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1. 发明授权

US5906747A Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates 失效
标题翻译：使用在高流速下具有高动态吸附容量的复合色谱介质从稀溶液中分离分子
公开(公告)号：US5906747A
公开(公告)日：1999-05-25
申请号：US556313
申请日：1995-11-13
申请人： Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
发明人： Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
IPC分类号： B01D15/08 , C07K1/18
CPC分类号： B01D15/08 , B01D15/361 , C07K1/18
摘要： This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.
摘要翻译：本发明一般涉及改性多孔固体色谱介质及其制备和使用方法。特别地，公开了多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体的色谱介质，其特征在于可逆的高吸附能力和高的颗粒内传质速率。为了防止非特异性吸附或与生物分子的相互作用，这些载体可以通过使用包含主单体，钝化单体和交联剂的钝化混合物进行钝化，该聚合物上的该混合物导致基本上不需要的与生物分子的非特异性相互作用。

2. 发明授权

US07326776B2 Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays 有权
标题翻译：制备和使用色谱吸附剂和生物芯片阵列的混合模式固体底物
公开(公告)号：US07326776B2
公开(公告)日：2008-02-05
申请号：US11531863
申请日：2006-09-14
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
IPC分类号： C07K1/22 , G01N33/53 , C12M1/34
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译：对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。合适的配体包括任选稠合的芳族基团，杂芳族基团或杂环基团，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。这些树脂在其使用条件下具有阴离子特性。生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。

3. 发明授权

US07144743B2 Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays 有权
标题翻译：制备和使用色谱吸附剂和生物芯片阵列的混合模式固体底物
公开(公告)号：US07144743B2
公开(公告)日：2006-12-05
申请号：US10660738
申请日：2003-09-12
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
IPC分类号： G01N33/544 , G01N33/548 , G01N33/545 , G01N30/02 , C07K1/04 , C07K1/14 , C07D277/62 , C07K1/16
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译：对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。这些树脂在其使用条件下具有阴离子特性。生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。

4. 发明申请

US20050269257A1 Small dense microporous solid support materials, their preparation, and use for purification for large macromolecules and bioparticles 审中-公开
标题翻译：小型微孔固体支持材料，它们的制备和用于大分子和生物颗粒的纯化
公开(公告)号：US20050269257A1
公开(公告)日：2005-12-08
申请号：US11185963
申请日：2005-07-21
申请人： Nicolas Voute , Egisto Boschetti , Pierre Girot
发明人： Nicolas Voute , Egisto Boschetti , Pierre Girot
IPC分类号： B01J20/281 , B01D15/02 , B01D15/08 , B01D15/18 , B01J20/02 , B01J20/06 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/32 , C04B38/00 , G01N30/88
CPC分类号： B01J20/3282 , B01D15/1807 , B01D2215/021 , B01J20/06 , B01J20/28004 , B01J20/28097 , B01J20/286 , B01J20/3028 , B01J20/3042 , B01J20/3078 , B01J20/3204 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J2220/42 , B01J2220/49 , B01J2220/52 , B01J2220/56 , C04B38/00 , C04B38/009 , C04B20/1029 , C04B38/0074
摘要： The present invention provides small, dense mineral oxide solid supports or microbeads, comprising dense microporous mineral oxides matrices in which a skin of polymers is rooted, and their use in downstream processing, especially for fluidized bed purification of bioparticles or high molecular weight macromolecules.
摘要翻译：本发明提供小而致密的矿物氧化物固体支持物或微珠，其包含其中根据聚合物皮肤的致密微孔矿物氧化物基质，以及它们在下游加工中的用途，特别是用于生物颗粒或高分子量大分子的流化床净化。

5. 发明授权

US5486293A Removal of small exogenous molecules from biological fluids 失效
标题翻译：从生物液体中去除小的外源性分子
公开(公告)号：US5486293A
公开(公告)日：1996-01-23
申请号：US215201
申请日：1994-03-21
申请人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
发明人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
IPC分类号： A61K35/14 , B01D15/00 , B01J20/28 , B01D15/08
CPC分类号： B01J20/3282 , B01D15/00 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28097
摘要： Novel sorbents and methods for removing small hydrophobic and amphophilic molecules from biological fluids were disclosed. The methods and materials were particularly useful for removing viral inactivating agents from blood and blood fractions. The novel sorbents comprise a porous mineral oxide matrix having its interior porous volume substantially filled with a crosslinked hydrophobic polymer network.
摘要翻译：公开了从生物液体中去除小疏水和两性分子的新型吸附剂和方法。所述方法和材料特别可用于从血液和血液部分中除去病毒灭活剂。新型吸附剂包括多孔矿物氧化物基质，其基本上填充有交联的疏水性聚合物网络的内部多孔体积。

6. 发明授权

US07815783B2 Multi-compartment filter and method of filtering using same 有权
标题翻译：多室过滤器和使用其的过滤方法
公开(公告)号：US07815783B2
公开(公告)日：2010-10-19
申请号：US11073999
申请日：2005-03-08
申请人： Egisto Boschetti , Lee O. Lomas , Pierre Girot
发明人： Egisto Boschetti , Lee O. Lomas , Pierre Girot
IPC分类号： G01N27/453 , B01D57/02
CPC分类号： G01N27/44704 , B01D57/02 , B01J20/3204 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J2220/54 , C07K1/24 , C07K1/34 , G01N27/44795
摘要： Each embodiment includes a central sample reservoir and a plurality of satellite reservoirs. In a first embodiment, a first electrode in electrical contact with the central reservoir is charged and second electrodes in electrical contact with the satellite reservoirs are sequentially charged, thereby pI filtering molecules in the central reservoir into the satellite reservoirs. In a second embodiment, the central reservoir is configured to rotate so that molecules in a sample in the central reservoir are centrifugally pI-filtered into the satellite reservoirs. In a third embodiment, first and second electrodes proximate opposite first and second satellite reservoirs, respectively, are charged. Some molecules in a sample are pI filtered into the first and second satellite reservoirs. Third and fourth electrodes proximate opposite third and fourth satellite reservoirs, respectively, are then charged. Some molecules in a sample are pI filtered into the third and fourth satellite reservoirs.
摘要翻译：每个实施例包括中央样品储存器和多个卫星储存器。在第一实施例中，与中央储存器电接触的第一电极被充电，并且与卫星储存器电接触的第二电极被顺序地充电，从而将中央储存器中的分子过滤到卫星储存器中。在第二实施例中，中央储存器被配置为旋转，使得中央储存器中的样品中的分子被离心地pI过滤到卫星储存器中。在第三实施例中，分别与第一和第二卫星储存器相邻的第一和第二电极被充电。样品中的一些分子被pI过滤到第一和第二卫星储层中。然后分别靠近相对的第三和第四卫星储存器的第三和第四电极被充电。样品中的一些分子被pI过滤到第三和第四卫星储层中。

7. 发明申请

US20070015143A1 PREPARATION AND USE OF MIXED MODE SOLID SUBSTRATES FOR CHROMATOGRAPHY ADSORBENTS AND BIOCHIP ARRAYS 有权
标题翻译：混合模式固体基质的制备和使用用于色谱吸附和生物体阵列
公开(公告)号：US20070015143A1
公开(公告)日：2007-01-18
申请号：US11531863
申请日：2006-09-14
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译：对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。这些树脂在其使用条件下具有阴离子特性。生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。

8. 发明授权

US06613234B2 Large pore volume composite mineral oxide beads, their preparation and their applications for adsorption and chromatography 失效
标题翻译：大孔体积复合矿物氧化物珠，其制备及其在吸附和色谱上的应用
公开(公告)号：US06613234B2
公开(公告)日：2003-09-02
申请号：US09274013
申请日：1999-03-22
申请人： Nicolas Voute , Egisto Boschetti , Pierre Girot , Marc Perez , Jean-Claude Viguie
发明人： Nicolas Voute , Egisto Boschetti , Pierre Girot , Marc Perez , Jean-Claude Viguie
IPC分类号： B01D1508
CPC分类号： B01J20/3204 , B01D15/1807 , B01D15/327 , B01D15/361 , B01D15/3804 , B01J20/0211 , B01J20/06 , B01J20/08 , B01J20/28069 , B01J20/28085 , B01J20/28097 , B01J20/282 , B01J20/3064 , B01J20/3272 , B01J20/3274 , B01J20/3282 , B01J2220/52
摘要： The present invention provides porous mineral oxide beads which have large pore volumes and enhanced stability. The beads are based on a tetravalent metal oxide, such as zirconia, titania or hafnia. These highly porous beads are produced from a mixture of tetravalent mineral oxides, mineral pore inducing agents which are oxides or salts of trivalent metals, and optional binders. The porous mineral beads can be filled with a polymer gel and used for adsorption and chromatography applications.
摘要翻译：本发明提供了具有大孔体积和增强的稳定性的多孔无机氧化物珠粒。珠粒基于四价金属氧化物，例如氧化锆，二氧化钛或铪。这些高度多孔的珠子由四价矿物氧化物，矿物孔诱导剂，三价金属的氧化物或盐，和任选的粘合剂的混合物制成。多孔矿物珠可以用聚合物凝胶填充并用于吸附和色谱应用。

9. 发明授权

US5906734A Passivated porous polymer supports and methods for the preparation and use of same 失效
公开(公告)号：US5906734A
公开(公告)日：1999-05-25
申请号：US858924
申请日：1997-05-19
申请人： Pierre Girot , Egisto Boschetti
发明人： Pierre Girot , Egisto Boschetti
IPC分类号： B01D15/08 , B01J20/32
CPC分类号： B01D15/08 , B01D15/20 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/26 , B01J41/20 , B01J2220/54 , B01J2220/58
摘要： This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating agent comprising polyethyleneimine, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

10. 发明授权

US5672276A Passivated porous polymer supports and methods for the preparation and use of same 失效
公开(公告)号：US5672276A
公开(公告)日：1997-09-30
申请号：US720799
申请日：1996-10-01
申请人： Pierre Girot , Egisto Boschetti
发明人： Pierre Girot , Egisto Boschetti
IPC分类号： B01D15/08 , B01J20/32 , B01J39/16
CPC分类号： B01D15/20 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/165 , B01D15/3804 , B01J2220/54 , B01J2220/58
摘要： This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous polymeric supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

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