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1. 发明申请

US20050123533A1 Prodrugs activated by targeted catalytic proteins 审中-公开
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US20050123533A1
公开(公告)日：2005-06-09
申请号：US10699966
申请日：2003-11-03
申请人： John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
发明人： John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
IPC分类号： A61K31/195 , A61K31/425 , A61K31/505 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K39/385 , A61K39/395 , A61K47/48 , A61P31/12 , A61P43/00 , C07C311/19 , C07D227/02 , C07D233/64 , C07D233/88 , C07D405/04 , C07D417/12 , C07D417/14 , C07F9/24 , C07F9/26 , C07F9/40 , C07F9/6509 , C07F9/6571 , C07F9/6574 , C07H15/252 , C07H19/04 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/11 , C07K16/46 , C12N15/09 , C12P21/08 , C12R1/92 , G01N33/50 , G01N33/53 , C07H15/24 , C07K16/18
CPC分类号： G01N33/5011 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K16/468 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5094 , G01N2500/00
摘要： Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents; e.g., as antitumor agents.
摘要翻译：披露和要求的是由催化蛋白如酶和催化抗体活化的前药。本发明包括这些前药以及半抗原以引发催化抗体以活化前药。前药可用作细胞毒性化学治疗剂; 例如作为抗肿瘤剂。

2. 发明授权

US06702705B1 Prodrugs activated by targeted catalytic proteins 失效
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US06702705B1
公开(公告)日：2004-03-09
申请号：US08392407
申请日：1995-02-22
申请人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
发明人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
IPC分类号： C12N900
CPC分类号： C07D207/404 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07C2601/04 , C07C2602/42 , C07D205/085 , C07F9/2408 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/4006 , C07F9/4075 , C07F9/5537 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K14/55 , C07K16/00 , C07K16/1063 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , C12Q1/25 , G01N33/5008 , G01N33/531 , G01N33/577 , G01N2333/16 , G01N2333/96472 , G01N2500/00
摘要： Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
摘要翻译：公开了催化抗体。催化抗体对前药化合物是特异性的。催化抗体增强了活性药物部分与前药残留物的切割，从而激活了药物。

3. 发明授权

US5593969A Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors 失效
标题翻译：脂质-A类似物：用于抑制脂质A受体与脂质A受体结合的单糖和非糖化合物
公开(公告)号：US5593969A
公开(公告)日：1997-01-14
申请号：US123590
申请日：1993-09-17
申请人： Balreddy Kamireddy , Michael J. Darsley , David M. Simpson , Richard J. Massey
发明人： Balreddy Kamireddy , Michael J. Darsley , David M. Simpson , Richard J. Massey
IPC分类号： A61K38/00 , C07H13/06 , C07H15/04 , C07K16/12 , A61K31/70 , C07H3/02 , C07H3/04
CPC分类号： C07H13/06 , C07H15/04 , C07K16/1203 , A61K38/00
摘要： A compound of the formula: ##STR1## wherein: each of R.sub.1, R.sub.1 ', R.sub.2 and R.sub.2 ' independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group, R.sub.3 is OH, OCH.sub.3, CH.sub.2 COOH or ##STR2## wherein each of R.sub.2" and R.sub.2 '41 independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group and:A=NH.sub.2, X=P(OH), Y=Z=C, B=OCH.sub.3, orA=OH, X=P(OH), X=Z=C, B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=P(OH), Y=Z=C, B=OCH.sub.3,wherein n=1-10, orA=OH, X=P(OH), Y=Z=C, B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=P(OH), Y=Z=C, B=(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub.3, orA=OH, X=Z=C, Y=P(OH), B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub.3, wherein n=1-10, orA=OH, X=Z=C, Y=P(OH), B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=Z=C, Y=P(OH), B=(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-11, orA=NH.sub.2, X=Y=C, Z=P(OH), B=OCH.sub.3, orA=OH, X=Y=C, Z=P(OH), B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=Y=C, Z=P(OH), B=OCH.sub.3, wherein n=1-10, orA=OH, X=Y=C, Z=P(OH), B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=Y=C, Z=P (OH), B=(CH.sub.2).sub.n CO.sub.2 H and n=1-11 is disclosed. The compounds may be use to inhibit binding of Lipid A to Lipid A receptors.
摘要翻译：下式的化合物：其中：R 1，R 1'，R 2和R 2'彼此独立地为取代或未取代的支链或直链C 1-12烷基，烯烃或炔基，R 3为 OH，OCH 3，CH 2 COOH或者其中每个R 2“和R 21'彼此独立地是取代或未取代的支链或直链C 1-12烷基，烯烃或炔基，并且：A = NH 2，X = P （OH），Y = Z = C，B = OCH 3或A = OH，X = P（OH），X = Z = C，B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = P（OH），Y = Z = C，B = OCH 3，其中n = 1-10，或A = OH，X = P（OH），Y = Z = C，B = O（CH 2）n CO 2 H，其中 n = 1-10，或A = OH，X = P（OH），Y = Z = C，B =（CH2）nCO2H，其中n = 1-10，或A = NH2，X = Z = C，Y = P（OH），B = OCH3或A = OH，X = Z = C，Y = P（OH），B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = Z = C ，Y = P（OH），B = OCH 3，其中n = 1-10，或A = OH，X = Z = C，Y = P（OH），B = O（CH 2）n CO 2 H，其中n = 10或A = OH，X = Z = C，Y = P（OH），B =（CH2）nCO2H，其中n = 1-11或A = NH2，X = Y = C，Z = P ），B = OCH 3或A = OH，X = Y = C，Z = P（OH），B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = Y = C，Z = P （OH），B = OCH 3，其中n = 1-10，或A = OH，X = Y = C，Z = P（OH），B = O（CH 2）n CO 2 H，其中n = 1-10，或A = OH，X = Y = C ，Z = P（OH），B =（CH2）nCO2H和n = 1-11。该化合物可用于抑制脂质A与脂质A受体的结合。

4. 发明授权

US06664400B2 N-arylsulfonamide and pyrrolidinecarboxylic acid intermediates, and their use for the preparation of herbicidal 1,3-dioxo-1h-pyrrolo[1,2-c]imidazole derivatives 失效
标题翻译： N-芳基磺酰胺和吡咯烷羧酸中间体及其用于制备除草1,3-二氧代-1H-吡咯并[1,2-c]咪唑衍生物
公开(公告)号：US06664400B2
公开(公告)日：2003-12-16
申请号：US10035136
申请日：2002-01-04
申请人： Eric Deguyon Taylor , Viacheslav Alexandrovich Petrov , Matthias Schaeffer , Karlheinz Drauz , Anne Vogt , Christoph Weckbecker , Steven H. Swearingen , Balreddy Kamireddy
发明人： Eric Deguyon Taylor , Viacheslav Alexandrovich Petrov , Matthias Schaeffer , Karlheinz Drauz , Anne Vogt , Christoph Weckbecker , Steven H. Swearingen , Balreddy Kamireddy
IPC分类号： C07D20712
CPC分类号： C07D487/04 , C07C311/08
摘要： The present invention relates to a compound of Formula 3 wherein X is H, F or Cl; Y is F or Cl; R1 is C1-C3 haloalkyl, C2-C4 alkoxyalkyl; C2-C6 haloalkoxyalkyl or C2-C6 cyanoalkyl; R2 is H, C1-C4 alkyl, C1-C4 haloalkyl, C3-C4 alkenyl, C3-C4 alkynyl, C2-C4 alkoxyalkyl, C2-C4 alkylcarbonyl or C2-C4 alkoxycarbonyl; R3 is H or OH; and R4 is H, F or Cl; provided that when R3 is H then R4 is F or Cl and when R3 is OH then R4 is H.
摘要翻译：本发明涉及式3的化合物，其中X是H，F或Cl; Y是F或Cl; R 1是C 1 -C 3卤代烷基，C 2 -C 4烷氧基烷基; C 2 -C 6卤代烷氧基烷基或C 2 -C 6氰基烷基; R 2是H，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 3 -C 4烯基，C 3 -C 4炔基，C 2 -C 4烷氧基烷基，C 2 -C 4烷基羰基或C 2 -C 4 烷氧基羰基; R 3是H或OH; 且R 4为H，F或Cl;条件是当R 3为H时，R 4为F或Cl，当R 3为OH时，R 4为H.

5. 发明授权

US06384234B1 N-arylsulfonamide- and pyrrolidinecarboxylic acid intermediates, and their use for the preparation of herbicidal 1,3-dioxo-1h-pyrrolo[1,2-c]imidazole derivatives 失效
标题翻译： N-芳基磺酰胺 - 和吡咯烷羧酸中间体及其用于制备除草1,3-二氧代-1H-吡咯并[1,2-c]咪唑衍生物
公开(公告)号：US06384234B1
公开(公告)日：2002-05-07
申请号：US09367899
申请日：1999-12-30
申请人： Eric Deguyon Taylor , Viacheslav Alexandrovich Petrov , Matthias Schaeffer , Karlheinz Drauz , Anne Vogt , Christoph Weckbecker , Steven Swearingen , Balreddy Kamireddy
发明人： Eric Deguyon Taylor , Viacheslav Alexandrovich Petrov , Matthias Schaeffer , Karlheinz Drauz , Anne Vogt , Christoph Weckbecker , Steven Swearingen , Balreddy Kamireddy
IPC分类号： C07D48702
CPC分类号： C07D487/04 , C07C311/08
摘要： This invention is directed to compounds and intermediates of Formulae 6 and 3, useful in preparing herbicidal sulfonamides of Formula 1, including all geometric and stereoisomers thereof, and agricultural salts thereof. wherein the substituents are defined in the specification.
摘要翻译：本发明涉及式6和3的化合物和中间体，其可用于制备式1的除草磺酰胺，包括其所有几何和立体异构体及其农业盐。其中取代基在说明书中定义。

6. 发明授权

US5874382A Cyclic sulfonamide herbicides 失效
标题翻译：环磺酰胺除草剂
公开(公告)号：US5874382A
公开(公告)日：1999-02-23
申请号：US12862
申请日：1998-01-23
申请人： Balreddy Kamireddy , William Mark Murray
发明人： Balreddy Kamireddy , William Mark Murray
IPC分类号： A01N43/80 , A01N43/88 , A01N43/90 , C07D275/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D275/06 , A01N43/80 , A01N43/88 , A01N43/90 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds of Formula I and II, and their agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein X is a direct bond; O; S; NH; N(C.sub.1 -C.sub.3 alkyl); N(C.sub.1 -C.sub.3 haloalkyl); or N(allyl);R.sup.1 is H; F; Cl; or Br;R.sup.2 is H; F; Cl; Br; CF.sub.3 ; nitro; or cyano;R.sup.4 is H; C.sub.1 -C.sub.3 alkyl; or halogen;R.sup.5 is H; C.sub.1 -C.sub.6 alkyl; C.sub.1 -C.sub.6 haloalkyl; halogen; S(O).sub.2 (C.sub.1 -C.sub.6 alkyl); or C(.dbd.O)R.sup.8 ; orR.sup.4 and R.sup.5 are taken together along with the carbon to which they are attached to form a spiro-cyclopropane ring;and R.sup.3, R.sup.8, and J are as defined in the disclosure.Also disclosed are compositions containing the compounds of Formulae I and II and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula I or II.
摘要翻译：公开了式I和II的化合物及其农业上合适的盐，其可用于控制不期望的植物; NH; N（C 1 -C 3烷基）; N（C 1 -C 3卤代烷基）; 或N（烯丙基）; R1是H; F; Cl; 或Br; R2为H; F; Cl; Br; CF3; 硝基或氰基; R4是H; C1-C3烷基; 或卤素; R5是H; C1-C6烷基; C1-C6卤代烷基; 卤素; S（O）2（C 1 -C 6烷基）; 或C（= O）R 8; 或R 4和R 5与它们所连接的碳一起形成螺环丙烷环; 并且R3，R8和J如本公开所定义。还公开了含有式I和II化合物的组合物和控制不期望植物的方法，其涉及将植物或其环境与有效量的式I或II化合物接触。

7. 发明授权

US08349870B2 Fungicidal hetercyclic compounds 失效
标题翻译：杀真菌异环化合物
公开(公告)号：US08349870B2
公开(公告)日：2013-01-08
申请号：US12863875
申请日：2009-01-22
申请人： Balreddy Kamireddy , Robert James Pasteris , Mary Ann Hanagan
发明人： Balreddy Kamireddy , Robert James Pasteris , Mary Ann Hanagan
IPC分类号： A61K31/445 , C07D405/00
CPC分类号： C07D417/04 , C07D417/14
摘要： Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein E, R2, G, Z1, J and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.
摘要翻译：公开了式1的化合物，包括所有几何和立体异构体，N-氧化物及其盐，其中E，R 2，G，Z 1，J和n如本公开所定义。还公开了含有式1化合物的组合物和用于控制由真菌病原体引起的植物病害的方法，包括施用有效量的本发明化合物或组合物。

8. 发明申请

US20100292275A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS 失效
标题翻译：真菌杂环化合物
公开(公告)号：US20100292275A1
公开(公告)日：2010-11-18
申请号：US12863875
申请日：2009-01-22
申请人： Balreddy Kamireddy , Robert James Pasteris , Mary Ann Hanagan
发明人： Balreddy Kamireddy , Robert James Pasteris , Mary Ann Hanagan
IPC分类号： A01N43/80 , C07D417/14 , A01P3/00
CPC分类号： C07D417/04 , C07D417/14
摘要： Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein E, R2, G, Z1, J and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.
摘要翻译：公开了式1的化合物，包括所有几何和立体异构体，N-氧化物及其盐，其中E，R 2，G，Z 1，J和n如本公开所定义。还公开了含有式1化合物的组合物和用于控制由真菌病原体引起的植物病害的方法，包括施用有效量的本发明化合物或组合物。

9. 发明授权

US6060432A Herbicidal sulfonamides 失效
标题翻译：除草磺酰胺
公开(公告)号：US6060432A
公开(公告)日：2000-05-09
申请号：US736636
申请日：1996-10-24
申请人： Edward John Adams , Karlheinz Drauz , Wonpyo Hong , Balreddy Kamireddy , Wallace Christian Petersen , Matthias Schaefer , Christoph Weckbecker
发明人： Edward John Adams , Karlheinz Drauz , Wonpyo Hong , Balreddy Kamireddy , Wallace Christian Petersen , Matthias Schaefer , Christoph Weckbecker
IPC分类号： C07D251/12 , A01N41/06 , A01N43/64 , A01N43/90 , A01N47/38 , C07D207/10 , C07D207/16 , C07D209/48 , C07D209/52 , C07D231/54 , C07D239/24 , C07D251/46 , C07D261/08 , C07D263/24 , C07D271/06 , C07D471/04 , C07D487/04 , C07D403/02 , A01N43/50 , C07D471/00 , C07D487/00
CPC分类号： C07D209/48 , A01N41/06 , A01N43/64 , A01N43/90 , A01N47/38 , C07D207/16 , C07D209/52 , C07D251/46 , C07D471/04 , C07D487/04
摘要： Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein X, Y, J, R.sup.1, and R.sup.2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula I.
摘要翻译：公开了式I化合物及其N-氧化物和农业上合适的盐，其可用于控制不期望的植物，其中X，Y，J，R 1和R 2如本公开所定义。还公开了含有式I化合物的组合物和控制不期望植物的方法，其涉及将植物或其环境与有效量的式I化合物接触。

10. 发明申请

US20060069132A1 Azolecarboxamide herbicides 审中-公开
标题翻译：偶氮甲酰胺除草剂
公开(公告)号：US20060069132A1
公开(公告)日：2006-03-30
申请号：US11096104
申请日：2005-03-31
申请人： Gregory Armel , Mark Casini , Dominic Chan , Balreddy Kamireddy , Hyeong Kim , Kanu Patel , Paula Sharpe , Thomas Stevenson , Ming Xu
发明人： Gregory Armel , Mark Casini , Dominic Chan , Balreddy Kamireddy , Hyeong Kim , Kanu Patel , Paula Sharpe , Thomas Stevenson , Ming Xu
IPC分类号： A61K31/4196 , A61K31/4192 , A61K31/415 , C07D249/04
CPC分类号： C07D231/06 , A01N43/56 , C07D231/14 , C07D249/04 , C07D277/56 , C07D401/12 , C07D403/12
摘要： Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation and R1a, R1b, R1c, R2a, R2b, R3, R4, R5, T, U, W, Y and Z are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula I. Also disclosed are mixtures and compositions comprising a herbicidally effective amount of a compound of Formula Iz wherein J, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, T, U, W, Y and Z are as defined in the disclosure; and an effective amount of another herbicide or herbicide safener. Also disclosed is a method for selectively controlling undesired vegetation in a crop that involves contacting the locus of a crop with an effective amount of a compound of Formula Iz and a effective amount of a safener.
摘要翻译：公开了式I化合物及其N-氧化物和农业上合适的盐，其可用于防治不期望的植物

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