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1. 发明申请

US20080226733A1 SPATIAL ARRANGEMENT OF PARTICLES IN A DRINKING DEVICE FOR ORAL DELIVERY OF PHARMACEUTICALS 有权
标题翻译：用于口服药物输送的饮料装置中的颗粒的空间布置
公开(公告)号：US20080226733A1
公开(公告)日：2008-09-18
申请号：US12032964
申请日：2008-02-18
申请人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
发明人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
IPC分类号： A61K9/14
CPC分类号： A61K9/50 , A61K9/0095
摘要： The present invention relates to spatially arranging a plurality of particles in a device for the oral delivery of a pharmaceutical. In particular, the plurality of particles is utilized for the oral delivery of a pharmaceutical to a subject via the drinking device.
摘要翻译：本发明涉及在用于口服给药的装置中空间布置多个颗粒。特别地，多个颗粒用于通过饮用装置将药物口服递送给受试者。

2. 发明授权

US08679541B2 Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals 有权
标题翻译：用于口服药物的饮料装置中的颗粒的空间排列
公开(公告)号：US08679541B2
公开(公告)日：2014-03-25
申请号：US12032964
申请日：2008-02-18
申请人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
发明人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
IPC分类号： A61K9/14
CPC分类号： A61K9/50 , A61K9/0095
摘要： The present invention relates to spatially arranging a plurality of particles in a device for the oral delivery of a pharmaceutical. In particular, the plurality of particles is utilized for the oral delivery of a pharmaceutical to a subject via the drinking device.
摘要翻译：本发明涉及在用于口服给药的装置中空间布置多个颗粒。特别地，多个颗粒用于通过饮用装置将药物口服递送给受试者。

3. 发明申请

US20080181932A1 COMPOSITIONS FOR ORAL DELIVERY OF PHARMACEUTICALS 审中-公开
标题翻译：用于口服药物输送的组合物
公开(公告)号：US20080181932A1
公开(公告)日：2008-07-31
申请号：US12021438
申请日：2008-01-29
申请人： Jonathan David Bortz , Paul Timothy Brady , Yury Lagoviyer
发明人： Jonathan David Bortz , Paul Timothy Brady , Yury Lagoviyer
IPC分类号： A61K9/50 , A61K38/43 , A61K9/52 , A61K9/00 , A61P43/00
CPC分类号： A61K9/1676
摘要： The invention provides methods and compositions for the oral delivery of pharmaceutically active agents. In particular, the compositions generally comprise a plurality of pharmaceutically active agents embedded in a matrix that is substantially erodable when contacted with an aqueous medium. The compositions may also include an inner core comprising an inert material. The compositions may be introduced into the oral cavity of a subject by liquid beverage or food product comprising a composition of the invention.
摘要翻译：本发明提供了用于口服递送药物活性剂的方法和组合物。特别地，组合物通常包含嵌入基质中的多种药学活性剂，当与水性介质接触时，其基本上可侵蚀。组合物还可以包括包含惰性材料的内核。组合物可以通过包含本发明组合物的液体饮料或食品引入受试者的口腔。

4. 发明授权

US5997475A Device for diabetes management 失效
标题翻译：糖尿病管理设备
公开(公告)号：US5997475A
公开(公告)日：1999-12-07
申请号：US912740
申请日：1997-08-18
申请人： Jonathan David Bortz
发明人： Jonathan David Bortz
IPC分类号： A61B5/00 , G06F15/02 , G06F19/00
CPC分类号： G06F15/025 , A61B5/7475 , G06F19/323 , G06F19/3406 , G06F19/3456 , G06F19/3475 , G06F19/3481 , A61B5/14532 , Y10S128/92
摘要： A device for management of diabetes using a programmable microprocessor based unit having a display, keyboard, and memory. The keyboard is for inputting information concerning carbohydrates ingested by a user. The microprocessor is programmed to determine an amount of insulin to be used by a user based upon the carbohydrates ingested and the display is for displaying the amount of insulin to be used.
摘要翻译：一种用于使用具有显示器，键盘和存储器的基于可编程微处理器的单元管理糖尿病的装置。键盘用于输入用户摄入的碳水化合物信息。微处理器被编程为基于摄入的碳水化合物来确定用户使用的胰岛素的量，并且显示器用于显示要使用的胰岛素的量。

5. 发明申请

US20090035370A1 DOSAGE FORM AND METHOD OF USE 审中-公开
标题翻译：剂型及使用方法
公开(公告)号：US20090035370A1
公开(公告)日：2009-02-05
申请号：US12183989
申请日：2008-07-31
申请人： Jonathan David Bortz , Michael Norman Grimshaw
发明人： Jonathan David Bortz , Michael Norman Grimshaw
IPC分类号： A61K9/52 , A61K31/554 , A61K9/22 , A61P25/00
CPC分类号： A61K31/553
摘要： A method for treating a medical condition for which quetiapine is indicated in a subject comprises comprising orally administering to the subject quetiapine or a pharmaceutically acceptable salt thereof in a daily dosage amount effective to treat said condition; wherein the quetiapine or salt thereof is administered in one to a plurality of dosage forms collectively comprising (a) a major quetiapine component in immediate-release form in a sedative effective amount, administered not earlier than about 3 hours prior to the start of a sleep period; and (b) either (i) a minor quetiapine component in extended-release, delayed extended-release or delayed pulsed-release form, wherein time of administration and release properties of the minor component provide substantial onset of release of quetiapine therefrom not earlier than about 6 hours after the start of the sleep period, or (ii) a plurality of minor quetiapine components in immediate-release form, administered sequentially during a waking period following the sleep period but not earlier than about 6 hours after the start of the sleep period; said minor component or components collectively being administered in an anxiolytic effective amount insufficient to cause an unacceptable degree of sedation. A dosage form suitable for use in such a method is also provided.
摘要翻译：用于治疗在受试者中表示喹硫平的医学状况的方法包括以有效治疗所述病症的日剂量来口服给予受试者喹硫平或其药学上可接受的盐; 其中喹硫平或其盐以一种至多种剂型的形式一起给药，包括（a）一种镇静有效量的即时释放形式的主要喹硫平组分，其不早于睡眠开始前约3小时施用期; （b）（i）延长释放，延迟释放或延迟脉冲释放形式中的次要喹硫平组分，其中次要组分的给药时间和释放特性提供了不迟于在睡眠期开始约6小时后，或（ii）多个次要的喹硫平组分，其在睡眠期后醒后期间依次施用，但不迟于睡眠开始后约6小时期; 所述次要成分或组分共同以抗焦虑有效量施用，不足以引起不可接受的镇静程度。还提供了适合用于这种方法的剂型。

6. 发明申请

US20080299189A1 CONTROLLED RELEASE DOPAMINE AGONIST COMPOSITIONS 审中-公开
标题翻译：受控释放多巴胺激动剂组合物
公开(公告)号：US20080299189A1
公开(公告)日：2008-12-04
申请号：US12126575
申请日：2008-05-23
申请人： Jonathan David Bortz , Michael Grimshaw , David F. Erkoboni
发明人： Jonathan David Bortz , Michael Grimshaw , David F. Erkoboni
IPC分类号： A61K9/52 , A61K9/24 , A61K31/428 , A61P25/16
CPC分类号： A61K31/428 , A61K9/2077 , A61K9/209 , A61K9/5084
摘要： The present invention relates to a multiphase release oral pharmaceutical formulation having a dopamine agonist as an active ingredient. The multiphase composition comprises at least two different release components. The invention relates to controlled release pharmaceutical compositions of pramipexole or a pharmaceutically acceptable salt thereof for once-daily administration.
摘要翻译：本发明涉及具有多巴胺激动剂作为活性成分的多相释放口服药物制剂。多相组合物包含至少两种不同的释放组分。本发明涉及普拉克索的控释药物组合物或其药学上可接受的盐，用于每日一次给药。

7. 发明申请

US20080299050A1 TOPICAL THERAPIES FOR ORAL MUCOSITIS AND OTHER CONDITIONS 审中-公开
标题翻译：口腔粘膜炎及其他病症的局限性治疗
公开(公告)号：US20080299050A1
公开(公告)日：2008-12-04
申请号：US11865476
申请日：2007-10-01
申请人： Jonathan David Bortz , R. Saul Levinson , Jisheng Ge , Jeremy Donald Wang
发明人： Jonathan David Bortz , R. Saul Levinson , Jisheng Ge , Jeremy Donald Wang
IPC分类号： A61K8/18 , A61K31/4166 , A61K31/485 , A61P25/04
CPC分类号： A61K31/415 , A61K31/485
摘要： A method for treating oral mucositis in a subject comprises topically administering to an oral mucosal surface of the subject phenyloin or a pharmaceutically acceptable salt thereof in an amount effective to inhibit mucosal degeneration or promote mucosal regeneration, and optionally an analgesic agent in an amount effective, in combination with the phenyloin or salt thereof, to reduce pain associated with the oral mucositis. The phenyloin or salt thereof and optionally the analgesic agent can be administered in a pharmaceutical composition comprising an excipient vehicle suitable for intraoral administration, said composition being bioadhesive to an oral mucosal surface, for example having at least one non-lipoidal internal phase and at least one lipoidal external phase that is bioadhesive to said surface.
摘要翻译：用于治疗受试者口腔粘膜炎的方法包括以有效抑制粘膜变性或促进粘膜再生的量局部给予受试者苯ylo嗪的口腔粘膜表面或其药学上可接受的盐，以及任选的止痛剂，与苯丙氨酸或其盐组合，以减少与口腔粘膜炎相关的疼痛。苯丙氨酸或其盐和任选的止痛剂可以在包含适合于口内给药的赋形剂载体的药物组合物中施用，所述组合物对口腔粘膜表面具有生物粘附性，例如具有至少一个非脂质内相，并且至少一个与所述表面生物粘附的脂质外部相。

8. 发明申请

US20130189374A1 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION 审中-公开
标题翻译：提高钢铁吸收的方法和组合物
公开(公告)号：US20130189374A1
公开(公告)日：2013-07-25
申请号：US13554243
申请日：2012-07-20
申请人： Jonathan David Bortz , Mitchell Kirschner
发明人： Jonathan David Bortz , Mitchell Kirschner
IPC分类号： A61K31/341 , A61K33/26 , A61K31/295 , A61K31/191 , A61K31/194
CPC分类号： A61K31/375 , A61K9/0053 , A61K31/19 , A61K31/191 , A61K31/194 , A61K31/295 , A61K31/341 , A61K33/26 , A61K2300/00
摘要： The present invention generally relates to methods and compositions useful in enhancing iron absorption in a patient. The methods and compositions of the present invention may be used independently to promote and/or maintain iron absorption in a patient or may be used in combination with one or more other compositions used in the treatment of one or more diseases having iron deficiency associated therewith.
摘要翻译：本发明一般涉及可用于增强患者铁吸收的方法和组合物。本发明的方法和组合物可以独立地用于促进和/或维持患者的铁吸收，或者可以与用于治疗一种或多种与其相关的缺铁的疾病中使用的一种或多种其它组合物组合使用。

9. 发明申请

US20090035385A1 COMPOSITIONS INCLUDING IRON 审中-公开
标题翻译：包括铁的组成
公开(公告)号：US20090035385A1
公开(公告)日：2009-02-05
申请号：US12195170
申请日：2008-08-20
申请人： Jonathan David Bortz
发明人： Jonathan David Bortz
IPC分类号： A61K33/42 , A61K33/26 , A61K31/295 , A61K38/16 , A61P3/02
CPC分类号： A61K33/26 , A61K31/19 , A61K31/375 , Y02A50/411 , A61K2300/00
摘要： Compositions and methods for prevent, stabilize, reverse or treat disorders related to iron deficiency in a human or other animal. In a first embodiment, the composition includes about 10 mg to about 500 mg of one or more forms of iron, wherein at least one form of iron is an aspartic acid-glycine chelate of iron; and about 5 mg to about 500 mg of one or more forms of an organic acid. In another embodiment, the composition includes about 50 to about 150 mg of one or more forms of iron, wherein at least one form of iron is an aspartic acid-glycine chelate of iron; about 50 to about 250 mg of one or more forms of an organic acid; about 150 to about 250 mg of one or more forms of ascorbic acid; about 0.5 mg to about 1.5 mg vitamin B12; about 50 to about 150 mg intrinsic factor; and about 0.5 mg to about 1.5 mg folic acid.
摘要翻译：用于预防，稳定，逆转或治疗与人类或其他动物中的铁缺乏有关的疾病的组合物和方法。在第一个实施方案中，组合物包含约10mg至约500mg的一种或多种形式的铁，其中至少一种形式的铁是铁的天冬氨酸 - 甘氨酸螯合物; 和约5mg至约500mg的一种或多种形式的有机酸。在另一个实施方案中，组合物包含约50至约150mg的一种或多种形式的铁，其中至少一种形式的铁是铁的天冬氨酸 - 甘氨酸螯合物; 约50至约250mg的一种或多种形式的有机酸; 约150至约250mg的一种或多种形式的抗坏血酸; 约0.5mg至约1.5mg维生素B12; 约50至约150毫克内在因素; 和约0.5mg至约1.5mg叶酸。

10. 发明申请

US20080193531A1 COMPOSITIONS FOR IMPROVING GASTROINTESTINAL NUTRIENT AND DRUG ABSORPTION 审中-公开
标题翻译：改善胃肠营养和药物吸收的组合物
公开(公告)号：US20080193531A1
公开(公告)日：2008-08-14
申请号：US12027538
申请日：2008-02-07
申请人： Marc S. Hermelin , Jonathan David Bortz , R. Saul Levinson
发明人： Marc S. Hermelin , Jonathan David Bortz , R. Saul Levinson
IPC分类号： A61K9/28 , A61K33/06 , A61K33/26 , A61K31/56
CPC分类号： A61K45/06 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/56 , A61K33/06 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61K33/42 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions and methods for improving the absorption of nutrients and/or drugs in the gastrointestinal tract of a subject. Typically, the pharmaceutical compositions comprise a first agent that increases the pH of the stomach, and one or more agents selected from a pH lowering agent, a vitamin, a mineral, and a drug.
摘要翻译：本发明提供用于改善受试者胃肠道中营养物质和/或药物吸收的药物组合物和方法。通常，药物组合物包含增加胃的pH的第一药剂和选自pH降低剂，维生素，矿物质和药物的一种或多种药物。

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