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1. 再颁专利

USRE40816E1 Biocompatible crosslinked coating and crosslinkable coating polymer composition for forming such a coating 失效
标题翻译：用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物
公开(公告)号：USRE40816E1
公开(公告)日：2009-06-30
申请号：US10946604
申请日：1996-11-01
申请人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe , Lee Rowan
发明人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe , Lee Rowan
IPC分类号： A61F2/06 , C08F230/02
CPC分类号： B21F45/008 , A61F2/0077 , A61F2/90 , A61F2/95 , A61F2/966 , A61F2002/9665 , A61F2210/0019 , A61F2220/0058 , A61F2220/0075 , B21F45/00
摘要： A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle α between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device. The present invention provides a biocompatible crosslinked coating and a crosslinkable coating polymer composition for forming such a coating. The biocompatible crosslinked coating may be formed by curing a polymer of 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate. The crosslinkable coating polymer may include 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate.
摘要翻译： <？delete-start id =“DEL-S-00001”date =“20090630”？>用于体腔内腔内植入的编织支架（1）是自膨胀的，并具有径向扩张构型，其中细丝之间的角度α 是急性的一些或全部细丝（6,7）在支架的每个端部（4,5）处成对地焊接在一起，以提供珠（8），从而加强支架并帮助其从输送装置展开。支架优选使用生物相容性聚合物涂层完全涂覆，所述聚合物优选具有侧链磷酰胆碱基团。描述通过编织和焊接制造支架的方法以及用于部署装置的递送装置。<？delete-end id =“DEL-S-00001”？> <？insert-start id =“INS-S -00001“date =”20090630“？本发明提供一种用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物。生物相容的交联涂层可以通过固化23摩尔％（甲基丙烯酰氧基乙基）-2-（三甲基铵乙基）磷酸盐内盐，47摩尔％甲基丙烯酸月桂酯，5摩尔％甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔％甲基丙烯酸羟丙酯。可交联涂料聚合物可以包括23摩尔％（甲基丙烯酰氧基乙基）-2-（三甲基铵乙基）磷酸盐内盐，47摩尔％甲基丙烯酸月桂酯，5摩尔％甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔％甲基丙烯酸羟丙酯。 id =“INS-S-00001”？>

2. 发明申请

US20090004335A1 Pod for Preparing a Beverage 审中-公开
标题翻译：荚准备饮料
公开(公告)号：US20090004335A1
公开(公告)日：2009-01-01
申请号：US11577631
申请日：2005-10-24
申请人： John MacMahon , Mark Norton , Adam Fennel , Satwinder Panesar , Bary Zeller , Susan Bodett , Anilkumar Gaonkar , Lee Rowan , Heather Hudson
发明人： John MacMahon , Mark Norton , Adam Fennel , Satwinder Panesar , Bary Zeller , Susan Bodett , Anilkumar Gaonkar , Lee Rowan , Heather Hudson
IPC分类号： B65D81/34 , B65D85/804 , A47J31/06
CPC分类号： B65D85/8043 , A47J31/0689 , B65D85/8046
摘要： The present invention provides a pod for preparing a beverage comprising: a lower compartment (31) defining a storage volume containing a water-soluble composition or a combination or mixture of water-soluble compositions for forming a beverage; the lower compartment comprising an upper surface (27) containing one or more apertures (25) forming an inlet of the lower compartment (31) and a lower surface formed at least partially from filtering material (12), the filtering material forming an outlet of the pod; the pod further comprising an open-topped upper compartment (21) above the lower compartment (31) which defines a chamber suitable for receiving one or more flexible pads containing one or more beverage ingredients; wherein an outlet of the chamber of the upper compartment communicates with the inlet of the lower compartment, wherein the apertures (25) of the inlet of the lower compartment are arranged for showering and or jetting in use water into the lower compartment (31).
摘要翻译：本发明提供了一种用于制备饮料的容器，包括：限定含有水溶性组合物或用于形成饮料的水溶性组合物的组合或混合物的储存体积的下隔室（31）所述下隔室包括上表面（27），所述上表面（27）包含形成所述下隔室（31）的入口的一个或多个孔（25）和至少部分地由过滤材料（12）形成的下表面，所述过滤材料形成荚所述容器还包括位于所述下隔室（31）上方的敞开的上隔室（21），所述上隔室限定适于容纳包含一种或多种饮料成分的一个或多个柔性垫的室; 其中所述上室的室的出口与所述下隔室的入口连通，其中所述下隔室的入口的孔（25）布置成用于在使用水中淋浴和/或喷射到所述下隔室（31）中。

3. 发明申请

US20080254169A1 Pad For Preparing a Beverage 审中-公开
标题翻译：准备饮料的垫
公开(公告)号：US20080254169A1
公开(公告)日：2008-10-16
申请号：US11577519
申请日：2005-10-24
申请人： John Macmahon , Mark Norton , Adam Fennel , Satwinder Panesar , Lee Rowan , Audrey Trouillot , Heather Hudson , Anilkumar Gaonkar , Bary Zeller , Phil Brown , Susan Bodett , Joseph Giacone
发明人： John Macmahon , Mark Norton , Adam Fennel , Satwinder Panesar , Lee Rowan , Audrey Trouillot , Heather Hudson , Anilkumar Gaonkar , Bary Zeller , Phil Brown , Susan Bodett , Joseph Giacone
IPC分类号： B65B29/02
CPC分类号： B65D85/8043 , B65D85/8046
摘要： A pad for preparing a beverage comprising: an upper part comprising a rigid or semi-rigid upper element containing one or more apertures forming an inlet of the pad; a flexible lower element depending from the upper part and formed at least partially from filtering material, the filtering material forming an outlet of the pad; the upper part and lower element together defining a storage volume containing a water-soluble composition or a combination or mixture of water-soluble compositions for forming a beverage, wherein the upper part comprises a flexible water-impermeable layer joined to the rigid or semi-rigid upper element.
摘要翻译：一种用于制备饮料的垫，包括：上部，包括刚性或半刚性上部元件，其包含形成所述垫的入口的一个或多个孔; 柔性下部元件，其从上部悬垂并且至少部分地由过滤材料形成，所述过滤材料形成所述焊盘的出口; 所述上部和下部元件一起限定含有水溶性组合物或用于形成饮料的水溶性组合物的组合或混合物的储存容器，其中所述上部包括连接到刚性或半固体的柔性不透水层，刚性上部元件。

4. 发明申请

US20100178391A1 FLEXIBLE PAD FOR PREPARING A BEVERAGE 审中-公开
标题翻译：用于制备饮料的柔性垫
公开(公告)号：US20100178391A1
公开(公告)日：2010-07-15
申请号：US11577078
申请日：2005-10-24
申请人： John MacMahon , Mark Norton , Phil Brown , Rodett Susan , Audrey Trouillot , ray Laudano , Adam Fennel , Satwinder Panesar , Lee Rowan , James Ferguson , Heather Hudson , Anilkumar Gaonkar , Bary Zeller
发明人： John MacMahon , Mark Norton , Phil Brown , Rodett Susan , Audrey Trouillot , ray Laudano , Adam Fennel , Satwinder Panesar , Lee Rowan , James Ferguson , Heather Hudson , Anilkumar Gaonkar , Bary Zeller
IPC分类号： B65B29/02 , A23F5/26
CPC分类号： B65D85/8046
摘要： The present invention provides a flexible pad for preparing a beverage comprising: a filter bag defining a storage volume; the storage volume containing a water-soluble composition or a combination or mixture of water-soluble compositions for forming a beverage; wherein the storage volume further contains one or more absorbent elements.
摘要翻译：本发明提供了一种用于制备饮料的柔性垫，包括：限定存储容积的过滤袋; 所述储存体积含有水溶性组合物或用于形成饮料的水溶性组合物的组合或混合物; 其中所述存储容积还包含一个或多个吸收元件。

5. 发明申请

US20090232944A1 FLEXIBLE PAD FOR PREPARING A BEVERAGE 审中-公开
标题翻译：用于制备饮料的柔性垫
公开(公告)号：US20090232944A1
公开(公告)日：2009-09-17
申请号：US11577169
申请日：2005-10-24
申请人： John MacMahon , Susan Bodett , Mark Norton , Satwinder Panesar , Lee Rowan , Joseph Giacone , Heather Hudson , Anilkumar Gaonkar , Bary Zeller
发明人： John MacMahon , Susan Bodett , Mark Norton , Satwinder Panesar , Lee Rowan , Joseph Giacone , Heather Hudson , Anilkumar Gaonkar , Bary Zeller
IPC分类号： B65B29/02 , A47J31/00 , B67D5/00 , A23L2/52
CPC分类号： B65D85/8046
摘要： The present invention provides a flexible pad (10) for preparing a beverage comprising: a flexible bag defining a storage volume (13); the storage volume containing a water-soluble composition or a combination or mixture of water-soluble compositions for forming a beverage; wherein at least a part of the flexible bag is formed from a flexible water-impermeable thin sheet material (11, 12), wherein said flexible water-impermeable thin sheet material comprises one or more apertures (40, 41) defining an inlet or an outlet of the storage volume.
摘要翻译：本发明提供了一种用于制备饮料的柔性垫（10），包括：限定存储容积（13）的柔性袋; 所述储存体积含有水溶性组合物或用于形成饮料的水溶性组合物的组合或混合物; 其中所述柔性袋的至少一部分由柔性不透水薄片材料（11,12）形成，其中所述柔性不透水薄片材料包括一个或多个孔（40,41），其限定入口或出口的存储量。

6. 发明授权

US07754272B2 Local drug delivery 有权
标题翻译：当地药物递送
公开(公告)号：US07754272B2
公开(公告)日：2010-07-13
申请号：US10842416
申请日：2004-05-11
申请人： Lee Rowan , Peter William Stratford , Alistair Stewart Taylor , Terrence Albert Vick
发明人： Lee Rowan , Peter William Stratford , Alistair Stewart Taylor , Terrence Albert Vick
IPC分类号： B05D3/02 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , C08L33/14
摘要： An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethyl-phosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
摘要翻译：具有包含聚合物基质的涂层的植入物在药物溶液中溶胀，由此将药物活性化合物吸入聚合物基质中。当植入产物时，发生药物活性化合物从涂层的释放。聚合物优选由包含两性离子单体，最优选2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内酯的烯属不饱和单体形成。形成聚合物的单体可以进一步包括表面结合单体，例如含疏水基团的单体和可交联单体，其含量可用于控制溶胀性。优选地，植入物是支架，并且外壁表面上的聚合物涂层比内表面上的聚合物涂层更厚。可以通过选择共聚单体来控制药物的释放。植入物适合用于心血管系统中的支架。

7. 发明申请

US20090311384A1 POD FOR PREPARING A BEVERAGE 审中-公开
标题翻译：用于制备饮料的POD
公开(公告)号：US20090311384A1
公开(公告)日：2009-12-17
申请号：US11577058
申请日：2004-10-24
申请人： John MacMahon , Mark Norton , Lee Rowan , Satwinder Panesar , Jim Ferguson , Adam Fennel , Heather Hudson , Nicholas F. David , Bary Zeller , Audrey Trouillot , Ken Cale , Joseph Giacone , Anilkumar Gaonkar , Susan Bodett
发明人： John MacMahon , Mark Norton , Lee Rowan , Satwinder Panesar , Jim Ferguson , Adam Fennel , Heather Hudson , Nicholas F. David , Bary Zeller , Audrey Trouillot , Ken Cale , Joseph Giacone , Anilkumar Gaonkar , Susan Bodett
IPC分类号： B65D85/804 , B65B29/02
CPC分类号： A23C11/08 , B65D85/8043 , B65D85/8046
摘要： A pod for preparing a beverage comprising: a rigid or semi-rigid sidewall; a rigid or semi-rigid upper surface containing one more apertures forming an inlet of the pod; a lower surface formed at least partially from filtering material, the filtering material forming an outlet of the pod; the sidewall, upper surface and lower surface together defining a storage volume extending from the inlet to the outlet and containing a water-soluble composition, or a combination or mixture of water-soluble compositions for forming a beverage; wherein the rigid or semi-rigid sidewall maintains a physical separation of the filtering material and the upper surface during use.
摘要翻译：一种用于制备饮料的容器，包括：刚性或半刚性侧壁; 刚性或半刚性的上表面，其包含一个形成所述荚的入口的孔; 至少部分地由过滤材料形成的下表面，所述过滤材料形成所述荚的出口; 侧壁，上表面和下表面一起限定从入口延伸到出口并且含有水溶性组合物或用于形成饮料的水溶性组合物的组合或混合物的储存容积; 其中刚性或半刚性侧壁在使用期间保持过滤材料和上表面的物理分离。

8. 外观设计

USD538658S1 Bottle 有权
公开(公告)号：USD538658S1
公开(公告)日：2007-03-20
申请号：US29234749
申请日：2005-07-22
申请人： Emma Louise Horne , Lee Rowan , Piaras De Cleir , Adge Gittens
设计人： Emma Louise Horne , Lee Rowan , Piaras De Cleir , Adge Gittens

9. 发明授权

US06872225B1 Local drug delivery 有权
标题翻译：当地药物递送
公开(公告)号：US06872225B1
公开(公告)日：2005-03-29
申请号：US09979602
申请日：2000-05-30
申请人： Lee Rowan , Peter William Stratford , Alistair Stewart Taylor , Terrence Albert Vick
发明人： Lee Rowan , Peter William Stratford , Alistair Stewart Taylor , Terrence Albert Vick
IPC分类号： A61F2/84 , A61K9/00 , A61K9/28 , A61L27/28 , A61L27/34 , A61L27/54 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , C08L33/14
摘要： An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethylphosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
摘要翻译：具有包含聚合物基质的涂层的植入物在药物溶液中溶胀，由此将药物活性化合物吸入聚合物基质中。当植入产物时，发生药物活性化合物从涂层的释放。聚合物优选由包含两性离子单体，最优选2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸酯内盐的烯属不饱和单体形成。形成聚合物的单体可以进一步包括表面结合单体，例如含疏水基团的单体和可交联单体，其含量可用于控制溶胀性。优选地，植入物是支架，并且外壁表面上的聚合物涂层比内表面上的聚合物涂层更厚。可以通过选择共聚单体来控制药物的释放。植入物适合用于心血管系统中的支架。

10. 发明授权

US06673883B1 Polymers containing zwitterionic monomers 有权
标题翻译：含有两性离子单体的聚合物
公开(公告)号：US06673883B1
公开(公告)日：2004-01-06
申请号：US09341476
申请日：1999-07-12
申请人： Lee Rowan
发明人： Lee Rowan
IPC分类号： C08F1218
CPC分类号： C08F220/58 , A61F9/00781 , C08F220/28 , C08F230/08
摘要： A cross-linkable polymer formed from monomer including a) a hydroxyl-group containing monomer of the formula I in which R26 is hydrogen or a C1-4-alkyl group; A1 is —O— or —NR27— where R27 is hydrogen or a C1-4-alkyl group or a group B9R—(OH)n; B9 is a bond, a straight or branched alkylene, oxa alkylene or oligooxa alkylene group; R13 is a n+1 functional C1-24 alkylene group which may be substituted, and n is an integer of one or more; b) a reactive monomer of the formula (II) in which R19 is hydrogen or a C1-4-alkyl group; A2 is —O— or —NR21— where R21 is hydrogen, or a C1-4-alkyl group R12 is a C1-24 straight or branched alkylene, oxaalkylene or oligo oxaalkylene group in which each alkylene group has 1 to 6 carbon atoms; A3 is a bond or —O—; and each R16 is independently selected from C1-6-alkyl groups. Preferably the polymer includes a zwitterionic monomer and is useful for providing stable biocompatible coatings on substrates.
摘要翻译：由单体形成的可交联聚合物，其包括a）式Ⅰin的含羟基的单体，其中R 26是氢或C 1-4 - 烷基; A 1是-O-或-NR 27 - 其中R 27是氢或C 1-4 - 烷基或基团B 9 - （OH）n; B 9是一个键，直链或支链亚烷基，氧杂亚烷基或寡氧亚烷基 ; R 13是可以被取代的n + 1官能的C 1-14亚烷基，n是一个或多个的整数; b）式（II）的反应性单体，其中R 19是氢或 C 1-4 - 烷基; A 2是-O-或-NR 21 - ，其中R 21是氢，或C 1-4 - 烷基R 12是直链或支链的C 1-4 亚烷基，氧杂亚烷基或低级氧杂亚烷基，其中每个亚烷基具有1至6个碳原子; A 3是键或-O-; 并且R 16独立地选自C 1-6 - 烷基。优选地，聚合物包括两性离子单体，并且可用于在基底上提供稳定的生物相容性涂层。

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