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1. 发明授权

US4863607A Method for removing amine from oil 失效
标题翻译：从油中除去胺的方法
公开(公告)号：US4863607A
公开(公告)日：1989-09-05
申请号：US81933
申请日：1987-08-03
申请人： John E. Andrew , Howard R. Herrigel , George R. Jones , James C. Nowak , Mark K. Tose , Robert Whalen
发明人： John E. Andrew , Howard R. Herrigel , George R. Jones , James C. Nowak , Mark K. Tose , Robert Whalen
IPC分类号： B01D3/36 , B01D3/38 , B01D17/05 , C02F1/26
CPC分类号： B01D3/36 , B01D3/38
摘要： The present invention is a method for using water to remove amine from an oil-amine component. The oil-amine component is typically produced in prior art processes using an amine having an inverse critical solution temperature with water to break emulsions and sludges. The steps of the present invention include adding water to the oil-amine component in an amount sufficient to form a water-amine azeotrope with substantially all the amine in the oil-amine component followed by heating to remove the azeotrope. The method of the present invention may be used to remove amine from an oil-amine component even where the amine is present in an amount as low as 10% or less by weight.

2. 发明授权

US3955933A Magnesium-boron particulate composites 失效
标题翻译：镁 - 硼颗粒复合材料
公开(公告)号：US3955933A
公开(公告)日：1976-05-11
申请号：US472577
申请日：1974-05-23
申请人： Oleg D. Sherby , Irvin C. Huseby , Robert Whalen , Steven L. Robinson
发明人： Oleg D. Sherby , Irvin C. Huseby , Robert Whalen , Steven L. Robinson
IPC分类号： B22F3/20 , C22C1/00 , C22C1/04 , C22C1/10 , C22C32/00 , B22F3/00 , B22F5/00 , C22C23/00
CPC分类号： C22C32/0073 , B22F3/20 , C22C1/00 , C22C1/0408 , C22C1/10
摘要： A magnesium-boron composite is made by mechanically mixing magnesium powders with boron powders. An alternative embodiment includes mixing a small amount of lithium powder with the magnesium boron composite to improve the ductility. The mixed powders are processed by cold pressing, hot pressing, sintering, extruding, rolling and re-extruding.
摘要翻译：通过将镁粉与硼粉机械混合制成镁 - 硼复合材料。一个替代实施例包括将少量的锂粉末与镁硼复合物混合以改善延展性。混合粉末通过冷压，热压，烧结，挤出，轧制和再挤压加工。

3. 发明申请

US20070150709A1 Method and system for state tracking and recovery in multiprocessing computing systems 有权
标题翻译：多处理计算系统中状态跟踪和恢复的方法和系统
公开(公告)号：US20070150709A1
公开(公告)日：2007-06-28
申请号：US11223733
申请日：2005-09-09
申请人： Janet Easton , Elke Nass , Kenneth Oakes , Andrew Piechowski , Martin Taubert , John Trotter , Ambrose Verdibello , Joachim Buttlar , Robert Whalen
发明人： Janet Easton , Elke Nass , Kenneth Oakes , Andrew Piechowski , Martin Taubert , John Trotter , Ambrose Verdibello , Joachim Buttlar , Robert Whalen
IPC分类号： G06F9/00 , G06F17/00
CPC分类号： G06F11/008 , G06F11/0715 , G06F11/0724 , G06F11/0766
摘要： Disclosed are a method and system of tracking real time use of I/O control blocks on a processing unit basis, in a multiprocessing system, such that in the case of a processing unit failure, a list accurately and concisely identifies the control blocks that need to be recovered. This eliminates the need to scan all the I/O control blocks, greatly reducing the overall system recovery time and minimizing impact to the rest of the running system. The preferred embodiment of the invention uses a task control block structure to record which I/O control blocks are in use by each Processing Unit. Also, the lock word structure defined in the I/O control blocks is provided with an index back into the task control block to facilitate managing the task control block entries.
摘要翻译：公开了一种在多处理系统中基于处理单元跟踪I / O控制块的实时使用的方法和系统，使得在处理单元故障的情况下，列表精确和简洁地识别需要的控制块要恢复这样就不需要扫描所有的I / O控制块，大大降低了整个系统的恢复时间，并最大限度地减少了对其他运行系统的影响。本发明的优选实施例使用任务控制块结构来记录每个处理单元使用哪个I / O控制块。此外，在I / O控制块中定义的锁定字结构被提供回到任务控制块中的索引，以便于管理任务控制块条目。

4. 发明申请

US20050050451A1 Automated inspection of packaging materials for package integrity 有权
标题翻译：自动检查包装材料的包装完整性
公开(公告)号：US20050050451A1
公开(公告)日：2005-03-03
申请号：US10734358
申请日：2003-12-12
申请人： Mohsen Abdollahi , Kevin Giles , Charles Guffey , Jun Liu , Bernard Roche , Peter Sites , Robert Whalen
发明人： Mohsen Abdollahi , Kevin Giles , Charles Guffey , Jun Liu , Bernard Roche , Peter Sites , Robert Whalen
IPC分类号： G01N21/95 , G06F17/00
CPC分类号： G01N21/95
摘要： An apparatus in one example comprises a computer component that receives one or more images of one or more packaging materials from one or more imaging components. The computer component employs an analysis of the one or more images to make a determination of a package integrity of the one or more packaging materials.
摘要翻译：一个示例中的装置包括从一个或多个成像部件接收一个或多个包装材料的一个或多个图像的计算机部件。计算机组件采用对一个或多个图像的分析来确定一个或多个包装材料的包装完整性。

5. 发明申请

US20070087374A1 Optimization of immunomodulatory properties of genetic vaccines 审中-公开
公开(公告)号：US20070087374A1
公开(公告)日：2007-04-19
申请号：US11607038
申请日：2006-12-01
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
IPC分类号： C40B30/06 , C40B40/08
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.

6. 发明申请

US20050222069A1 Optimization of immunomodulatory properties of genetic vaccines 审中-公开
公开(公告)号：US20050222069A1
公开(公告)日：2005-10-06
申请号：US10981535
申请日：2004-11-05
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
IPC分类号： A61K39/00 , C07K14/02 , C07K14/16 , C07K14/24 , C12N15/10 , C40B40/02 , A61K48/00 , C12Q1/68
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.

7. 发明申请

US20050038232A1 Antibody diversity generation 审中-公开
标题翻译：抗体多样性生成
公开(公告)号：US20050038232A1
公开(公告)日：2005-02-17
申请号：US10686945
申请日：2003-10-16
申请人： Erik Karrer , Steven Bass , Robert Whalen , Phillip Patten
发明人： Erik Karrer , Steven Bass , Robert Whalen , Phillip Patten
IPC分类号： C07K16/00 , C07K16/12 , C12N1/21 , C12N15/13 , C12N15/49 , C07K16/46 , C07H21/04
CPC分类号： C07K16/1271 , C07K16/00 , C07K16/1275 , C07K2317/24
摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
摘要翻译：提供了通过多种DNA多样化和选择程序改进抗体的方法。改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。人性化。提供重组抗体序列的文库，以及表达这些文库成员的细胞。提供了新的噬菌体展示载体。提供了抗体及其同源抗原共转化方法。共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。提供了改进用于检测生物战剂的抗体的方法。

8. 发明授权

US4179954A Jar and bottle opener 失效
标题翻译：罐子和开瓶器
公开(公告)号：US4179954A
公开(公告)日：1979-12-25
申请号：US897556
申请日：1978-04-18
申请人： Robert Whalen
发明人： Robert Whalen
IPC分类号： B67B7/18 , B67B7/00
CPC分类号： B67B7/18
摘要： A pair of symmetrical elongated gripping members are affixed to each other in angular relation by a generally V-shaped resilient joining member. Each of the gripping members has a length-extending edge with a plurality of spaced partially circular notches formed therein. The notches have diameters varying from a minimum in the area of the joining member to a maximum in the area of the free ends. Handles extend from the free ends of the gripping members to facilitate urging such free ends toward each other to grasp a lid of a container between corresponding notches of the gripping members.
摘要翻译：一对对称的细长的夹持构件通过大致V形的弹性连接构件以角度关系彼此固定。每个夹持构件具有长度延伸的边缘，其中形成有多个间隔开的部分圆形的凹口。切口的直径从接合部件的面积的最小值在自由端的面积上变化到最大。手柄从夹持构件的自由端延伸，以便于将这些自由端朝向彼此推动，以抓握夹持构件的相应凹口之间的容器盖。

9. 发明申请

US20080207459A1 ANTIBODY DIVERSITY GENERATION 失效
标题翻译：抗体多样性生成
公开(公告)号：US20080207459A1
公开(公告)日：2008-08-28
申请号：US12026412
申请日：2008-02-05
申请人： Erik Karrer , Steven H. Bass , Robert Whalen , Phillip A. Patten
发明人： Erik Karrer , Steven H. Bass , Robert Whalen , Phillip A. Patten
IPC分类号： C40B10/00 , C40B50/00 , C40B30/00 , C40B30/02 , C40B30/04 , C07K1/00 , C40B40/08 , C12N5/06 , C12N15/00
CPC分类号： C07K16/1271 , C07K16/00 , C07K16/1275 , C07K2317/24
摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
摘要翻译：提供了通过多种DNA多样化和选择程序改进抗体的方法。改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。人性化。提供重组抗体序列的文库，以及表达这些文库成员的细胞。提供了新的噬菌体展示载体。提供了抗体及其同源抗原共转化方法。共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。提供了改进用于检测生物战剂的抗体的方法。

10. 发明申请

US20070087373A1 Optimization of immunomodulatory properties of genetic vaccines 审中-公开
标题翻译：遗传疫苗免疫调节特性的优化
公开(公告)号：US20070087373A1
公开(公告)日：2007-04-19
申请号：US11607035
申请日：2006-12-01
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
IPC分类号： C40B30/06 , C40B40/08
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
摘要翻译：本发明提供了获得可调节免疫应答的分子的方法，以及使用该方法获得的免疫调节分子。分子可用于例如为了期望目的而定制由遗传疫苗诱导的免疫应答。

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