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1. 发明授权

US08382689B2 Device and method for high intensity focused ultrasound ablation with acoustic lens 有权
标题翻译：声透镜高强度聚焦超声消融的装置和方法
公开(公告)号：US08382689B2
公开(公告)日：2013-02-26
申请号：US11703783
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61H1/00
CPC分类号： A61N7/02 , A61N2007/0056 , A61N2007/006 , A61N2007/0078
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

2. 发明授权

US08102734B2 High intensity focused ultrasound transducer with acoustic lens 有权
标题翻译：高强度聚焦超声波换能器与声透镜
公开(公告)号：US08102734B2
公开(公告)日：2012-01-24
申请号：US11703784
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B17/2251
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

3. 发明申请

US20080194967A1 High intensity focused ultrasound transducer with acoustic lens 有权
标题翻译：高强度聚焦超声波换能器与声透镜
公开(公告)号：US20080194967A1
公开(公告)日：2008-08-14
申请号：US11703784
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B17/2251
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

4. 发明授权

US06582249B1 Apparatus for contacting foil conductors, in particular of a solar module 有权
标题翻译：用于接触箔导体，特别是太阳能模块的装置
公开(公告)号：US06582249B1
公开(公告)日：2003-06-24
申请号：US09715590
申请日：2000-11-17
申请人： Werner Boeck , Klaus-Peter Goetz , Guenter Feldmeier , Heinz Scherer , Martin Szelag , Andreas Woeber
发明人： Werner Boeck , Klaus-Peter Goetz , Guenter Feldmeier , Heinz Scherer , Martin Szelag , Andreas Woeber
IPC分类号： H01R1224
CPC分类号： H01R12/62 , H01R13/5208 , H02S40/34 , Y10S439/936
摘要： An apparatus for making contact with a foil conductor, in particular of a solar module, the apparatus having a housing, a first connecting region for connecting to the foil conductor, and a second connecting region with at least one contact for connecting at least one plug connector. At least one conductor rail connects the contact to the foil conductor. The conductor rail has a contact region for detachable connection to the foil conductor. The conductor rail has a terminal area for receiving electronic modules, for example a diode or lead portions. Each conductor rail is connected to the contact of the second connecting region.
摘要翻译：一种用于与箔导体（特别是太阳能模块）接触的装置，该装置具有壳体，用于连接到箔导体的第一连接区域和具有至少一个触点的第二连接区域，用于连接至少一个插头连接器。至少一个导轨将触点连接到箔导体。导轨具有用于可拆卸地连接到箔导体的接触区域。导体导轨具有用于接收电子模块的端子区域，例如二极管或引线部分。每个导轨连接到第二连接区域的触点。

5. 发明授权

US09445211B2 Methods for manufacturing high intensity ultrasound transducers 有权
标题翻译：制造高强度超声波换能器的方法
公开(公告)号：US09445211B2
公开(公告)日：2016-09-13
申请号：US11104294
申请日：2005-04-11
申请人： Jack Sliwa , Jonathan L. Podmore , Chris Bagley , John E. Crowe , Michael Holzbaur , Derek Hillstrom , Steve Schellenberg , Peter Goetz , Stephen A. Morse
发明人： Jack Sliwa , Jonathan L. Podmore , Chris Bagley , John E. Crowe , Michael Holzbaur , Derek Hillstrom , Steve Schellenberg , Peter Goetz , Stephen A. Morse
IPC分类号： H04R31/00 , H03H3/02 , H03H3/04 , H03H3/08 , B06B1/06
CPC分类号： H03H3/04 , B06B1/06 , B23K26/351 , B23K2101/36 , G01N29/245 , H03H3/02 , H03H3/08 , H03H2003/0407 , H03H2003/045 , H04R31/00 , Y10T29/42 , Y10T29/49004 , Y10T29/49005
摘要： A method of manufacturing an ultrasound transducer is provided. The ultrasound transducer is activated and the activity across the transducer is measured to determine whether the activity at any area does not meet an acceptance criteria. The transducer is then modified so that the area meets the acceptance criteria. The transducer may be modified with a laser which removes material from the area which does not meet the acceptance criteria.
摘要翻译：提供一种制造超声换能器的方法。激活超声换能器，测量换能器的活动，以确定任何区域的活动是否不符合验收标准。然后对传感器进行修改，使得该区域满足接受标准。传感器可以用激光器进行修改，该激光器从不满足接受标准的区域去除材料。

6. 外观设计

USD609870S1 Surface cleaner 有权
标题翻译：表面清洁剂
公开(公告)号：USD609870S1
公开(公告)日：2010-02-09
申请号：US29332701
申请日：2009-02-23
申请人： Michael Joseph Hilger , Herbert John Peter Goetz , Mark S. Payne
设计人： Michael Joseph Hilger , Herbert John Peter Goetz , Mark S. Payne

7. 发明申请

US20080194965A1 Device and method for high intensity focused ultrasound ablation with acoustic lens 有权
标题翻译：声透镜高强度聚焦超声消融的装置和方法
公开(公告)号：US20080194965A1
公开(公告)日：2008-08-14
申请号：US11703783
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B17/00
CPC分类号： A61N7/02 , A61N2007/0056 , A61N2007/006 , A61N2007/0078
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

8. 发明申请

US20130019487A1 LINE MARKING ASSEMBLY 有权
标题翻译：线路标线装配
公开(公告)号：US20130019487A1
公开(公告)日：2013-01-24
申请号：US13550475
申请日：2012-07-16
申请人： Keith Gerard Fritsch , Herbert John Peter Goetz , Mark S. Payne
发明人： Keith Gerard Fritsch , Herbert John Peter Goetz , Mark S. Payne
IPC分类号： B44D3/38
CPC分类号： B44D3/38
摘要： A line marking assembly for applying a marking a straight line with a marking powder onto a surface is disclosed. The line marking assembly comprises two chambers configured to mount one on each side of a level. Each chamber contains a cord wound on a spool, marking powder and a tensioning assembly that exerts a constant and continuous pull on the cord. The cords from each of the chambers may be combined with a coupler. Moving the coupler back and forth between the chambers coats the cords with marking powder. Placing the assembly onto a surface and snapping the cord marks a straight line on the surface.
摘要翻译：公开了一种用于将具有标记粉末的直线标记施加到表面上的线标记组件。线标记组件包括被配置成在水平面的每一侧安装一个的两个室。每个室包含缠绕在卷轴上的绳索，标记粉末和张紧组件，其在绳索上施加恒定且连续的拉力。来自每个室的帘线可以与耦合器组合。在两个室之间来回移动耦合器，用标记粉末涂覆电线。将组件放置在表面上并扣住绳索在表面上标记直线。

9. 发明申请

US20060236525A1 High intensity ultrasound transducers and methods and devices for manufacturing high intensity ultrasound transducers 有权
标题翻译：高强度超声波换能器以及用于制造高强度超声换能器的方法和装置
公开(公告)号：US20060236525A1
公开(公告)日：2006-10-26
申请号：US11104294
申请日：2005-04-11
申请人： Jack Sliwa , Jonathan Podmore , Chris Bagley , John Crowe , Michael Holzbaur , Derek Hillstrom , Steve Schellenberg , Peter Goetz , Stephen Morse
发明人： Jack Sliwa , Jonathan Podmore , Chris Bagley , John Crowe , Michael Holzbaur , Derek Hillstrom , Steve Schellenberg , Peter Goetz , Stephen Morse
IPC分类号： H04R31/00
CPC分类号： H03H3/04 , B06B1/06 , B23K26/351 , B23K2101/36 , G01N29/245 , H03H3/02 , H03H3/08 , H03H2003/0407 , H03H2003/045 , H04R31/00 , Y10T29/42 , Y10T29/49004 , Y10T29/49005
摘要： A method of manufacturing an ultrasound transducer is provided. The ultrasound transducer is activated and the activity across the transducer is measured to determine whether the activity at any area does not meet an acceptance criteria. The transducer is then modified so that the area meets the acceptance criteria. The transducer may be modified with a laser which removes material from the area which does not meet the accceptance criteria.
摘要翻译：提供一种制造超声换能器的方法。激活超声换能器，测量换能器的活动，以确定任何区域的活动是否不符合验收标准。然后对传感器进行修改，使得该区域满足接受标准。传感器可以用激光器进行修改，该激光器从不符合接受标准的区域去除材料。

10. 发明申请

US20190257832A1 NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS 审中-公开
公开(公告)号：US20190257832A1
公开(公告)日：2019-08-22
申请号：US16318532
申请日：2017-07-18
申请人： Philippe ULSEMER , Steffen GOLETZ , Peter GOETZ
发明人： Philippe ULSEMER , Steffen GOLETZ , Peter GOETZ
IPC分类号： G01N33/569 , C12N1/16 , C12N1/20 , A61P1/00 , A61K35/74
摘要： The present invention relates to means and method for isolating naturally-occurring microorganisms (non-pathogenic bacteria, yeasts or fungi) capable of binding toxins from microorganisms such as bacteria, viruses, fungi, yeasts, or protozoans and/or receptors for these toxins on the surface of mammalian cells, thereby making these receptors inaccessible for said toxins. The naturally-occurring microorganisms that are obtainable by the means and methods of the present invention can be used for adsorbing toxins from pathogenic microorganisms and/or blocking receptors for such toxins on the surface of mammalian cells. These toxin-receptor interactions are known to be critical for disease pathogenesis, making both the toxins and receptors a target for the naturally-occurring microorganisms of the present invention.

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