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1. 发明授权

US06256541B1 Endocardial lead having defibrillation and sensing electrodes with septal anchoring 失效
标题翻译：具有除颤和感应/起搏电极的心内膜导联
公开(公告)号：US06256541B1
公开(公告)日：2001-07-03
申请号：US09062268
申请日：1998-04-17
申请人： John E. Heil , Ronald W. Heil, Jr. , Avram Scheiner , Yayun Lin , Lyle A. Bye , J. John Lattuca
发明人： John E. Heil , Ronald W. Heil, Jr. , Avram Scheiner , Yayun Lin , Lyle A. Bye , J. John Lattuca
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N1/0573
摘要： An endocardial lead comprising an elongate body having a first defibrillation coil electrode, a second defibrillation coil electrode and a first pacing/sensing electrode. The first defibrillation coil electrode has a first end and a second end, where the first end is at or near the distal end of the elongate body and the second end spaced longitudinally from the distal end. The first pacing/sensing electrode is spaced longitudinally along the peripheral surface from the second end of the first defibrillation coil electrode. The second defibrillation coil electrode is spaced longitudinally along the peripheral surface from the first pacing/sensing electrode to afford positioning the first defibrillation coil longitudinally adjacent an apical location of the right ventricle of a heart with the first pacing/sensing electrode within the right ventricle of the heart and the second defibrillation coil within the right atrial chamber or a major vein leading to the right atrial chamber of the heart. The elongate body further includes a curved portion on which the first pacing/sensing electrode is positioned such that the first pacing/sensing electrode extends beyond the peripheral surface of the elongate body to engage the tissue of the heart. The first pacing/sensing electrode further includes a retaining element, where the retaining element is adapted to be embedded in the right ventricle of the heart to secure the first pacing/sensing electrode and the elongate body of the endocardial lead to the right ventricle of the heart.
摘要翻译：一种心内膜，其包括具有第一除颤线圈电极，第二除颤线圈电极和第一起搏感测电极的细长体。第一除颤线圈电极具有第一端和第二端，其中第一端处于细长体的远端处或其附近，并且第二端与远端纵向间隔开。第一起搏感测电极沿着与第一除颤线圈电极的第二端的外周表面纵向间隔开。第二除颤线圈电极沿着与第一起搏/感测电极的外周表面纵向间隔开，以使第一除颤线圈与心脏右心室的顶端位置纵向相邻，其中第一起搏/感测电极位于右心室内右心房中的心脏和第二除颤线圈或通向心脏右心房的主要静脉。细长主体还包括弯曲部分，第一起搏/感测电极定位在弯曲部分上，使得第一起搏/感测电极延伸超出细长体的周边表面以接合心脏的组织。第一起搏/感测电极还包括保持元件，其中保持元件适于嵌入心脏的右心室，以将第一起搏/感测电极和心内膜引导件的细长体固定到右心室心。

2. 发明授权

US06212434B1 Single pass lead system 失效
公开(公告)号：US06212434B1
公开(公告)日：2001-04-03
申请号：US09120824
申请日：1998-07-22
申请人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
发明人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
IPC分类号： A61N105
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

3. 发明授权

US06321122B1 Single pass defibrillation/pacing lead with passively attached electrode for pacing and sensing 失效
标题翻译：单次除颤/起搏导联带有被动连接的电极用于起搏和感测
公开(公告)号：US06321122B1
公开(公告)日：2001-11-20
申请号：US09121018
申请日：1998-07-22
申请人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
发明人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
IPC分类号： A61N100
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.
摘要翻译：适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。引线包括具有第一导电表面的第一远端电极。引线体还具有具有第二导电表面的第二电极。第二电极适于定位并固定在心脏心房的壁上。被动固定元件可以用作第二电极的一部分。引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

4. 发明授权

US06505082B1 Single pass lead system 失效
公开(公告)号：US06505082B1
公开(公告)日：2003-01-07
申请号：US09643125
申请日：2000-08-21
申请人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W Goebel , Douglas A Heitkamp , Randall M. Peterfeso
发明人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W Goebel , Douglas A Heitkamp , Randall M. Peterfeso
IPC分类号： A61N105
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

5. 发明授权

US08498721B2 Coronary vein leads having pre-formed biased portions for fixation 有权
标题翻译：冠状静脉引导具有预先形成的用于固定的偏置部分
公开(公告)号：US08498721B2
公开(公告)日：2013-07-30
申请号：US13251466
申请日：2011-10-03
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley , Bruce Tockman , Randy Westlund , Jay A. Warren , Christina Repasky , Lyle A. Bye , Brian D. Soltis
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley , Bruce Tockman , Randy Westlund , Jay A. Warren , Christina Repasky , Lyle A. Bye , Brian D. Soltis
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead having a pre-formed biased portion is adapted for implantation with a body vessel and for connection to a signal generator. The lead is constructed and arranged so that when it is implanted, the electrodes are biased toward a vessel wall by the preformed biased portion, which operates to fixate the lead against the vessel wall.
摘要翻译：具有预成形的偏置部分的引线适于用身体容器注入并连接到信号发生器。引线被构造和布置成使得当其被植入时，电极通过预先形成的偏压部分朝向血管壁偏压，该部分操作以将引线固定在血管壁上。

6. 发明授权

US06345204B1 Single pass lead having retractable, actively attached electrode for pacing and sensing 失效
标题翻译：单通引线具有可伸缩的，主动连接的用于起搏和感测的电极
公开(公告)号：US06345204B1
公开(公告)日：2002-02-05
申请号：US09661531
申请日：2000-09-14
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
IPC分类号： A61N105
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.
摘要翻译：一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。第一和第二电极都适于定位和固定在墙上。活性固定元件用作第二电极的一部分。引线体还包括有助于第二电极的定位和固定的弯曲部分。在另一实施例中，主引线体包括凹部，其中一个端部的心房引线体和主动固定元件可以从凹部位置到固定在心脏壁上的位置。主动固定元件也可以通过转动端子销来移动。

7. 发明授权

US6152954A Single pass lead having retractable, actively attached electrode for pacing and sensing 失效
标题翻译：单通引线具有可伸缩的，主动连接的用于起搏和感测的电极
公开(公告)号：US6152954A
公开(公告)日：2000-11-28
申请号：US121006
申请日：1998-07-22
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.
摘要翻译：一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。第一和第二电极都适于定位和固定在墙上。活性固定元件用作第二电极的一部分。引线体还包括有助于第二电极的定位和固定的弯曲部分。在另一个实施例中，主引线主体包括凹部，其中安装在一端的心房引线主体和主动固定元件可以从凹陷位置行进到用于固定到心脏壁的位置。主动固定元件也可以通过转动端子销来移动。

8. 发明授权

US08473076B2 Lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：用于刺激肺动脉中的压力感受器的铅
公开(公告)号：US08473076B2
公开(公告)日：2013-06-25
申请号：US13225769
申请日：2011-09-06
申请人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
发明人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0476 , A61N1/05 , A61N1/056 , A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The plurality of zones can be tested to determine which zone delivers the best baroreflex response. At least one of the electrode zones can be selected to deliver a stimulation signal based on the testing. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器到可膨胀电极。可膨胀电极包括多个电极区。可以测试多个区域以确定哪个区域提供最佳的压力反射响应。可以选择至少一个电极区域以基于测试传递刺激信号。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

9. 发明授权

US08126560B2 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：刺激肺动脉压力感受器的刺激
公开(公告)号：US08126560B2
公开(公告)日：2012-02-28
申请号：US10746852
申请日：2003-12-24
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
IPC分类号： A61N1/18 , A61N1/362
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线体，所述远端具有偏压部分，所述偏压部分的外径尺寸设计成邻接肺动脉壁，邻近远端连接的电极和可植入脉冲发电机电耦合到电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

10. 发明申请

US20100076511A1 BAROREFLEX STIMULATION SYSTEM TO REDUCE HYPERTENSION 有权
标题翻译： BAROREFLEX刺激系统降低高血压
公开(公告)号：US20100076511A1
公开(公告)日：2010-03-25
申请号：US12627562
申请日：2009-11-30
申请人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

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