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1. 发明授权

US08545409B2 Arrangement and interface for RF ablation system with acoustic feedback 有权
标题翻译：具有声学反馈的RF消融系统的布置和接口
公开(公告)号：US08545409B2
公开(公告)日：2013-10-01
申请号：US13191690
申请日：2011-07-27
申请人： John Sliwa , Tho Hoang Nguyen , Zhenyi Ma , Stephen Morse
发明人： John Sliwa , Tho Hoang Nguyen , Zhenyi Ma , Stephen Morse
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/5223 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00738 , A61B2034/303 , A61B2090/3784
摘要： A system for ablation with acoustic feedback comprises: a catheter which includes an elongated catheter body; at least one ablation element to ablate a targeted tissue region; and a pulse-echo ultrasonic transducer arranged to emit and receive an acoustic beam along a centroid in a beam direction, at a transducer beam angle of between about 30 degrees and about 60 degrees relative to a distal direction of the longitudinal axis at a location of intersection between the longitudinal axis and the beam direction of the centroid of the acoustic beam of the ultrasonic transducer, wherein the transducer transmits and receives acoustic pulses to provide lesion information in the targeted tissue region; an ablation power subsystem; an ultrasonic transmit and receive subsystem to operate the ultrasonic transducer; a control subsystem to control operation of the ablation power subsystem and the ultrasonic transmit and receive subsystem; and a display.
摘要翻译：一种具有声反馈消融的系统包括：导管，其包括细长的导管体; 至少一个消融元件以消融靶向组织区域; 以及脉冲回波超声波换能器，被布置成沿着波束方向沿着质心发射和接收声束，相对于纵轴的远端方向以约30度至约60度之间的换能器射束角度在所述超声波换能器的声束的心轴的纵轴与所述梁的方向的交点，其中所述换能器发射和接收声脉冲以在所述目标组织区域中提供病变信息; 消融电源子系统; 超声波发射和接收子系统来操作超声波换能器; 用于控制消融电力子系统和超声波发射和接收子系统的操作的控制子系统; 和显示器。

2. 发明授权

US08628473B2 Acoustic transducer for pulse-echo monitoring and control of thermally ablative lesioning in layered and nonlayered tissues, catheter contact monitoring, tissue thickness measurement and pre-pop warning 有权
标题翻译：用于脉冲回波监测和控制层状和非层状组织中热烧蚀损伤的声学传感器，导管接触监测，组织厚度测量和弹前预警
公开(公告)号：US08628473B2
公开(公告)日：2014-01-14
申请号：US13085867
申请日：2011-04-13
申请人： John Sliwa , Zhenyi Ma , Stephen Morse
发明人： John Sliwa , Zhenyi Ma , Stephen Morse
IPC分类号： A61B8/00
CPC分类号： A61B8/12 , A61B8/085 , A61B8/0858 , A61B8/4272 , A61B8/445 , A61B8/4477 , A61B18/1492 , A61B2018/00023 , A61B2018/00577 , A61B2090/3784 , A61N7/022 , F04C2270/041
摘要： An ablation catheter with acoustic monitoring comprises an elongated catheter body; a distal member disposed adjacent a distal end and including an ablation element to ablate a biological member at a target region outside the catheter body; and one or more acoustic transducers each configured to direct an acoustic beam toward a respective target ablation region and receive reflection echoes therefrom. The distal member includes a transducer housing in which the acoustic transducers are disposed, the transducer housing including at least one transducer window which is the only portion in the distal member through which the acoustic beam passes, at least the at least one transducer window portion of the distal member being made of a material comprising at least 50% carbon by volume, the transducer window material having an acoustic impedance between that of the acoustic transducers and that of the biological member.
摘要翻译：具有声学监测的消融导管包括细长导管体; 远端构件邻近远端设置并且包括消融元件以在导管主体外部的目标区域处烧蚀生物构件; 以及一个或多个声学换能器，每个声学换能器被配置为将声束引向相应的目标消融区域并且从其接收反射回波。远端构件包括换能器壳体，声学换能器设置在其中，换能器壳体包括至少一个换能器窗口，其是声束通过的远端构件中的唯一部分，至少一个换能器窗口部分所述远端构件由包含至少50体积％碳的材料制成，所述换能器窗口材料在所述声学换能器和所述生物构件的声学阻抗之间具有声阻抗。

3. 发明授权

US08986292B2 Optical feedback RF ablator and ablator tip 有权
标题翻译：光反馈射频消融器和消音器尖端
公开(公告)号：US08986292B2
公开(公告)日：2015-03-24
申请号：US13085789
申请日：2011-04-13
申请人： John Sliwa , Stephen Morse , Zhenyi Ma
发明人： John Sliwa , Stephen Morse , Zhenyi Ma
IPC分类号： A61B18/18 , A61B18/14 , A61B5/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/4836 , A61B5/6852 , A61B2017/00061 , A61B2018/00577 , A61B2018/00642 , A61B2018/00738 , A61B2018/1472 , A61B2218/002 , A61B2562/0233 , A61B2576/00
摘要： An ablation catheter comprises an elongated catheter body; at least one ablation element disposed in a distal portion which is adjacent the distal end of the catheter body; an illumination optical element disposed in the distal portion, the illumination optical element being light-transmissive to emit light from the illumination optical element to the targeted tissue region; and a collection optical element disposed in the distal portion, the collection optical element being light-transmissive to collect one or more of returned, backscattered or newly excited light from the targeted tissue region. The illumination or excitation optical element and the collection optical element are axially spaced from one another and axially optically isolated from one another within the distal portion to substantially prevent light from traveling between the illumination optical element and the collection optical element along a path within the distal portion.
摘要翻译：消融导管包括细长的导管体; 至少一个消融元件设置在与导管主体的远端相邻的远侧部分中; 所述照明光学元件设置在所述远侧部分中，所述照明光学元件是透光的，以将光从所述照明光学元件发射到所述目标组织区域; 以及收集光学元件，其设置在所述远端部分中，所述收集光学元件是透光的，以收集来自所述目标组织区域的返回的，后向散射的或新激发的光的一种或多种。照明或激发光学元件和收集光学元件彼此轴向间隔开并且在远端部分内彼此轴向光学隔离，以基本上防止光在照明光学元件和收集光学元件之间沿着远端内的路径行进一部分。

4. 发明授权

US08777857B2 Single transducer with angular orientation for lesion feedback in ablation catheter 有权
标题翻译：单个换能器，角度取向用于消融导管中的病变反馈
公开(公告)号：US08777857B2
公开(公告)日：2014-07-15
申请号：US13086605
申请日：2011-04-14
申请人： John Sliwa , Zhenyi Ma , Stephen Morse
发明人： John Sliwa , Zhenyi Ma , Stephen Morse
IPC分类号： A61B8/00
CPC分类号： A61B8/4483 , A61B8/085 , A61B8/12 , A61B8/445 , A61B8/5223 , A61B18/1492 , A61B2017/00106 , A61B2017/003 , A61B2018/00357 , A61B2018/00738 , A61B2018/00815 , A61B2018/00982 , A61B2090/065 , A61B2090/3966 , A61B2217/007
摘要： An ablation catheter comprises: an elongated catheter body extending along a longitudinal axis; at least one ablation element disposed in a distal portion which is adjacent the distal end of the catheter body to ablate a targeted tissue region outside the catheter body; a single pulse-echo ultrasonic transducer disposed in the distal portion and arranged to emit and receive an acoustic beam along a centroid in a beam direction, at a transducer angle of about 30-60 degrees relative to a distal direction of the longitudinal axis at a location of intersection between the longitudinal axis and the beam direction of the centroid of the acoustic beam; and a mechanism to manipulate the distal portion in movement including rotation of at least the distal portion around the longitudinal axis. The single ultrasonic transducer emits and receives acoustic pulses to provide lesion information in the targeted tissue region being ablated.
摘要翻译：消融导管包括：沿着纵向轴线延伸的细长导管主体; 至少一个消融元件设置在远侧部分中，所述远端部分邻近所述导管主体的远端以烧蚀所述导管主体外部的目标组织区域; 单脉冲回波超声波换能器，其设置在远端部分中，并布置成沿着波束方向沿着心形发射和接收声束，所述声束相对于纵向轴线的远端方向以约30-60度的换能器角度纵轴与声束重心的波束方向的交点位置; 以及用于操纵所述远端部分的运动的机构，包括至少所述远侧部分围绕所述纵向轴线的旋转。单个超声换能器发射和接收声脉冲以在被烧蚀的目标组织区域中提供病变信息。

5. 发明授权

US08545408B2 Combination catheter for forward and side lesioning with acoustic lesion feedback capability 有权
标题翻译：组合导管用于正面和侧面损伤，具有声学病变反馈能力
公开(公告)号：US08545408B2
公开(公告)日：2013-10-01
申请号：US13113170
申请日：2011-05-23
申请人： John Sliwa , Zhenyi Ma , Stephen Morse
发明人： John Sliwa , Zhenyi Ma , Stephen Morse
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/4461 , A61B8/461 , A61B8/5223 , A61B8/5284 , A61B18/02 , A61B18/06 , A61B18/1206 , A61B18/1492 , A61B18/24 , A61B2018/00202 , A61B2018/00208 , A61B2018/00357 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00648 , A61B2018/00738 , A61B2018/00779 , A61B2018/00863 , A61B2018/00886 , A61B2018/1807 , A61B2018/1861 , A61B2090/067 , A61B2218/002
摘要： An ablation system comprises a catheter including a pulse-echo ultrasonic transducer disposed in a distal portion and arranged to emit and receive an acoustic beam. The transducer emits and receives acoustic pulses to provide transducer detected information regarding the targeted tissue region being ablated. A rotation mechanism rotates at least the distal portion around a longitudinal axis of the catheter. A control and interface system processes the transducer detected information and provides feedback to a user via a user interface and/or the control and interface system to be used to control ablation. The transducer detected information includes a detected lesion depth along a beam emanation direction. The control and interface system includes a lesion depth correction module which converts the detected lesion depth along the beam direction to a corrected lesion depth in a normal direction which is perpendicular to the tissue surface in contact with the ablation element.
摘要翻译：消融系统包括导管，其包括设置在远端部分中并被布置成发射和接收声束的脉冲回波超声换能器。换能器发射并接收声脉冲以提供关于被消融的目标组织区域的换能器检测信息。旋转机构至少围绕导管的纵向轴线旋转远端部分。控制和接口系统处理换能器检测信息，并通过用于控制消融的用户接口和/或控制和接口系统向用户提供反馈。换能器检测信息包括沿着束发射方向的检测到的病变深度。控制和界面系统包括病变深度校正模块，其将检测到的沿着束方向的病变深度转换成垂直于与消融元件接触的组织表面的正常方向的校正病变深度。

6. 发明授权

US08382689B2 Device and method for high intensity focused ultrasound ablation with acoustic lens 有权
标题翻译：声透镜高强度聚焦超声消融的装置和方法
公开(公告)号：US08382689B2
公开(公告)日：2013-02-26
申请号：US11703783
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61H1/00
CPC分类号： A61N7/02 , A61N2007/0056 , A61N2007/006 , A61N2007/0078
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

7. 发明授权

US08102734B2 High intensity focused ultrasound transducer with acoustic lens 有权
标题翻译：高强度聚焦超声波换能器与声透镜
公开(公告)号：US08102734B2
公开(公告)日：2012-01-24
申请号：US11703784
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B17/2251
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

8. 发明申请

US20080194967A1 High intensity focused ultrasound transducer with acoustic lens 有权
标题翻译：高强度聚焦超声波换能器与声透镜
公开(公告)号：US20080194967A1
公开(公告)日：2008-08-14
申请号：US11703784
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B17/2251
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

9. 发明申请

US20080194965A1 Device and method for high intensity focused ultrasound ablation with acoustic lens 有权
标题翻译：声透镜高强度聚焦超声消融的装置和方法
公开(公告)号：US20080194965A1
公开(公告)日：2008-08-14
申请号：US11703783
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B17/00
CPC分类号： A61N7/02 , A61N2007/0056 , A61N2007/006 , A61N2007/0078
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

10. 发明申请

US20050245918A1 Methods and devices for ablation 审中-公开
公开(公告)号：US20050245918A1
公开(公告)日：2005-11-03
申请号：US11058108
申请日：2005-02-15
申请人： John Sliwa , Matthias Vaska , Jonathan Podmore , Gary Miller , Scott Anderson , Gerard Champsaur , John Crowe , Stephen Morse
发明人： John Sliwa , Matthias Vaska , Jonathan Podmore , Gary Miller , Scott Anderson , Gerard Champsaur , John Crowe , Stephen Morse
IPC分类号： A61B5/042 , A61B17/00 , A61B17/22 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/14 , A61B19/00 , A61N1/06 , A61N1/362 , A61N7/00 , A61N7/02
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

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