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1. 发明授权

US07766840B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US07766840B2
公开(公告)日：2010-08-03
申请号：US11291525
申请日：2005-12-01
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

2. 发明申请

US20100298733A1 Method and System for Heart Failure Status Evaluation Based on a Disordered Breathing Index 有权
标题翻译：基于无序呼吸指数的心力衰竭状态评估方法与系统
公开(公告)号：US20100298733A1
公开(公告)日：2010-11-25
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

3. 发明申请

US20070129643A1 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US20070129643A1
公开(公告)日：2007-06-07
申请号：US11291525
申请日：2005-12-01
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

4. 发明授权

US08696589B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US08696589B2
公开(公告)日：2014-04-15
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
发明人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

5. 发明申请

US20060116593A1 Cardiac activation sequence monitoring for ischemia detection 有权
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US20060116593A1
公开(公告)日：2006-06-01
申请号：US11079744
申请日：2005-03-14
申请人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
发明人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

6. 发明申请

US20070150015A1 Implantable cardiac device with ischemia response capability 有权
标题翻译：具有缺血反应能力的植入式心脏装置
公开(公告)号：US20070150015A1
公开(公告)日：2007-06-28
申请号：US11318257
申请日：2005-12-23
申请人： Yi Zhang , Aaron McCabe , Kevin Stalsberg , Kent Lee , Marina Brockway , Joseph Pastore , Allan Shuros
发明人： Yi Zhang , Aaron McCabe , Kevin Stalsberg , Kent Lee , Marina Brockway , Joseph Pastore , Allan Shuros
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61B5/1102 , A61B2562/0219 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3925 , A61N1/3962
摘要： A cardiac device is described with the capability of detecting cardiac ischemia using multiple sensing modalities. The device may be configured to modify its behavior in delivering therapies to treat bradycardia or tachyarrhythmias in response to detection of cardiac ischemia.
摘要翻译：描述了具有使用多种感测方式检测心脏缺血的能力的心脏装置。该装置可以被配置为在递送疗法时修改其行为以响应于心脏缺血的检测来治疗心动过缓或快速性心律失常。

7. 发明授权

US07922669B2 Ischemia detection using a heart sound sensor 有权
标题翻译：使用心脏声音传感器进行缺血检测
公开(公告)号：US07922669B2
公开(公告)日：2011-04-12
申请号：US11148107
申请日：2005-06-08
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Z. Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Z. Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

8. 发明申请

US20090287106A1 ISCHEMIA DETECTION USING A HEART SOUND SENSOR 有权
标题翻译：使用心音传感器进行ISCHEMIA检测
公开(公告)号：US20090287106A1
公开(公告)日：2009-11-19
申请号：US12510962
申请日：2009-07-28
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Z. Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Z. Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

9. 发明申请

US20080139951A1 Detection of Stenosis 审中-公开
标题翻译：狭窄检测
公开(公告)号：US20080139951A1
公开(公告)日：2008-06-12
申请号：US11608578
申请日：2006-12-08
申请人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
发明人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
IPC分类号： A61B5/026 , A61F2/82
CPC分类号： A61B5/411 , A61B5/0031 , A61B5/02007 , A61B5/02158 , A61B5/026 , A61B5/0402 , A61B5/076 , A61B2562/0204 , A61B2562/0219 , A61F2/02 , A61F2/91 , A61F2250/0002
摘要： A system for detecting stenosis in a patient. The system includes an implantable sensing unit having a turbulence sensor and a communication device for transmitting a signal from the turbulence sensor. The system also includes a cardiac sensor for generating a signal corresponding to cardiac activity and a processing device configured to receive signals from the sensing unit and from the cardiac sensor. The processing device is configured to determine a time window corresponding to cardiac activity, to determine a turbulence level from the turbulence signal within the time window, and to detect the presence of stenosis from the turbulence level.
摘要翻译：一种用于检测患者狭窄的系统。该系统包括具有湍流传感器的可植入感测单元和用于从湍流传感器发送信号的通信装置。该系统还包括用于产生对应于心脏活动的信号的心脏传感器和被配置为从感测单元和心脏传感器接收信号的处理装置。处理装置被配置为确定对应于心脏活动的时间窗口，以确定在时间窗口内的湍流信号的湍流水平，并且从湍流水平检测狭窄的存在。

10. 发明申请

US20060282000A1 Ischemia detection using a heart sound sensor 有权
标题翻译：使用心脏声音传感器进行缺血检测
公开(公告)号：US20060282000A1
公开(公告)日：2006-12-14
申请号：US11148107
申请日：2005-06-08
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

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