专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090035370A1 DOSAGE FORM AND METHOD OF USE 审中-公开
标题翻译：剂型及使用方法
公开(公告)号：US20090035370A1
公开(公告)日：2009-02-05
申请号：US12183989
申请日：2008-07-31
申请人： Jonathan David Bortz , Michael Norman Grimshaw
发明人： Jonathan David Bortz , Michael Norman Grimshaw
IPC分类号： A61K9/52 , A61K31/554 , A61K9/22 , A61P25/00
CPC分类号： A61K31/553
摘要： A method for treating a medical condition for which quetiapine is indicated in a subject comprises comprising orally administering to the subject quetiapine or a pharmaceutically acceptable salt thereof in a daily dosage amount effective to treat said condition; wherein the quetiapine or salt thereof is administered in one to a plurality of dosage forms collectively comprising (a) a major quetiapine component in immediate-release form in a sedative effective amount, administered not earlier than about 3 hours prior to the start of a sleep period; and (b) either (i) a minor quetiapine component in extended-release, delayed extended-release or delayed pulsed-release form, wherein time of administration and release properties of the minor component provide substantial onset of release of quetiapine therefrom not earlier than about 6 hours after the start of the sleep period, or (ii) a plurality of minor quetiapine components in immediate-release form, administered sequentially during a waking period following the sleep period but not earlier than about 6 hours after the start of the sleep period; said minor component or components collectively being administered in an anxiolytic effective amount insufficient to cause an unacceptable degree of sedation. A dosage form suitable for use in such a method is also provided.
摘要翻译：用于治疗在受试者中表示喹硫平的医学状况的方法包括以有效治疗所述病症的日剂量来口服给予受试者喹硫平或其药学上可接受的盐; 其中喹硫平或其盐以一种至多种剂型的形式一起给药，包括（a）一种镇静有效量的即时释放形式的主要喹硫平组分，其不早于睡眠开始前约3小时施用期; （b）（i）延长释放，延迟释放或延迟脉冲释放形式中的次要喹硫平组分，其中次要组分的给药时间和释放特性提供了不迟于在睡眠期开始约6小时后，或（ii）多个次要的喹硫平组分，其在睡眠期后醒后期间依次施用，但不迟于睡眠开始后约6小时期; 所述次要成分或组分共同以抗焦虑有效量施用，不足以引起不可接受的镇静程度。还提供了适合用于这种方法的剂型。

IPRDB

热门服务

关于我们

友情链接

联系方式