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1. 发明授权

US08633303B2 Heterobifunctional pan-selectin inhibitors 有权
公开(公告)号：US08633303B2
公开(公告)日：2014-01-21
申请号：US13165609
申请日：2011-06-21
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H17/04 , C07H15/22 , C07H5/04 , C07H1/00 , A61K31/715 , A61K38/36
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

2. 发明授权

US07728117B2 Heterobifunctional pan-selectin inhibitors 有权
标题翻译：异双功能泛选择素抑制剂
公开(公告)号：US07728117B2
公开(公告)日：2010-06-01
申请号：US11515343
申请日：2006-09-01
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H17/04 , C07H15/22
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

3. 发明授权

US07517980B2 Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas 有权
标题翻译： PA-IL凝集素，PA-IIL凝集素或来自假单胞菌的凝集素的两者的模拟抑制剂
公开(公告)号：US07517980B2
公开(公告)日：2009-04-14
申请号：US11501464
申请日：2006-08-08
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar
IPC分类号： C07H3/06 , A61K31/702 , C07H3/02
CPC分类号： C07H17/04 , C07H3/06 , G01N33/56911 , G01N2333/21
摘要： Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
摘要翻译：提供了与假单胞菌属相关的组合物和方法。组合物和方法可用于诊断和治疗涉及感染假单胞菌的医学病症。这种感染包括铜绿假单胞菌在囊性纤维化患者的肺部。可用于本发明方法的化合物可与治疗剂组合使用或可与治疗剂连接。通过阻断定植，抑制毒力因子，阻止生长或杀死细菌，可以抑制假单胞菌。

4. 再颁专利

USRE44778E1 Heterobifunctional pan-selectin inhibitors 有权
标题翻译：异双功能泛选择素抑制剂
公开(公告)号：USRE44778E1
公开(公告)日：2014-02-25
申请号：US13484020
申请日：2012-05-30
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H15/22
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

5. 发明授权

US07989601B2 Heterobifunctional pan-selectin inhibitors 有权
标题翻译：异双功能泛选择素抑制剂
公开(公告)号：US07989601B2
公开(公告)日：2011-08-02
申请号：US12764027
申请日：2010-04-20
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H17/04 , C07H15/224 , C07H15/22 , C07H5/04 , A61K31/715
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

6. 发明授权

US07361644B2 Specific antagonist for both E- and P-selectins 有权
标题翻译： E-和P-选择素的特异性拮抗剂
公开(公告)号：US07361644B2
公开(公告)日：2008-04-22
申请号：US10992480
申请日：2004-11-18
申请人： John L. Magnani , John T. Patton, Jr.
发明人： John L. Magnani , John T. Patton, Jr.
IPC分类号： A61K31/7072 , C08B37/00
CPC分类号： C07H15/18
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a particular glycomimetic linked to a particular BASA (Benzyl Amino Sulfonic Acid).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如抑制或增强）选择素介导的功能的选择素调节剂包含与特定BASA（苄基氨基磺酸）连接的特定的糖模拟物。

7. 发明授权

US08530448B2 Compounds and methods for inhibiting selectin-mediated function 有权
标题翻译：抑制选择蛋白介导功能的化合物和方法
公开(公告)号：US08530448B2
公开(公告)日：2013-09-10
申请号：US12753452
申请日：2010-04-02
申请人： John L. Magnani , John T. Patton, Jr. , Leonard M. Williams
发明人： John L. Magnani , John T. Patton, Jr. , Leonard M. Williams
IPC分类号： A61K31/70 , C07H15/00
CPC分类号： C07H15/252
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof) linked to a carbohydrate or glycomimetic.
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂包含称为BASAs的一类化合物（苄基氨基磺酸，其包括其部分或类似物）与碳水化合物或糖模拟物连接。

8. 发明授权

US08518896B2 Treatment of cancers of the blood using selected glycomimetic compounds 有权
标题翻译：使用选择的糖模拟化合物治疗血液中的癌症
公开(公告)号：US08518896B2
公开(公告)日：2013-08-27
申请号：US12482180
申请日：2009-06-10
申请人： John L. Magnani , John T. Patton, Jr. , Theodore A. G. Smith
发明人： John L. Magnani , John T. Patton, Jr. , Theodore A. G. Smith
IPC分类号： A61K31/7036 , A61P35/02 , A61P35/04 , A61P7/00
CPC分类号： A61K31/7072 , A61K31/7064
摘要： Methods and medicaments therefor are provided for the treatment of cancers of the blood or a complication therewith in an individual. More specifically, the use of particular glycomimetics for the treatment is described. Methods and medicaments therefor are also provided without regard to cancer type for reducing in an individual the myeloablative bone marrow toxicities of chemotherapy.
摘要翻译：其方法和药物用于治疗个体的血液或其并发症。更具体地，描述了使用特定的糖模拟物进行治疗。还提供了其方法和药物，而不考虑癌症类型，以减少个体中化学治疗的骨髓清除性骨髓毒性。

9. 发明授权

US4455397A Polyisocyanurate foams prepared from partially etherified methylolamines 失效
标题翻译：由部分醚化的羟甲基胺制备的聚异氰脲酸酯泡沫
公开(公告)号：US4455397A
公开(公告)日：1984-06-19
申请号：US531867
申请日：1983-09-14
申请人： Curtis J. Reichel , Thirumurti Narayan , John T. Patton, Jr.
发明人： Curtis J. Reichel , Thirumurti Narayan , John T. Patton, Jr.
IPC分类号： C08G18/09 , C08G18/38 , C08G18/65 , C08G18/14
CPC分类号： C08G18/092 , C08G18/3851 , C08G18/65
摘要： Polyisocyanurate foams are prepared from reacting partially etherified methylolmelamines either alone or in mixture with polyoxyalkylene polyether polyols with polyisocyanates. Improved friability and flame retardancy are obtained.
摘要翻译：聚异氰脲酸酯泡沫是由部分醚化的羟甲基三聚氰胺单独或与聚氧化烯聚醚多元醇与多异氰酸酯混合制备的。获得了改善的脆性和阻燃性。

10. 发明授权

US4424288A Carbodiimide-modified polymethylene polyphenylene polyisocyanates for use in the preparation of polyisocyanurate-polyurethane foams 失效
标题翻译：用于制备聚异氰脲酸酯 - 聚氨酯泡沫的碳二亚胺改性聚亚甲基多亚苯基多异氰酸酯
公开(公告)号：US4424288A
公开(公告)日：1984-01-03
申请号：US334158
申请日：1981-12-24
申请人： John T. Patton, Jr. , Peter T. Kan , Thirumurti Narayan
发明人： John T. Patton, Jr. , Peter T. Kan , Thirumurti Narayan
IPC分类号： C08G18/48 , C08G18/79 , C08G18/14 , C08G18/78
CPC分类号： C08G18/797 , C08G18/4829 , C08G2105/02 , Y10S521/901 , Y10S521/902
摘要： Liquid carbodiimide-modified organic polyisocyanates are prepared by reacting a crude polymethylene polyphenylene polyisocyanate containing no more than 70 weight percent diphenylmethane diisocyanate with an isomer mixture of 40 to 100 weight percent 4,4'-, 0 to 50 weight percent 2,4- and 0 to 10 weight percent 2,2'-diphenylmethane diisocyanate and having an average functionality of 2.1 to 2.7 and a free NCO content of at least 30 percent weight percent in the presence of an effective amount of carbodimidization catalyst. Polyisocyanurate-polyurethane foams prepared by reacting the modified polyisocyanates and polyols selected from the group consisting of diethylene glycol and ethylene oxide adducts of trimethylolpropane, trimethylolethane, glycerine, pentaerythritol, .alpha.-methylglucoside, sucrose, toluene diamine and methylene dianiline in the presence of trimerization catalysts exhibit improved compression strengths and K-factors with low friability and smoke density.
摘要翻译：液体碳二亚胺改性的有机多异氰酸酯通过使含有不超过70重量％的二苯基甲烷二异氰酸酯的粗多亚甲基多亚苯基多异氰酸酯与40至100重量％的4,4'-，0至50重量％的2,4-和 0至10重量％的2,2'-二苯基甲烷二异氰酸酯，并且在有效量的碳二亚胺化催化剂存在下，其平均官能度为2.1至2.7，游离NCO含量为至少30重量％。通过在三聚催化剂存在下，使改性多异氰酸酯和选自二甘醇和三羟甲基丙烷，三羟甲基乙烷，甘油，季戊四醇，α-甲基葡糖苷，蔗糖，甲苯二胺和亚甲基二苯胺的环氧乙烷加成物反应制备的聚异氰脲酸酯聚氨酯泡沫表现出改善的压缩强度和具有低脆性和烟密度的K因子。

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