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1. 发明授权

US6130900A Pulsed intracavity frequency-converted solid-state laser with long-pulse simulation 有权
标题翻译：脉冲腔内频率转换固态激光器与长脉冲模拟
公开(公告)号：US6130900A
公开(公告)日：2000-10-10
申请号：US263338
申请日：1999-03-05
申请人： John F. Black , George Frangineas , Hartmuth Hecht
发明人： John F. Black , George Frangineas , Hartmuth Hecht
IPC分类号： A61B18/20 , H01S3/108 , H01S3/109 , H01S3/10
CPC分类号： H01S3/108 , A61B18/203 , A61B2018/00452 , H01S3/1083 , H01S3/109
摘要： In an intracavity frequency-converted pulsed laser, output-pulses having a duration longer than three milliseconds are simulated by a burst of temporally spaced-apart pulses having a shorter duration, the burst duration being about equal to the duration of the pulse being simulated. In an example of the laser including a KTP crystal providing frequency-doubling and having an Nd:YAG gain-medium for providing fundamental radiation at a wavelength of 1064 nm, a thin-etalon having a thickness of about 75 micrometers is included in the laser cavity to suppress generation of laser-radiation at wavelengths of 1061 and 1074 nm. Suppression of oscillation at these wavelengths prevents damage in the KTP crystal due to abrupt intracavity power surges thereby preventing damage to the KTP crystal. Examples of intracavity-pumped optical parametric oscillators including a thin etalon and operated in a similar manner are also disclosed.
摘要翻译：在腔内频率转换的脉冲激光器中，具有长于三毫秒的持续时间的输出脉冲由具有较短持续时间的时间间隔脉冲的脉冲串来模拟，脉冲串持续时间大约等于被模拟的脉冲的持续时间。在包括提供倍频并且具有用于提供1064nm波长的基本辐射的Nd：YAG增益介质的激光器的实例中，激光器包括厚度为约75微米的薄标准具以抑制波长为1061和1074nm的激光辐射的产生。抑制这些波长的振荡可防止KTP晶体由于突发性腔内功率浪涌而造成的损坏，从而防止对KTP晶体的损坏。还公开了包括精密标准具并以类似方式操作的腔内泵浦光学参量振荡器的实例。

2. 发明申请

US20120238941A1 Treatment of Alopecia By Micropore Delivery of Stem Cells 审中-公开
标题翻译：通过干细胞的微孔递送治疗脱发
公开(公告)号：US20120238941A1
公开(公告)日：2012-09-20
申请号：US13485475
申请日：2012-05-31
申请人： Basil M. Hantash , George Frangineas , Leonard C. Debenedictis
发明人： Basil M. Hantash , George Frangineas , Leonard C. Debenedictis
IPC分类号： A61M37/00
CPC分类号： A61K48/0075 , A61K48/0091
摘要： A method of restoring hair to skin that has suffered hair loss includes optically ablating an array of spaced-apart microchannels or voids into the skin and transplanting into the voids stem cells, a scaffold and a differentiation factor for causing the stem cells to differentiate into hair follicles.
摘要翻译：一种将头发恢复成脱发的方法包括将间隔开的微通道或空隙的阵列光学消融到皮肤中并移植到空隙干细胞中，支架和分化因子，以使干细胞分化为毛发滤泡。

3. 发明申请

US20120092739A1 Optical Pattern Generator Using Multiple Reflective Surfaces 失效
标题翻译：使用多个反射面的光学图案发生器
公开(公告)号：US20120092739A1
公开(公告)日：2012-04-19
申请号：US13334799
申请日：2011-12-22
申请人： George Frangineas
发明人： George Frangineas
IPC分类号： G02B26/08 , B29D11/00
CPC分类号： G02B26/129
摘要： An optical pattern generator uses reflection from multiple (e.g., two) internal mirror surfaces mounted on a rotating support structure.
摘要翻译：光学图案发生器使用安装在旋转支撑结构上的多个（例如，两个）内镜面的反射。

4. 发明授权

US07411711B2 High speed, high efficiency optical pattern generator using rotating optical elements 失效
公开(公告)号：US07411711B2
公开(公告)日：2008-08-12
申请号：US11679117
申请日：2007-02-26
申请人： Leonard C. DeBenedictis , C. David Nabors , George Frangineas
发明人： Leonard C. DeBenedictis , C. David Nabors , George Frangineas
IPC分类号： G02B26/08
CPC分类号： G02B26/105 , G02B13/0095 , G02B26/0875 , G02B26/10 , G02B27/30 , Y10S359/90
摘要： An optical pattern generator includes one or more multi-faceted rotating optical elements that introduce an offset that is rotation insensitive. The component that generates the offset is rotationally symmetric around the rotational axis of the optical element. Thus, as the optical element rotates, the effect of the offset component does not change. In addition, rotating optical elements may be designed to counteract unwanted optical effects of each other.

5. 发明申请

US20080015557A1 Apparatus and Method for Adjustable Fractional Optical Dermatological Treatment 有权
标题翻译：可调分数光学皮肤病治疗的装置和方法
公开(公告)号：US20080015557A1
公开(公告)日：2008-01-17
申请号：US11778012
申请日：2007-07-13
申请人： Kin Chan , George Frangineas , David Dewey , Leonard DeBenedictis
发明人： Kin Chan , George Frangineas , David Dewey , Leonard DeBenedictis
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B18/20 , A61B2018/00452 , A61B2018/00636 , A61B2018/20351
摘要： In a fractional treatment system, an adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements. In one aspect, the fractional treatment is configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue decreases as the tissue is heated by the laser (e.g., 1480-1640 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 7 cm−1 to about 26 cm−1.
摘要翻译：在分数处理系统中，可以使用可调节的机构来调整光束形状，光束数值孔径，光束聚焦深度和/或光束尺寸，以影响治疗深度或所得损伤的特征。这些参数的调整可以提高治疗的效率和疗效。可调节机构的说明性实例包括一组不同长度的间隔物，具有不同焦距的透镜元件的可旋转转台，光学变焦透镜和用于调节两个光学透镜元件之间的间距的机械调节装置。在一个方面，分数处理配置有激光波长，激光波长被选择为使得组织内的激光波长的吸收随着组织被激光加热而减小（例如，1480-1640nm）。期望地，激光波长主要被水吸收在皮肤的处理区域内，并且具有在约7cm -1至约26cm -1的范围内的热调节吸收系数， SUP>。

6. 发明申请

US20070265606A1 Method and Apparatus for Fractional Light-based Treatment of Obstructive Sleep Apnea 审中-公开
标题翻译：阻塞性睡眠呼吸暂停的基于光的治疗方法与装置
公开(公告)号：US20070265606A1
公开(公告)日：2007-11-15
申请号：US11749066
申请日：2007-05-15
申请人： Leonard DeBenedictis , George Frangineas , Barry Broome
发明人： Leonard DeBenedictis , George Frangineas , Barry Broome
IPC分类号： A61B18/20
CPC分类号： A61B18/20 , A61B18/201 , A61B2018/20351 , A61B2018/2055 , A61B2018/20554 , A61B2018/205547
摘要： An apparatus and method are described that uses fractional light based treatment to shrink soft tissue in the mouth or throat to reduce obstruction of the airways for patients suffering from obstructive sleep apnea. A light delivery probe with scanning optics can be used to deliver treatment. Cooling systems can be added to reduce damage to epithelial layers of tissue. Light based treatment can be nonablative or ablative and is preferably performed with a laser.
摘要翻译：描述了一种使用基于分数光的处理以收缩口腔或咽喉中的软组织以减少患有阻塞性睡眠呼吸暂停的患者气道阻塞的装置和方法。可以使用带有扫描光学元件的发光探头来进行治疗。可以加入冷却系统以减少对组织上皮层的损伤。基于光的处理可以是非烧蚀的或烧蚀的，并且优选用激光进行。

7. 发明申请

US20070264626A1 Apparatus and Method for a Combination of Ablative and Nonablative Dermatological Treatment 审中-公开
标题翻译：烧伤和非消融性皮肤病治疗组合的装置和方法
公开(公告)号：US20070264626A1
公开(公告)日：2007-11-15
申请号：US11747711
申请日：2007-05-11
申请人： Leonard C. DeBenedictis , George Frangineas
发明人： Leonard C. DeBenedictis , George Frangineas
IPC分类号： C12Q1/00 , A61N5/067
CPC分类号： A61B18/203 , A61B18/20 , A61B2017/00061 , A61B2017/00106 , A61B2018/00452 , A61B2018/00458 , A61B2018/00642 , A61B2018/00904 , A61B2018/20351 , A61B2018/20554 , A61B2018/207 , A61N5/0616
摘要： The invention describes a treatment for skin wherein a pattern of holes is ablated in a selected region of skin tissue using an optical source. Substantially nonablative energy is delivered to the selected region to at least two holes in the pattern to thermally heat a target in or just beneath the skin, such as hair follicles, sebaceous glands, or subcutaneous fat. The invention may further be improved by adding a feedback mechanism that adapts the nonablative energy in response to a measurement enabled by the ablation of holes. The apparatus may include a positional sensor to provide additional dosage control, particularly when the inventive method is used with a continuously movable handpiece.
摘要翻译：本发明描述了使用光源在皮肤组织的选定区域中消除孔的图案的皮肤治疗。将基本上不消耗的能量输送到所选择的区域至图案中的至少两个孔，以热处理皮肤内或正下方的靶，例如毛囊，皮脂腺或皮下脂肪。本发明还可以通过添加一种反馈机制来改进，该机制响应于通过孔的消融实现的测量来适应非消耗能量。该设备可以包括位置传感器以提供额外的剂量控制，特别是当本发明的方法与连续移动的手持件一起使用时。

8. 发明授权

US07265884B2 High speed, high efficiency optical pattern generator using rotating optical elements 有权
公开(公告)号：US07265884B2
公开(公告)日：2007-09-04
申请号：US11339097
申请日：2006-01-24
申请人： Leonard C. DeBenedictis , C. David Nabors , George Frangineas
发明人： Leonard C. DeBenedictis , C. David Nabors , George Frangineas
IPC分类号： G02B26/08
CPC分类号： G02B26/105 , G02B13/0095 , G02B26/0875 , G02B26/10 , G02B27/30 , Y10S359/90
摘要： An optical pattern generator includes one or more multi-faceted rotating optical elements that introduce an offset that is rotation insensitive. The component that generates the offset is rotationally symmetric around the rotational axis of the optical element. Thus, as the optical element rotates, the effect of the offset component does not change. In addition, rotating optical elements may be designed to counteract unwanted optical effects of each other.

9. 发明授权

US07184184B2 High speed, high efficiency optical pattern generator using rotating optical elements 有权
公开(公告)号：US07184184B2
公开(公告)日：2007-02-27
申请号：US10750790
申请日：2003-12-31
申请人： Leonard C. DeBenedictis , C. David Nabors , George Frangineas
发明人： Leonard C. DeBenedictis , C. David Nabors , George Frangineas
IPC分类号： G02B26/08
CPC分类号： G02B26/105 , G02B13/0095 , G02B26/0875 , G02B26/10 , G02B27/30 , Y10S359/90
摘要： An optical pattern generator includes one or more multi-faceted rotating optical elements that introduce an offset that is rotation insensitive. The component that generates the offset is rotationally symmetric around the rotational axis of the optical element. Thus, as the optical element rotates, the effect of the offset component does not change. In addition, rotating optical elements may be designed to counteract unwanted optical effects of each other.

10. 发明申请

US20090318909A1 APPARATUS AND METHOD FOR ABLATION-RELATED DERMATOLOGICAL TREATMENT OF SELECTED TARGETS 审中-公开
标题翻译：用于与选定目标相关的相关脱发治疗的装置和方法
公开(公告)号：US20090318909A1
公开(公告)日：2009-12-24
申请号：US12497487
申请日：2009-07-02
申请人： Leonard C. DeBenedictis , George Frangineas
发明人： Leonard C. DeBenedictis , George Frangineas
IPC分类号： A61B18/20 , A61B18/18
CPC分类号： A61B18/22 , A61B18/20 , A61B18/203 , A61B34/20 , A61B2017/00057 , A61B2017/00106 , A61B2017/00765 , A61B2018/00452 , A61B2018/00577 , A61B2018/00636 , A61B2018/20351 , A61B2018/208 , A61B2090/062 , A61N5/0616
摘要： The invention describes a treatment for skin containing selected targets that provides feedback in response to a measurement enabled by the ablation of holes. The inventive apparatus includes an electromagnetic source configured to emit ablative electromagnetic energy, a delivery system, a sensing element, and a controller. The delivery system can be configured to receive ablative energy from the electromagnetic source and deliver it to multiple discrete locations at the selected region to form a pattern of discrete holes in epidermal and dermal tissue of the skin. The lipid content a portion of the tissue can be evaluated using a sensing element. At least one pulse of electromagnetic energy is delivered to the skin under control of a controller in response to the result of a measurement by the sensing element. The apparatus may include a positional sensor to provide additional dosage control, particularly when the inventive method is used with a continuously movable handpiece.
摘要翻译：本发明描述了含有选择的靶的皮肤的治疗，其响应于通过消融孔所进行的测量而提供反馈。本发明的装置包括被配置为发射消融电磁能的电磁源，输送系统，感测元件和控制器。递送系统可以被配置为从电磁源接收消融能量并将其递送到所选区域处的多个离散位置，以在皮肤的表皮和皮肤组织中形成离散孔的图案。可以使用感测元件来评估组织的一部分的脂质含量。响应于感测元件的测量结果，至少一个电磁能脉冲在控制器的控制下传送到皮肤。该设备可以包括位置传感器以提供额外的剂量控制，特别是当本发明的方法与连续移动的手持件一起使用时。

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