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    • 4. 发明授权
    • Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials
    • 富马酸二乙酯/聚(富马酸丙烯酯)生物材料的光交联
    • US06753358B2
    • 2004-06-22
    • US10185473
    • 2002-06-28
    • John P. FisherAntonios G. Mikos
    • John P. FisherAntonios G. Mikos
    • C08F250
    • C08F22/00A61L27/18B33Y80/00C08L67/06
    • A polymer network formed by crosslinking poly(propylene fumarate) with a fumarate derivative. The fumarate derivative is one in which the PPF is soluble, is preferably an alkyl fumarate, and is more preferably selected from the group consisting of diethyl fumarate, dimethyl fumarate, methyl ethyl fumarate, diisopropyl fumarate, and dibutyl fumarate. The network can be formed by photo-crosslinking and can be porous. In some embodiments, the poly(propylene fumarate) and the fumarate derivative are each present in an amount effective to produce a polymeric network useful for in vivo applications. The network can be formed from an injectable, in situ crosslinkable composite formulation, or can be prefabricated from a crosslinkable composite formulation such as stereolithography, rapid prototyping, injection molding, and extrusion molding.
    • 通过将富马酸(富马酸)与富马酸衍生物交联而形成的聚合物网络。 富马酸盐衍生物是其中PPF是可溶的,优选富马酸烷基酯,更优选选自富马酸二乙酯,富马酸二甲酯,富马酸甲酯,富马酸二异丙酯和富马酸二丁酯。 网络可以通过光交联形成,并且可以是多孔的。 在一些实施方案中,聚(丙烯富马酸酯)和富马酸酯衍生物各自以有效产生可用于体内应用的聚合物网络的量存在。 网络可以由可注射的原位可交联的复合制剂形成,或者可以从可交联的复合制剂例如立体光刻,快速成型,注射成型和挤出成型制成。