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1. 外观设计

USD648025S1 Microdermabrasion treatment tip 有权
标题翻译：微晶磨皮治疗提示
公开(公告)号：USD648025S1
公开(公告)日：2011-11-01
申请号：US29304428
申请日：2008-02-29
申请人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik
设计人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik

2. 发明申请

US20110190726A1 Method and apparatus for micro-needle array electrode treatment of tissue 审中-公开
标题翻译：微针阵列电极治疗组织的方法和装置
公开(公告)号：US20110190726A1
公开(公告)日：2011-08-04
申请号：US13085971
申请日：2011-04-13
申请人： Basil M. Hantash , Joseph L. Dallarosa , D. Bommi Bommannan
发明人： Basil M. Hantash , Joseph L. Dallarosa , D. Bommi Bommannan
IPC分类号： A61M37/00 , A61N5/00
CPC分类号： A61N1/06 , A61B18/14 , A61B18/1477 , A61B2018/00023 , A61B2018/00083 , A61B2018/0016 , A61B2018/00452 , A61B2018/00476 , A61B2018/143 , A61B2018/1497 , A61M2037/0023 , A61M2037/0061 , A61N1/0502 , A61N1/40
摘要： Systems and methods for revitalizing aging skin using electromagnetic energy that is delivered using a plurality of needles that are capable of penetrating the skin to desired depths. A particular aspect is the capability to spare zones of tissue from thermal exposure. This sparing of tissue allows new tissue to be regenerated while the heat treatment can shrink the collagen and tighten the underlying structures. Additionally, the system is capable of delivering therapeutically beneficial substances either through the penetrating needles or through channels that have been created by the penetration of the needles.
摘要翻译：使用使用能够将皮肤穿透到期望深度的多个针递送的电磁能来振兴老化皮肤的系统和方法。一个特定的方面是从热暴露中排除组织区域的能力。这种组织的保留允许新组织再生，而热处理可以收缩胶原并收紧下面的结构。此外，该系统能够通过穿透针或通过由针的穿透产生的通道递送治疗有益的物质。

3. 外观设计

USD616094S1 Microdermabrasion treatment tip 有权
标题翻译：微晶磨皮治疗提示
公开(公告)号：USD616094S1
公开(公告)日：2010-05-18
申请号：US29322102
申请日：2008-07-29
申请人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik
设计人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik

4. 发明申请

US20080262482A1 METHOD AND DEVICE FOR TIGHTENING TISSUE USING ELECTROMAGNETIC RADIATION 失效
标题翻译：使用电磁辐射加强组织的方法和装置
公开(公告)号：US20080262482A1
公开(公告)日：2008-10-23
申请号：US12035956
申请日：2008-02-22
申请人： Basil M. Hantash , Kin F. Chan
发明人： Basil M. Hantash , Kin F. Chan
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00452 , A61B2018/20351
摘要： Methods and devices for treatment of skin are disclosed. These methods and devices use electromagnetic radiation to create networks or patterns of treatment zones. The networks or patterns of treatment zones comprise at least four treatment zones, at least two of the treatment zones in the network or pattern are slanted at angles in the skin, and the treatment zones extend at least as deep as the dermal-epidermal junction of the skin. Producing intersecting treatment zones and/or overlapping treatment patterns can increase the effectiveness of the treatments. The devices comprise a hand piece operably coupled to a delivery element, wherein delivery of electromagnetic radiation through the device to a portion of skin produces a network or pattern of treatment zones. The use of these methods and devices results in tightening of the skin and/or improvement in the cosmetic appearance of wrinkles in the portion of skin treated.
摘要翻译：公开了治疗皮肤的方法和装置。这些方法和设备使用电磁辐射来创建治疗区域的网络或模式。处理区域的网络或图案包括至少四个处理区域，网络或图案中的至少两个处理区域以皮肤的角度倾斜，并且处理区域至少与真皮 - 表皮连接处皮。产生相交处理区和/或重叠处理模式可以提高处理的有效性。这些装置包括可操作地耦合到输送元件的手部件，其中将电磁辐射通过该装置传送到皮肤的一部分产生处理区域的网络或图案。这些方法和装置的使用导致皮肤收紧和/或皱纹化妆品外观的改善。

5. 发明授权

US09320698B2 Peptide tyrosinase inhibitors and uses thereof 有权
标题翻译：肽酪氨酸酶抑制剂及其用途
公开(公告)号：US09320698B2
公开(公告)日：2016-04-26
申请号：US14117012
申请日：2012-05-10
申请人： Basil M. Hantash , Anan Abu Ubeid
发明人： Basil M. Hantash , Anan Abu Ubeid
IPC分类号： A61K8/64 , C07K7/06 , C12N9/02 , A61Q19/02 , A61K8/14 , C07K5/11 , A61Q19/00 , A61K38/00
CPC分类号： A61K8/64 , A61K8/14 , A61K38/00 , A61K2800/30 , A61K2800/782 , A61K2800/81 , A61K2800/82 , A61Q19/007 , A61Q19/02 , C07K5/1019 , C07K7/06 , C12N9/0071 , C12Y114/18001
摘要： Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory pep tides in a topical formulation. Preferred octapeptide sequences are internally rich in tryptophan and/or tyrosine or arginine. The present invention is further directed to kits and compositions containing the present peptides, and methods of treatment of conditions involving expression of tyrosinase, in which the present peptides are administered topically for the treatment of conditions involving melanocyte activity in the skin.
摘要翻译：公开了抑制酪氨酸酶的酶活性的肽，以及其用于减少皮肤色素沉积的制剂和方法，以及在局部制剂中施用抑制性肽的方法。优选的八肽序列在内部富含色氨酸和/或酪氨酸或精氨酸。本发明进一步涉及包含本发明肽的试剂盒和组合物，以及治疗涉及酪氨酸酶表达的病症的方法，其中本发明的肽被局部施用以治疗涉及皮肤中黑素细胞活性的病症。

6. 发明授权

US08690863B2 Laser-induced transepidermal elimination of content by fractional photothermolysis 有权
$Laser-induced transepidermal elimination of content by fractional photothermolysis$
标题翻译：通过分光光热法激光诱导经皮去除含量
公开(公告)号：US08690863B2
公开(公告)日：2014-04-08
申请号：US11548248
申请日：2006-10-10
申请人： Kin F. Chan , Basil M. Hantash , G. Scott Herron , Vikramaditya P. Bedi
发明人： Kin F. Chan , Basil M. Hantash , G. Scott Herron , Vikramaditya P. Bedi
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00452
摘要： Subjects treated with nonablative fractional photothermolysis (FP) have an intact stratum corneum, but can have microscopic lesions and vacuole formation within the epidermis. The vacuoles thus formed can trap dermal material and extrude it through the epidermis. Thus, FP can be used for the treatment of recalcitrant melasma, solar elastosis, and tattoos.
摘要翻译：用非消融性分光光热解（FP）处理的受试者具有完整的角质层，但可以在表皮内具有微观损伤和液泡形成。这样形成的空泡可以捕获真皮材料并通过表皮挤出。因此，FP可用于治疗顽固性黑斑病，太阳能弹性病和纹身。

7. 发明授权

US08323253B2 Method and device for tightening tissue using electromagnetic radiation 失效
标题翻译：使用电磁辐射来收紧组织的方法和装置
公开(公告)号：US08323253B2
公开(公告)日：2012-12-04
申请号：US12035956
申请日：2008-02-22
申请人： Basil M. Hantash , Kin F. Chan
发明人： Basil M. Hantash , Kin F. Chan
IPC分类号： A61M35/00 , A61B18/04
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00452 , A61B2018/20351
摘要： Methods and devices for treatment of skin are disclosed. These methods and devices use electromagnetic radiation to create networks or patterns of treatment zones. The networks or patterns of treatment zones comprise at least four treatment zones, at least two of the treatment zones in the network or pattern are slanted at angles in the skin, and the treatment zones extend at least as deep as the dermal-epidermal junction of the skin. Producing intersecting treatment zones and/or overlapping treatment patterns can increase the effectiveness of the treatments. The devices comprise a hand piece operably coupled to a delivery element, wherein delivery of electromagnetic radiation through the device to a portion of skin produces a network or pattern of treatment zones. The use of these methods and devices results in tightening of the skin and/or improvement in the cosmetic appearance of wrinkles in the portion of skin treated.
摘要翻译：公开了治疗皮肤的方法和装置。这些方法和设备使用电磁辐射来创建治疗区域的网络或模式。处理区域的网络或图案包括至少四个处理区域，网络或图案中的至少两个处理区域以皮肤的角度倾斜，并且处理区域至少与真皮 - 表皮连接处皮。产生相交处理区和/或重叠处理模式可以提高处理的有效性。这些装置包括可操作地耦合到输送元件的手部件，其中将电磁辐射穿过该装置传送到皮肤的一部分产生处理区域的网络或图案。这些方法和装置的使用导致皮肤收紧和/或皱纹化妆品外观的改善。

8. 发明申请

US20110091530A1 OLIGOPEPTIDE TYROSINASE INHIBITORS AND USES THEREOF 有权
标题翻译：寡糖类酪氨酸酶抑制剂及其用途
公开(公告)号：US20110091530A1
公开(公告)日：2011-04-21
申请号：US12975030
申请日：2010-12-21
申请人： Basil M. Hantash
发明人： Basil M. Hantash
IPC分类号： A61K8/64 , C07K7/06 , A61K9/127 , A61Q19/02
CPC分类号： A61K38/08 , A61K8/64 , A61K2300/00
摘要： Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Peptide sequences disclosed include KFEKKFEK (SEQ ID NO: 1) and YRSRKYSSWY (SEQ ID NO: 2).
摘要翻译：公开了抑制酪氨酸酶的酶活性的肽，以及其用于减少皮肤色素沉积的制剂和方法，以及在局部制剂中施用抑制肽的方法。所公开的肽序列包括KFEKKFEK（SEQ ID NO：1）和YRSRKYSSWY（SEQ ID NO：2）。

9. 发明申请

US20110081326A1 DIFFERENTIATION OF MESENCHYMAL STEM CELLS INTO FIBROBLASTS, COMPOSITIONS COMPRISING MESENCHYMAL STEM CELL-DERIVED FIBROBLASTS, AND METHODS OF USING THE SAME 有权
标题翻译：骨髓间充质干细胞分化成纤维蛋白，包含间质干细胞衍生的纤维蛋白的组合物及其使用方法
公开(公告)号：US20110081326A1
公开(公告)日：2011-04-07
申请号：US12999532
申请日：2009-06-17
申请人： Basil M. HANTASH
发明人： Basil M. HANTASH
IPC分类号： A61K35/12 , C12N5/071 , A61P17/02
CPC分类号： C12N5/0656 , A61L27/60 , C12N2501/11 , C12N2501/115 , C12N2501/15
摘要： Methods and compositions are provided for the differentiation and characterization of mammalian fibroblast from mesenchymal stem cells. The methods of the invention provide a means to obtain mesenchymal stem cell-derived fibroblast populations, e.g., seeded on a scaffold, which may be used in wound healing.
摘要翻译：提供了用于从间充质干细胞分化和表征哺乳动物成纤维细胞的方法和组合物。本发明的方法提供了获得间充质干细胞来源的成纤维细胞群体的手段，例如接种在支架上，其可用于伤口愈合。

10. 外观设计

USD612939S1 Microdermabrasion treatment tip mount 有权
标题翻译： Microdermabrasion治疗尖端安装
公开(公告)号：USD612939S1
公开(公告)日：2010-03-30
申请号：US29322106
申请日：2008-07-29
申请人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik
设计人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik

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