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1. 发明授权

US06794416B2 Methods, compositions and modes of delivery for the treatment of emphysema using 13-cis-retinoic acid 失效
标题翻译：使用13-顺 - 视黄酸治疗肺气肿的方法，组合物和输送方式
公开(公告)号：US06794416B2
公开(公告)日：2004-09-21
申请号：US09966202
申请日：2001-09-26
申请人： Paula N Belloni
发明人： Paula N Belloni
IPC分类号： A61K3107
CPC分类号： A61K9/008 , A61K31/203
摘要： The current invention is directed to methods of treating or preventing emphysema, pharmaceutical compositions suitable for the treatment or prevention of emphysema and methods for delivering formulations into the lung of a mammal suffering from emphysema. More generally, the invention encompasses the use of 13-cis-retinoic acid to treat or prevent certain chronic obstructive airway disorders, particularly chronic obstructive pulmonary disease including chronic bronchitis, emphysema and asthma in mammals, especially humans that smoke or smoked cigarettes. In another aspect, the present invention encompasses the use of pharmaceutical compositions of 13-cis-retinoic acid to treat emphysema. Moreover, the current invention encompasses the use of electrohydrodynamic aerosol devices, aerosol devices and nebulizers to deliver formulations of 13-cis-retinoic acid into the lung of a mammal suffering from emphysema. The invention also encompasses the systemic use as well as the local use of 13-cis-retinoic acid. In a another aspect the current invention encompasses a pharmaceutical composition for preventing emphysema in a human at risk of emphysema through administration of a amount of 13-cis-retinoic acid, or a pharmaceutically acceptable salt, hydrate, solvate, or pro-drug thereof in a pharmaceutically acceptable carrier, that is sufficient to prevent emphysema.
摘要翻译：本发明涉及治疗或预防肺气肿的方法，适用于治疗或预防肺气肿的药物组合物和将制剂递送到患有肺气肿的哺乳动物的肺中的方法。更一般地，本发明包括使用13-顺式视黄酸用于治疗或预防某些慢性阻塞性气道障碍，特别是慢性阻塞性肺疾病，包括哺乳动物，特别是吸烟或熏香烟的人的慢性支气管炎，肺气肿和哮喘。另一方面，本发明包括使用13-顺 - 视黄酸的药物组合物来治疗肺气肿。此外，本发明包括使用电动力学气溶胶装置，气溶胶装置和喷雾器将13-顺 - 视黄酸的制剂输送到患有肺气肿的哺乳动物的肺中。本发明还包括全身用途以及局部使用的13-顺 - 视黄酸。在另一方面，本发明包括用于通过将13-顺 - 视黄酸或其药学上可接受的盐，水合物，溶剂化物或前体药物的给药量控制在用于预防肺气肿风险的人中的肺气肿的药物组合物药学上可接受的载体，其足以防止肺气肿。

2. 发明授权

US6034137A Cationic lipids for gene therapy 失效
标题翻译：阳离子脂质用于基因治疗
公开(公告)号：US6034137A
公开(公告)日：2000-03-07
申请号：US954428
申请日：1997-10-20
申请人： Paula N. Belloni , Donald R. Hirschfeld , John O. Link , John J. Nestor, Jr. , Gary A. Peltz
发明人： Paula N. Belloni , Donald R. Hirschfeld , John O. Link , John J. Nestor, Jr. , Gary A. Peltz
IPC分类号： C12N15/09 , A61K47/46 , A61K47/48 , C07C237/06 , C07C279/14 , C07C279/22 , C07C279/24 , C07C317/44 , C07C323/52 , C07D233/30 , C07H21/00 , A61K31/16 , C07C233/04
CPC分类号： C07C279/24 , A61K47/48046 , A61K47/48815 , C07C237/06 , C07C279/14 , C07C279/22 , C07D233/30 , Y02P20/55
摘要： This invention provides novel cationic lipids, particularly guanidino lipids, and methods for their preparation. Also provided are polyanionic-lipid complexes comprising the lipids of the invention, their preparation and use to deliver biologically active substances, particularly nucleic acids to cells.
摘要翻译：本发明提供新的阳离子脂质，特别是胍基脂质及其制备方法。还提供了包含本发明的脂质的聚阴离子 - 脂质复合物，其制备和将生物活性物质特别是核酸递送至细胞的用途。

3. 发明授权

US06339107B1 Methods for treatment of Emphysema using 13-cis retinoic acid 失效
标题翻译：使用13-顺式视黄酸治疗肺气肿的方法
公开(公告)号：US06339107B1
公开(公告)日：2002-01-15
申请号：US09631151
申请日：2000-08-02
申请人： Paula N Belloni
发明人： Paula N Belloni
IPC分类号： A61K3107
CPC分类号： A61K9/008 , A61K31/203
摘要： The current invention is directed to methods of treating or preventing emphysema, pharmaceutical compositions suitable for the treatment or prevention of emphysema and methods for delivering formulations into the lung of a mammal suffering from emphysema. More generally, the invention encompasses the use of 13-cis-retinoic acid to treat or prevent certain chronic obstructive airway disorders, particularly chronic obstructive pulmonary disease including chronic bronchitis, emphysema and asthma in mammals, especially humans that smoke or smoked cigarettes. In another aspect, the present invention encompasses the use of pharmaceutical compositions of 13-cis-retinoic acid to treat emphysema. Moreover, the current invention encompasses the use of electrohydrodynamic aerosol devices, aerosol devices and nebulizers to deliver formulations of 13-cis-retinoic acid into the lung of a mammal suffering from emphysema. The invention also encompasses the systemic use as well as the local use of 13-cis-retinoic acid. In a another aspect the current invention encompasses a pharmaceutical composition for preventing emphysema in a human at risk of emphysema through administration of a amount of 13-cis-retinoic acid, or a pharmaceutically acceptable salt, hydrate, solvate, or pro-drug thereof in a pharmaceutically acceptable carrier, that is sufficient to prevent emphysema.
摘要翻译：本发明涉及治疗或预防肺气肿的方法，适用于治疗或预防肺气肿的药物组合物和将制剂递送到患有肺气肿的哺乳动物的肺中的方法。更一般地，本发明包括使用13-顺式视黄酸用于治疗或预防某些慢性阻塞性气道障碍，特别是慢性阻塞性肺疾病，包括哺乳动物，特别是吸烟或熏香烟的人的慢性支气管炎，肺气肿和哮喘。另一方面，本发明包括使用13-顺 - 视黄酸的药物组合物来治疗肺气肿。此外，本发明包括使用电动力学气溶胶装置，气溶胶装置和喷雾器将13-顺 - 视黄酸的制剂输送到患有肺气肿的哺乳动物的肺中。本发明还包括全身用途以及局部使用的13-顺 - 视黄酸。在另一方面，本发明包括用于通过将13-顺 - 视黄酸或其药学上可接受的盐，水合物，溶剂合物或前体药物的给药量在肺内风险中预防肺气肿的药物组合物药学上可接受的载体，其足以防止肺气肿。

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