会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明授权
    • Synthetic peptide sequences useful in biological and pharmaceutical
applications and methods of manufacture
    • 用于生物和药物应用的合成肽序列和制造方法
    • US4859765A
    • 1989-08-22
    • US628678
    • 1984-07-06
    • John J. Nestor, Jr.John G. MoffattHardy W. Chan
    • John J. Nestor, Jr.John G. MoffattHardy W. Chan
    • A61K39/00C07K14/61
    • C07K14/61A61K39/00Y10S930/12Y10S930/26
    • The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the polypeptide having from 8 to 20 amino acid residues, having an amino-terminal amino acid and a carboxyl-terminal amino acid, wherein the polypeptide includes:(a) a four amino acid sequence which corresponds to the four amino acid sequence of a .beta.-turn of the protein;(b) a sequence of two to eight amino acid residues attached to the amino terminal (H.sub.2 N--) of the four amino acid sequence; and(c) a sequence of two to eight amino acid residues attached to the carboxyl terminal (--COOH) of the four amino acid sequence,wherein the amino acid residues of subparts (b) and (c) correspond to those attached to the amino terminal and the carboxyl terminal, respectively of the .beta.-turn of the protein, and the pharmaceutically acceptable salts of the polypeptide. The invention relates to a conjugate which comprises the polypeptide described above with a macromolecular carrier. The invention also relates to antibodies and the production thereof which are specific for the polypeptide or the conjugate of the peptide described above.The synthetic polypeptide sequences, peptide conjugates and antibodies thereof are useful as antigens in the production of vaccines, antiviral agents, diagnostic reagents and the like, for the detection and treatment of infectious and immune diseases such as polio and cancer, and the like in mammals, particularly human beings.
    • 本发明涉及基于特定肽序列的新型合成抗原,缀合物和抗体及其生产。 更具体地,本发明涉及作为蛋白质的决定簇位点的多肽,所述多肽具有8至20个氨基酸残基,具有氨基末端氨基酸和羧基末端氨基酸,其中所述多肽包括:( a)对应于蛋白质β转角的四个氨基酸序列的四个氨基酸序列; (b)连接在四个氨基酸序列的氨基末端(H2N-)上的2至8个氨基酸残基的序列; 和(c)连接到四个氨基酸序列的羧基末端(-COOH)的2至8个氨基酸残基的序列,其中(b)和(c)子部分的氨基酸残基对应于氨基酸 末端和羧基末端,以及该多肽的药学上可接受的盐。 本发明涉及包含上述多肽与大分子载体的缀合物。 本发明还涉及对上述肽的多肽或缀合物特异的抗体及其生产。 合成多肽序列,肽缀合物及其抗体在疫苗,抗病毒剂,诊断试剂等的生产中用作抗原,用于检测和治疗哺乳动物等感染性和免疫性疾病如脊髓灰质炎和癌症等 ,特别是人类。
    • 5. 发明授权
    • Synthetic peptide sequences useful in biological and pharmaceutical
applications and methods of manufacture
    • 用于生物和药物应用的合成肽序列和制造方法
    • US4493795A
    • 1985-01-15
    • US542633
    • 1983-10-17
    • John J. Nestor, Jr.John G. MoffattHardy W. Chan
    • John J. Nestor, Jr.John G. MoffattHardy W. Chan
    • A61K39/00C07K14/61C07C103/52
    • C07K14/61A61K39/00Y10S930/12Y10S930/26
    • The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the polypeptide having from 8 to 20 amino acid residues, having an amino-terminal amino acid and a carboxyl-terminal amino acid, wherein the polypeptide includes:(a) a four amino acid sequence which corresponds to the four amino acid sequence of a .beta.-turn of the protein;(b) a sequence of two to eight amino acid residues attached to the amino terminal (H.sub.2 N--) of the four amino acid sequence; and(c) a sequence of two to eight amino acid residues attached to the carboxyl terminal (--COOH) of the four amino acid sequence,wherein the amino acid residues of subparts (b) and (c) correspond to those attached to the amino terminal and the carboxyl terminal, respectively of the .beta.-turn of the protein, and the pharmaceutically acceptable salts of the polypeptide. The invention relates to a conjugate which comprises the polypeptide described above with a macromolecular carrier. The invention also relates to antibodies and the production thereof which are specific for the polypeptide or the conjugate of the peptide described above.The synthetic polypeptide sequences, peptide conjugates and antibodies thereof are useful as antigens in the production of vaccines, antiviral agents, diagnostic reagents and the like, for the detection and treatment of infectious and immune diseases such as polio and cancer, and the like in mammals, particularly human beings.
    • 本发明涉及基于特定肽序列的新型合成抗原,缀合物和抗体及其生产。 更具体地,本发明涉及作为蛋白质的决定簇位点的多肽,所述多肽具有8至20个氨基酸残基,具有氨基末端氨基酸和羧基末端氨基酸,其中所述多肽包括:( a)对应于蛋白质β转角的四个氨基酸序列的四个氨基酸序列; (b)连接在四个氨基酸序列的氨基末端(H2N-)上的2至8个氨基酸残基的序列; 和(c)连接到四个氨基酸序列的羧基末端(-COOH)的2至8个氨基酸残基的序列,其中(b)和(c)子部分的氨基酸残基对应于氨基酸 末端和羧基末端,以及该多肽的药学上可接受的盐。 本发明涉及包含上述多肽与大分子载体的缀合物。 本发明还涉及对上述肽的多肽或缀合物特异的抗体及其生产。 合成多肽序列,肽缀合物及其抗体在疫苗,抗病毒剂,诊断试剂等的生产中用作抗原,用于检测和治疗哺乳动物等感染性和免疫性疾病如脊髓灰质炎和癌症等 ,特别是人类。