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    • 8. 再颁专利
    • Biocompatible crosslinked coating and crosslinkable coating polymer composition for forming such a coating
    • 用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物
    • USRE40816E1
    • 2009-06-30
    • US10946604
    • 1996-11-01
    • Alistair Stewart TaylorPeter William StratfordYiannakis Petrou YianniMatthew John WoodroffeLee Rowan
    • Alistair Stewart TaylorPeter William StratfordYiannakis Petrou YianniMatthew John WoodroffeLee Rowan
    • A61F2/06C08F230/02
    • B21F45/008A61F2/0077A61F2/90A61F2/95A61F2/966A61F2002/9665A61F2210/0019A61F2220/0058A61F2220/0075B21F45/00
    • A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle α between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device. The present invention provides a biocompatible crosslinked coating and a crosslinkable coating polymer composition for forming such a coating. The biocompatible crosslinked coating may be formed by curing a polymer of 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate. The crosslinkable coating polymer may include 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate.
    • <?delete-start id =“DEL-S-00001”date =“20090630”?>用于体腔内腔内植入的编织支架(1)是自膨胀的,并具有径向扩张构型,其中细丝之间的角度α 是急性的 一些或全部细丝(6,7)在支架的每个端部(4,5)处成对地焊接在一起,以提供珠(8),从而加强支架并帮助其从输送装置展开。 支架优选使用生物相容性聚合物涂层完全涂覆,所述聚合物优选具有侧链磷酰胆碱基团。 描述通过编织和焊接制造支架的方法以及用于部署装置的递送装置。<?delete-end id =“DEL-S-00001”?> <?insert-start id =“INS-S -00001“date =”20090630“?本发明提供一种用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物。 生物相容的交联涂层可以通过固化23摩尔%(甲基丙烯酰氧基乙基)-2-(三甲基铵乙基)磷酸盐内盐,47摩尔%甲基丙烯酸月桂酯,5摩尔%甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔%甲基丙烯酸羟丙酯 。 可交联涂料聚合物可以包括23摩尔%(甲基丙烯酰氧基乙基)-2-(三甲基铵乙基)磷酸盐内盐,47摩尔%甲基丙烯酸月桂酯,5摩尔%甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔%甲基丙烯酸羟丙酯。 id =“INS-S-00001”?>
    • 9. 发明授权
    • Local drug delivery
    • 当地药物递送
    • US07754272B2
    • 2010-07-13
    • US10842416
    • 2004-05-11
    • Lee RowanPeter William StratfordAlistair Stewart TaylorTerrence Albert Vick
    • Lee RowanPeter William StratfordAlistair Stewart TaylorTerrence Albert Vick
    • B05D3/02A61F2/06
    • A61L31/16A61L27/34A61L27/54A61L31/10A61L2300/416A61L2300/42A61L2300/606A61L2420/02C08L33/14
    • An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethyl-phosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
    • 具有包含聚合物基质的涂层的植入物在药物溶液中溶胀,由此将药物活性化合物吸入聚合物基质中。 当植入产物时,发生药物活性化合物从涂层的释放。 聚合物优选由包含两性离子单体,最优选2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内酯的烯属不饱和单体形成。 形成聚合物的单体可以进一步包括表面结合单体,例如含疏水基团的单体和可交联单体,其含量可用于控制溶胀性。 优选地,植入物是支架,并且外壁表面上的聚合物涂层比内表面上的聚合物涂层更厚。 可以通过选择共聚单体来控制药物的释放。 植入物适合用于心血管系统中的支架。