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1. 发明授权

US4473555A Nona- and dodecapeptides for augmenting natural killer cell activity 失效
标题翻译：非 - 和十二肽用于增强自然杀伤细胞活性
公开(公告)号：US4473555A
公开(公告)日：1984-09-25
申请号：US542632
申请日：1983-10-17
申请人： John J. Nestor, Jr. , John G. Moffatt , John M. Sims
发明人： John J. Nestor, Jr. , John G. Moffatt , John M. Sims
IPC分类号： C07K7/08 , A61K38/00 , A61P37/00 , C07K14/57 , A61K37/00 , C07C103/52
CPC分类号： C07K14/57 , A61K38/00
摘要： The abstract is disclosed herein are nonapeptides and dodecapeptides which augment natural killer cell activity.
摘要翻译：本文公开的摘要是增加自然杀伤细胞活性的非肽和十二肽。

2. 发明授权

US4082736A Novel immunological adjuvant compounds and methods of preparation thereof 失效
标题翻译：新型免疫调节剂及其制备方法
公开(公告)号：US4082736A
公开(公告)日：1978-04-04
申请号：US680618
申请日：1976-04-26
申请人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
发明人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
IPC分类号： C07K9/00 , C07C103/52 , A61K37/00
CPC分类号： C07K9/005
摘要： This application relates to novel immunological adjuvant compounds of the formula: ##STR1## wherein each of R and R.sup.1 are the same or different and are hydrogen or an acyl radical; R.sup.2 is an unsubstituted or substituted alkyl radical, or an unsubstituted or substituted aryl radical; R.sup.6 is an alkyl radical X is an aminoacyl moiety; and Y is D-isoasparagine or D-isoglutamine.

3. 发明授权

US4082735A Novel immunological adjuvant compounds and methods of preparation thereof 失效
公开(公告)号：US4082735A
公开(公告)日：1978-04-04
申请号：US680260
申请日：1976-04-26
申请人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
发明人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
IPC分类号： A61K38/00 , A61K31/70 , A61K31/7028 , A61K39/39 , A61P31/04 , A61P37/04 , C07H15/04 , C07K1/06 , C07K9/00 , C07C103/52 , A61K37/00
CPC分类号： C07K9/005
摘要： This application relates to novel immunological adjuvant compounds of the formula: ##STR1## wherein each of R and R.sup.1 are the same or different and are hydrogen or an acyl radical; R.sup.2 is an unsubstituted or substituted alkyl radical, or an unsubstituted or substituted aryl radical; X is an aminoacyl moiety; and Y is D-isoasparagine or D-isoglutamine.

4. 发明授权

US4859765A Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture 失效
标题翻译：用于生物和药物应用的合成肽序列和制造方法
公开(公告)号：US4859765A
公开(公告)日：1989-08-22
申请号：US628678
申请日：1984-07-06
申请人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
发明人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
IPC分类号： A61K39/00 , C07K14/61
CPC分类号： C07K14/61 , A61K39/00 , Y10S930/12 , Y10S930/26
摘要： The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the polypeptide having from 8 to 20 amino acid residues, having an amino-terminal amino acid and a carboxyl-terminal amino acid, wherein the polypeptide includes:(a) a four amino acid sequence which corresponds to the four amino acid sequence of a .beta.-turn of the protein;(b) a sequence of two to eight amino acid residues attached to the amino terminal (H.sub.2 N--) of the four amino acid sequence; and(c) a sequence of two to eight amino acid residues attached to the carboxyl terminal (--COOH) of the four amino acid sequence,wherein the amino acid residues of subparts (b) and (c) correspond to those attached to the amino terminal and the carboxyl terminal, respectively of the .beta.-turn of the protein, and the pharmaceutically acceptable salts of the polypeptide. The invention relates to a conjugate which comprises the polypeptide described above with a macromolecular carrier. The invention also relates to antibodies and the production thereof which are specific for the polypeptide or the conjugate of the peptide described above.The synthetic polypeptide sequences, peptide conjugates and antibodies thereof are useful as antigens in the production of vaccines, antiviral agents, diagnostic reagents and the like, for the detection and treatment of infectious and immune diseases such as polio and cancer, and the like in mammals, particularly human beings.
摘要翻译：本发明涉及基于特定肽序列的新型合成抗原，缀合物和抗体及其生产。更具体地，本发明涉及作为蛋白质的决定簇位点的多肽，所述多肽具有8至20个氨基酸残基，具有氨基末端氨基酸和羧基末端氨基酸，其中所述多肽包括：（ a）对应于蛋白质β转角的四个氨基酸序列的四个氨基酸序列; （b）连接在四个氨基酸序列的氨基末端（H2N-）上的2至8个氨基酸残基的序列; 和（c）连接到四个氨基酸序列的羧基末端（-COOH）的2至8个氨基酸残基的序列，其中（b）和（c）子部分的氨基酸残基对应于氨基酸末端和羧基末端，以及该多肽的药学上可接受的盐。本发明涉及包含上述多肽与大分子载体的缀合物。本发明还涉及对上述肽的多肽或缀合物特异的抗体及其生产。合成多肽序列，肽缀合物及其抗体在疫苗，抗病毒剂，诊断试剂等的生产中用作抗原，用于检测和治疗哺乳动物等感染性和免疫性疾病如脊髓灰质炎和癌症等，特别是人类。

5. 发明授权

US4493795A Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture 失效
标题翻译：用于生物和药物应用的合成肽序列和制造方法
公开(公告)号：US4493795A
公开(公告)日：1985-01-15
申请号：US542633
申请日：1983-10-17
申请人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
发明人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
IPC分类号： A61K39/00 , C07K14/61 , C07C103/52
CPC分类号： C07K14/61 , A61K39/00 , Y10S930/12 , Y10S930/26
摘要： The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the polypeptide having from 8 to 20 amino acid residues, having an amino-terminal amino acid and a carboxyl-terminal amino acid, wherein the polypeptide includes:(a) a four amino acid sequence which corresponds to the four amino acid sequence of a .beta.-turn of the protein;(b) a sequence of two to eight amino acid residues attached to the amino terminal (H.sub.2 N--) of the four amino acid sequence; and(c) a sequence of two to eight amino acid residues attached to the carboxyl terminal (--COOH) of the four amino acid sequence,wherein the amino acid residues of subparts (b) and (c) correspond to those attached to the amino terminal and the carboxyl terminal, respectively of the .beta.-turn of the protein, and the pharmaceutically acceptable salts of the polypeptide. The invention relates to a conjugate which comprises the polypeptide described above with a macromolecular carrier. The invention also relates to antibodies and the production thereof which are specific for the polypeptide or the conjugate of the peptide described above.The synthetic polypeptide sequences, peptide conjugates and antibodies thereof are useful as antigens in the production of vaccines, antiviral agents, diagnostic reagents and the like, for the detection and treatment of infectious and immune diseases such as polio and cancer, and the like in mammals, particularly human beings.
摘要翻译：本发明涉及基于特定肽序列的新型合成抗原，缀合物和抗体及其生产。更具体地，本发明涉及作为蛋白质的决定簇位点的多肽，所述多肽具有8至20个氨基酸残基，具有氨基末端氨基酸和羧基末端氨基酸，其中所述多肽包括：（ a）对应于蛋白质β转角的四个氨基酸序列的四个氨基酸序列; （b）连接在四个氨基酸序列的氨基末端（H2N-）上的2至8个氨基酸残基的序列; 和（c）连接到四个氨基酸序列的羧基末端（-COOH）的2至8个氨基酸残基的序列，其中（b）和（c）子部分的氨基酸残基对应于氨基酸末端和羧基末端，以及该多肽的药学上可接受的盐。本发明涉及包含上述多肽与大分子载体的缀合物。本发明还涉及对上述肽的多肽或缀合物特异的抗体及其生产。合成多肽序列，肽缀合物及其抗体在疫苗，抗病毒剂，诊断试剂等的生产中用作抗原，用于检测和治疗哺乳动物等感染性和免疫性疾病如脊髓灰质炎和癌症等，特别是人类。

6. 发明授权

US5695955A Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis 失效
标题翻译：甲状旁腺激素和甲状旁腺激素相关肽的类似物：合成和用于治疗骨质疏松症
公开(公告)号：US5695955A
公开(公告)日：1997-12-09
申请号：US448070
申请日：1995-05-23
申请人： John L. Krstenansky , John J. Nestor, Jr. , Teresa H. Ho , Brian H. Vickery , Chinh T. Bach
发明人： John L. Krstenansky , John J. Nestor, Jr. , Teresa H. Ho , Brian H. Vickery , Chinh T. Bach
IPC分类号： A61K38/22 , A61K9/00 , A61K38/00 , A61K47/28 , A61K47/40 , A61P3/00 , A61P19/10 , A61P43/00 , C07K1/04 , C07K1/06 , C07K1/113 , C07K14/575 , C07K14/635 , C12N1/21 , C12N15/16 , C12N15/18 , C12P21/06
CPC分类号： A61K9/0043 , C07K14/635 , A61K38/00 , A61K47/28 , A61K47/40 , C07K2319/00
摘要： Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, these residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa (Laa Laa Haa Haa).sub.2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
摘要翻译：甲状旁腺激素PTH，甲状旁腺激素相关肽PTHrp和PTH和PTHrp的生理活性截短的同系物和类似物的合成多肽类似物，其中氨基酸残基（22-31）形成两亲性α-螺旋，这些残基（22- 选自Haa（Laa Laa Haa）2 Laa及其药学上可接受的盐的亲水性氨基酸（Haa）和亲脂性氨基酸（Laa））可用于预防和治疗哺乳动物的骨质疏松症。提供了通过固相和重组方法生产多肽的方法。

7. 发明授权

US4690916A Nona and decapeptide analogs of LHRH useful as LHRH antagonists 失效
标题翻译： LHRH的壬基和十肽类似物可用作LHRH拮抗剂
公开(公告)号：US4690916A
公开(公告)日：1987-09-01
申请号：US671153
申请日：1984-11-13
申请人： John J. Nestor, Jr. , Brian Vickery
发明人： John J. Nestor, Jr. , Brian Vickery
IPC分类号： A61K38/04 , A61K38/00 , A61K38/22 , A61P13/02 , A61P15/00 , A61P43/00 , C07C277/00 , C07C279/14 , C07K1/113 , C07K7/06 , C07K7/23 , C07K14/575 , A61K37/43 , C07K7/20
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
摘要： Synthetic nonapeptide and decapeptide LHRH antagonist analogues having a halo lower alkyl guanadino-substituted amino acyl residue at position six are disclosed herein.
摘要翻译：在本文中公开了在6位具有卤代低级烷基瓜那丁取代的氨基酰基残基的合成的非肽和十肽LHRH拮抗剂类似物。

8. 发明授权

US5589452A Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis 失效
公开(公告)号：US5589452A
公开(公告)日：1996-12-31
申请号：US915247
申请日：1992-07-14
申请人： John L. Krstenansky , John J. Nestor, Jr. , Teresa H. Ho , Brian H. Vickery , Chinh T. Bach
发明人： John L. Krstenansky , John J. Nestor, Jr. , Teresa H. Ho , Brian H. Vickery , Chinh T. Bach
IPC分类号： A61K38/22 , A61K9/00 , A61K38/00 , A61K47/28 , A61K47/40 , A61P3/00 , A61P19/10 , A61P43/00 , C07K1/04 , C07K1/06 , C07K1/113 , C07K14/575 , C07K14/635 , C12N1/21 , C12N15/16 , C12N15/18 , A61K38/29
CPC分类号： A61K9/0043 , C07K14/635 , A61K38/00 , A61K47/28 , A61K47/40 , C07K2319/00
摘要： Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa).sub.2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.

9. 发明授权

US4667014A Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists 失效
标题翻译： LHRH的非肽和十肽类似物，可用作LHRH拮抗剂
公开(公告)号：US4667014A
公开(公告)日：1987-05-19
申请号：US495226
申请日：1983-05-20
申请人： John J. Nestor, Jr. , Brian H. Vickery
发明人： John J. Nestor, Jr. , Brian H. Vickery
IPC分类号： A61K38/00 , C07K7/23 , C07K7/20 , A61K37/28
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
摘要： Synthetic nonpeptide and decapeptide LHRH antagonist analogs have a novel guanido-substituted, amidine, tertiary or quaternary amine water-soluble aminoacyl residue at position 6.
摘要翻译：合成的非肽和十肽LHRH拮抗剂类似物在6位具有新的胍基取代的脒，叔胺或季胺水溶性氨酰基残基。

10. 发明授权

US6034137A Cationic lipids for gene therapy 失效
标题翻译：阳离子脂质用于基因治疗
公开(公告)号：US6034137A
公开(公告)日：2000-03-07
申请号：US954428
申请日：1997-10-20
申请人： Paula N. Belloni , Donald R. Hirschfeld , John O. Link , John J. Nestor, Jr. , Gary A. Peltz
发明人： Paula N. Belloni , Donald R. Hirschfeld , John O. Link , John J. Nestor, Jr. , Gary A. Peltz
IPC分类号： C12N15/09 , A61K47/46 , A61K47/48 , C07C237/06 , C07C279/14 , C07C279/22 , C07C279/24 , C07C317/44 , C07C323/52 , C07D233/30 , C07H21/00 , A61K31/16 , C07C233/04
CPC分类号： C07C279/24 , A61K47/48046 , A61K47/48815 , C07C237/06 , C07C279/14 , C07C279/22 , C07D233/30 , Y02P20/55
摘要： This invention provides novel cationic lipids, particularly guanidino lipids, and methods for their preparation. Also provided are polyanionic-lipid complexes comprising the lipids of the invention, their preparation and use to deliver biologically active substances, particularly nucleic acids to cells.
摘要翻译：本发明提供新的阳离子脂质，特别是胍基脂质及其制备方法。还提供了包含本发明的脂质的聚阴离子 - 脂质复合物，其制备和将生物活性物质特别是核酸递送至细胞的用途。

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