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1. 发明申请

US20080226733A1 SPATIAL ARRANGEMENT OF PARTICLES IN A DRINKING DEVICE FOR ORAL DELIVERY OF PHARMACEUTICALS 有权
标题翻译：用于口服药物输送的饮料装置中的颗粒的空间布置
公开(公告)号：US20080226733A1
公开(公告)日：2008-09-18
申请号：US12032964
申请日：2008-02-18
申请人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
发明人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
IPC分类号： A61K9/14
CPC分类号： A61K9/50 , A61K9/0095
摘要： The present invention relates to spatially arranging a plurality of particles in a device for the oral delivery of a pharmaceutical. In particular, the plurality of particles is utilized for the oral delivery of a pharmaceutical to a subject via the drinking device.
摘要翻译：本发明涉及在用于口服给药的装置中空间布置多个颗粒。特别地，多个颗粒用于通过饮用装置将药物口服递送给受试者。

2. 发明授权

US06465010B1 Means for creating a mass having structural integrity 有权
标题翻译：用于创造具有结构完整性的物体的方法
公开(公告)号：US06465010B1
公开(公告)日：2002-10-15
申请号：US09902751
申请日：2001-07-12
申请人： Yury Lagoviyer , R. Saul Levinson , Denis Stotler , Thomas C. Riley
发明人： Yury Lagoviyer , R. Saul Levinson , Denis Stotler , Thomas C. Riley
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/1623 , A61K9/1658 , A61K9/2081 , Y10S514/96 , Y10S514/961
摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.
摘要翻译：本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。本发明具有多种不同的用途和应用。一个实施方案是用于口服给药的片剂。片剂包含至少一种活性成分和赋形剂混合物。赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。片剂主要用于口服给药，并在水的存在下溶解。还公开了制备用于或不使用水的快速崩解片剂的方法。该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。

3. 发明授权

US06284270B1 Means for creating a mass having structural integrity 失效
标题翻译：用于创造具有结构完整性的物体的方法
公开(公告)号：US06284270B1
公开(公告)日：2001-09-04
申请号：US09366686
申请日：1999-08-04
申请人： Yury Lagoviyer , R. Saul Levinson , Denis Stotler , Thomas C. Riley
发明人： Yury Lagoviyer , R. Saul Levinson , Denis Stotler , Thomas C. Riley
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/1623 , A61K9/1658 , A61K9/2081 , Y10S514/96 , Y10S514/961
摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.
摘要翻译：本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。本发明具有多种不同的用途和应用。一个实施方案是用于口服给药的片剂。片剂包含至少一种活性成分和赋形剂混合物。赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。片剂主要用于口服给药，并在水的存在下溶解。还公开了制备用于或不使用水的快速崩解片剂的方法。该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。

4. 发明授权

US08679541B2 Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals 有权
标题翻译：用于口服药物的饮料装置中的颗粒的空间排列
公开(公告)号：US08679541B2
公开(公告)日：2014-03-25
申请号：US12032964
申请日：2008-02-18
申请人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
发明人： Jonathan David Bortz , Yury Lagoviyer , Paul Timothy Brady
IPC分类号： A61K9/14
CPC分类号： A61K9/50 , A61K9/0095
摘要： The present invention relates to spatially arranging a plurality of particles in a device for the oral delivery of a pharmaceutical. In particular, the plurality of particles is utilized for the oral delivery of a pharmaceutical to a subject via the drinking device.
摘要翻译：本发明涉及在用于口服给药的装置中空间布置多个颗粒。特别地，多个颗粒用于通过饮用装置将药物口服递送给受试者。

5. 发明申请

US20080181932A1 COMPOSITIONS FOR ORAL DELIVERY OF PHARMACEUTICALS 审中-公开
标题翻译：用于口服药物输送的组合物
公开(公告)号：US20080181932A1
公开(公告)日：2008-07-31
申请号：US12021438
申请日：2008-01-29
申请人： Jonathan David Bortz , Paul Timothy Brady , Yury Lagoviyer
发明人： Jonathan David Bortz , Paul Timothy Brady , Yury Lagoviyer
IPC分类号： A61K9/50 , A61K38/43 , A61K9/52 , A61K9/00 , A61P43/00
CPC分类号： A61K9/1676
摘要： The invention provides methods and compositions for the oral delivery of pharmaceutically active agents. In particular, the compositions generally comprise a plurality of pharmaceutically active agents embedded in a matrix that is substantially erodable when contacted with an aqueous medium. The compositions may also include an inner core comprising an inert material. The compositions may be introduced into the oral cavity of a subject by liquid beverage or food product comprising a composition of the invention.
摘要翻译：本发明提供了用于口服递送药物活性剂的方法和组合物。特别地，组合物通常包含嵌入基质中的多种药学活性剂，当与水性介质接触时，其基本上可侵蚀。组合物还可以包括包含惰性材料的内核。组合物可以通过包含本发明组合物的液体饮料或食品引入受试者的口腔。

6. 发明申请

US20060008527A1 Controlled phase composition technology as an improved process for protection of drugs 审中-公开
标题翻译：控制相组成技术作为药物保护的改进方法
公开(公告)号：US20060008527A1
公开(公告)日：2006-01-12
申请号：US11177762
申请日：2005-07-08
申请人： Yury Lagoviyer , Syed Ali , Gerard Moskowitz
发明人： Yury Lagoviyer , Syed Ali , Gerard Moskowitz
IPC分类号： A61K9/24
CPC分类号： A61K31/137 , A61K9/0053 , A61K9/5015 , A61K9/5073 , A61K31/19 , A61K31/485 , A61K31/52 , A61K31/60
摘要： The present invention relates to novel processes and compositions for protecting drugs, especially water soluble drugs in aqueous environments. More specifically, this process entails coating drugs with a controlled phase composition wax/lipid middle layer for controlling migration of the drug toward the composition's surface during preparation and a polymeric outer layer.
摘要翻译：本发明涉及在水性环境中保护药物，特别是水溶性药物的新方法和组合物。更具体地，该方法需要用控制相组合物蜡/脂质中间层涂覆药物以控制药物在制备期间向组合物表面的迁移和聚合物外层。

7. 发明授权

US5494681A Tastemasked pharmaceutical materials 失效
标题翻译：过滤药材
公开(公告)号：US5494681A
公开(公告)日：1996-02-27
申请号：US288849
申请日：1994-08-11
申请人： Robert C. Cuca , Ronald S. Harland , Thomas C. Riley, Jr. , Yury Lagoviyer , R. Saul Levinson
发明人： Robert C. Cuca , Ronald S. Harland , Thomas C. Riley, Jr. , Yury Lagoviyer , R. Saul Levinson
IPC分类号： A61K9/14 , A61K9/16 , A61K47/30 , A61K47/44
CPC分类号： A61K9/1617 , A61K9/1652
摘要： A substantially tasteless pharmaceutical delivery system, which comprises a) an active material; and b) a spatially oriented matrix comprising (i) a wax core material having a melting point within the range of about 50.degree. C. and about 200.degree. C.; and (ii) a regional hydrophobic polymer material and method for making the same.
摘要翻译：一种基本无味的药物递送系统，其包括a）活性物质; 和b）空间取向的基质，其包含（i）熔点在约50℃和约200℃范围内的蜡芯材料; 和（ii）区域疏水性聚合物材料及其制造方法。

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