior volume of the implant is plugged with a drug-release material comprising at least one active agent that elutes through at least one opening in the implant, wherein the drug-release material degrades from the interior volume of the implant over a period time.

9. 发明授权

US08460374B2 Mask configured to maintain nutrient transport without producing visible diffraction patterns 有权
$Mask configured to maintain nutrient transport without producing visible diffraction patterns$
公开(公告)号：US08460374B2
公开(公告)日：2013-06-11
申请号：US11290201
申请日：2005-11-30
申请人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
发明人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
IPC分类号： A61F2/14
CPC分类号： A61F2/15 , A61B3/152 , A61F2/14 , A61F2/147 , A61F9/007 , A61F2002/1699 , A61F2250/0023 , A61F2250/0067 , A61F2250/0098 , G02C7/04 , G02C7/165
摘要： A mask configured to be implanted in a cornea of a patient to increase the depth of focus of the patient includes an anterior surface, a posterior surface, and a plurality of holes. The anterior surface is configured to reside adjacent a first corneal layer. The posterior surface is configured to reside adjacent a second corneal layer. The plurality of holes extends at least partially between the anterior surface and the posterior surface. The holes of the plurality of holes are configured to substantially eliminate visible diffraction patterns.

10. 发明授权

US08444589B2 Ocular implant with fluid outflow pathways having microporous membranes 有权
标题翻译：具有微孔膜的流体流出路径的眼植入物
公开(公告)号：US08444589B2
公开(公告)日：2013-05-21
申请号：US13157221
申请日：2011-06-09
申请人： Thomas A. Silvestrini
发明人： Thomas A. Silvestrini
IPC分类号： A61B19/00
CPC分类号： A61F9/00781
摘要： Disclosed are devices, methods and systems for treatment of eye disease such as glaucoma. Implants are described herein that enhance aqueous flow through the normal outflow system of the eye with minimal to no complications. The implant can include reversibly deformable portions that have a plurality of openings layered, covered or otherwise spanned by an elastomeric film or membrane having micropores. The micropores allow for fluid flow out of the implant while inhibit cellular infiltration and blockage of the openings.
摘要翻译：公开了用于治疗诸如青光眼的眼睛疾病的装置，方法和系统。这里描述的植入物增强了通过眼睛的正常流出系统的水流量，而极少到没有并发症。植入物可包括可逆变形部分，其具有由具有微孔的弹性体膜或膜层叠，覆盖或以其它方式跨越的多个开口。微孔允许流体从植入物流出，同时抑制细胞浸润和堵塞开口。

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