专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08697452B2 Thermal cycling assay apparatus and method 有权
标题翻译：热循环测定装置和方法
公开(公告)号：US08697452B2
公开(公告)日：2014-04-15
申请号：US13491989
申请日：2012-06-08
申请人： John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
发明人： John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
IPC分类号： G01N21/00 , G01N1/10
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译：用于容纳至少一个样品和试剂用于分析的系统。该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。框架设置在盖之间，以相对于盖限定内部空间。框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。微流体阵列设置在内部体积中。阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

2. 发明授权

US07682565B2 Assay apparatus and method using microfluidic arrays 有权
标题翻译：使用微流控阵列的测定装置和方法
公开(公告)号：US07682565B2
公开(公告)日：2010-03-23
申请号：US10744580
申请日：2003-12-22
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： G01N31/22 , G01N21/01 , G01N21/77
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译：用于容纳至少一个样品和试剂用于分析的系统。该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。框架设置在盖之间，以相对于盖限定内部空间。框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。微流体阵列设置在内部体积中。阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

3. 发明申请

US20120245038A1 THERMAL CYCLING APPARATUS AND METHOD 有权
标题翻译：热循环装置和方法
公开(公告)号：US20120245038A1
公开(公告)日：2012-09-27
申请号：US13491989
申请日：2012-06-08
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B20/00 , C40B40/06 , C40B60/10
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译：用于容纳至少一个样品和试剂用于分析的系统。该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。框架设置在盖之间，以相对于盖限定内部空间。框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。微流体阵列设置在内部体积中。阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

4. 发明申请

US20090062134A1 ASSAY IMAGING APPARATUS AND METHODS 审中-公开
标题翻译：测定成像装置和方法
公开(公告)号：US20090062134A1
公开(公告)日：2009-03-05
申请号：US12245027
申请日：2008-10-03
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B30/00
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.
摘要翻译：提供了对多个样品进行测定的方法。该方法包括以下步骤：在具有大于100个样品位点的样品阵列中的每个样品位置处进行测定，同时使用一个或多个LED照亮每个样品位点，并且同时对每个样品位点成像以产生与光学相关的成像数据每个网站的效果。每个测定提供光学效果。

5. 发明申请

US20090062152A1 THERMAL CYCLING APPARATUS AND METHOD 审中-公开
标题翻译：热循环装置和方法
公开(公告)号：US20090062152A1
公开(公告)日：2009-03-05
申请号：US12243503
申请日：2008-10-01
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B60/12
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.
摘要翻译：提供热循环装置和热循环方法。热循环装置包括流体装置系统，壳体和循环头部。流体输送系统产生受控温度流体的流动。该壳体具有用于保持微流体阵列的流体密封腔。阵列包括具有一对相对表面的厚度的材料片和穿过表面之间的厚度的多个通孔。循环头部保持壳体，并将流体流过壳体。

6. 发明申请

US20060105453A1 Coating process for microfluidic sample arrays 审中-公开
标题翻译：微流体样品阵列的涂布工艺
公开(公告)号：US20060105453A1
公开(公告)日：2006-05-18
申请号：US11198882
申请日：2005-08-04
申请人： Colin Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
发明人： Colin Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
IPC分类号： C12N5/00
CPC分类号： B01J19/0046 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L2200/12 , B01L2200/16 , B01L2300/16
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积规定的反应的差异涂覆的装置，所述装置包括具有至少一个被修饰至指定理化特性的外表面的压板，多个纳米体积通道，每个纳米体积通道具有至少一个与所述至少一个外表面连通的内表面，其被选择性地涂覆有物理吸附到至少一个内表面上的任选可溶解的涂覆剂，其中所述任选可溶解的涂覆剂包含涂层剂和用于多个特定反应的第一组分。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列登记分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个可相对于框架移动，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架是固定的。确定与分配器阵列和微流体阵列之一上的对准位置到固定位置的矢量位移有关的量。这样确定的量用于引导分配器阵列相对于微流体阵列的定位。

7. 发明申请

US20110003699A1 Thermal Cycler for Microfluidic Array Assays 审中-公开
标题翻译：用于微流控阵列测定的热循环仪
公开(公告)号：US20110003699A1
公开(公告)日：2011-01-06
申请号：US12642715
申请日：2009-12-18
申请人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
发明人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
IPC分类号： C40B30/00 , C40B60/14 , C40B60/08 , C40B50/06
CPC分类号： B01L3/508 , B01L3/50857 , B01L7/02 , B01L7/52 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/1822 , B01L2300/1838 , B01L2300/185
摘要： A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
摘要翻译：一种用于热循环多个样品的系统。该系统包括具有限定内部容积的流体密封腔的壳体。微流体阵列设置在内部体积中，该阵列包括具有一对相对表面的材料片，厚度和穿过表面之间的厚度的多个通孔。具有至少一个热控表面的热循环器适于热接触壳体。

8. 发明申请

US20060094108A1 Thermal cycler for microfluidic array assays 审中-公开
标题翻译：用于微流控阵列测定的热循环仪
公开(公告)号：US20060094108A1
公开(公告)日：2006-05-04
申请号：US11227425
申请日：2005-09-15
申请人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
发明人： Karl Yoder , Colin Brenan , John Linton , Leila Hasan , Robert Ellis , Arrin Katz , Tom Morrison , Jorge Fonseca
IPC分类号： C12M1/34
CPC分类号： B01L3/508 , B01L3/50857 , B01L7/02 , B01L7/52 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/1822 , B01L2300/1838 , B01L2300/185
摘要： A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
摘要翻译：一种用于热循环多个样品的系统。该系统包括具有限定内部容积的流体密封腔的壳体。微流体阵列设置在内部体积中，该阵列包括具有一对相对表面的材料片，厚度和穿过表面之间的厚度的多个通孔。具有至少一个热控表面的热循环器适于热接触壳体。

9. 发明授权

US08545772B2 Nanoliter array loading 有权
标题翻译： Nanoliter阵列加载
公开(公告)号：US08545772B2
公开(公告)日：2013-10-01
申请号：US13336902
申请日：2011-12-23
申请人： Tanya Kanigan , Steve Smith , John Linton , Robert Hess , Karl Yoder , Colin Brennan
发明人： Tanya Kanigan , Steve Smith , John Linton , Robert Hess , Karl Yoder , Colin Brennan
IPC分类号： G01N1/00 , B01L3/00
CPC分类号： B01L3/5085 , B01L3/0241 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L3/563 , B01L2200/021 , B01L2200/027 , B01L2200/0605 , B01L2200/0636 , B01L2200/0642 , B01L2200/16 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/12 , B01L2300/161 , B33Y70/00 , B33Y80/00 , Y10T137/0318 , Y10T137/1624 , Y10T137/206 , Y10T436/2525
摘要： An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
摘要翻译：提供了用于将微流体样品存储在纳升级样品芯片中的界面。流体通道结构从样品阱阵列向选定的样品阱子集提供流体通路区域。流体引入机构将样品流体引入流体存取区域，使得所选择的子集中的样品孔填充有样品流体，而未选择的样品池填充有样品流体。

10. 发明申请

US20070003448A1 Nanoliter array loading 有权
标题翻译： Nanoliter阵列加载
公开(公告)号：US20070003448A1
公开(公告)日：2007-01-04
申请号：US11078196
申请日：2005-03-11
申请人： Tanya Kanigan , Steve Smith , John Linton , Robert Hess , Karl Yoder , Colin Brennan
发明人： Tanya Kanigan , Steve Smith , John Linton , Robert Hess , Karl Yoder , Colin Brennan
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L3/0241 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L3/563 , B01L2200/021 , B01L2200/027 , B01L2200/0605 , B01L2200/0636 , B01L2200/0642 , B01L2200/16 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/12 , B01L2300/161 , B33Y70/00 , B33Y80/00 , Y10T137/0318 , Y10T137/1624 , Y10T137/206 , Y10T436/2525
摘要： An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
摘要翻译：提供了用于将微流体样品存储在纳升级样品芯片中的界面。流体通道结构从样品阱阵列向选定的样品阱子集提供流体通路区域。流体引入机构将样品流体引入流体存取区域，使得所选择的子集中的样品孔填充有样品流体，而未选择的样品池填充有样品流体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式