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1. 发明授权

US09301520B2 Systems and methods for freezing, storing and thawing biopharmaceutical materials 有权
公开(公告)号：US09301520B2
公开(公告)日：2016-04-05
申请号：US11963106
申请日：2007-12-21
申请人： Jonathan Cutting , Isabelle Gay , Eric K. Lee , Nicolas Voute
发明人： Jonathan Cutting , Isabelle Gay , Eric K. Lee , Nicolas Voute
IPC分类号： B65D1/32 , A01N1/02 , F25C1/22
CPC分类号： F17C3/085 , A01N1/02 , A01N1/0263 , B01L7/00 , F25C1/22 , Y10T29/53443
摘要： A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim.

2. 发明申请

US20100072216A1 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 有权
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：US20100072216A1
公开(公告)日：2010-03-25
申请号：US12236933
申请日：2008-09-24
申请人： Nicolas VOUTE , Jonathan CUTTING , Isabelle GAY
发明人： Nicolas VOUTE , Jonathan CUTTING , Isabelle GAY
IPC分类号： B65D25/20 , B65B5/00
CPC分类号： A01N1/0263
摘要： A system for use in storing biopharmaceutical materials includes a holder and a container for holding biopharmaceutical materials therein. The container includes a storage portion and a sampling portion connected to each other by a connecting portion. The holder has a storage cavity receiving the storage portion and a sampling cavity receiving the sampling portion. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior storage cradle bounding the storage cavity of the holder. The holder includes an interior sampling cradle bounding the sampling cavity. The sampling cradle is separated from the storage cradle and connected to the storage cradle by a passage receiving the connecting portion connecting the storage portion to the sampling portion. An outer rim of the holder is connected to the cradle and separated from the cavity.
摘要翻译：用于储存生物药物材料的系统包括保持器和用于在其中保持生物药物材料的容器。容器包括通过连接部分彼此连接的存储部分和采样部分。保持器具有容纳存储部的存储空间和接收采样部的采样腔。保持器包括第一部分和第二部分。容器容纳在第一部分和第二部分之间，以将容器连接到保持器。保持器包括限定保持器的存储腔的内部存储支架。支架包括一个限定采样腔的内部采样支架。采样托架与存储托架分离，并通过接收将存储部分连接到采样部分的连接部分的通道连接到存储支架。保持器的外缘连接到支架并与空腔分离。

3. 发明授权

US06945056B2 Systems and methods for freezing, mixing and thawing biopharmaceutical material 有权
标题翻译：用于冷冻，混合和解冻生物药物材料的系统和方法
公开(公告)号：US06945056B2
公开(公告)日：2005-09-20
申请号：US10455222
申请日：2003-06-04
申请人： David C. Brown , Jonathan Cutting , Eric K. Lee , Nicolas Voute , Brian J. Woodard
发明人： David C. Brown , Jonathan Cutting , Eric K. Lee , Nicolas Voute , Brian J. Woodard
IPC分类号： A01N1/02 , A01N31/02 , A23L3/36 , A23L3/365 , A61M1/02 , F25C1/04 , F25D25/00 , F25D31/00 , G01N1/42 , F25C1/00
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61M1/0272 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25C1/04 , F25C2600/04 , F25D25/00 , F25D25/005 , F25D31/001 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , G01N1/42 , A01N2300/00
摘要： A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.
摘要翻译：用于受控冷冻，储存和解冻生物药物材料的系统包括用于容纳用于保持生物药物材料的容器的空腔。还包括面向生物药物材料保持容器的至少一对相对表面。相对表面中的至少一个包括可移动的接触表面，其构造成与容器接触以阻止容器和可动接触表面之间的间隙。还包括至少一个热传递表面，当可移动接触表面接触容器时，热传递表面热耦合到生物药物材料保持容器。此外，空腔可以被配置为容纳用于支撑容纳生物药物材料的容器的框架。此外，系统可以包括驱动器，以将保持容器的框架移动到腔体内。

4. 发明授权

US09161527B2 Systems and methods for freezing, storing and thawing biopharmaceutical materials 有权
标题翻译：用于冷冻，储存和解冻生物药物材料的系统和方法
公开(公告)号：US09161527B2
公开(公告)日：2015-10-20
申请号：US13167484
申请日：2011-06-23
申请人： Jonathan Cutting , Isabelle Gay , Eric K. Lee , Nicolas Voute
发明人： Jonathan Cutting , Isabelle Gay , Eric K. Lee , Nicolas Voute
IPC分类号： G06F17/00 , A01N1/02 , F25C1/22
CPC分类号： F17C3/085 , A01N1/02 , A01N1/0263 , B01L7/00 , F25C1/22 , Y10T29/53443
摘要： A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim.
摘要翻译：一种用于使用冷冻，储存和解冻生物药物材料的系统，其包括用于在其中保持生物药物材料的保持器和容器。保持器具有空腔并且容器容纳在空腔中。保持器包括第一部分和第二部分。容器容纳在第一部分和第二部分之间，以将容器连接到保持器。保持器包括具有从底部延伸的底部和边缘的内部支架。摇篮限定了空腔。外缘连接到支架并与空腔分离。底部包括面向容纳容器的空腔的内表面和外表面。底部的外表面相对于外缘的外表面凹陷。

5. 发明申请

US20120128275A1 POCHE A TEMOIN DE PERTE D'INTEGRITE INCORPORE, PROCEDE DE REALISATION D'UNE TELLE POCHE ET PROCEDE D'UTILISATION 有权
标题翻译： POCHE A TEMOIN DE PERTE D'INTEGRITE INCORPORE，PROCEDE DE REALATIONATION D'UNE TELLE POCHE ET PROCEDE D'UTILIZATION
公开(公告)号：US20120128275A1
公开(公告)日：2012-05-24
申请号：US13378369
申请日：2010-06-14
申请人： Nicolas Voute
发明人： Nicolas Voute
IPC分类号： B65D33/00
CPC分类号： B65D79/02 , B65B31/02 , B65D75/38 , B65D77/04 , B65D81/2084 , G01N31/22
摘要： A pouch includes: a first closed, inner casing, made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a first space, forming a pouch stricto sensu for accommodating a biopharmaceutical product or device, a second closed, outer casing, made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a second space in which the pouch stricto sensu is located, spacer elements, at least one selected tracer gas, located in the first or second space outside of the pouch stricto sensu, with a higher partial pressure than in the second space outside of the pouch stricto sensu or in the first space, at least one colorimetric detector located, respectively, in the second space outside of the pouch stricto sensu or in the first space responsive to the concentration of the tracer gas, by switching from a first color to a second different color.
摘要翻译：袋包括：第一封闭的内壳，由至少一个具有高容量气体屏障的无孔塑料材料制成，限定第一空间，形成用于容纳生物药物产品或装置的密封袋，第二封闭外壳，由具有高容量气体屏障的至少一个无孔塑料材料制成，限定其中所述密封袋位于的第二空间，间隔元件，至少一个选定的示踪气体，位于第一或在密封袋之外的第二空间，具有比在狭缝感觉下的第二空间或第一空间中更高的分压，至少一个比色检测器分别位于密封袋外部的第二空间中或者在第一空间中，通过从第一颜色切换到第二不同颜色来响应于示踪气体的浓度。

6. 发明申请

US20070240432A1 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 有权
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：US20070240432A1
公开(公告)日：2007-10-18
申请号：US11682558
申请日：2007-03-06
申请人： Nicolas Voute , Eric Lee , Dimitry Yakoushkin
发明人： Nicolas Voute , Eric Lee , Dimitry Yakoushkin
IPC分类号： F25C1/00
CPC分类号： F25D25/005 , A61J1/165 , F25D2331/809
摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.
摘要翻译：用于冷冻，储存和解冻生物药物材料的系统包括用于在其中保持生物药物材料的柔性无菌容器装置和比所述容器装置更刚性的保持器。容器装置被容纳在保持器的空腔中，并且保持器沿着容器装置的周边延伸。保持器固定地连接到容器装置。保持器包括限定开口的相对侧，并且容器装置在限定开口的保持器的相对侧之间延伸。容器装置包括在相对的侧面之间延伸的基本光滑的外表面。

7. 发明申请

US20050269257A1 Small dense microporous solid support materials, their preparation, and use for purification for large macromolecules and bioparticles 审中-公开
标题翻译：小型微孔固体支持材料，它们的制备和用于大分子和生物颗粒的纯化
公开(公告)号：US20050269257A1
公开(公告)日：2005-12-08
申请号：US11185963
申请日：2005-07-21
申请人： Nicolas Voute , Egisto Boschetti , Pierre Girot
发明人： Nicolas Voute , Egisto Boschetti , Pierre Girot
IPC分类号： B01J20/281 , B01D15/02 , B01D15/08 , B01D15/18 , B01J20/02 , B01J20/06 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/32 , C04B38/00 , G01N30/88
CPC分类号： B01J20/3282 , B01D15/1807 , B01D2215/021 , B01J20/06 , B01J20/28004 , B01J20/28097 , B01J20/286 , B01J20/3028 , B01J20/3042 , B01J20/3078 , B01J20/3204 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J2220/42 , B01J2220/49 , B01J2220/52 , B01J2220/56 , C04B38/00 , C04B38/009 , C04B20/1029 , C04B38/0074
摘要： The present invention provides small, dense mineral oxide solid supports or microbeads, comprising dense microporous mineral oxides matrices in which a skin of polymers is rooted, and their use in downstream processing, especially for fluidized bed purification of bioparticles or high molecular weight macromolecules.
摘要翻译：本发明提供小而致密的矿物氧化物固体支持物或微珠，其包含其中根据聚合物皮肤的致密微孔矿物氧化物基质，以及它们在下游加工中的用途，特别是用于生物颗粒或高分子量大分子的流化床净化。

8. 发明申请

US20120017609A1 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 有权
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：US20120017609A1
公开(公告)日：2012-01-26
申请号：US13213638
申请日：2011-08-19
申请人： Nicolas VOUTE , Eric K. LEE , Dimitry YAKOUSHKIN
发明人： Nicolas VOUTE , Eric K. LEE , Dimitry YAKOUSHKIN
IPC分类号： F25D25/00 , F25D23/00
CPC分类号： F25D25/005 , A61J1/165 , F25D2331/809
摘要： A system for use in freezing, storing and thawing biopharmaceutical materials includes a flexible sterile container means for holding biopharmaceutical material therein and a holder more rigid than said container means. The container means is received in a cavity of the holder and the holder extends along a perimeter of the container means. The holder is fixedly connected to the container means. The holder includes opposing sides defining an opening and the container means extends between the opposing sides of the holder defining the opening. The container means includes a substantially smooth exterior surface extending between the opposing sides.
摘要翻译：用于冷冻，储存和解冻生物药物材料的系统包括用于在其中保持生物药物材料的柔性无菌容器装置和比所述容器装置更刚性的保持器。容器装置被容纳在保持器的空腔中，并且保持器沿着容器装置的周边延伸。保持器固定地连接到容器装置。保持器包括限定开口的相对侧，并且容器装置在限定开口的保持器的相对侧之间延伸。容器装置包括在相对的侧面之间延伸的基本光滑的外表面。

9. 发明授权

US07353658B2 Systems and methods for freezing, storing, transporting, and thawing biopharmacuetical material 失效
标题翻译：冷冻，储存，运输和解冻生物药物学材料的系统和方法
公开(公告)号：US07353658B2
公开(公告)日：2008-04-08
申请号：US11501329
申请日：2006-08-09
申请人： Nicolas Voute , Eric K. Lee , James Edward DeBeers , Brian J. Woodard , Ngee Jenn Lee
发明人： Nicolas Voute , Eric K. Lee , James Edward DeBeers , Brian J. Woodard , Ngee Jenn Lee
IPC分类号： F25D15/00
CPC分类号： F25D25/005 , A01N1/00 , A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61G12/001 , A61J1/165 , A61M1/0272 , A61M1/0277 , A61M1/0281 , A61M2209/084 , F25B2600/07 , F25D25/00 , F25D31/001 , F25D2331/801 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02 , Y10S165/919 , A01N2300/00
摘要： A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material therein for freezing, thawing, storing, and transporting, with the container also being receivable in the supporting structure. The temperature control unit has a cavity for receiving the supporting structure, when the supporting structure supports the container, and the transportation cart has a channel for receiving the supporting structure, when the supporting structure supports the container.
摘要翻译：一种用于冷冻，解冻，运输和储存生物药物材料的系统，其包括容器，支撑结构，温度控制单元和运输车。容器适于容纳其中的生物药物用于冷冻，解冻，储存和运输，容器也可接收在支撑结构中。当支撑结构支撑容器时，温度控制单元具有用于接收支撑结构的空腔，并且当支撑结构支撑容器时，运输车具有用于接收支撑结构的通道。

10. 发明授权

US07228688B2 Scaled down freezing and thawing system for biopharmaceuticals and biologics 有权
标题翻译：缩小生物制药和生物制剂的冷冻和解冻系统
公开(公告)号：US07228688B2
公开(公告)日：2007-06-12
申请号：US10735378
申请日：2003-12-12
申请人： Nicolas Voute , Richard Wisniewski , Eric K. Lee , Jonathan N. Webb
发明人： Nicolas Voute , Richard Wisniewski , Eric K. Lee , Jonathan N. Webb
IPC分类号： F25D25/00 , F25D23/12 , F25D11/00
CPC分类号： A01N1/00 , F25D31/006 , F25D2331/809 , F25D2500/02 , F28D7/08 , F28F1/22 , G06F19/00
摘要： A freezing and thawing unit for small amounts of biopharmaceuticals and biologics. The freezing and thawing unit is reduced in scale, as compared to a corresponding commercial or large-scale process. The freezing and thawing unit can be used for testing, preservation and/or processing of small quantities of biopharmaceuticals and biologics.
摘要翻译：用于少量生物制药和生物制剂的冷冻和解冻装置。与相应的商业或大规模过程相比，冷冻和解冻单元的规模缩小。冷冻和解冻单元可用于测试，保存和/或加工少量生物药物和生物制剂。

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