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1. 发明授权

US07048716B1 MR-compatible devices 有权
标题翻译： MR兼容设备
公开(公告)号：US07048716B1
公开(公告)日：2006-05-23
申请号：US09448720
申请日：1999-11-24
申请人： John Kucharczyk , Charles L. Truwit , Haiying Liu , Michael E. Moseley
发明人： John Kucharczyk , Charles L. Truwit , Haiying Liu , Michael E. Moseley
IPC分类号： A61M5/178 , A61M29/00 , A61B5/05
CPC分类号： A61M25/0043 , A61M25/0108 , A61M25/0127 , G01R33/285
摘要： A catheter is used for medical treatments within an organism. The catheter comprises at least one lumen. Within the at least one lumen are at least two microcatheters, with at least one of the at least two microcatheters being connected to a source of liquid material to be delivered to the organism and another of the at least two microcatheters being connected to a system capable of effecting a medical treatment other than delivery of the liquid.
摘要翻译：导管用于生物体内的医疗治疗。导管包括至少一个内腔。所述至少一个腔内至少有两个微导管，所述至少两个微导管中的至少一个微小导管连接到待传递给所述生物的液体材料源，并且所述至少两个微导管中的另一个连接到能够除了输送液体之外进行医疗。

2. 发明授权

US06537232B1 Intracranial pressure monitoring device and method for use in MR-guided drug delivery 有权
标题翻译：用于MR导向药物输送的颅内压力监测装置和方法
公开(公告)号：US06537232B1
公开(公告)日：2003-03-25
申请号：US09541288
申请日：2000-04-03
申请人： John Kucharczyk , Charles L. Truwit
发明人： John Kucharczyk , Charles L. Truwit
IPC分类号： A61B505
CPC分类号： A61B5/411 , A61B5/031 , A61B5/055 , A61B5/4839 , A61B90/11 , A61B2034/2051 , A61B2090/365 , A61B2090/3958 , A61B2562/028 , A61M31/005 , A61M2025/0057 , A61M2025/0073 , A61M2210/0693 , G01R33/5601 , G01R33/563
摘要： A device and method for monitoring intracranial pressure during magnetic resonance (MR) image-guided neurosurgical procedures, such as intracranial drug delivery procedures, wherein an MR-compatible microsensor pressure transducer coupled to a pressure sensing diaphragm located a) at the tip, b) on a lateral side, and/or c) in multiple locations of an MR-compatible catheter is inserted into a lateral cerebral ventricle, cerebral cistern, subarachnoid space, subdural or extradural spaces, venous sinuses, or intraparenchymal tissue locations under MR imaging guidance, and is used to record intracranial pressures over hours to days in patients undergoing diagnostic or therapeutic neurologic interventions.
摘要翻译：一种用于在磁共振（MR）图像引导神经外科程序（例如颅内药物递送程序）中监测颅内压的装置和方法，其中耦合到位于尖端处的压力感测膜片的MR兼容微传感器压力传感器，b）在MR成像指导下，在MR相容导管的多个位置和/或c）插入到外侧脑室，脑水箱，蛛网膜下腔，硬膜下或硬膜下腔，静脉窦或实质内组织位置，并用于在接受诊断或治疗性神经干预的患者中记录数日至数天的颅内压。

3. 发明授权

US06994841B1 Relating to magnetic resonance imaging 失效
标题翻译：关于磁共振成像
公开(公告)号：US06994841B1
公开(公告)日：2006-02-07
申请号：US09189043
申请日：1998-11-09
申请人： Scott M Rocklage , John Kucharczyk , Michael E Moseley
发明人： Scott M Rocklage , John Kucharczyk , Michael E Moseley
IPC分类号： A61B5/055
CPC分类号： G01R33/563 , A61B5/0263 , A61B5/0275 , G01R33/5601 , G01R33/56366
摘要： The invention shows a method for obtaining temporally spaced images of tissues, including blood vessels, to reveal blood flow abnormalities within those tissues and vessels.
摘要翻译：本发明示出了用于获得包括血管在内的组织的时间间隔图像以显示那些组织和血管内的血流异常的方法。

4. 发明授权

US5833947A Magnetic resonance imaging 失效
标题翻译：磁共振成像
公开(公告)号：US5833947A
公开(公告)日：1998-11-10
申请号：US604778
申请日：1996-02-23
申请人： Scott M. Rocklage , John Kucharczyk , Michael E. Moseley
发明人： Scott M. Rocklage , John Kucharczyk , Michael E. Moseley
IPC分类号： A61K49/06 , G01R33/28 , G01R33/465 , G01R33/561 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/465 , G01R33/563 , G01R33/56308 , Y10S514/836 , Y10T436/24
摘要： The invention provides a method of monitoring the vasodilatory or vasoconstrictive effects of a physiologically active substance administered to a human or non-human animal body, said method comprising the steps of: administering said substance into said body; administering into the systemic vasculature of said body a contrast enhancing amount of an intravascular paramagnetic metal containing magnetic resonance imaging contrast agent; subjecting said body to a magnetic resonance imaging procedure capable of generating from magnetic resonance signals from said body a series of temporally spaced images of at least a part of said body into which said agent passes, said procedure being a fast imaging procedure having an image acquisition time of less than five seconds; and detecting temporal variations in said signals or images whereby to monitor the vasoconstriction or vasodilation induced by said substance.
摘要翻译：本发明提供了监测施用于人或非人动物体的生理活性物质的血管扩张或血管收缩作用的方法，所述方法包括以下步骤：将所述物质施用于所述体内; 对所述体内的系统性脉管系统施用对比度增加量的含血管内顺磁性金属的磁共振成像造影剂; 对所述身体进行磁共振成像程序，所述磁共振成像程序能够从所述身体的磁共振信号产生所述身体的至少一部分的一系列时间间隔的图像，所述过程是具有图像采集的快速成像过程时间少于5秒; 以及检测所述信号或图像中的时间变化，从而监测由所述物质引起的血管收缩或血管舒张。

5. 发明授权

US08706187B2 Imaging methods for early detection of brain tumors following embryonic stem cell implants 失效
标题翻译：用于早期检测胚胎干细胞植入物后脑肿瘤的成像方法
公开(公告)号：US08706187B2
公开(公告)日：2014-04-22
申请号：US11386394
申请日：2006-03-22
申请人： John Kucharczyk , Michael E. Moseley
发明人： John Kucharczyk , Michael E. Moseley
IPC分类号： A61B5/055
CPC分类号： A61B5/413 , A61B5/055 , A61B5/14532 , A61B5/4082 , G01R33/54
摘要： Non-invasive imaging methods and minimally invasive sensing methods are used for assessing the viability of cells implanted in the central nervous system for therapeutic purposes and for detecting the transformation of such cells, including embryonic stem cells, into brain tumors. In particular, the present invention provides an imaging means for differentiating normal cell proliferation and angiogenesis following a cell implant from abnormal tumor growth and neovascularization associated with teratoma-inducing implanted embryonic stem cells.
摘要翻译：非侵入性成像方法和微创感测方法用于评估植入中枢神经系统中用于治疗目的的细胞的存活力，并用于检测这些细胞（包括胚胎干细胞）转化入脑肿瘤。特别地，本发明提供了一种用于区分正常细胞增殖和细胞植入之后的异常肿瘤生长和与引起畸胎瘤的植入胚胎干细胞相关的新生血管形成的成像装置。

6. 发明授权

US07505807B1 Magnetic resonance apparatus for use with active electrode and drug deliver catheter 有权
标题翻译：用于活性电极和药物输送导管的磁共振装置
公开(公告)号：US07505807B1
公开(公告)日：2009-03-17
申请号：US09566798
申请日：2000-05-08
申请人： John Kucharczyk , Michael E. Moseley
发明人： John Kucharczyk , Michael E. Moseley
IPC分类号： A61B5/055
CPC分类号： A61M31/005 , A61B5/14525 , A61B17/3421 , A61B90/11 , A61B2034/2051 , A61B2090/3954 , A61B2090/3958 , A61B2562/17 , A61M2025/0057 , A61M2025/0073 , A61M2210/06 , A61M2210/0693 , G01R33/281 , G01R33/285 , G01R33/286 , G01R33/287 , G01R33/5601 , G01R33/563 , G01R33/56341
摘要： The invention is an apparatus and method for treatments and targeted drug delivery into a living patient, particularly but not exclusively using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at a target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spinal distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
摘要翻译：本发明是一种用于治疗和靶向药物递送到生命患者中的装置和方法，特别但不排他地使用磁共振（MR）成像。该装置和方法在递送到所有类型的活组织中是有用的，并且使用MR成像来跟踪药物递送的位置并估计药物递送速率。定位在靶位点（例如，颅内递送）的MR-可见药物递送装置将诊断或治疗药物溶液递送到组织（例如，脑）中。使用水质子定向扩散MR成像定量和非侵入性地监测注射或输注的药物的脊髓分布动力学，以确定靶向位置的药物递送的功效。

7. 发明授权

US6061587A Method and apparatus for use with MR imaging 失效
公开(公告)号：US6061587A
公开(公告)日：2000-05-09
申请号：US856894
申请日：1997-05-15
申请人： John Kucharczyk , Michael E. Moseley
发明人： John Kucharczyk , Michael E. Moseley
IPC分类号： A61B19/00 , A61M25/00 , A61M31/00 , G01R33/28 , G01R33/563 , A61B5/05
CPC分类号： G01R33/5601 , A61M31/005 , A61B2034/2051 , A61B2090/365 , A61B2090/3958 , A61B90/11 , A61M2025/0057 , A61M2025/0073 , A61M2210/0693 , G01R33/563
摘要： The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.

8. 发明授权

US6026316A Method and apparatus for use with MR imaging 失效
标题翻译：用于MR成像的方法和装置
公开(公告)号：US6026316A
公开(公告)日：2000-02-15
申请号：US857043
申请日：1997-05-15
申请人： John Kucharczyk , Michael E. Moseley
发明人： John Kucharczyk , Michael E. Moseley
IPC分类号： A61M25/00 , A61M31/00 , G01R33/28 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5601 , A61M31/005 , A61M2025/0036 , A61M2025/004 , A61M2025/0057 , A61M2025/0073 , G01R33/563
摘要： The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
摘要翻译：本发明是使用磁共振（MR）成像将靶向药物递送至生活患者的装置和方法。该装置和方法在递送到所有类型的活组织中是有用的，并且使用MR成像来跟踪药物递送的位置并估计药物递送速率。定位在靶位点（例如颅内递送）的MR-可见药物递送装置将诊断或治疗药物溶液递送到组织（例如，脑）中。使用水质子定向扩散MR成像定量和非侵入性地监测注射或输注的药剂的空间分布动力学，以确定靶向位置的药物递送的功效。

9. 发明授权

US5190744A Methods for detecting blood perfusion variations by magnetic resonance imaging 失效
标题翻译：通过磁共振成像检测血液膨胀变化的方法
公开(公告)号：US5190744A
公开(公告)日：1993-03-02
申请号：US490859
申请日：1990-03-09
申请人： Scott M. Rocklage , John Kucharczyk , Michael E. Moseley
发明人： Scott M. Rocklage , John Kucharczyk , Michael E. Moseley
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , G01R33/28 , G01R33/465 , G01R33/561 , G01R33/563
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/465 , G01R33/563 , G01R33/56308 , Y10S514/836 , Y10T436/24
摘要： The invention provides a method of detecting blood flow abnormality or variation in a human or non-human body, said method comprising administering into the cardiovascular system of a said body a contrast enhancing amount of an intravascular paramagnetic metal containing magnetic resonance imaging contrast agent, subject said body to a magnetic resonance imaging procedure capable of generating from magnetic resonance signals from said body a series of temporally spaced images of at least a part of said body into which said agent passes, and detecting temporal variations in said signals or images whereby to identify regions of abnormal or modified blood flow in said body and to indicate the degree of blood flow abnormality or modification therein.
摘要翻译：本发明提供一种检测人体或非人体血流异常或变异的方法，所述方法包括向所述体内的心血管系统施用对比度增加量的含有血管内顺磁性金属的磁共振成像造影剂，对象所述身体到磁共振成像程序，其能够从所述身体的磁共振信号产生所述身体的至少一部分的一系列时间间隔的图像，所述代理人通过该图像，并且检测所述信号或图像中的时间变化，从而识别所述身体中异常或改变的血流的区域，并指示其中的血流异常或改变的程度。

10. 发明申请

US20220054153A1 DEVICE AND METHOD FOR TREATMENT OF DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM 有权
公开(公告)号：US20220054153A1
公开(公告)日：2022-02-24
申请号：US17460210
申请日：2021-08-28
申请人： Sheri Albers , John Kucharczyk , Gregory Latchaw , Johannes van Vaals
发明人： Sheri Albers , John Kucharczyk , Gregory Latchaw , Johannes van Vaals
IPC分类号： A61B17/221
摘要： An intravascular thrombus retraction device and method utilizing wires compressible into a compact form within a catheter and are self-expandable into a wire mesh web with fluid-penetrable openings in the wire mesh small enough to filter clot particles. A base of the wire mesh web is connected to a radially ring-shaped structure supporting and maintaining an opening in the base of the wire mesh and forming a thrombus capture volume. The ring-shaped structure is compressible into the catheter and is self-expandable when free of compressive forces within the catheter to open up into the open, expanded ring-shaped structure, maintaining the opening in the opening in the base of the wire mesh.

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