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1. 发明授权

US06320051B1 Quinolones used as MRS inhibitors and bactericides 失效
标题翻译：喹诺酮用作MRS抑制剂和杀菌剂
公开(公告)号：US06320051B1
公开(公告)日：2001-11-20
申请号：US09674102
申请日：2000-10-26
申请人： John Michael Berge , Pamela Brown , John Stephen Elder , Andrew Keith Forrest , Dieter Wolfgang Hamprecht , Richard Lewis Jarvest , David Jonathan McNair , Robert John Sheppard
发明人： John Michael Berge , Pamela Brown , John Stephen Elder , Andrew Keith Forrest , Dieter Wolfgang Hamprecht , Richard Lewis Jarvest , David Jonathan McNair , Robert John Sheppard
IPC分类号： A61K3147
CPC分类号： C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Compounds of formula (I) are inhibitors of the bacterial enzyme S aureus methionyl tRNA synthetase and are of use in treating bacterial infections.
摘要翻译：式（I）化合物是细菌性金黄色葡萄球菌甲硫氨酰tRNA合成酶的抑制剂，可用于治疗细菌感染。

2. 发明申请

US20220324094A1 Sanitary Touch Stick Apparatus 有权
公开(公告)号：US20220324094A1
公开(公告)日：2022-10-13
申请号：US17224569
申请日：2021-04-07
申请人： Pamela Brown
发明人： Pamela Brown
IPC分类号： B25J1/04 , B25J19/00
摘要： A sanitary touch stick apparatus for sanitary pressing of buttons and touch screens includes a base having a base stick end, a base cap end, and a base sidewall. A sponge is coupled within the base. The sponge has a stick aperture extending from a sponge stick end through a sponge cap end. The sponge is saturated with a disinfectant solution. A cap is coupled to the base. The cap is selectively engageable with the base cap end. A handle is coupled to the base. The handle has an open handle engagement end selectively engageable with the base stick end and a sealed handle outer end. A touch stick is coupled to the handle. The touch stick protrudes from the handle engagement end and is selectively engageable within the stick aperture of the sponge.

3. 发明申请

US20110009394A1 TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：三氯化合物及其作为抗菌剂
公开(公告)号：US20110009394A1
公开(公告)日：2011-01-13
申请号：US12811386
申请日：2009-01-07
申请人： Pamela Brown , Steven Dabbs , Alan Joseph Hennessy
发明人： Pamela Brown , Steven Dabbs , Alan Joseph Hennessy
IPC分类号： A61K31/542 , C07D471/16 , C07D513/04 , C07D497/04 , C07D491/052 , C07D491/056 , A61K31/519 , A61P31/04
CPC分类号： C07D498/04 , C07D471/14 , C07D491/052 , C07D497/02
摘要： Tricyclic nitrogen containing compounds and their use as antibacterials.
摘要翻译：三环含氮化合物及其作为抗菌剂的用途。

4. 发明授权

US4410533A .beta.-Lactam antibiotics, their preparation and use 失效
标题翻译： β-内酰胺抗生素，其制备和使用
公开(公告)号：US4410533A
公开(公告)日：1983-10-18
申请号：US345485
申请日：1982-02-03
申请人： Roger J. Ponsford , Pamela Brown , Steven Coulton
发明人： Roger J. Ponsford , Pamela Brown , Steven Coulton
IPC分类号： C07D477/00 , A61K31/397 , A61K31/505 , A61P31/04 , C07D239/46 , C07D477/20 , C07F9/568 , C07D487/04
CPC分类号： C07D239/47 , C07D477/20 , C07F9/5683
摘要： The present invention provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in-vivo hydrolyzable ester thereof wherein R.sup.1 is a hydrogen atom, an .alpha.-sulphonato-oxyethyl group, an .alpha.-sulphonato-oxypropyl group or is a group CR.sup.3 R.sup.4 R.sup.5 wherein R.sup.3 is a hydrogen atom or a hydroxy group; R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl group; and R.sup.5 is a hydrogen atom or a C.sub.1-6 alkyl group, a benzyl group, a phenyl group or is joined to R.sup.4 to form together with the carbon atom to which they are joined a carbocyclic ring of 5 to 7 carbon atoms; R.sup.2 is a pyrimidinyl group substituted by one two or three groups selected from nitro, halo, amino or substituted amino, and in addition may be optionally substituted by one or two C.sub.1-6 alkyl groups as the degree of substitution permits; and x is zero or one.These compounds are antibacterial agents. Their preparation and use are described.
摘要翻译：本发明提供了式（I）化合物：其中R 1是氢原子，α-磺酰氧基乙基，α-磺酸根，或其药学上可接受的盐或体内可水解的酯或是基团CR 3 R 4 R 5，其中R 3是氢原子或羟基; R4是氢原子或C1-6烷基; R5为氢原子或C1-6烷基，苄基，苯基或与R4结合形成与碳原子数5〜7个碳环的碳原子一起形成的基团。 R2是被一个选自硝基，卤素，氨基或取代的氨基的两个或三个基团取代的嘧啶基，并且另外可任选地被一个或两个C 1-6烷基取代，作为取代许可的程度; x为0或1。这些化合物是抗菌剂。描述了它们的制备和使用。

5. 发明申请

US20100087424A1 TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：含有三聚氰胺的杂环化合物作为抗菌剂
公开(公告)号：US20100087424A1
公开(公告)日：2010-04-08
申请号：US12596691
申请日：2008-04-17
申请人： Pamela Brown , Steven Dabbs
发明人： Pamela Brown , Steven Dabbs
IPC分类号： A61K31/4745 , C07D471/06 , C07D491/056 , C07D498/16 , C07D513/04 , A61P31/04 , A61K31/5025 , A61K31/5383 , A61K31/542
CPC分类号： C07D519/00
摘要： Tricyclic nitrogen containing compounds and their use as antibacterials.
摘要翻译：三环含氮化合物及其作为抗菌剂的用途。

6. 发明申请

US20060041123A1 Antibacterial agents 审中-公开
公开(公告)号：US20060041123A1
公开(公告)日：2006-02-23
申请号：US10538931
申请日：2003-12-17
申请人： Jeffrey Axten , Gerald Brooks , Pamela Brown , David Davies , Timothy Gallagher , Roger Markwell , William Miller , Neil Pearson , Mark Seefeld
发明人： Jeffrey Axten , Gerald Brooks , Pamela Brown , David Davies , Timothy Gallagher , Roger Markwell , William Miller , Neil Pearson , Mark Seefeld
IPC分类号： C07D513/02
CPC分类号： C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D497/04 , C07D513/04
摘要： Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.

7. 发明申请

US20050020937A1 Method for detecting pathogenic agents 审中-公开
标题翻译：检测病原体的方法
公开(公告)号：US20050020937A1
公开(公告)日：2005-01-27
申请号：US10625164
申请日：2003-07-23
申请人： Eddie Reed , Barbara Ducatman , Timothy Tracy , A. Soisson , Pamela Brown
发明人： Eddie Reed , Barbara Ducatman , Timothy Tracy , A. Soisson , Pamela Brown
IPC分类号： A61B10/00 , C12Q1/68 , C12Q1/70 , G01N33/569 , G01N33/48
CPC分类号： G01N33/56983 , A61B10/0045 , A61B2010/0074 , C12Q1/6806 , C12Q1/708 , G01N2333/025
摘要： The invention provides methods and kits for collection of cervical/vaginal specimen. The specimen is collected for the purpose of detecting the presence or absence of etiological agents, e.g., bacterial or viral agents, including but not limited to human papilloma virus (HPV). The endocervical cells is not required for HPV testing or Pap smear. The methods and kits allow the self-sampling without the aid of trained medical personnel.
摘要翻译：本发明提供用于收集宫颈/阴道标本的方法和试剂盒。为了检测病原体的存在或不存在，例如细菌或病毒剂，包括但不限于人乳头状瘤病毒（HPV），收集标本。宫颈癌细胞不需要HPV检测或巴氏涂片。这些方法和试剂盒可以在经过培训的医务人员的帮助下进行自我采样。

8. 发明申请

US20100056502A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：US20100056502A1
公开(公告)日：2010-03-04
申请号：US12532639
申请日：2008-03-20
申请人： Pamela Brown , Steven Dabbs , David Thomas Davies , Neil David Pearson
发明人： Pamela Brown , Steven Dabbs , David Thomas Davies , Neil David Pearson
IPC分类号： A61K31/542 , C07D513/00 , C07D498/04 , A61K31/5365 , C07D487/00 , A61K31/5025 , C07D453/00 , A61K31/4375
CPC分类号： C07D471/06 , C07D519/00
摘要： Tricyclic nitrogen containing compounds and their use as antibacterials.
摘要翻译：三环含氮化合物及其作为抗菌剂的用途。

9. 发明申请

US20070167495A1 Pleuromutilin derivatives, process for their preparation and uses thereof 审中-公开
标题翻译： Pleuromutilin衍生物，其制备方法及其应用
公开(公告)号：US20070167495A1
公开(公告)日：2007-07-19
申请号：US10552238
申请日：2004-04-06
申请人： Pamela Brown , Eric Hunt
发明人： Pamela Brown , Eric Hunt
IPC分类号： A61K31/4412 , A61K31/22 , C07C323/06
CPC分类号： C07D213/80 , C07C323/62 , C07C2603/99
摘要： Pleuromutilin compounds of the formula: are of use in antibacterial therapy.
摘要翻译：具有下列公式的Pleuromutilin化合物：用于抗菌治疗。

10. 发明授权

US4521337A Chemical process 失效
标题翻译：化学工艺
公开(公告)号：US4521337A
公开(公告)日：1985-06-04
申请号：US475247
申请日：1983-03-14
申请人： Robert Southgate , Pamela Brown
发明人： Robert Southgate , Pamela Brown
IPC分类号： C07D507/04 , A61K31/535 , A61P31/04 , C07C29/62 , C07C31/36 , C07D265/06 , C07D265/14 , C07D265/16 , C07D498/04 , C07D507/06 , C07D507/08
CPC分类号： C07D265/14 , C07C247/00 , C07C29/62 , C07C31/36 , C07D265/06
摘要： A process for the preparation of a compound of the formulae (Ia) and/or (Ib): ##STR1## wherein R.sup.1 and R.sup.2 are independently substituted or unsubstituted hydrocarbon groups or are joined together so as to form a carbocyclic or heterocyclic ring, and R.sup.3 is a substituted or unsubstituted hydrocarbon group; which process comprises the ring-closing cyclization of a compound of the formula (II): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in relation to formulae (Ia) and (Ib).
摘要翻译：制备式（Ia）和/或（Ib）化合物的方法：其中R 1和R 2独立地是取代或未取代的烃基或连接在一起以形成碳环或杂环，以及 R3是取代或未取代的烃基; 该方法包括式（II）化合物的闭环环化：其中R 1，R 2和R 3如关于式（Ia）和（Ib）所定义）。

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