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1. 发明申请

US20180264491A1 FLUID DISPENSING SYSTEM AND METHOD 审中-公开
公开(公告)号：US20180264491A1
公开(公告)日：2018-09-20
申请号：US15919779
申请日：2018-03-13
申请人： Jonas Goldowsky , Noa Schmid , Siegfried F. Graf , Helmut Knapp
发明人： Jonas Goldowsky , Noa Schmid , Siegfried F. Graf , Helmut Knapp
IPC分类号： B05B7/24 , G01F1/36 , G01F15/075 , G01F23/14
CPC分类号： B05B7/2489 , B01L3/0293 , B01L2200/0605 , B01L2200/146 , B01L2400/0487 , G01F1/36 , G01F11/284 , G01F13/006 , G01F15/0755 , G01F22/00 , G01F22/02 , G01F23/14
摘要： An apparatus and method for precisely dispensing liquid fluid from a container are disclosed. The apparatus comprises a metering unit having a gas feedthrough channel with a first end extending in a gas containing part of the chamber and a second end opposite the first end extending outside the chamber, the metering unit further comprising a flow sensing assembly configured to measure a gas pressure differential Δp and/or gas flow V{dot over ( )} within the gas feedthrough channel and to introduce or release a determined volume of gas in the chamber to dispense a controlled volume of liquid from the chamber.

2. 发明授权

US08656792B2 Pipette device having a throttle point in the pipette duct 有权
标题翻译：移液器装置在移液管中具有节流点
公开(公告)号：US08656792B2
公开(公告)日：2014-02-25
申请号：US13190686
申请日：2011-07-26
申请人： Vinzenz Kirste , Helmut Knapp , Urs Lendenmann , Noa Schmid , Tobias Seiler , Fabian Winter
发明人： Vinzenz Kirste , Helmut Knapp , Urs Lendenmann , Noa Schmid , Tobias Seiler , Fabian Winter
IPC分类号： B01L3/00
CPC分类号： B01L3/021 , B01L2200/14 , B01L2200/148 , B01L2300/14 , B01L2400/0487 , B01L2400/06
摘要： A pipette device including a metering liquid receptacle designed to be filled, at least in part, with working fluid and which has a pipette opening as a first tapering of cross-section of flow, a pressure change device which is designed to change the pressure of the working fluid in the metering liquid receptacle, and a throttle point in a pipette duct designed to be filled with working fluid as a further tapering of cross-section of flow. The throttle point is arranged fluid-mechanically between the metering liquid receptacle and the pressure change device and is dimensioned in such a way that a ratio of a flow resistance of the pipette opening for dispensed metering liquid to a flow resistance of the throttle point for working fluid, which flows through the throttle point when the metering fluid is dispensed, is less than 0.5.
摘要翻译：一种移液器装置，包括计量液体容器，其设计成至少部分地与工作流体填充，并且具有作为流动横截面的第一渐缩的移液管开口;压力改变装置，其设计成改变压力计量液体容器中的工作流体和移液管中的节流点被设计成填充有工作流体作为流动横截面的进一步渐缩。节流点在流量机械之间布置在计量液体容器和压力改变装置之间，并且其尺寸设计成使得用于分配的计量液体的移液管开口的流动阻力与用于工作的节流点的流动阻力的比率当分配计量流体时流过节流点的流体小于0.5。

3. 发明申请

US20120017704A1 PIPETTE DEVICE HAVING A THROTTLE POINT IN THE PIPETTE DUCT 有权
标题翻译：在管道管道中具有节流点的管道装置
公开(公告)号：US20120017704A1
公开(公告)日：2012-01-26
申请号：US13190686
申请日：2011-07-26
申请人： Vinzenz KIRSTE , Helmut Knapp , Urs Lendenmann , Noa Schmid , Tobias Seiler , Fabian Winter
发明人： Vinzenz KIRSTE , Helmut Knapp , Urs Lendenmann , Noa Schmid , Tobias Seiler , Fabian Winter
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01L2200/14 , B01L2200/148 , B01L2300/14 , B01L2400/0487 , B01L2400/06
摘要： Pipette device (10), at least for dispensing metering liquid by increasing the pressure of a working fluid, comprising a metering liquid receptacle (38) which is filled, at least in part, with working fluid and has a pipette opening (36) as a first tapering of cross-section of flow, through which metering liquid can be dispensed from the metering liquid receptacle (38) as a function of the pressure of the working fluid, and comprising a pressure change device (40) which is designed to change the pressure of the working fluid in the metering liquid receptacle (38), wherein the pipette device (10) comprises a throttle point (42) in a pipette duct (12) filled with working fluid during normal operation as a further tapering of cross-section of flow, said throttle point being arranged fluid-mechanically between the metering liquid receptacle (38) and the pressure change device (40) and being dimensioned in such a way that a ratio of a flow resistance (R1) of the pipette opening (36) for dispensed metering liquid to a flow resistance (R2) of the throttle point (42) for working fluid, which flows through the throttle point (42) when the metering fluid is dispensed, is less than 0.5, preferably less than 0.3, most preferably less than 0.225, the flow resistances of the respective tapering of cross-section of flow (36 or 42) being calculated under consideration of the product of the viscosity of the medium of working fluid and metering liquid associated with the respective tapering of cross-section of flow (36 or 42) and the characteristic length (lDst, lPof) of the associated tapering of cross-section of flow (36 or 42), divided by the fourth power of the characteristic dimension (dDst, dPof) of the cross-section of flow of the associated tapering of cross-section of flow (36 or 42).
摘要翻译：吸液装置（10）至少用于通过增加工作流体的压力来分配计量液体，包括计量液体容器（38），其至少部分地与工作流体填充，并且具有吸管开口（36）作为流动的横截面的第一渐缩，通过该流量可以从计量液体容器（38）中分配计量液体，作为工作流体的压力的函数，并且包括压力改变装置（40），其被设计成改变所述计量液体容器（38）中的所述工作流体的压力，其中所述移液管装置（10）包括在正常操作期间填充有工作流体的移液管（12）中的节流点（42）所述节流点在所述计量液体容器（38）和所述压力变化装置（40）之间以机械方式布置，并且尺寸设计成使得所述移液管开口的流动阻力（R1） 36）for dis 当计量流体分配时，通过节流点（42）流动的工作流体的节流点（42）的流动阻力（R2）小于0.5，优选小于0.3，最优选小于0.3 考虑到工作流体和计量液体的介质的粘度与相应的横截面逐渐变细的关系，计算流量（36或42）横截面相应渐缩的流动阻力流量（36或42）和流量（36或42）相关的锥形截面的特征长度（lDst，lPof）除以横截面的特征尺寸（dDst，dPof）的第四功率流动横截面的流动（36或42）的流动。

4. 发明授权

US08091405B2 Device and method for calibrating a pipette or a dispensing system 有权
标题翻译：用于校准移液器或分配系统的装置和方法
公开(公告)号：US08091405B2
公开(公告)日：2012-01-10
申请号：US11900543
申请日：2007-09-12
申请人： Noa Schmid , Janko Auerswald , Thomas Stöckli , Helmut Knapp
发明人： Noa Schmid , Janko Auerswald , Thomas Stöckli , Helmut Knapp
IPC分类号： G01F19/00
CPC分类号： B01L3/021 , B01L3/5027 , B01L99/00 , B01L2200/148 , B01L2300/028 , G01F25/0092
摘要： The present invention relates to a device (1) for calibrating a pipette or a dispensing system comprising a plate (2), said plate (2) comprising at least one channel (3) with a loading port (4) for receiving a test volume of a fluid at one end of the at least one channel and an opening (5) at the other end of the at least one channel, wherein the at least one channel (3) is constructed as a capillary. Furthermore, the invention relates to a method for calibrating a pipette or a dispensing system, comprising the steps of introducing a first volume of a fluid into a loading port (4) of a device (1), recording a first length of the fluid column in a channel (3) of the device (1), introducing a second volume of a fluid from the pipette or the dispensing system to be calibrated to the same loading port (4), recording a second length of the fluid column in the channel (3), and computing the volume dispensed by the pipette or the dispensing system by calculating the distance between the second length and the first length and multiplying said distance with the cross-section of the channel (3).
摘要翻译：本发明涉及一种用于校准移液管的装置（1）或包括板（2）的分配系统，所述板（2）包括至少一个通道（3），其具有装载端口（4），用于接收测试体积在所述至少一个通道的一端处的流体和在所述至少一个通道的另一端的开口（5），其中所述至少一个通道（3）构造为毛细管。此外，本发明涉及一种用于校准移液管或分配系统的方法，包括以下步骤：将第一体积的流体引入装置（1）的装载口（4），记录第一长度的流体柱在装置（1）的通道（3）中，将来自移液管或待校准的分配系统的第二体积的流体引入相同的装载口（4），将流体柱的第二长度记录在通道（3），并且通过计算第二长度和第一长度之间的距离并将所述距离与通道（3）的横截面相乘来计算由移液管或分配系统分配的体积。

5. 发明授权

US07788981B2 Pressure measurement device and system, and method for manufacturing and using the same 有权
标题翻译：压力测量装置和系统及其制造和使用方法
公开(公告)号：US07788981B2
公开(公告)日：2010-09-07
申请号：US12075864
申请日：2008-03-14
申请人： Noa Schmid , Helmut Knapp , Janko Auerswald , Christian Andreas Bosshard , Mark Fretz , Anne-Claire Pliska
发明人： Noa Schmid , Helmut Knapp , Janko Auerswald , Christian Andreas Bosshard , Mark Fretz , Anne-Claire Pliska
IPC分类号： G01L9/06
CPC分类号： G01L15/00 , G01M9/06
摘要： The present invention discloses a pressure measurement device comprising: a substrate that includes at least one pressure sensing module and at least one fluid-conductive channel, wherein each channel has a first aperture and a second aperture. The substrate is flexible such that the pressure measurement device is conformably adjustable onto an object's surface. The first aperture is located on the substrate such that when the substrate is suitably adjusted onto the object's surface, the first aperture is open to the exterior of the object's surface. The pressure sensors module is operatively connected to at least one of the second apertures, such that the at least one pressure sensing module is generally being subjected to the pressure being present at the first aperture.
摘要翻译：本发明公开了一种压力测量装置，包括：衬底，其包括至少一个压力感测模块和至少一个流体导电通道，其中每个通道具有第一孔和第二孔。衬底是柔性的，使得压力测量装置可以一致地调节到物体的表面上。第一孔位于衬底上，使得当衬底适当地调节到物体的表面上时，第一孔径向物体表面的外部敞开。压力传感器模块可操作地连接到至少一个第二孔，使得至少一个压力感测模块通常被承受存在于第一孔处的压力。

6. 发明授权

US08940541B2 Device, system and method for storing and sorting cellular samples 有权
标题翻译：用于存储和分类细胞样品的装置，系统和方法
公开(公告)号：US08940541B2
公开(公告)日：2015-01-27
申请号：US12554078
申请日：2009-09-04
申请人： Siegfried Graf , Helmut Knapp , Noa Schmid
发明人： Siegfried Graf , Helmut Knapp , Noa Schmid
IPC分类号： C12Q1/02 , C12Q1/00 , C12M1/00 , G01N35/08 , G01N15/14
CPC分类号： G01N15/14 , G01N15/1404 , G01N15/147 , G01N35/08 , G01N2015/1006 , G01N2015/1081 , G01N2015/149 , Y10T436/143333
摘要： The present invention discloses a sample sorter system adapted to receive and sort samples according to predetermined criteria. The sample sorter system comprises a receptacle that is adapted to receive and retain fluid and samples. The receptacle is operatively coupled with a drive and with a power source such that actuation of the drive causes the rotation of at least one circular component, which in turn causes the development of a flow regime in the receptacle such that the samples suspended in the fluid are conveyable along a closed path to at least one sample handling site that are positioned along said closed path.
摘要翻译：本发明公开了一种适于根据预定标准接收和分类样品的样品分选机系统。样品分拣机系统包括适于接收和保留流体和样品的容器。容器与驱动器和动力源可操作地联接，使得驱动器的致动导致至少一个圆形部件的旋转，这反过来导致容器中的流动状态的发展，使得悬浮在流体中的样品沿着封闭的路径可输送到沿着所述封闭路径定位的至少一个样品处理位置。

7. 发明申请

US20080223141A1 Pressure measurement device and system, and method for manufacturing and using the same 有权
标题翻译：压力测量装置和系统及其制造和使用方法
公开(公告)号：US20080223141A1
公开(公告)日：2008-09-18
申请号：US12075864
申请日：2008-03-14
申请人： Noa Schmid , Helmut Knapp , Janko Auerswald , Christian Andreas Bosshard , Mark Fretz , Anne-Claire Pliska
发明人： Noa Schmid , Helmut Knapp , Janko Auerswald , Christian Andreas Bosshard , Mark Fretz , Anne-Claire Pliska
IPC分类号： G01L9/06
CPC分类号： G01L15/00 , G01M9/06
摘要： The present invention discloses a pressure measurement device comprising: a substrate that includes at least one pressure sensing module and at least one fluid-conductive channel, wherein each channel has a first aperture and a second aperture. The substrate is flexible such that the pressure measurement device is conformably adjustable onto an object's surface. The first aperture is located on the substrate such that when the substrate is suitably adjusted onto the object's surface, the first aperture is open to the exterior of the object's surface. The pressure sensors module is operatively connected to at least one of the second apertures, such that the at least one pressure sensing module is generally being subjected to the pressure being present at the first aperture.
摘要翻译：本发明公开了一种压力测量装置，包括：衬底，其包括至少一个压力感测模块和至少一个流体导电通道，其中每个通道具有第一孔和第二孔。衬底是柔性的，使得压力测量装置可以一致地调节到物体的表面上。第一孔位于衬底上，使得当衬底适当地调节到物体的表面上时，第一孔径向物体表面的外部敞开。压力传感器模块可操作地连接到至少一个第二孔，使得至少一个压力感测模块通常被承受存在于第一孔处的压力。

8. 发明申请

US20080066523A1 Device and method for calibrating a pipette or a dispensing system 有权
标题翻译：用于校准移液器或分配系统的装置和方法
公开(公告)号：US20080066523A1
公开(公告)日：2008-03-20
申请号：US11900543
申请日：2007-09-12
申请人： Noa Schmid , Janko Auerswald , Thomas Stockli , Helmut Knapp
发明人： Noa Schmid , Janko Auerswald , Thomas Stockli , Helmut Knapp
IPC分类号： G01F25/00
CPC分类号： B01L3/021 , B01L3/5027 , B01L99/00 , B01L2200/148 , B01L2300/028 , G01F25/0092
摘要： The present invention relates to a device (1) for calibrating a pipette or a dispensing system comprising a plate (2), said plate (2) comprising at least one channel (3) with a loading port (4) for receiving a test volume of a fluid at one end of the at least one channel and an opening (5) at the other end of the at least one channel, wherein the at least one channel (3) is constructed as a capillary. Furthermore, the invention relates to a method for calibrating a pipette or a dispensing system, comprising the steps of introducing a first volume of a fluid into a loading port (4) of a device (1), recording a first length of the fluid column in a channel (3) of the device (1), introducing a second volume of a fluid from the pipette or the dispensing system to be calibrated to the same loading port (4), recording a second length of the fluid column in the channel (3), and computing the volume dispensed by the pipette or the dispensing system by calculating the distance between the second length and the first length and multiplying said distance with the cross-section of the channel (3).
摘要翻译：本发明涉及一种用于校准移液管的装置（1）或包括板（2）的分配系统，所述板（2）包括至少一个通道（3），其具有装载端口（4），用于接收测试体积在所述至少一个通道的一端处的流体和在所述至少一个通道的另一端的开口（5），其中所述至少一个通道（3）构造为毛细管。此外，本发明涉及一种用于校准移液管或分配系统的方法，包括以下步骤：将第一体积的流体引入装置（1）的装载口（4），记录第一长度的流体柱在装置（1）的通道（3）中，将来自移液管或待校准的分配系统的第二体积的流体引入相同的装载口（4），将流体柱的第二长度记录在通道（3），并且通过计算第二长度和第一长度之间的距离并将所述距离与通道（3）的横截面相乘来计算由移液管或分配系统分配的体积。

9. 发明申请

US20110003326A1 MICROINJECTION APPARATUS AND METHOD 有权
标题翻译：微型装置和方法
公开(公告)号：US20110003326A1
公开(公告)日：2011-01-06
申请号：US12864349
申请日：2009-01-22
申请人： Siegfried Graf , Helmut Knapp
发明人： Siegfried Graf , Helmut Knapp
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： C12M23/50 , C12M35/00
摘要： The present invention discloses a microinjection apparatus (100) for microinjection of substances into individual substances comprising at least one carrier (120, 130) on which at least one sample is immobilizable. In embodiments, the apparatus comprises at drivable support (110) on which at least one carrier is positioned, wherein the support drives the at least one carrier in a closed loop to a respective plurality of stations along the loop. The plurality of stations constitutes at least one sample-substance-providing station (141), at least one sample-substance microinjection station (142) and at least one sample-extraction station (143).
摘要翻译：本发明公开了一种用于将物质显微注射到单个物质中的显微注射装置（100），其包括至少一个载体（120,130），至少一个样品在其上是可固定的。在实施例中，该装置包括在其上定位有至少一个载体的可驱动支撑件（110）处，其中所述支撑件将所述至少一个载体以闭环方式驱动到沿着所述环路的相应多个站。多个站构成至少一个样本物质提供站（141），至少一个样本物质显微注射站（142）和至少一个取样提取站（143）。

10. 发明申请

US20060102482A1 Fluidic system 审中-公开
标题翻译：流体系统
公开(公告)号：US20060102482A1
公开(公告)日：2006-05-18
申请号：US10527389
申请日：2003-09-11
申请人： Janko Auerswald , Helmut Knapp
发明人： Janko Auerswald , Helmut Knapp
IPC分类号： B03C5/02
CPC分类号： G01N33/54346 , B03C5/026 , G01N33/5438
摘要： A fluidic system for analysing biomolecules in solution comprises a microchannel (21) having a inlet port (22) and an outlet port (23) across which extends a set of interdigitated electrodes (24) to which an AC voltage source having a voltage of 0-20V and a frequency of 100 Hz to 20 MHz. A fluid flow (25) through the microchannel (21) carries functionalised microbeads (26) and by applying the appropriate AC voltage and frequency to the electrodes (24) the microbeads (26) can be retained at the site of the electrodes (24) to form a packed bed (27). The packed bed (27) of microbeads is then subsequently perfused with a sample containing the analyte (28) specifically bound by the ligand immobilised on the microbeads. The analyte is separated and concentrated by the packed microbeads and can be detected directly or indirectly by further perfusion of labelled reagent molecules.
摘要翻译：用于分析溶液中的生物分子的流体系统包括具有入口端口（22）和出口（23）的微通道（21），跨过这些通道延伸一组交叉电极（24），AC电压源的电压为0 -20V，频率为100Hz至20MHz。通过微通道（21）的流体流（25）承载功能化微珠（26），并通过向电极（24）施加适当的交流电压和频率，微珠（26）可以保持在电极（24）的位置，以形成填充床（27）。然后随后用含有固定在微珠上的配体特异性结合的分析物（28）的样品灌注微珠的填充床（27）。分析物被包装的微珠分离和浓缩，并且可以通过进一步灌注标记的试剂分子直接或间接检测。

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