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1. 发明授权

US08110213B2 Method of forming a tissue structure by introducing cells into an implanted matrix 失效
标题翻译：通过将细胞引入到植入的基质中形成组织结构的方法
公开(公告)号：US08110213B2
公开(公告)日：2012-02-07
申请号：US12218448
申请日：2008-07-15
申请人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
IPC分类号： A61F2/00 , C12N11/08 , C12N11/04 , C12N5/07
CPC分类号： C08J9/28 , A61F2/0077 , A61F2/18 , A61F2/186 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2/4241 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , A61L27/18 , A61L27/38 , B01D67/003 , B01D2325/02 , C08J9/26 , C08L67/04
摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：聚合材料用于制造一种柔韧，无毒，可注射的多孔模板，用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

2. 发明授权

US07462471B2 Porous biodegradable polymeric materials for cell transplantation 失效
标题翻译：用于细胞移植的多孔可生物降解聚合物材料
公开(公告)号：US07462471B2
公开(公告)日：2008-12-09
申请号：US10775768
申请日：2004-02-10
申请人： Antonios G. Mikos , Joseph P. Vacanti , Robert S. Langer , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Joseph P. Vacanti , Robert S. Langer , Linda G. Griffith , Georgios Sarakinos
IPC分类号： C12N11/08 , C12N11/04 , C12N5/00 , C12N5/06 , C12N5/08 , A61F2/00
CPC分类号： G02B27/0031 , A61L27/18 , A61L27/56 , A61L2400/06 , G03F7/40 , H01L21/0273 , H01L21/32139 , C08L67/04
摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：聚合材料用于制造一种柔韧，无毒，可注射的多孔模板，用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

3. 发明申请

US20090060969A1 Porous biodegradable polymeric materials for cell transplantation 失效
标题翻译：用于细胞移植的多孔可生物降解聚合物材料
公开(公告)号：US20090060969A1
公开(公告)日：2009-03-05
申请号：US12218448
申请日：2008-07-15
申请人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
IPC分类号： A61K9/00 , A61K35/12 , A61P17/02
CPC分类号： C08J9/28 , A61F2/0077 , A61F2/18 , A61F2/186 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2/4241 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , A61L27/18 , A61L27/38 , B01D67/003 , B01D2325/02 , C08J9/26 , C08L67/04
摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：聚合材料用于制造一种柔韧，无毒，可注射的多孔模板，用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

4. 发明授权

US06689608B1 Porous biodegradable polymeric materials for cell transplantation 失效
标题翻译：用于细胞移植的多孔可生物降解聚合物材料
公开(公告)号：US06689608B1
公开(公告)日：2004-02-10
申请号：US09669760
申请日：2000-09-26
申请人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
IPC分类号： C12N506
CPC分类号： C08J9/28 , A61F2/0077 , A61F2/18 , A61F2/186 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2/4241 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , A61L27/18 , A61L27/38 , B01D67/003 , B01D2325/02 , C08J9/26 , C08L67/04
摘要： Polymeric materials are used,to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：使用聚合材料制成柔韧，无毒，可注射的多孔模板用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

5. 发明授权

US5514378A Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures 失效
标题翻译：生物相容性聚合物膜和制备三维膜结构的方法
公开(公告)号：US5514378A
公开(公告)日：1996-05-07
申请号：US012270
申请日：1993-02-01
申请人： Antonios G. Mikos , Georgios Sarakinos , Joseph P. Vacanti , Robert S. Langer , Linda G. Cima
发明人： Antonios G. Mikos , Georgios Sarakinos , Joseph P. Vacanti , Robert S. Langer , Linda G. Cima
IPC分类号： A61F2/00 , A61F2/02 , A61F2/18 , A61F2/28 , A61F2/30 , A61F2/42 , A61L27/18 , B01D67/00 , C08J9/26 , C08J9/28 , C08J5/20
CPC分类号： C08J9/28 , A61F2/4241 , A61L27/18 , B01D67/003 , C08J9/26 , A61F2/0077 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , B01D2323/12 , B01D67/0083 , B01D71/40 , B01D71/48
摘要： Biocompatible porous polymer membranes are prepared by dispersing salt particles in a biocompatible polymer solution. The solvent in which the polymer is dissolved is evaporated to produce a polymer/salt composite membrane. The polymer can then be heated and cooled at a predetermined constant rate to provide the desired amount of crystallinity. Salt particles are leached out of the membrane by immersing the membrane in water or another solvent for the salt but not the polymer. The membrane is dried, resulting in a porous, biocompatible membrane to which dissociated cells can attach and proliferate. A three-dimensional structure can be manufactured using the polymer membranes by preparing a contour drawing of the shape of the structure, determining the dimensions of thin cross-sectional layers of the shape, forming porous polymer membranes corresponding to the dimensions of the layers, and laminating the membranes together to form a three-dimensional matrix having the desired shape.
摘要翻译：通过将盐颗粒分散在生物相容的聚合物溶液中来制备生物相容的多孔聚合物膜。溶解聚合物的溶剂被蒸发以产生聚合物/盐复合膜。然后可以以预定的恒定速率加热和冷却聚合物，以提供所需量的结晶度。通过将膜浸入水或其它溶剂中而不是聚合物将盐颗粒浸出膜外。将膜干燥，得到多孔的，生物相容的膜，离解的细胞可附着和增殖。可以通过制备结构形状的轮廓图，确定形状的薄截面层的尺寸，形成对应于层的尺寸的多孔聚合物膜，可以使用聚合物膜制造三维结构，以及将膜层压在一起以形成具有所需形状的三维矩阵。

6. 发明授权

US5696175A Preparation of bonded fiber structures for cell implantation 失效
标题翻译：用于细胞植入的粘合纤维结构的制备
公开(公告)号：US5696175A
公开(公告)日：1997-12-09
申请号：US473216
申请日：1995-06-07
申请人： Antonios G. Mikos , Robert S. Langer
发明人： Antonios G. Mikos , Robert S. Langer
IPC分类号： A61L27/34 , A61L27/38 , B29B15/12 , C12N5/00 , D04H1/42 , C08K9/00
CPC分类号： A61L27/34 , A61L27/38 , B29B15/10 , C12N5/0068 , D04H1/4266 , D04H1/43 , D04H1/4382 , C12M25/14 , C12N2533/40 , Y10T442/60
摘要： A novel processing technique is reported to bond non-woven fibers and, thus, prepare structural interconnecting fiber networks with different shapes for organ implants. The fibers are physically joined without any surface or bulk modification and have their initial diameter.
摘要翻译：据报道，一种新型的加工技术可以粘合无纺纤维，从而制备用于器官植入物的具有不同形状的结构互连纤维网络。纤维物理连接，没有任何表面或体积改性并具有其初始直径。

7. 发明授权

US5512600A Preparation of bonded fiber structures for cell implantation 失效
标题翻译：用于细胞植入的粘合纤维结构的制备
公开(公告)号：US5512600A
公开(公告)日：1996-04-30
申请号：US5910
申请日：1993-01-15
申请人： Antonios G. Mikos , Robert S. Langer
发明人： Antonios G. Mikos , Robert S. Langer
IPC分类号： A61L27/34 , A61L27/38 , B29B15/12 , C12N5/00 , D04H1/42 , C08K9/00
CPC分类号： A61L27/34 , A61L27/38 , B29B15/10 , C12N5/0068 , D04H1/4266 , D04H1/43 , D04H1/4382 , C12M25/14 , C12N2533/40 , Y10T442/60
摘要： A novel processing technique is reported to bond non-woven fibers and, thus, prepare structural interconnecting fiber networks with different shapes for organ implants. The fibers are physically joined without any surface or bulk modification and have their initial diameter.
摘要翻译：据报道，一种新型的加工技术可以粘合无纺纤维，从而制备用于器官植入物的具有不同形状的结构互连纤维网络。纤维物理连接，没有任何表面或体积改性并具有其初始直径。

8. 发明授权

US11865785B2 Continuous digital light processing additive manufacturing of implants 有权
公开(公告)号：US11865785B2
公开(公告)日：2024-01-09
申请号：US15634792
申请日：2017-06-27
申请人： H. David Dean , Al Siblani , Eric J. Mott , John P. Fisher , Martha O. Wang , Antonios G. Mikos
发明人： H. David Dean , Al Siblani , Eric J. Mott , John P. Fisher , Martha O. Wang , Antonios G. Mikos
IPC分类号： A61L27/56 , B29C64/386 , A61L27/50 , B33Y30/00 , B33Y80/00 , A61L27/60 , B33Y50/00 , B33Y70/00 , G03F7/105 , G03F7/029 , G03F7/20 , G03F7/004 , B29C64/135 , G02B26/08
CPC分类号： B29C64/386 , A61L27/50 , A61L27/56 , A61L27/60 , B33Y30/00 , B33Y50/00 , B33Y70/00 , B33Y80/00 , G03F7/0047 , G03F7/029 , G03F7/105 , G03F7/2008 , B29C64/135 , G02B26/0833
摘要： A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer.

9. 发明授权

US5733951A Poly(propylene fumarate) 失效
标题翻译：聚（富马酸丙烯酯）
公开(公告)号：US5733951A
公开(公告)日：1998-03-31
申请号：US234551
申请日：1994-04-28
申请人： Michael J. Yaszemski , Richard G. Payne , Antonios G. Mikos
发明人： Michael J. Yaszemski , Richard G. Payne , Antonios G. Mikos
IPC分类号： A61L24/04 , C08G63/52 , C08G63/02 , A61F2/00 , C08K3/32
CPC分类号： C08G63/52 , A61L24/046
摘要： A novel pathway for the synthesis of poly(propylene fumarate) includes first producing bis-hydroxypropyl fumarate and then its transesterification into poly(propylene fumarate). This synthetic pathway permits production of high molecular weight poly(propylene fumarate) and enables the production of a composite material useful in orthopedic procedures.
摘要翻译：用于合成聚（富马酸丙烯酯）的新途径包括首先生产富马酸双羟丙酯，然后将其酯交换成聚（富马酸丙烯酯）。该合成途径允许生产高分子量聚（富马酸丙烯酯），并且能够生产用于矫形程序的复合材料。

10. 发明授权

US5644005A Method of making poly(propylene fumarate-coethylene oxide) 失效
标题翻译：聚（丙烯酸富马酸酯 - 环氧乙烷）的制备方法
公开(公告)号：US5644005A
公开(公告)日：1997-07-01
申请号：US637355
申请日：1996-04-24
申请人： Laura J. Suggs , Richard G. Payne , Michael J. Yaszemski , Antonios G. Mikos
发明人： Laura J. Suggs , Richard G. Payne , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： A61K47/48 , C08F283/01 , C08G63/676 , C08G81/00 , C08L71/02 , C08F20/00
CPC分类号： C08G81/00 , A61K47/48992 , C08F283/01 , C08G63/676 , C08L71/02
摘要： A biodegradable block copolymer made from the transesterfication of a poly(propylene fumarate) prepolymer and a poly(ethylene oxide) prepolymer. The block copolymer poly(propylene fumarate -co- ethylene oxide) is capable of crosslinking at body temperature. Crosslinking requires an appropriate crosslinking monomer and an initiator. The biodegradable block copolymer has utility as a vascular implant became it can be injected as a fluid into the vascular system and crosslinked in situ.
摘要翻译：由聚（丙烯富马酸酯）预聚物和聚（环氧乙烷）预聚物的酯交换制备的可生物降解的嵌段共聚物。嵌段共聚物聚（富马酸丙烯酯 - 环氧乙烷）能够在体温下交联。交联需要合适的交联单体和引发剂。可生物降解的嵌段共聚物具有作为血管植入物的效用，其可以作为流体注入血管系统并原位交联。

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