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1. 发明授权

US5763172A Method of phosphate ester hydrolysis 失效
标题翻译：磷酸酯水解方法
公开(公告)号：US5763172A
公开(公告)日：1998-06-09
申请号：US486962
申请日：1995-06-07
申请人： Darren Magda , Jonathan L. Sessler , Meredith Wright , Richard A. Miller , William C. Dow
发明人： Darren Magda , Jonathan L. Sessler , Meredith Wright , Richard A. Miller , William C. Dow
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , C12Q1/68 , A01N61/00 , C07H19/00
CPC分类号： A61K47/48069 , A61K41/0038 , A61K49/0021 , A61K49/0054 , B01J31/1658 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/38 , B01J31/061
摘要： A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a metallotexaphyrin complex under conditions and for a time sufficient to hydrolyze the phosphate ester. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution. Phosphate ester substrates include nucleic acid such as RNA, phosphoric anhydrides, phospholipids, and alkyl phosphate esters.
摘要翻译：一种磷酸酯水解方法，包括在足以水解磷酸酯的条件和时间下孵育磷酸酯水溶液与金属脱甲苯吡啶络合物的溶液。金属是在水溶液中具有酯键水解的催化活性的金属阳离子。磷酸酯底物包括核酸如RNA，磷酸酐，磷脂和磷酸烷基酯。

2. 发明授权

US5559207A Texaphyrin metal complex mediated ester hydrolysis 失效
标题翻译： Texaphyrin金属络合物介导酯水解
公开(公告)号：US5559207A
公开(公告)日：1996-09-24
申请号：US227370
申请日：1994-04-14
申请人： Jonathan L. Sessler , Daniel A. Smith , Richard A. Miller , Kevin L. Ross , Meredith Wright , William C. Dow , Vladimir A. Kr al , Brent Iverson , Darren Magda
发明人： Jonathan L. Sessler , Daniel A. Smith , Richard A. Miller , Kevin L. Ross , Meredith Wright , William C. Dow , Vladimir A. Kr al , Brent Iverson , Darren Magda
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/04 , A61L2/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07B61/00 , C07D487/22 , C07F9/06 , C07F9/6558 , C07F9/6561 , C07H21/00 , C07K2/00 , C07F5/00 , C07H3/00 , C07K16/00
CPC分类号： A61K47/48069 , A61K41/0038 , A61K41/0076 , A61K49/0021 , A61K49/0036 , A61K49/085 , A61K49/106 , A61K49/126 , A61K51/0485 , A61L2/0011 , B01J31/1658 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.
摘要翻译：磷酸酯水解的方法，包括将磷酸酯水溶液与泰克萨菲金属络合物的溶液孵育。金属是具有催化活性的金属阳离子，用于在水溶液中酯键水解，特别是镧系元素金属阳离子，优选Eu（III）或Dy（III）。优选的底物是RNA，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到定点分子，优选寡核苷酸的泰克萨菲林。

3. 发明授权

US5530122A Method of isolating texaphyrins 失效
标题翻译：分离泰克萨菲的方法
公开(公告)号：US5530122A
公开(公告)日：1996-06-25
申请号：US294344
申请日：1994-08-23
申请人： William C. Dow , Joan F. Carvalho , Miguel Rosingana
发明人： William C. Dow , Joan F. Carvalho , Miguel Rosingana
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： A process for the isolation of sp.sup.3 reduced nonaromatic macrocyclic texaphyrin precursors, aromatic texaphyrin compounds and texaphyrin-metal complexes from aqueous salt solutions.
摘要翻译：从盐水溶液中分离sp3还原的非芳族大环状泰克萨菲瑞前体，芳族泰克萨菲林化合物和特沙弗林 - 金属络合物的方法。

4. 发明授权

US5446145A Polychelant compounds 失效
标题翻译：聚合物化合物
公开(公告)号：US5446145A
公开(公告)日：1995-08-29
申请号：US86996
申请日：1993-07-07
申请人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
发明人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
IPC分类号： A61K49/00 , A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D241/06 , C07D257/02 , C07D295/185 , C07D403/14 , C07F9/6524 , C07F19/00 , C07D225/02
CPC分类号： C07D241/06 , A61K49/0002 , A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D257/02 , C07D295/185 , C07D403/14 , C07F19/005 , C07F9/6524
摘要： There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly suitable for use in diagnostic imaging, heavy metal detoxification or radiotherapy. The polychelants have a linear or branched oligomeric structure comprising alternating chelant and linker moieties bound together by amide or ester moieties the carbonyl groups whereof being adjacent the chelant moieties, each polychelant comprising at least two said chelant moieties capable of complexing a metal ion.
摘要翻译：公开了多层金属螯合剂和由此形成的螯合物的聚合物化合物。复合物，特别是它们的顺磁金属，重金属或放射性金属聚合物特别适用于诊断成像，重金属解毒或放射治疗。聚合物具有直链或支链低聚结构，其包含交替的螯合剂和通过酰胺或酯部分连接在一起的接头部分，其羰基与螯合剂部分相邻，每个聚合物包含至少两个能够络合金属离子的所述螯合剂部分。

5. 发明授权

US5281704A Polychelant compounds 失效
标题翻译：聚合物化合物
公开(公告)号：US5281704A
公开(公告)日：1994-01-25
申请号：US468107
申请日：1990-01-19
申请人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
发明人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
IPC分类号： A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D241/06 , C07D257/02 , C07D295/185 , C07F19/00 , C07H15/12 , C07H19/02 , C07H23/00
CPC分类号： C07D241/06 , A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D257/02 , C07D295/185 , C07F19/005
摘要： There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly suitable for use in diagnostic imaging, heavy metal detoxification or radiotherapy. The polychelants have a linear or branched oligomeric structure comprising alternating chelant and linker moieties bound together by amide or ester moieties the carbonyl groups whereof being adjacent the chelant moieties, each polychelant comprising at least two said chelant moieties capable of complexing a metal ion.
摘要翻译：公开了多层金属螯合剂和由此形成的螯合物的聚合物化合物。复合物，特别是它们的顺磁金属，重金属或放射性金属聚合物特别适用于诊断成像，重金属解毒或放射治疗。聚合物具有直链或支链低聚结构，其包含交替的螯合剂和通过酰胺或酯部分连接在一起的接头部分，其羰基与螯合剂部分相邻，每个聚合物包含至少两个能够络合金属离子的所述螯合剂部分。

6. 发明授权

US4791110A Fungicidal pyridazines 失效
标题翻译：杀真菌哒嗪
公开(公告)号：US4791110A
公开(公告)日：1988-12-13
申请号：US859558
申请日：1986-05-05
申请人： Wendell R. Arnold , William C. Dow , George W. Johnson
发明人： Wendell R. Arnold , William C. Dow , George W. Johnson
IPC分类号： A01N43/56 , A01N55/00 , A01N55/10 , C07D237/08 , C07D237/12 , C07D237/24 , C07D405/12 , C07F7/08 , A01N43/58
CPC分类号： C07D405/12 , A01N43/56 , A01N55/00 , C07D237/08 , C07D237/12 , C07D237/24 , C07F7/0814
摘要： Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula ##STR1## wherein R.sup.3 is chloro, bromo, methyl, cyano or iodo;R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy;R.sup.1 is hydrogen, methyl, ethyl or n-propyl;R.sup.2 is ##STR2## X is fluoro, chloro, bromo or iodo; X.sup.1 and X.sup.2 independently represent X or hydrogen, provided that no more than one of X.sup.1 and X.sup.2 is hydrogen;R.sup.4 is hydrogen, chloro, bromo, methyl or ethyl;R.sup.5 is hydrogen, chloro, methyl, ethyl, chloromethyl or dichloromethyl;or R.sup.4 and R.sup.5 combine with the group to which they are attached to form a C.sub.3 -C.sub.7 cycloalkyl group substituted with a R.sup.1 group;R.sup.6 is hydrogen, chloro, bromo, methyl or ethyl;R.sup.7 is hydrogen, methyl, ethyl, chloromethyl or dichloromethyl;one of m and n is 0 or 1, and the other is 0;p is 0-4.
摘要翻译：保护植物免受Phycomycetoto真菌的破坏作用，通过一系列式（ⅩⅤ）的哒嗪其中R3是氯，溴，甲基，氰基或碘; R是氯，溴，碘，甲基，氰基或呋喃-2-基甲氧基; R1是氢，甲基，乙基或正丙基; R2是X，X是氟，氯，溴或碘; X1和X2独立地表示X或氢，条件是X1和X2中不超过一个为氢; R4是氢，氯，溴，甲基或乙基; R5是氢，氯，甲基，乙基，氯甲基或二氯甲基; 或R 4和R 5与它们所连接的基团结合形成被R 1基团取代的C 3 -C 7环烷基; R6是氢，氯，溴，甲基或乙基; R7是氢，甲基，乙基，氯甲基或二氯甲基; m和n之一为0或1，另一个为0; p为0-4。

7. 发明授权

US5679810A Linear oligomeric polychelant compounds 失效
标题翻译：线性低聚聚合物化合物
公开(公告)号：US5679810A
公开(公告)日：1997-10-21
申请号：US480056
申请日：1995-06-07
申请人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
发明人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
IPC分类号： A61K49/06 , C07F15/00 , C07F3/08
CPC分类号： A61K49/06
摘要： Linear oligomer polychelant compounds and chelates formed therewith have alternating chelant and linker moieties bound together by amide or ester moieties. The compounds have between 3 and 100 chelant moieties, at least one of which complexes a paramagnetic metal ion. The polychelants and especially their paramagnetic metal polychelates are particularly suitable for diagnostic imaging.
摘要翻译：由此形成的线型低聚物聚合物和螯合物具有通过酰胺或酯部分结合在一起的交替螯合剂和连接部分。化合物具有3至100个螯合剂部分，其中至少一种与顺磁性金属离子复合。多层，特别是它们的顺磁性金属聚合物特别适用于诊断成像。

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