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1. 发明授权

US11865785B2 Continuous digital light processing additive manufacturing of implants 有权
公开(公告)号：US11865785B2
公开(公告)日：2024-01-09
申请号：US15634792
申请日：2017-06-27
申请人： H. David Dean , Al Siblani , Eric J. Mott , John P. Fisher , Martha O. Wang , Antonios G. Mikos
发明人： H. David Dean , Al Siblani , Eric J. Mott , John P. Fisher , Martha O. Wang , Antonios G. Mikos
IPC分类号： A61L27/56 , B29C64/386 , A61L27/50 , B33Y30/00 , B33Y80/00 , A61L27/60 , B33Y50/00 , B33Y70/00 , G03F7/105 , G03F7/029 , G03F7/20 , G03F7/004 , B29C64/135 , G02B26/08
CPC分类号： B29C64/386 , A61L27/50 , A61L27/56 , A61L27/60 , B33Y30/00 , B33Y50/00 , B33Y70/00 , B33Y80/00 , G03F7/0047 , G03F7/029 , G03F7/105 , G03F7/2008 , B29C64/135 , G02B26/0833
摘要： A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer.

2. 发明申请

US20130304233A1 CONTINUOUS DIGITAL LIGHT PROCESSING ADDITIVE MANUFACTURING OF IMPLANTS 有权
标题翻译：连续数字加工植物的添加剂制造
公开(公告)号：US20130304233A1
公开(公告)日：2013-11-14
申请号：US13817612
申请日：2011-08-22
申请人： H. David Dean , Jonathan E. Wallace , Antonios G. Mikos , Martha Wang , Ali Siblani , Kyobum Kim , John P. Fisher
发明人： H. David Dean , Jonathan E. Wallace , Antonios G. Mikos , Martha Wang , Ali Siblani , Kyobum Kim , John P. Fisher
IPC分类号： A61L27/60
CPC分类号： B29C67/0066 , A61L27/50 , A61L27/56 , A61L27/60 , B29C64/135 , B33Y30/00 , B33Y50/00 , B33Y80/00 , G02B26/0833
摘要： A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer.
摘要翻译：可植入患者的可再吸收植入物的添加制造方法包括提供生物相容性树脂，其包括在聚合后可再吸收的液体光可聚合材料和引发剂。该方法还包括致动添加剂制造设备以将一定量的生物相容性树脂暴露于光以至少部分地固化暴露量的生物相容性树脂以形成可再吸收的植入物的层并致动添加剂制造设备以暴露至少一些附加的生物相容性树脂的量至少部分地固化暴露的额外量的生物相容性树脂以形成另外的可再吸收植入物层，并且至少部分地过度固化先前固化的层，以在先前固化的层之间至少部分层间结合附加层。

3. 发明授权

US06753358B2 Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials 有权
标题翻译：富马酸二乙酯/聚（富马酸丙烯酯）生物材料的光交联
公开(公告)号：US06753358B2
公开(公告)日：2004-06-22
申请号：US10185473
申请日：2002-06-28
申请人： John P. Fisher , Antonios G. Mikos
发明人： John P. Fisher , Antonios G. Mikos
IPC分类号： C08F250
CPC分类号： C08F22/00 , A61L27/18 , B33Y80/00 , C08L67/06
摘要： A polymer network formed by crosslinking poly(propylene fumarate) with a fumarate derivative. The fumarate derivative is one in which the PPF is soluble, is preferably an alkyl fumarate, and is more preferably selected from the group consisting of diethyl fumarate, dimethyl fumarate, methyl ethyl fumarate, diisopropyl fumarate, and dibutyl fumarate. The network can be formed by photo-crosslinking and can be porous. In some embodiments, the poly(propylene fumarate) and the fumarate derivative are each present in an amount effective to produce a polymeric network useful for in vivo applications. The network can be formed from an injectable, in situ crosslinkable composite formulation, or can be prefabricated from a crosslinkable composite formulation such as stereolithography, rapid prototyping, injection molding, and extrusion molding.
摘要翻译：通过将富马酸（富马酸）与富马酸衍生物交联而形成的聚合物网络。富马酸盐衍生物是其中PPF是可溶的，优选富马酸烷基酯，更优选选自富马酸二乙酯，富马酸二甲酯，富马酸甲酯，富马酸二异丙酯和富马酸二丁酯。网络可以通过光交联形成，并且可以是多孔的。在一些实施方案中，聚（丙烯富马酸酯）和富马酸酯衍生物各自以有效产生可用于体内应用的聚合物网络的量存在。网络可以由可注射的原位可交联的复合制剂形成，或者可以从可交联的复合制剂例如立体光刻，快速成型，注射成型和挤出成型制成。

4. 发明授权

US10183477B2 Absorbant and reflecting biocompatible dyes for highly accurate medical implants 有权
公开(公告)号：US10183477B2
公开(公告)日：2019-01-22
申请号：US14648446
申请日：2013-12-02
申请人： H. David Dean , Al Siblani , Eric J. Mott , John P. Fisher , Martha O. Wang , Antonios G. Mikos
发明人： H. David Dean , Al Siblani , Eric J. Mott , John P. Fisher , Martha O. Wang , Antonios G. Mikos
IPC分类号： B33Y50/00 , A61L27/50 , B33Y30/00 , B33Y80/00 , A61L27/56 , G02B26/08 , A61L27/60 , B29C64/135
摘要： A light-polymerizable composition for additive manufacturing of resorbable scaffolds and implants comprising a biocompatible resin. The biocompatible resin includes a combination of photo-initiators or a dye-initiator package tailored to manufacture implants with the desired physical and chemical properties. A dye or other constituent controls between layer (z) resolution of the manufactured part built in an additive manufacturing device. A light absorber or other constituent controls within layer (x-y) resolution of the manufactured part.

5. 发明授权

US09688023B2 Continuous digital light processing additive manufacturing of implants 有权
公开(公告)号：US09688023B2
公开(公告)日：2017-06-27
申请号：US13817612
申请日：2011-08-22
申请人： H. David Dean , Jonathan E. Wallace , Antonios G. Mikos , Martha Wang , Ali Siblani , Kyobum Kim , John P. Fisher
发明人： H. David Dean , Jonathan E. Wallace , Antonios G. Mikos , Martha Wang , Ali Siblani , Kyobum Kim , John P. Fisher
IPC分类号： B29C67/00 , A61L27/50 , A61L27/56 , G02B26/08 , A61L27/60
CPC分类号： B29C67/0066 , A61L27/50 , A61L27/56 , A61L27/60 , B29C64/135 , B33Y30/00 , B33Y50/00 , B33Y80/00 , G02B26/0833
摘要： A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer.

6. 发明授权

US5733951A Poly(propylene fumarate) 失效
标题翻译：聚（富马酸丙烯酯）
公开(公告)号：US5733951A
公开(公告)日：1998-03-31
申请号：US234551
申请日：1994-04-28
申请人： Michael J. Yaszemski , Richard G. Payne , Antonios G. Mikos
发明人： Michael J. Yaszemski , Richard G. Payne , Antonios G. Mikos
IPC分类号： A61L24/04 , C08G63/52 , C08G63/02 , A61F2/00 , C08K3/32
CPC分类号： C08G63/52 , A61L24/046
摘要： A novel pathway for the synthesis of poly(propylene fumarate) includes first producing bis-hydroxypropyl fumarate and then its transesterification into poly(propylene fumarate). This synthetic pathway permits production of high molecular weight poly(propylene fumarate) and enables the production of a composite material useful in orthopedic procedures.
摘要翻译：用于合成聚（富马酸丙烯酯）的新途径包括首先生产富马酸双羟丙酯，然后将其酯交换成聚（富马酸丙烯酯）。该合成途径允许生产高分子量聚（富马酸丙烯酯），并且能够生产用于矫形程序的复合材料。

7. 发明授权

US5644005A Method of making poly(propylene fumarate-coethylene oxide) 失效
标题翻译：聚（丙烯酸富马酸酯 - 环氧乙烷）的制备方法
公开(公告)号：US5644005A
公开(公告)日：1997-07-01
申请号：US637355
申请日：1996-04-24
申请人： Laura J. Suggs , Richard G. Payne , Michael J. Yaszemski , Antonios G. Mikos
发明人： Laura J. Suggs , Richard G. Payne , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： A61K47/48 , C08F283/01 , C08G63/676 , C08G81/00 , C08L71/02 , C08F20/00
CPC分类号： C08G81/00 , A61K47/48992 , C08F283/01 , C08G63/676 , C08L71/02
摘要： A biodegradable block copolymer made from the transesterfication of a poly(propylene fumarate) prepolymer and a poly(ethylene oxide) prepolymer. The block copolymer poly(propylene fumarate -co- ethylene oxide) is capable of crosslinking at body temperature. Crosslinking requires an appropriate crosslinking monomer and an initiator. The biodegradable block copolymer has utility as a vascular implant became it can be injected as a fluid into the vascular system and crosslinked in situ.
摘要翻译：由聚（丙烯富马酸酯）预聚物和聚（环氧乙烷）预聚物的酯交换制备的可生物降解的嵌段共聚物。嵌段共聚物聚（富马酸丙烯酯 - 环氧乙烷）能够在体温下交联。交联需要合适的交联单体和引发剂。可生物降解的嵌段共聚物具有作为血管植入物的效用，其可以作为流体注入血管系统并原位交联。

8. 发明授权

US5522895A Biodegradable bone templates 失效
标题翻译：可生物降解骨模板
公开(公告)号：US5522895A
公开(公告)日：1996-06-04
申请号：US96780
申请日：1993-07-23
申请人： Antonios G. Mikos
发明人： Antonios G. Mikos
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/38 , A61L27/48 , A61L27/56 , A61L27/58
CPC分类号： A61L27/3821 , A61F2/28 , A61L27/3847 , A61L27/48 , A61L27/56 , A61L27/58 , A61F2/30965 , A61F2002/30062 , A61F2002/30199 , A61F2210/0004 , A61F2230/0063
摘要： A biodegradable, bioresorbable, three-dimensional template for repair and replacement of diseased or injured bone which provides mechanical strength to bone while also providing a guide for growth of bone tissue. Preferably, the template is formed of biodegradable materials, for example, poly(L-lactic acid), poly(D, L-lactic acid), poly (D, L-lactic-co-glycolic acid), poly (glycolic acid), poly (.epsilon.-caprolactone), polyortho esters, and polyanhydrides, and has the capacity of being rendered porous, either in vitro or in vivo. A pore-forming component, which may or may not be a polymeric material, is mixed within a continuous matrix formed of a biodegradable material, the pore-forming component having a rate of degradation which exceeds that of the matrix. Differential dissolution or biodegradation provides porosity to the template.
摘要翻译：一种可生物降解的生物可吸收的三维模板，用于修复和更换患骨或受伤的骨骼，为骨骼提供机械强度，同时也为骨组织生长提供指导。优选地，模板由生物可降解材料形成，例如聚（L-乳酸），聚（D，L-乳酸），聚（D，L-乳酸 - 共 - 乙醇酸），聚（乙醇酸），聚（ε-己内酯），聚原酸酯和聚酐，并且具有在体外或体内被赋予多孔性的能力。可以是或可以不是聚合物材料的成孔组分在由可生物降解材料形成的连续基质中混合，成孔组分的降解速率超过基质的成分速率。差示溶解或生物降解为模板提供孔隙度。

9. 发明申请

US20120141543A1 Carbon Nanotube Based Nanocomposites 审中-公开
标题翻译：碳纳米管基纳米复合材料
公开(公告)号：US20120141543A1
公开(公告)日：2012-06-07
申请号：US11972886
申请日：2008-01-11
申请人： Balaji Sitharaman , Antonios G. Mikos , Lon J. Wilson , Xinfeng Shi
发明人： Balaji Sitharaman , Antonios G. Mikos , Lon J. Wilson , Xinfeng Shi
IPC分类号： A61K31/765 , A61P19/00 , A61K9/00 , B82Y5/00 , B82Y30/00
CPC分类号： B82Y40/00 , A61K9/0092 , A61K31/765 , B82Y30/00
摘要： Novel methods and compositions of nanocomposites are provided. One exemplary composition comprises a biocompatible polymer, such as polypropylene fumarate, and a carbon nanotube, such as a single walled carbon nanotube, an ultra-short carbon nanotube, or a substituted ultra-short carbon nanotube. An exemplary method comprises providing a biocompatible polymer and a carbon nanotube and combining a biocompatible polymer and a carbon nanotube to form a nanocomposite. Another exemplary method comprises providing a nanocomposite comprising a biocompatible polymer and a carbon nanotube and administering the composition to a subject.
摘要翻译：提供了纳米复合材料的新方法和组成。一种示例性组合物包括生物相容性聚合物，例如富马酸聚丙烯酯和碳纳米管，例如单壁碳纳米管，超短碳纳米管或取代的超短碳纳米管。一种示例性方法包括提供生物相容性聚合物和碳纳米管，并结合生物相容性聚合物和碳纳米管以形成纳米复合材料。另一个示例性方法包括提供包含生物相容性聚合物和碳纳米管的纳米复合材料，并将所述组合物施用于受试者。

10. 发明授权

US07462471B2 Porous biodegradable polymeric materials for cell transplantation 失效
标题翻译：用于细胞移植的多孔可生物降解聚合物材料
公开(公告)号：US07462471B2
公开(公告)日：2008-12-09
申请号：US10775768
申请日：2004-02-10
申请人： Antonios G. Mikos , Joseph P. Vacanti , Robert S. Langer , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Joseph P. Vacanti , Robert S. Langer , Linda G. Griffith , Georgios Sarakinos
IPC分类号： C12N11/08 , C12N11/04 , C12N5/00 , C12N5/06 , C12N5/08 , A61F2/00
CPC分类号： G02B27/0031 , A61L27/18 , A61L27/56 , A61L2400/06 , G03F7/40 , H01L21/0273 , H01L21/32139 , C08L67/04
摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：聚合材料用于制造一种柔韧，无毒，可注射的多孔模板，用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

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