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1. 发明授权

US07741453B2 Long lasting fusion peptide inhibitors for HIV infection 失效
标题翻译：持久的融合肽抑制剂用于HIV感染
公开(公告)号：US07741453B2
公开(公告)日：2010-06-22
申请号：US10478811
申请日：2002-05-31
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
IPC分类号： C08H1/00
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

2. 发明申请

US20110166061A1 LONG LASTING FUSION PEPTIDE INHIBITORS FOR HIV INFECTION 审中-公开
标题翻译：长激素融合蛋白抑制剂艾滋病毒感染
公开(公告)号：US20110166061A1
公开(公告)日：2011-07-07
申请号：US12767646
申请日：2010-04-26
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
IPC分类号： A61K38/16 , C07K14/00 , A61P31/18
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

3. 发明申请

US20050065075A1 Long lasting fusion peptide inhibitors for hiv infection 失效
标题翻译：持久的融合肽抑制剂用于HIV感染
公开(公告)号：US20050065075A1
公开(公告)日：2005-03-24
申请号：US10478811
申请日：2002-05-31
申请人： John Erickson , Dominique Bridon , Martin Robitaille , Grant Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
发明人： John Erickson , Dominique Bridon , Martin Robitaille , Grant Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
IPC分类号： A61K47/48 , A61K38/00 , A61P31/14 , A61P31/18 , C07K1/113 , C07K14/00 , C07K14/16 , A61K38/16 , C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的C34肽衍生物。特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物的治疗各自病毒感染的作用。

4. 发明授权

US07087373B2 Methods for determining plasma free drug concentration by direct measurement of binding affinity of protease inhibitors to plasma proteins 失效
公开(公告)号：US07087373B2
公开(公告)日：2006-08-08
申请号：US10161613
申请日：2002-06-05
申请人： Dong Xie , Wei Cao , John W. Erickson
发明人： Dong Xie , Wei Cao , John W. Erickson
IPC分类号： C12Q1/37 , G01N33/53 , G01N33/48
CPC分类号： G01N33/566 , C12Q1/18 , G01N33/94 , G01N2500/02
摘要： Methods for isothermal titration calorimetry analysis of the binding affinity of protease inhibitors to plasma proteins. A method that can quantitatively calculate free drug concentrations of protease inhibitors in human plasma, as well as a method to calculate therapeutic amounts and dosage regimens. Furthermore, the present invention provides a method that can calculate the effect of plasma proteins on the antiviral activity (EC50 values) of protease inhibitors from their binding affinities to plasma proteins. The present invention provides as well a method that can evaluate the in vivo anti-HIV efficacy of PIs in human plasma.

5. 发明授权

US08121288B2 Encrypting and decrypting a data stream 有权
标题翻译：加密和解密数据流
公开(公告)号：US08121288B2
公开(公告)日：2012-02-21
申请号：US12250144
申请日：2008-10-13
申请人： Dong Xie , Rong Yan , Jian Zhang
发明人： Dong Xie , Rong Yan , Jian Zhang
IPC分类号： H04K1/04 , H04L9/00 , H04L9/32 , G06F11/30
CPC分类号： H04N21/44055 , H04L9/0637 , H04L9/088 , H04L29/06027 , H04L65/607 , H04N7/1675 , H04N21/23476
摘要： The present invention provides methods, systems and apparatus for encrypting and for decrypting a data stream, for securely sending a data stream and for securely receiving a data stream, and for secure transmission of a data stream. The data stream, after at least a part of it being encrypted, is transmitted from a sender to a receiver via a channel. An exemplary method for encrypting comprises: adjusting encryption attributes during transmission; encrypting the data stream according to the adjusted encryption attributes; and transmitting the encrypted data stream and information of the encryption attributes to the receiver.
摘要翻译：本发明提供了用于加密和解密数据流的方法，系统和装置，用于安全地发送数据流和用于安全地接收数据流以及数据流的安全传输。数据流在其至少一部分被加密之后，经由信道从发送者发送到接收者。一种用于加密的示例性方法包括：在传输期间调整加密属性; 根据调整后的加密属性加密数据流; 并将加密的数据流和加密属性的信息发送到接收机。

6. 发明申请

US20110276737A1 METHOD AND SYSTEM FOR REORDERING THE REQUEST QUEUE OF A HARDWARE ACCELERATOR 审中-公开
标题翻译：用于重新加密硬件加速器的请求队列的方法和系统
公开(公告)号：US20110276737A1
公开(公告)日：2011-11-10
申请号：US13091511
申请日：2011-04-21
申请人： Xiaolu Mei , Dong Xie , Jun Zheng , Xiaotao Chang , Kuan Feng
发明人： Xiaolu Mei , Dong Xie , Jun Zheng , Xiaotao Chang , Kuan Feng
IPC分类号： G06F13/12
CPC分类号： G06F9/3881
摘要： The invention discloses a system and method for reordering the request queue of the hardware accelerator, wherein, the request queue stores therein a plurality of coprocessor request blocks (CRBs) to be input into the hardware accelerator. The system including: content addressable memory connected to the request queue for storing the state pointer of each CRB in the request queue at a same physical storage location in the request queue, receiving the state pointer of a new CRB in response to the new CRB asking to join in the request queue and outputting the physical storage location of a CRB in the request queue whose state pointer stored in the content addressable memory is the same as the state pointer of the new CRB; and CRB insertion module for receiving the physical storage location of a CRB in the request queue whose state pointer is the same as the state pointer of the new CRB and inputting the new CRB in the request queue and the CRB in the request queue whose state pointer is the same as the state pointer of the new CRB adjacently into the hardware accelerator in the order of entering the request queue. The system and method can improve the process efficiency of the hardware accelerator.
摘要翻译：本发明公开了一种用于对硬件加速器的请求队列进行重新排序的系统和方法，其中，请求队列中存储要输入硬件加速器的多个协处理器请求块（CRB）。该系统包括：连接到请求队列的内容寻址存储器，用于将请求队列中的每个CRB的状态指针存储在请求队列中的相同物理存储位置处，响应于新的CRB请求接收新CRB的状态指针加入请求队列并将CRB的物理存储位置输出到存储在内容可寻址存储器中的状态指针与新CRB的状态指针相同的请求队列中; CRB插入模块，用于在状态指针与新CRB的状态指针相同的接收请求队列中接收CRB的物理存储位置，并将新的CRB输入到请求队列中，并在请求队列中输入CRB，状态指针与进入硬件加速器的新CRB的状态指针按照进入请求队列的顺序相同。该系统和方法可以提高硬件加速器的处理效率。

7. 发明申请

US20110003735A1 PEPTIDE DERIVATIVE FUSION INHIBITORS OF HIV INFECTION 有权
标题翻译：艾滋病毒感染的肽衍生物融合抑制剂
公开(公告)号：US20110003735A1
公开(公告)日：2011-01-06
申请号：US12567250
申请日：2009-09-25
申请人： Dong Xie , He Jiang
发明人： Dong Xie , He Jiang
IPC分类号： A61K38/16 , C07K14/00 , C12N5/00 , A61P31/18
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K45/06 , A61K47/643 , A61K2121/00 , C07K14/162 , C12N2740/16122
摘要： This invention relates to gp41 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to gp41 derivatives having inhibiting activity against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) with enhanced duration of action for the treatment of the respective viral infections.
摘要翻译：本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的gp41肽衍生物。特别地，本发明涉及具有抑制人体免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒（SIV）的活性的gp41衍生物，其具有用于治疗各自病毒感染的作用持续时间。

8. 发明申请

US20060205002A1 Methods for determining plasma free drug concentration by direct measurement of binding affinity of protease inhibitors to plasma proteins 审中-公开
公开(公告)号：US20060205002A1
公开(公告)日：2006-09-14
申请号：US11429481
申请日：2006-05-05
申请人： Dong Xie , Wei Cao , John Erickson
发明人： Dong Xie , Wei Cao , John Erickson
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： G01N33/566 , C12Q1/18 , G01N33/94 , G01N2500/02
摘要： Methods for isothermal titration calorimetry analysis of the binding affinity of protease inhibitors to plasma proteins. A method that can quantitatively calculate free drug concentrations of protease inhibitors in human plasma, as well as a method to calculate therapeutic amounts and dosage regimens. Furthermore, the present invention provides a method that can calculate the effect of plasma proteins on the antiviral activity (EC50 values) of protease inhibitors from their binding affinities to plasma proteins. The present invention provides as well a method that can evaluate the in vivo anti-HIV efficacy of PIs in human plasma.

9. 发明授权

US08139769B2 Processing multi-key content 有权
标题翻译：处理多键内容
公开(公告)号：US08139769B2
公开(公告)日：2012-03-20
申请号：US12418938
申请日：2009-04-06
申请人： Jian Zhang , Ling Shao , Dong Xie
发明人： Jian Zhang , Ling Shao , Dong Xie
IPC分类号： H04L9/00
CPC分类号： G06F21/10
摘要： Multi-key content processing systems and methods, for processing content with at least one distribution target position. Each of the distribution target positions corresponds to an authorization key. An example method includes the steps of: encrypting said content with a content key; forming a key link based on said content key and the authorization key of said at least one distribution target position; and attaching said key link to the encrypted content.
摘要翻译：多键内容处理系统和方法，用于处理具有至少一个分发目标位置的内容。分配目标位置中的每一个对应于授权密钥。一种示例性方法包括以下步骤：用内容密钥加密所述内容; 基于所述内容密钥和所述至少一个分发目标位置的授权密钥形成密钥链路; 以及将所述密钥链接附加到加密的内容。

10. 发明授权

US07673318B2 Channel merging method for VOD system 失效
标题翻译： VOD系统的频道合并方法
公开(公告)号：US07673318B2
公开(公告)日：2010-03-02
申请号：US11924324
申请日：2007-10-25
申请人： Yun Zhang Pei , Ling Shao , Dong Xie
发明人： Yun Zhang Pei , Ling Shao , Dong Xie
IPC分类号： H04N7/173
CPC分类号： H04N21/26616 , H04N7/17336 , H04N21/2408 , H04N21/47202 , H04N21/6125
摘要： A channel merging method for a VOD system, said method comprises the steps of: in response to requests from a plurality of clients for a video program, establishing a root channel (S1) and at least one sub-channel (S11), said root channel (S1) being established according to a request from a client that makes the earliest request, each of said sub-channels (S11) being established in response to a request from a client that makes a later request; and monitoring variation of the number of the clients that are using each of said established channels, and maintaining the channel if the number of the clients using the monitored channel is not zero, and closing the channel if the number of the clients using the monitored channel becomes zero.
摘要翻译：一种用于VOD系统的信道合并方法，所述方法包括以下步骤：响应多个客户端对视频节目的请求，建立根信道（S1）和至少一个子信道（S11），所述根信道（S1）根据来自最早请求的客户端的请求被建立，每个所述子信道（S11）响应于来自客户端的稍后请求的请求被建立; 以及监视正在使用每个所述建立的信道的客户端的数量的变化，以及如果使用所监视的信道的客户端的数量不为零，则维持该信道，并且如果使用所监视的信道的客户端的数量，则关闭该信道变成零。

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