专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07741453B2 Long lasting fusion peptide inhibitors for HIV infection 失效
标题翻译：持久的融合肽抑制剂用于HIV感染
公开(公告)号：US07741453B2
公开(公告)日：2010-06-22
申请号：US10478811
申请日：2002-05-31
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
IPC分类号： C08H1/00
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

2. 发明申请

US20110166061A1 LONG LASTING FUSION PEPTIDE INHIBITORS FOR HIV INFECTION 审中-公开
标题翻译：长激素融合蛋白抑制剂艾滋病毒感染
公开(公告)号：US20110166061A1
公开(公告)日：2011-07-07
申请号：US12767646
申请日：2010-04-26
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
IPC分类号： A61K38/16 , C07K14/00 , A61P31/18
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

3. 发明授权

US07087373B2 Methods for determining plasma free drug concentration by direct measurement of binding affinity of protease inhibitors to plasma proteins 失效
公开(公告)号：US07087373B2
公开(公告)日：2006-08-08
申请号：US10161613
申请日：2002-06-05
申请人： Dong Xie , Wei Cao , John W. Erickson
发明人： Dong Xie , Wei Cao , John W. Erickson
IPC分类号： C12Q1/37 , G01N33/53 , G01N33/48
CPC分类号： G01N33/566 , C12Q1/18 , G01N33/94 , G01N2500/02
摘要： Methods for isothermal titration calorimetry analysis of the binding affinity of protease inhibitors to plasma proteins. A method that can quantitatively calculate free drug concentrations of protease inhibitors in human plasma, as well as a method to calculate therapeutic amounts and dosage regimens. Furthermore, the present invention provides a method that can calculate the effect of plasma proteins on the antiviral activity (EC50 values) of protease inhibitors from their binding affinities to plasma proteins. The present invention provides as well a method that can evaluate the in vivo anti-HIV efficacy of PIs in human plasma.

4. 发明授权

US07157495B2 Hexahydrofuro[2,3-B]furan-3-YL-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor 有权
标题翻译：六氢呋喃并[2,3-B]呋喃-3-基）-N- {3 - [（1,3-苯并间二氧杂环戊烯-5-基磺酰基）（异丁基）氨基] -1-苄基-2-羟丙基}氨基甲酸酯作为逆转录病毒蛋白酶抑制剂
公开(公告)号：US07157495B2
公开(公告)日：2007-01-02
申请号：US10606342
申请日：2003-06-25
申请人： Guangyang Wang , Michael Eissenstat , John W. Erickson , Piet T. B. P. Wigerinck
发明人： Guangyang Wang , Michael Eissenstat , John W. Erickson , Piet T. B. P. Wigerinck
IPC分类号： A61K31/35
CPC分类号： C07D493/04
摘要： Compositions comprising bis-tetrahydrofuran benzodioxyolyl sulfonamide compounds that are surprisingly effective protease inhibitors and a second antiretroviral compound are disclosed. Methods of inhibiting retrovirus proteases, in particular multi-drug resistant retrovirus proteases, methods of treating or preventing infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication are also disclosed.
摘要翻译：公开了包含令人惊讶的有效蛋白酶抑制剂和第二抗逆转录病毒化合物的双 - 四氢呋喃苯并二氧基甲硅烷基磺酰胺化合物的组合物。还公开了抑制逆转录病毒蛋白酶，特别是多药耐药逆转录病毒蛋白酶的方法，治疗或预防哺乳动物中与逆转录病毒感染相关的感染或疾病的方法，以及抑制病毒复制的方法。

5. 发明授权

US07151163B2 Antiviral agents for the treatment, control and prevention of infections by coronaviruses 有权
标题翻译：用于治疗，控制和预防冠状病毒感染的抗病毒剂
公开(公告)号：US07151163B2
公开(公告)日：2006-12-19
申请号：US10833304
申请日：2004-04-28
申请人： John W. Erickson , Abelardo Silva
发明人： John W. Erickson , Abelardo Silva
IPC分类号： C07K14/165 , C07K17/00 , A61K39/215 , A61K39/385
CPC分类号： C07K14/005 , A61K38/162 , C12N2770/20022
摘要： The invention provides compositions and methods that are useful for preventing and treating a coronavirus infection in a subject. More specifically, the invention provides peptides and conjugates and pharmaceutical compositions containing those peptides and conjugates that block fusion of a coronavirus, such as the SARS virus, to a target cell. This blocking mechanism prevents or treats a coronavirus infection, such as a SARS infection, in a subject, such as a human subject.
摘要翻译：本发明提供可用于预防和治疗受试者冠状病毒感染的组合物和方法。更具体地，本发明提供了含有阻断冠状病毒例如SARS病毒融合的那些肽和缀合物的肽和缀合物和药物组合物与靶细胞。这种阻断机制防止或治疗诸如人受试者的受试者中的冠状病毒感染，例如SARS感染。

6. 发明授权

US07132420B2 Aspartic protease inhibitors 有权
标题翻译：天冬氨酸蛋白酶抑制剂
公开(公告)号：US07132420B2
公开(公告)日：2006-11-07
申请号：US10458873
申请日：2003-06-11
申请人： Ramnarayan S. Randad , John W. Erickson , Michael A. Eissenstat , Lucyna Lubkowska
发明人： Ramnarayan S. Randad , John W. Erickson , Michael A. Eissenstat , Lucyna Lubkowska
IPC分类号： A61K31/5375 , A61K31/505 , C07D413/12 , C07D239/04
CPC分类号： C07D207/27 , C07C235/20 , C07C235/50 , C07C237/34 , C07C271/20 , C07C271/22 , C07C311/29 , C07D211/60 , C07D213/30 , C07D215/48 , C07D239/10 , C07D277/24 , C07D295/215 , C07D307/20 , C07D405/12 , C07D417/12
摘要： The present invention provides an aspartic proteinase-inhibiting compound of the formula: wherein a, b, c, d, and e, can be the same or different and each are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen, wherein R7 and R8 are independently H or an alkyl. Substituents R1 or R2 are each H or an alkyl. Substituent R3 is a straight chain or branched alkyl, alkenyl, or alkynyl substituent, or is a cycloalkyl. Substituent A is OH, NH2, or SH. Further provided are pharmaceutical compositions, which include a therapeutically effective amount of at least one of the foregoing compounds, and therapeutic methods of using the foregoing compounds.
摘要翻译：本发明提供了下式的天冬氨酸蛋白酶抑制化合物：其中a，b，c，d和e可以相同或不同，分别为R 7，或7 7，7号，7号，8号，7号，7号，7号， CN，NO 2，NH 2，N 3，或卤素，其中R 1，R 2， R 7和R 8独立地是H或烷基。取代基R 1或R 2各自为H或烷基。取代基R 3是直链或支链烷基，烯基或炔基取代基，或是环烷基。取代基A是OH，NH 2或SH。还提供药物组合物，其包括治疗有效量的至少一种前述化合物，以及使用前述化合物的治疗方法。

7. 发明授权

US06613764B1 Aspartic protease inhibitors 有权
标题翻译：天冬氨酸蛋白酶抑制剂
公开(公告)号：US06613764B1
公开(公告)日：2003-09-02
申请号：US09868775
申请日：2001-09-28
申请人： Ramnarayan S. Randad , John W. Erickson , Michael A. Eissenstat , Lucyna Lubkowska
发明人： Ramnarayan S. Randad , John W. Erickson , Michael A. Eissenstat , Lucyna Lubkowska
IPC分类号： A61K315377
CPC分类号： C07D207/27 , C07C235/20 , C07C235/50 , C07C237/34 , C07C271/20 , C07C271/22 , C07C311/29 , C07D211/60 , C07D213/30 , C07D215/48 , C07D239/10 , C07D277/24 , C07D295/215 , C07D307/20 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound of formula (I) wherein a, b, c, d, and e, are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen. R7 and R8 are H or alkyl, R1 and R2 are H or alkyl, and R3 is a non-aromatic substituent. Substituent A is OH, NH2, or SH. Substituents B and B1 include amide and sulfonamide groups, which can be cyclic, acyclic, or amino acid derivatives. Alternatively, B and R′ together with the nitrogen to which they are bonded, and/or B′ and R2 together with the nitrogen to which they are bonded, define a heterocycle. The present invention further provides a pharmaceutical composition that includes a carrier and a therapeutically effective amount of at least one compound of the present invention. The present invention further provides therapeutic methods that include administering a therapeutically effective amount of at least one compound of the present invention
摘要翻译：本发明提供式（I）化合物，其中a，b，c，d和e分别是R 7，OR 7，SR 7，NR 7 R 8，NHCOR 7，CO 2 R 7，CN，NO 2，NH 2，N 3或卤素。 R 7和R 8是H或烷基，R 1和R 2是H或烷基，R 3是非芳族取代基。取代基A是OH，NH 2或SH。取代基B和B1包括酰胺和磺酰胺基团，其可以是环状，非环状或氨基酸衍生物。或者，B和R'与它们所键合的氮一起，和/或B'和R 2与它们所键合的氮一起定义杂环。本发明还提供了包含载体和治疗有效量的至少一种本发明化合物的药物组合物。本发明进一步提供治疗方法，其包括施用治疗有效量的至少一种本发明化合物

8. 发明授权

US5763464A Retroviral agents containing anthranilamide, substituted benzamide and other subunits, and methods of using same 失效
标题翻译：含有邻氨基苯甲酰胺，取代苯甲酰胺和其他亚基的逆转录病毒剂及其使用方法
公开(公告)号：US5763464A
公开(公告)日：1998-06-09
申请号：US562013
申请日：1995-11-22
申请人： Ramnarayan S. Randad , John W. Erickson , Talapadi N. Bhat
发明人： Ramnarayan S. Randad , John W. Erickson , Talapadi N. Bhat
IPC分类号： C07C235/50 , C07C235/60 , C07C237/34 , C07C271/20 , C07C271/22 , C07D213/30 , C07D213/70 , A61K31/44
CPC分类号： C07D213/30 , C07C235/50 , C07C235/60 , C07C237/34 , C07C271/20 , C07C271/22
摘要： The present invention provides novel retroviral agents containing anthranilamide, substituted benzamide, amino acid, and other subunits, a pharmaceutical composition comprising such compound, and a method of using such compounds to treat retroviral infections in mammals, specifically HIV and more specifically HIV-1 and HIV-2, in humans.
摘要翻译：本发明提供了含有邻氨基苯甲酰胺，取代苯甲酰胺，氨基酸和其他亚基的新型逆转录病毒剂，包含这种化合物的药物组合物，以及使用这些化合物治疗哺乳动物，特别是HIV和更具体地HIV-1的逆转录病毒感染的方法， HIV-2，在人类。

9. 发明授权

US5728718A 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same 失效
公开(公告)号：US5728718A
公开(公告)日：1998-03-17
申请号：US359612
申请日：1994-12-20
申请人： Ramnarayan S. Randad , John W. Erickson
发明人： Ramnarayan S. Randad , John W. Erickson
IPC分类号： G01N33/15 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/27 , A61K31/395 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P31/12 , A61P31/18 , C07C233/40 , C07C233/73 , C07C233/78 , C07C235/34 , C07C235/44 , C07C235/48 , C07C235/50 , C07C235/60 , C07C237/32 , C07C237/34 , C07C269/04 , C07C271/20 , C07C271/28 , C07C275/42 , C07C311/13 , C07C311/18 , C07C311/29 , C07D211/08 , C07D213/38 , C07D213/56 , C07D213/82 , C07D215/56 , C07D277/20 , C07D277/26 , C07D277/28 , C07D277/34 , C07D277/36 , C07D277/44 , C07D277/50 , C07D295/14 , C07D311/22 , C07D401/02
CPC分类号： C07D213/82 , C07C233/40 , C07C233/73 , C07C235/34 , C07C235/48 , C07C235/60 , C07C237/32 , C07C271/28
摘要： The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such compounds to treat retroviral, specifically HIV and more specifically HIV-1 and HIV-2, infections in mammals, particularly humans, a method of synthesizing asymmetric DAD isosteres comprising benzamide, sulfonamide and anthranilamide subunits, and a method of using such compounds to assay new compounds for antiretroviral activity.

10. 发明授权

US4591024A Lube oil ring pump 失效
标题翻译：润滑油环泵
公开(公告)号：US4591024A
公开(公告)日：1986-05-27
申请号：US591210
申请日：1984-03-19
申请人： John W. Erickson
发明人： John W. Erickson
IPC分类号： F04B19/10 , F16N7/22 , F01M9/06
CPC分类号： F16N7/22
摘要： A lubrication system for moveable machine parts within a housing have a sump containing a fluid and a rotatable shaft comprising a ring eccentrically encircling and being frictionally rotated by shaft, ring being at least partially immersed in sump fluid to carry fluid during rotation for machine parts, a plurality of fluid carrying fins attached to ring to increase the fluid carrying capacity of ring, fins commencing from each outer edge and extending partially inwardly along the ring width towards each other thereby forming an annular space between fins and ring, conduit means having an inlet located within annular space for receiving fluid carried in annular space and delivering fluid to moveable machine parts, and first and second abutments attach to shaft, one on each side of ring and spaced from ring sufficiently to form an axial gap for a fluid film which transmits rotational power from abutments to ring.
摘要翻译：用于壳体内的可移动机器部件的润滑系统具有容纳流体的贮槽和可旋转轴，其包括偏心环绕的环，并且通过轴摩擦地旋转，环至少部分地浸没在贮槽流体中以在机器部件的旋转期间承载流体，附接到环上的多个流体承载翅片以增加环的流体承载能力，从每个外边缘开始并沿着环宽度朝向彼此部分地向内延伸，从而在翅片和环之间形成环形空间，导管装置具有入口位于环形空间内，用于接收携带在环形空间中的流体并且将流体输送到可移动的机器部件，并且第一和第二邻接件附接到轴，一个在环的每一侧上并与环隔开，以形成用于流体膜的轴向间隙，从基座到环的旋转动力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式