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1. 发明申请

US20140054454A1 Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers 有权
标题翻译：用于校正飞行时间质谱误差的静电万向节
公开(公告)号：US20140054454A1
公开(公告)日：2014-02-27
申请号：US14004946
申请日：2012-03-13
申请人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

2. 发明授权

US08895920B2 Mass spectrometer with beam expander 有权
公开(公告)号：US08895920B2
公开(公告)日：2014-11-25
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/00 , H01J49/06
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.

3. 发明授权

US08283628B2 Ion mobility spectrometer 有权
标题翻译：离子迁移谱仪
公开(公告)号：US08283628B2
公开(公告)日：2012-10-09
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： B01D59/44
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

4. 发明申请

US20110291001A1 Ion Mobility Spectrometer 有权
标题翻译：离子流动光谱仪
公开(公告)号：US20110291001A1
公开(公告)日：2011-12-01
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： H01J49/26
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

5. 发明授权

US09214328B2 Space focus time of flight mass spectrometer 有权
标题翻译：空间聚焦时间飞行质谱仪
公开(公告)号：US09214328B2
公开(公告)日：2015-12-15
申请号：US13996893
申请日：2011-12-22
申请人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyzer is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译：公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致减少到达离子检测器的离子到达时间和离子浓度Dgr。

6. 发明授权

US08921775B2 Electrostatic gimbal for correction of errors in time of flight mass spectrometers 有权
标题翻译：用于校正飞行时间质谱仪误差的静电万向架
公开(公告)号：US08921775B2
公开(公告)日：2014-12-30
申请号：US14004946
申请日：2012-03-13
申请人： David J. Langridge , Jason Lee Wildgoose , John Brian Hoyes
发明人： David J. Langridge , Jason Lee Wildgoose , John Brian Hoyes
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

7. 发明申请

US20140014830A1 Space Focus Time of Flight Mass Spectrometer 有权
标题翻译：空间聚焦时间飞行质谱仪
公开(公告)号：US20140014830A1
公开(公告)日：2014-01-16
申请号：US13996893
申请日：2011-12-22
申请人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译：公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致降低到达离子检测器的离子到达时间ΔT的离子扩散。

8. 发明申请

US20130256524A1 Mass Spectrometer With Beam Expander 有权
公开(公告)号：US20130256524A1
公开(公告)日：2013-10-03
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.

9. 发明授权

US07960694B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07960694B2
公开(公告)日：2011-06-14
申请号：US12373204
申请日：2007-07-09
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4235
摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass ((analyser 2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC′ or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser (2).
摘要翻译：提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。沿着质量轴（（分析仪2））产生多个伪电位波纹，伪电位波纹的振幅或深度与离子的质荷比成反比，一个或多个瞬态直流电压被施加到质量分析器（2）的电极，以沿着质量分析器（2）的长度推动离子，施加到电极的瞬态DC电压的幅度随时间增加并且离子被发射从质量分析器（2）以其质量与电荷比的相反顺序将两个AC或RF电压施加到电极上，第一AC或RF电压被布置成提供最佳伪电位波纹，而第二AC'或RF 电压被布置成在质量分析器（2）内提供离子的最佳径向约束。

10. 发明授权

US06992283B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06992283B2
公开(公告)日：2006-01-31
申请号：US10739041
申请日：2003-12-19
申请人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/0036 , H01J49/004
摘要： A mass spectrometer is disclosed wherein ions are passed through an ion mobility separator and are then mass analysed by a Time of Flight mass analyzer. Multiple sets of mass spectral data are obtained which are then post-processed so that mass spectral data relating to ions having undesired charge state(s) is filtered out. The resultant mass spectrum comprises ions having a desired charge state.
摘要翻译：公开了一种质谱仪，其中离子通过离子迁移率分离器，然后通过飞行时间质量分析仪进行质量分析。获得多组质谱数据，然后对其进行后处理，从而滤出与具有不期望的电荷状态的离子相关的质谱数据。所得质谱包括具有所需电荷状态的离子。

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