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1. 发明申请

US20110166061A1 LONG LASTING FUSION PEPTIDE INHIBITORS FOR HIV INFECTION 审中-公开
标题翻译：长激素融合蛋白抑制剂艾滋病毒感染
公开(公告)号：US20110166061A1
公开(公告)日：2011-07-07
申请号：US12767646
申请日：2010-04-26
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
IPC分类号： A61K38/16 , C07K14/00 , A61P31/18
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

2. 发明授权

US07741453B2 Long lasting fusion peptide inhibitors for HIV infection 失效
标题翻译：持久的融合肽抑制剂用于HIV感染
公开(公告)号：US07741453B2
公开(公告)日：2010-06-22
申请号：US10478811
申请日：2002-05-31
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
IPC分类号： C08H1/00
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

3. 发明申请

US20050065075A1 Long lasting fusion peptide inhibitors for hiv infection 失效
标题翻译：持久的融合肽抑制剂用于HIV感染
公开(公告)号：US20050065075A1
公开(公告)日：2005-03-24
申请号：US10478811
申请日：2002-05-31
申请人： John Erickson , Dominique Bridon , Martin Robitaille , Grant Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
发明人： John Erickson , Dominique Bridon , Martin Robitaille , Grant Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
IPC分类号： A61K47/48 , A61K38/00 , A61P31/14 , A61P31/18 , C07K1/113 , C07K14/00 , C07K14/16 , A61K38/16 , C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

4. 发明授权

US08985832B2 Quick installation multifunctional display 有权
标题翻译：快速安装多功能显示屏
公开(公告)号：US08985832B2
公开(公告)日：2015-03-24
申请号：US13814937
申请日：2012-06-01
申请人： Jun Liang , Wenying Yong , Zhan Liang
发明人： Jun Liang , Wenying Yong , Zhan Liang
IPC分类号： G09F13/04 , F21V21/005 , H05K5/02 , G09F9/302
CPC分类号： H05K5/0208 , G09F9/3026
摘要： The invention relates to a quick installation multifunctional display comprising at least two display units, connecting pieces for connecting the display units together; said display unit comprises a frame formed by four side walls, and through-holes are formed in the side walls of the frame, said connecting pieces connect the display units together by the through-holes in the side walls of the frame. The quick installation multifunctional display of the present invention could be formed by connecting the display units together through the connecting pieces, which makes the installation very convenient; furthermore, the workload and time for installation of the quick installation multifunctional display could be decreased, which lowers the installation costs.
摘要翻译：本发明涉及一种快速安装多功能显示器，其包括至少两个显示单元，用于将显示单元连接在一起的连接件; 所述显示单元包括由四个侧壁形成的框架，并且在框架的侧壁中形成通孔，所述连接件通过框架的侧壁中的通孔将显示单元连接在一起。本发明的快速安装多功能显示器可以通过连接件将显示单元连接在一起形成，这使得安装非常方便; 此外，可以减少安装快速安装多功能显示器的工作量和时间，这降低了安装成本。

5. 发明授权

US08835434B2 Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors 有权
标题翻译：羟基化的嘧啶基环戊烷作为蛋白激酶抑制剂
公开(公告)号：US08835434B2
公开(公告)日：2014-09-16
申请号：US12811957
申请日：2009-01-09
申请人： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith Lee Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
发明人： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith Lee Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
IPC分类号： A61K31/517 , C07D403/04 , A61P35/00 , A61P25/28 , A61P9/00 , A61P29/00 , A61P15/00 , C07D239/70
CPC分类号： C07D239/70
摘要： The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供包含式（I）的化合物，包括其药学上可接受的盐：还提供使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

6. 发明授权

US08828215B2 Process for producing a coating on the surface of a substrate based on lightweight metals by plasma-electrolytic oxidation 有权
标题翻译：通过等离子体电解氧化在基于轻质金属的基板表面上生产涂层的方法
公开(公告)号：US08828215B2
公开(公告)日：2014-09-09
申请号：US13438418
申请日：2012-04-03
申请人： Carsten Blawert , Daniel Hoche , Yuanding Huang , Jun Liang
发明人： Carsten Blawert , Daniel Hoche , Yuanding Huang , Jun Liang
IPC分类号： C25D11/00 , C25D9/00 , C25D15/00 , C25D11/02 , C25D11/34 , C25D11/30 , C25D11/06
CPC分类号： C25D11/026 , C25D11/06 , C25D11/30 , C25D11/34 , C25D15/00
摘要： The present invention relates to a process for producing a coating on the surface of a substrate by plasma-electrolytic oxidation. Improved corrosion protection for lightweight metals, in particular for magnesium or magnesium alloys, is achieved by the process. Furthermore, biocompatible protective layers can also be produced on these materials, with the option of controlling degradation of the substrate. The layers are amorphous. They are produced by plasma-electrolytic oxidation in which the substrate is dipped as electrode together with a counterelectrode into an electrolyte liquid and a sufficient electric potential for generating spark discharges at the surface of the substrate is applied, wherein the electrolyte comprises clay particles dispersed therein. Substrates can therefore be any machine components, automobile components, railroad components, aircraft components, ships' components, etc., or bioimplants such as bone replacement materials or medical bone screws made of a lightweight metal such as magnesium or a magnesium alloy.
摘要翻译：本发明涉及通过等离子体电解氧化在基板的表面上制造涂层的方法。通过该过程可以实现轻金属，特别是镁或镁合金的改进的防腐蚀保护。此外，还可以在这些材料上产生生物相容的保护层，并且可以选择控制底物的降解。这些层是无定形的。它们是通过等离子体 - 电解氧化制备的，其中将基底作为电极与反电极一起浸入电解质液体中，并且施加足够的电位以在基底表面产生火花放电，其中电解质包括分散在其中的粘土颗粒。因此，底物可以是任何机械部件，汽车部件，铁路部件，飞机部件，船舶部件等，或诸如骨替代材料或由诸如镁或镁合金的轻质金属制成的医用骨螺钉的生物体。

7. 发明授权

US08486950B2 Janus kinase inhibitor compounds and methods 失效
标题翻译： Janus激酶抑制剂化合物和方法
公开(公告)号：US08486950B2
公开(公告)日：2013-07-16
申请号：US12813142
申请日：2010-06-10
申请人： Simon Charles Goodacre , Yingjie Lai , Jun Liang , Steven R. Magnuson , Kirk D. Robarge , Mark S. Stanley , Vickie Hsiao-Wei Tsui , Karen Williams , Birong Zhang , Aihe Zhou
发明人： Simon Charles Goodacre , Yingjie Lai , Jun Liang , Steven R. Magnuson , Kirk D. Robarge , Mark S. Stanley , Vickie Hsiao-Wei Tsui , Karen Williams , Birong Zhang , Aihe Zhou
IPC分类号： C07D401/12 , C07D213/75 , A61K31/4439
CPC分类号： C07D213/75 , C07D401/12
摘要： The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and methods of use thereof.
摘要翻译：本发明提供式I化合物，其立体异构体或其药学上可接受的盐，其中A，B，D，R 1，R 2，R 4和R 5在本文中定义，药物组合物包括式I化合物及其使用方法。

8. 发明申请

US20120261266A1 Process for Producing A Coating On The Surface Of A Substrate Based On Lightweight Metals By Plasma-electrolytic Oxidation 有权
标题翻译：通过等离子体电解氧化在基于轻质金属的基板表面上生产涂层的方法
公开(公告)号：US20120261266A1
公开(公告)日：2012-10-18
申请号：US13438418
申请日：2012-04-03
申请人： Carsten Blawert , Daniel Hoche , Yuanding Huang , Jun Liang
发明人： Carsten Blawert , Daniel Hoche , Yuanding Huang , Jun Liang
IPC分类号： C25D9/04 , C25D7/00
CPC分类号： C25D11/026 , C25D11/06 , C25D11/30 , C25D11/34 , C25D15/00
摘要： The present invention relates to a process for producing a coating on the surface of a substrate by plasma-electrolytic oxidation. Improved corrosion protection for lightweight metals, in particular for magnesium or magnesium alloys, is achieved by the process. Furthermore, biocompatible protective layers can also be produced on these materials, with the option of controlling degradation of the substrate. The layers are amorphous. They are produced by plasma-electrolytic oxidation in which the substrate is dipped as electrode together with a counterelectrode into an electrolyte liquid and a sufficient electric potential for generating spark discharges at the surface of the substrate is applied, wherein the electrolyte comprises clay particles dispersed therein. Substrates can therefore be any machine components, automobile components, railroad components, aircraft components, ships' components, etc., or bioimplants such as bone replacement materials or medical bone screws made of a lightweight metal such as magnesium or a magnesium alloy.
摘要翻译：本发明涉及通过等离子体电解氧化在基板的表面上制造涂层的方法。通过该过程可以实现轻金属，特别是镁或镁合金的改进的防腐蚀保护。此外，还可以在这些材料上产生生物相容的保护层，并且可以选择控制底物的降解。这些层是无定形的。它们是通过等离子体 - 电解氧化制造的，其中将基底作为电极与反电极一起浸入电解液中，并且施加足够的电位以在基底表面产生火花放电，其中电解质包括分散在其中的粘土颗粒。因此，底物可以是任何机械部件，汽车部件，铁路部件，飞机部件，船舶部件等，或诸如骨替代材料或由诸如镁或镁合金的轻质金属制成的医用骨螺钉的生物体。

9. 发明申请

US20100292244A1 HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR 有权
标题翻译：羟丙基吡咯烷酮作为AKT蛋白激酶抑制剂
公开(公告)号：US20100292244A1
公开(公告)日：2010-11-18
申请号：US12811983
申请日：2009-01-09
申请人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mtchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
发明人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mtchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
IPC分类号： A61K31/517 , C07D403/04 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00 , A61P17/00 , A61P15/02
CPC分类号： C07D239/70
摘要： The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供了包含式I的化合物及其药学上可接受的盐。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

10. 发明申请

US20080058327A1 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 有权
标题翻译：作为AKT蛋白激酶抑制剂的PYRIMIDYL CYCLOPENTANES
公开(公告)号：US20080058327A1
公开(公告)日：2008-03-06
申请号：US11773946
申请日：2007-07-05
申请人： Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
发明人： Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
IPC分类号： A61K31/517 , A61K31/535 , A61P43/00 , C07D211/00 , C07D239/70
CPC分类号： C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

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