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1. 发明授权

US09880129B2 Mass spectrometer 有权
公开(公告)号：US09880129B2
公开(公告)日：2018-01-30
申请号：US11568167
申请日：2005-04-20
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J49/06 , G01N27/62
CPC分类号： G01N27/624 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes (9a, 9b) in series with an ion mobility separator (12) forming part of a mass spectrometer. Ions are separated in the FAIMS device (9a, 9b) according to their rate of change of ion mobility with electric field strength. The ions which are onwardly transmitted from the FAIMS device (9a, 9b) are then passed to an ion separator device (12) comprising a plurality of electrodes (12) and an optional ion trapping region (33). Ions are radially confined with the ion separator by application of an AC or RF voltage to the electrodes (12) and ions are separated according to their ion mobility by applying an axial DC voltage gradient which may remain constant as a function of time or which may vary with time.

2. 发明授权

US08952320B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08952320B2
公开(公告)日：2015-02-10
申请号：US11719665
申请日：2005-11-18
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器装置（6）。

3. 发明授权

US08809768B2 Mass spectrometer with bypass of a fragmentation device 有权
标题翻译：质谱仪旁路碎片装置
公开(公告)号：US08809768B2
公开(公告)日：2014-08-19
申请号：US12952619
申请日：2010-11-23
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
摘要翻译：用于分析组分混合物的方法包括从组分形成前体离子，交替地使前体离子传递到并绕过碎裂装置，以从通过装置的前体离子形成产物离子并基本上形成来自前体离子的产物离子越过旁路器件，并且从从器件接收的产物离子和从器件旁路的前体离子获得质谱。用于分析样品的装置包括用于从样品的组分形成前体离子的离子源，用于从前体离子形成产物离子的碎裂装置，设置在碎裂装置上游的旁路装置，用于可切换的旁路碎片装置和质量分析器。

4. 发明授权

US07943900B2 Mass analysis using alternating fragmentation modes 有权
标题翻译：使用交替分片模式进行质量分析
公开(公告)号：US07943900B2
公开(公告)日：2011-05-17
申请号：US12272117
申请日：2008-11-17
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Transfer Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Transfer Dissociation fragmentation device.
摘要翻译：用于分析组分混合物的方法包括通过使组分在一段时间内顺序洗脱的方式分离或部分分离样品混合物的组分，从洗脱液中的组分形成前体离子，重复切换，在高分裂模式和低碎裂模式之间来回地改变或改变电子转移离解断裂装置，以在高分裂模式中交替地从前体离子产生产物离子，并在低分散化模式中产生基本上更少的产物离子，从电子转移解离分离装置接收的前体和产物离子获得质谱。

5. 发明授权

US07851751B2 Mass analysis with alternating bypass of a fragmentation device 有权
标题翻译：用分段装置的交替旁路进行质量分析
公开(公告)号：US07851751B2
公开(公告)日：2010-12-14
申请号：US12272213
申请日：2008-11-17
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
摘要翻译：用于分析组分混合物的方法包括从组分形成前体离子，交替地使前体离子传递到并绕过碎裂装置，以从通过装置的前体离子形成产物离子并基本上形成来自前体离子的产物离子越过旁路器件，并且从从器件接收的产物离子和从器件旁路的前体离子获得质谱。用于分析样品的装置包括用于从样品的组分形成前体离子的离子源，用于从前体离子形成产物离子的碎裂装置，设置在碎裂装置上游的旁路装置，用于可切换的旁路碎片装置和质量分析器。

6. 发明授权

US07586088B2 Mass spectrometer and method of mass spectrometry 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US07586088B2
公开(公告)日：2009-09-08
申请号：US10176072
申请日：2002-06-21
申请人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/40 , G01N27/624 , H01J49/004 , H01J49/4215
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer in combination with a quadrupole mass filter which is scanned in synchronization with the pulsing of ions into the ion mobility spectrometer thereby enabling ions having a particular charge state to be preferentially transmitted. Another embodiment replaces the quadrupole mass filter with an axial time of flight mass filter and an injection electrode.
摘要翻译：公开了一种质谱仪，其包括与四极质量过滤器组合的离子迁移谱仪，其与离子脉冲离子扫描到离子迁移谱仪中，从而使具有特定电荷状态的离子能够被优先传输。另一实施例用轴向飞行时间质量过滤器和注入电极取代四极质量过滤器。

7. 发明申请

US20090194688A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090194688A1
公开(公告)日：2009-08-06
申请号：US11719665
申请日：2005-11-18
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器装置（6）。

8. 发明申请

US20090173877A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090173877A1
公开(公告)日：2009-07-09
申请号：US12092601
申请日：2005-11-10
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/004 , G01N27/622 , H01J49/0031 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译：公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器）。在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。

9. 发明申请

US20090065690A1 MASS ANALYSIS WITH ALTERNATING BYPASS OF A FRAGMENTATION DEVICE 有权
标题翻译：具有分段设备旁路的质量分析
公开(公告)号：US20090065690A1
公开(公告)日：2009-03-12
申请号：US12272213
申请日：2008-11-17
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
摘要翻译：用于分析组分混合物的方法包括从组分形成前体离子，交替地使前体离子传递到并绕过碎裂装置，以从通过装置的前体离子形成产物离子并基本上形成来自前体离子的产物离子越过旁路器件，并且从从器件接收的产物离子和从器件旁路的前体离子获得质谱。用于分析样品的装置包括用于从样品的组分形成前体离子的离子源，用于从前体离子形成产物离子的碎裂装置，设置在碎裂装置上游的旁路装置，用于可切换的旁路碎片装置和质量分析器。

10. 发明授权

US07427752B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07427752B2
公开(公告)日：2008-09-23
申请号：US10535053
申请日：2003-10-28
申请人： Gareth Rhys Jones , Robert Harold Bateman
发明人： Gareth Rhys Jones , Robert Harold Bateman
IPC分类号： H01J49/30 , H01J49/32
CPC分类号： H01J49/30
摘要： A magnetic sector mass spectrometer is disclosed comprising an ion detector (11) wherein a reflecting electrode (13) is used to divide an ion beam in the direction of mass dispersion into two separate ion beams. The two ion beams are directed onto two detectors which preferably comprise two or more conversion dynodes (15a, 15b) and two or more corresponding microchannel plate detectors (14a, 14b) to detect electrons produced by the conversion dynodes (15a, 15b). If the signal from the two detectors differs substantially then the ion beam can be determined to include interference ions. Conversely, if the signal from the two detectors is substantially the same then the ion beam can be determined to be substantially free from interference ions.
摘要翻译：公开了一种磁性扇形质谱仪，其包括离子检测器（11），其中使用反射电极（13）将质谱分散的离子束分成两个分离的离子束。两个离子束被引导到两个检测器上，优选地包括两个或更多个转换倍增极（15a，15b）和两个或更多个相应的微通道板检测器（14a，14b），以检测由转换倍增电极（15a）产生的电子，15 b）。如果来自两个检测器的信号基本相差，则可以确定离子束包括干涉离子。相反，如果来自两个检测器的信号基本相同，则可以确定离子束基本上不含干扰离子。

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