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1. 发明授权

US06825032B2 High capacity assay platforms 失效
标题翻译：高容量测定平台
公开(公告)号：US06825032B2
公开(公告)日：2004-11-30
申请号：US09854638
申请日：2001-05-14
申请人： John Dapron , William Karl Kappel , Handong Li
发明人： John Dapron , William Karl Kappel , Handong Li
IPC分类号： C12M134
CPC分类号： G01N33/54346 , G01N33/54366
摘要： A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 &mgr;g/cm2.
摘要翻译：能够结合靶分子的高容量测定平台包括底物和附着于基底的聚合物基质。聚合物基质包括多个聚合物分子，其中至少一些聚合物分子直接共价连接到基底上，并且其中至少一些分子与其它聚合物分子交联。一些聚合物分子具有共价连接到其上的至少一个结合配体，并且基底上的聚合物基质的密度为至少2mug / cm 2。

2. 发明申请

US20050119415A1 High capacity assay platforms 审中-公开
标题翻译：高容量测定平台
公开(公告)号：US20050119415A1
公开(公告)日：2005-06-02
申请号：US10982942
申请日：2004-11-05
申请人： John Dapron , William Kappel , Handong Li
发明人： John Dapron , William Kappel , Handong Li
IPC分类号： G01N33/48 , C12M1/00 , G01N33/543 , C08F2/00
CPC分类号： G01N33/54346 , G01N33/54366
摘要： A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 μg/cm2.
摘要翻译：能够结合靶分子的高容量测定平台包括底物和附着于基底的聚合物基质。聚合物基质包括多个聚合物分子，其中至少一些聚合物分子直接共价连接到基底上，并且其中至少一些分子与其它聚合物分子交联。一些聚合物分子具有共价连接到其上的至少一个结合配体，并且基材上的聚合物基质的密度为至少2mug / cm 2。

3. 发明申请

US20050118709A1 High capacity assay platforms 审中-公开
公开(公告)号：US20050118709A1
公开(公告)日：2005-06-02
申请号：US10983034
申请日：2004-11-05
申请人： John Dapron , William Kappel , Handong Li
发明人： John Dapron , William Kappel , Handong Li
IPC分类号： G01N33/48 , C12M1/00 , G01N33/543 , A61M36/14
CPC分类号： G01N33/54346 , G01N33/54366
摘要： A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 μg/cm2.

4. 发明申请

US20060148090A1 Metal chelating compositions for protein purification, detection or binding 有权
标题翻译：用于蛋白质纯化，检测或结合的金属螯合组合物
公开(公告)号：US20060148090A1
公开(公告)日：2006-07-06
申请号：US11364928
申请日：2006-03-01
申请人： William Kappel , Vankatappa Viswanatha , Handong Li , Richard Mehigh , John Dapron
发明人： William Kappel , Vankatappa Viswanatha , Handong Li , Richard Mehigh , John Dapron
IPC分类号： G01N33/48
CPC分类号： G01N33/5306 , B01J45/00 , C07B2200/11 , C07C323/58 , G01N33/6803 , Y10T436/25125
摘要： A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(═O)—; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is —(CH2)kCH3, —(CH2)kCOOH, —(CH2)kSO3H, —(CH2)kPO3H2, —(CH2)kN(J)2, or —(CH2)kP(J)2, preferably —(CH2)kCOOH or —(CH2)kSO3H; k is an integer from 0 to 2; J is hydrocarbyl or substituted hydrocarbyl; Y is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; Z is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; and i is an integer from 0 to 4, preferably 1 or 2.
摘要翻译：一种具有下式的金属螯合组合物：其中Q是载体; S 是间隔物; L是-A-T-CH（X） - 或-C（-O） - ; A是醚，硫醚，硒醚或酰胺键; T是键或取代或未取代的烷基或链烯基; X是 - （CH 2 CH 2）n CH 3， - （CH 2 CH 2） 3，COOH， - （CH 2）2 H 3 - ， - （CH 2 CH 2） N（J）＆lt; SUB＆gt; N（J）＆lt; SUB＆gt; （CH 2）2，或 - （CH 2）2，优选 - （CH 2） COOH或 - （CH 2 CH 2）n SO 3 H; k是0至2的整数; J是烃基或取代的烃基; Y是-COOH，-H，-SO 3 H，-PO 3 H 2，-N（J）2， /或> -P（J）2，优选-COOH; Z是-COOH，-H，-SO 3 H，-PO 3 H 2，-N（J）2， /或> -P（J）2，优选-COOH; 且i为0至4，优选1或2的整数。

5. 发明申请

US20050123968A1 High capacity assay platforms 审中-公开
公开(公告)号：US20050123968A1
公开(公告)日：2005-06-09
申请号：US10982345
申请日：2004-11-05
申请人： John Dapron , William Kappel , Handong Li
发明人： John Dapron , William Kappel , Handong Li
IPC分类号： G01N33/48 , C12M1/00 , G01N33/543 , C12Q1/68 , C12M1/34 , G01N33/53
CPC分类号： G01N33/54346 , G01N33/54366
摘要： A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 μg/cm2.

6. 发明申请

US20140178862A1 PHOTOINDUCED REDOX CURRENT (PIRC) DETECTION FOR DNA SEQUENCING USING INTEGRATED TRANSDUCER ARRAY 审中-公开
标题翻译：使用集成传感器阵列进行DNA序列测定的红外线电流（PIRC）检测
公开(公告)号：US20140178862A1
公开(公告)日：2014-06-26
申请号：US13721488
申请日：2012-12-20
申请人： Xing Su , Handong Li
发明人： Xing Su , Handong Li
IPC分类号： G01N27/00
CPC分类号： C12Q1/6874 , G01N27/3277 , C12Q2565/607
摘要： Photoinduced redox current (PIRC) detection for DNA sequencing using integrated transducer arrays is described. For example, a method of determining DNA sequencing using photoinduced redox current (PIRC) includes providing a template having a primer region and a second region of one or more unknown bases. The template is coupled to a transducer array. The method also includes incorporating a tagged nucleotide at the second region of the template. The method also includes exposing the template to a light source. The method also includes electrically detecting, by the transducer, a state of the template. The method also includes removing a photosensitizer tag of the tagged nucleotide.
摘要翻译：描述了使用集成的换能器阵列的DNA测序的光诱导的氧化还原电流（PIRC）检测。例如，使用光诱导氧化还原电流（PIRC）测定DNA测序的方法包括提供具有引物区和一个或多个未知碱基的第二区的模板。模板耦合到换能器阵列。该方法还包括在模板的第二区域掺入标记的核苷酸。该方法还包括将模板暴露于光源。该方法还包括通过换能器电检测模板的状态。该方法还包括去除标记的核苷酸的光敏剂标签。

7. 发明授权

US08658093B2 Devices and methods for the detection of analytes 有权
标题翻译：用于检测分析物的装置和方法
公开(公告)号：US08658093B2
公开(公告)日：2014-02-25
申请号：US12167292
申请日：2008-07-03
申请人： Aldrich N. K. Lau , Robert G. Eason , Kristian M. Scaboo , Handong Li
发明人： Aldrich N. K. Lau , Robert G. Eason , Kristian M. Scaboo , Handong Li
IPC分类号： G01N1/26
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , G01N33/54326 , G01N2400/00
摘要： System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
摘要翻译：描述了用于检测分析物如致病细胞的系统和方法。这些方法允许直接测量分析物如病原体，而不需要样品制备和/或PCR。这些装置可以单独用作食品和农产品中的空气传播病原体和其他致病生物的使用点传感器。

8. 发明申请

US20130264669A1 METHOD OF MAKING A SEMICONDUCTOR RADIATION DETECTOR 有权
标题翻译：制造半导体辐射探测器的方法
公开(公告)号：US20130264669A1
公开(公告)日：2013-10-10
申请号：US13442957
申请日：2012-04-10
申请人： Handong Li , Michael Prokesch , John Francis Eger
发明人： Handong Li , Michael Prokesch , John Francis Eger
IPC分类号： H01L27/14 , H01L31/18
CPC分类号： H01L31/022408 , H01L27/14676 , H01L27/14696 , H01L31/085 , H01L31/1828 , Y02E10/543
摘要： A method of making a semiconductor radiation detector wherein the metal layers which serve as the cathode and anode electrodes are recessed from the designated prospective dice lines which define the total upper and lower surface areas for each detector such that the dicing blade will not directly engage the metal during dicing and therefore prevent metal from intruding upon (smearing) the vertical side walls of the detector substrate.
摘要翻译：一种制造半导体辐射检测器的方法，其中用作阴极和阳极电极的金属层从指定的预期骰子线凹下，其限定每个检测器的总上表面积和下表面积，使得切割刀片不会直接接合金属，因此防止金属侵入（污染）检测器基板的垂直侧壁。

9. 发明授权

US08003408B2 Modification of metal nanoparticles for improved analyte detection by surface enhanced Raman spectroscopy (SERS) 有权
标题翻译：通过表面增强拉曼光谱（SERS）改进金属纳米粒子改进分析物检测
公开(公告)号：US08003408B2
公开(公告)日：2011-08-23
申请号：US11319747
申请日：2005-12-29
申请人： Jingwu Zhang , Narayan Sundararajan , Sarah M. Ngola , Handong Li
发明人： Jingwu Zhang , Narayan Sundararajan , Sarah M. Ngola , Handong Li
IPC分类号： G01N33/553 , G01N33/20 , G01N21/00 , A61K9/54
CPC分类号： G01N33/54373 , B82Y30/00 , G01N21/658 , G01N33/54346 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： A SERS active particle having a metal-containing particle and a cationic coating on the metal-containing particle, wherein the SERS active particle carries a positive charge is disclosed. Also, a SERS active particle having a metal-containing particle and a non-metallic molecule, wherein the metal-containing particle is derivatized with the non-metallic molecule is disclosed. In addition, several methods of modifying the nanoparticles surfaces of a SERS active particle and of improving the interaction between the SERS active particle and an analyte are disclosed.
摘要翻译：公开了一种SERS活性颗粒，其具有含金属颗粒和阳离子涂层在含金属颗粒上，其中SERS活性颗粒携带正电荷。另外，公开了含有金属的粒子和非金属分子的SERS活性粒子，其中含金属的粒子被非金属分子衍生化。另外，公开了改进SERS活性颗粒的纳米颗粒表面和改善SERS活性颗粒与分析物之间的相互作用的几种方法。

10. 发明授权

US07753987B2 High vacuum in-situ refining method for high-purity materials and an apparatus thereof 失效
标题翻译：用于高纯度材料的高真空原位精制方法及其装置
公开(公告)号：US07753987B2
公开(公告)日：2010-07-13
申请号：US12067835
申请日：2006-04-11
申请人： Xiaolong Du , Zhaoquan Zeng , Hongtao Yuan , Handong Li , Qikun Xue , Jinfeng Jia
发明人： Xiaolong Du , Zhaoquan Zeng , Hongtao Yuan , Handong Li , Qikun Xue , Jinfeng Jia
IPC分类号： C22B9/04 , C22B9/05 , C22B26/00 , C22B30/04
CPC分类号： C22B9/02 , C22B9/04 , C22B9/14 , C22B19/12 , C22B19/18 , F27B14/04 , F27B14/20 , Y02P10/234
摘要： The present invention concerns a high vacuum in-situ refining method for high-purity and superhigh-purity materials and the apparatus thereof, characterized in heating the upper part and lower part of crucible separately using double-heating-wires diffusion furnace under vacuum, thereby forming the temperature profile which is high at upper part and low at lower part of crucible, or in reverse during different stages; then heating the crucible in two steps to remove impurities with high saturation vapor pressure and low saturation vapor pressure respectively in efficiency; and obtaining high-purity materials eventually. The whole procedure is isolated from atmosphere, reducing contamination upon stuff remarkably. The present invention could provide products with high-quality and high production capacity, which are stable in performance, therefore is reliable and free from contamination. The present invention is appropriate for manufacture of high-purity and superhigh-purity materials, particularly for manufacture of high-activity high-purity materials.
摘要翻译：本发明涉及一种用于高纯度和超高纯度材料的高真空原位精制方法及其装置，其特征在于使用双重加热丝扩散炉在真空下分别加热坩埚的上部和下部，由此形成坩埚上部和下部较高的温度分布，或在不同阶段形成相反的温度分布; 然后分两步加热坩埚以分别以高饱和蒸气压和低饱和蒸气压去除杂质; 并最终获得高纯度材料。整个过程与大气隔离，减少了污染物的显着。本发明可以提供具有高质量和高生产能力的产品，性能稳定，因此可靠，无污染。本发明适用于制造高纯度和超高纯度材料，特别是用于制造高活性高纯度材料。

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