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1. 发明授权

US5486293A Removal of small exogenous molecules from biological fluids 失效
标题翻译：从生物液体中去除小的外源性分子
公开(公告)号：US5486293A
公开(公告)日：1996-01-23
申请号：US215201
申请日：1994-03-21
申请人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
发明人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
IPC分类号： A61K35/14 , B01D15/00 , B01J20/28 , B01D15/08
CPC分类号： B01J20/3282 , B01D15/00 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28097
摘要： Novel sorbents and methods for removing small hydrophobic and amphophilic molecules from biological fluids were disclosed. The methods and materials were particularly useful for removing viral inactivating agents from blood and blood fractions. The novel sorbents comprise a porous mineral oxide matrix having its interior porous volume substantially filled with a crosslinked hydrophobic polymer network.
摘要翻译：公开了从生物液体中去除小疏水和两性分子的新型吸附剂和方法。所述方法和材料特别可用于从血液和血液部分中除去病毒灭活剂。新型吸附剂包括多孔矿物氧化物基质，其基本上填充有交联的疏水性聚合物网络的内部多孔体积。

2. 发明授权

US5609763A Porous support for the removal of small exogenous molecules from biological fluids 失效
标题翻译：多孔支持从生物流体中去除小的外源性分子
公开(公告)号：US5609763A
公开(公告)日：1997-03-11
申请号：US564994
申请日：1995-11-30
申请人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
发明人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
IPC分类号： A61K35/14 , B01D15/00 , B01J20/28 , B01D15/08
CPC分类号： B01J20/3282 , B01D15/00 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28097
摘要： Novel sorbents and methods for removing small hydrophobic and amphophilic molecules from biological fluids were disclosed. The methods and materials were particularly useful for removing viral inactivating agents from blood and blood fractions. The novel sorbents comprise a porous mineral oxide matrix having its interior porous volume substantially filled with a crosslinked hydrophobic polymer network.
摘要翻译：公开了从生物液体中去除小疏水和两性分子的新型吸附剂和方法。所述方法和材料特别可用于从血液和血液部分中除去病毒灭活剂。新型吸附剂包括多孔矿物氧化物基质，其基本上填充有交联的疏水性聚合物网络的内部多孔体积。

3. 发明授权

US07326776B2 Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays 有权
标题翻译：制备和使用色谱吸附剂和生物芯片阵列的混合模式固体底物
公开(公告)号：US07326776B2
公开(公告)日：2008-02-05
申请号：US11531863
申请日：2006-09-14
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
IPC分类号： C07K1/22 , G01N33/53 , C12M1/34
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译：对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。合适的配体包括任选稠合的芳族基团，杂芳族基团或杂环基团，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。这些树脂在其使用条件下具有阴离子特性。生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。

4. 发明授权

US07144743B2 Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays 有权
标题翻译：制备和使用色谱吸附剂和生物芯片阵列的混合模式固体底物
公开(公告)号：US07144743B2
公开(公告)日：2006-12-05
申请号：US10660738
申请日：2003-09-12
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
IPC分类号： G01N33/544 , G01N33/548 , G01N33/545 , G01N30/02 , C07K1/04 , C07K1/14 , C07D277/62 , C07K1/16
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译：对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。这些树脂在其使用条件下具有阴离子特性。生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。

5. 发明申请

US20050269257A1 Small dense microporous solid support materials, their preparation, and use for purification for large macromolecules and bioparticles 审中-公开
标题翻译：小型微孔固体支持材料，它们的制备和用于大分子和生物颗粒的纯化
公开(公告)号：US20050269257A1
公开(公告)日：2005-12-08
申请号：US11185963
申请日：2005-07-21
申请人： Nicolas Voute , Egisto Boschetti , Pierre Girot
发明人： Nicolas Voute , Egisto Boschetti , Pierre Girot
IPC分类号： B01J20/281 , B01D15/02 , B01D15/08 , B01D15/18 , B01J20/02 , B01J20/06 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/32 , C04B38/00 , G01N30/88
CPC分类号： B01J20/3282 , B01D15/1807 , B01D2215/021 , B01J20/06 , B01J20/28004 , B01J20/28097 , B01J20/286 , B01J20/3028 , B01J20/3042 , B01J20/3078 , B01J20/3204 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J2220/42 , B01J2220/49 , B01J2220/52 , B01J2220/56 , C04B38/00 , C04B38/009 , C04B20/1029 , C04B38/0074
摘要： The present invention provides small, dense mineral oxide solid supports or microbeads, comprising dense microporous mineral oxides matrices in which a skin of polymers is rooted, and their use in downstream processing, especially for fluidized bed purification of bioparticles or high molecular weight macromolecules.
摘要翻译：本发明提供小而致密的矿物氧化物固体支持物或微珠，其包含其中根据聚合物皮肤的致密微孔矿物氧化物基质，以及它们在下游加工中的用途，特别是用于生物颗粒或高分子量大分子的流化床净化。

6. 发明申请

US20070039891A1 Separation of proteins based on isoelectric point using solid-phase buffers 审中-公开
标题翻译：使用固相缓冲液分离基于等电点的蛋白质
公开(公告)号：US20070039891A1
公开(公告)日：2007-02-22
申请号：US11493923
申请日：2006-07-27
申请人： Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
发明人： Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
IPC分类号： B01D15/08
CPC分类号： B01D15/362 , B01D15/1871 , B01D15/36 , B01D15/363 , B01J20/28033 , B01J39/26 , B01J41/20 , B01J47/018 , B01J2220/603 , B01J2220/82 , C07K1/18 , G01N30/461
摘要： Proteins can be separated from mixtures, based on their pI values, through the use of a series of chromatographic materials, each comprising a solid buffer and an ion exchange resin. Each solid buffer generates a stable pH, such that passing proteins possess a net charge and can be separated by means of an appropriate ion exchanger. In this fashion, proteins from complex biological fluids can be separated for identification and study.
摘要翻译：通过使用一系列色谱材料，每种包含固体缓冲液和离子交换树脂，蛋白质可以基于其pI值与混合物分离。每个固体缓冲液产生稳定的pH，使得通过的蛋白质具有净电荷并且可以通过合适的离子交换剂分离。以这种方式，可以分离来自复杂生物流体的蛋白质进行鉴定和研究。

7. 发明授权

US5906747A Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates 失效
标题翻译：使用在高流速下具有高动态吸附容量的复合色谱介质从稀溶液中分离分子
公开(公告)号：US5906747A
公开(公告)日：1999-05-25
申请号：US556313
申请日：1995-11-13
申请人： Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
发明人： Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
IPC分类号： B01D15/08 , C07K1/18
CPC分类号： B01D15/08 , B01D15/361 , C07K1/18
摘要： This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.
摘要翻译：本发明一般涉及改性多孔固体色谱介质及其制备和使用方法。特别地，公开了多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体的色谱介质，其特征在于可逆的高吸附能力和高的颗粒内传质速率。为了防止非特异性吸附或与生物分子的相互作用，这些载体可以通过使用包含主单体，钝化单体和交联剂的钝化混合物进行钝化，该聚合物上的该混合物导致基本上不需要的与生物分子的非特异性相互作用。

8. 发明授权

US5599453A Passivated porous supports and methods for the preparation and use of same 失效
标题翻译：钝化多孔载体及其制备和使用方法
公开(公告)号：US5599453A
公开(公告)日：1997-02-04
申请号：US471541
申请日：1995-06-06
申请人： Pierre Girot , Egisto Boschetti
发明人： Pierre Girot , Egisto Boschetti
IPC分类号： B01D15/08 , B01J20/32 , B01J39/16
CPC分类号： B01D15/20 , B01J20/08 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/165 , B01D15/363 , B01D15/3804 , B01J2220/54 , B01J2220/58
摘要： This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.
摘要翻译：本发明一般涉及改性多孔固体载体及其制备和使用方法。特别地，公开了钝化的多孔矿物氧化物载体，其特征在于具有可逆的高吸附能力，其基本上不伴随生物分子的非特异性吸附或相互作用。通过使用包含主单体，钝化单体和交联剂的钝化混合物实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。

9. 发明授权

US4478713A Automatic installation for liquid chromatography 失效
标题翻译：自动安装液相色谱仪
公开(公告)号：US4478713A
公开(公告)日：1984-10-23
申请号：US535308
申请日：1983-09-23
申请人： Pierre Girot , Egisto Boschetti
发明人： Pierre Girot , Egisto Boschetti
IPC分类号： B01D15/08 , G01N30/24 , G01N30/82
CPC分类号： B01D15/08 , B01D15/14 , B01D15/247 , G01N30/24 , G01N30/82
摘要： In the automatic installation for liquid chromatography according to the invention, the container of product to be fractionated is associated to a measuring container and is provided, as are the containers of eluents, with low level detector means; feed valves are interposed between said containers and the injection pump whereas output valves are interposed between the outlet from the column and the collector containers; a control unit comprises a safety device connected to the low level detectors to control the stoppage of the pump whenever necessary, and a control device receiving the signals from detection means connected to the output of the column and controlling the measuring container and said valves to perform successive cycles of chromatography each one including the steps of injecting a quantity of product, admitting at least one eluent and collecting the or each corresponding fraction.
摘要翻译：在根据本发明的液相色谱的自动安装中，要分级的产品的容器与测量容器相关联，并且与洗涤液的容器一样设置有低水平检测器装置; 进料阀介于所述容器和注射泵之间，而输出阀插入在塔的出口和收集容器之间; 控制单元包括连接到低电平检测器的安全装置，以在必要时控制泵的停止;以及控制装置，其接收来自连接到列的输出的检测装置的信号，并控制测量容器和所述阀执行连续的色谱层析每个包括以下步骤：注入一定数量的产物，允许至少一种洗脱剂并收集或相应的部分。

10. 发明授权

US08021889B2 Chromatographic material for the absorption of proteins at physiological ionic strength 有权
标题翻译：用于在生理离子强度下吸收蛋白质的色谱材料
公开(公告)号：US08021889B2
公开(公告)日：2011-09-20
申请号：US10583509
申请日：2005-01-14
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
IPC分类号： G01N30/00 , B01D15/08 , C07C7/12
CPC分类号： B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01J20/289 , B01J20/3242 , B01J20/3285 , B01J41/20 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0074 , B01J2220/54 , C07K1/16 , C07K1/18 , G01N30/02 , G01N33/54353 , G01N2035/00158 , Y10S435/803
摘要： Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.
摘要翻译：离子交换和疏水相互作用层析材料是通过一个疏水性接头将末端结合官能团连接到固体支持物构成的。接头的骨架通常包含含硫部分。合适的末端结合官能团是叔胺，季铵盐或疏水基团。这些色谱材料在规定的条件下具有疏水性和离子性。通过施加pH或离子强度梯度，可以用这种类型的色谱材料在生理离子强度下从粗混合物中分离蛋白质，从而进行蛋白质吸附和解吸。

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