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1. 发明授权

US07091000B2 Bacterial strains which overproduce riboflavin and methods of use thereof 失效
标题翻译：过度生产核黄素的细菌菌株及其使用方法
公开(公告)号：US07091000B2
公开(公告)日：2006-08-15
申请号：US10361522
申请日：2003-02-10
申请人： John B. Perkins , Alan Sloma , Janice G. Pero , Randolph T. Hatch , Theron Hermann , Thomas Erdenberger
发明人： John B. Perkins , Alan Sloma , Janice G. Pero , Randolph T. Hatch , Theron Hermann , Thomas Erdenberger
IPC分类号： C12P21/00 , C07H21/04 , A61K38/16 , A61K38/43
CPC分类号： C12P25/00 , C12N15/52
摘要： Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
摘要翻译：用于过量产生核黄素的载体和重组细菌，其中过量产生核黄素生物合成蛋白的核酸被引入宿主生物体的染色体，例如。在多个站点和每个站点的多个副本。使用具有至少五个基因的rib操纵子来制备这样的重组细菌。

2. 发明授权

US06551813B1 Nutrient medium for bacterial strains which overproduce riboflavin 失效
标题翻译：用于生产核黄素的细菌菌株的营养培养基
公开(公告)号：US06551813B1
公开(公告)日：2003-04-22
申请号：US09306615
申请日：1999-05-06
申请人： John B. Perkins , Alan Sloma , Janice G. Pero , Randolph T. Hatch , Theron Hermann , Thomas Erdenberger
发明人： John B. Perkins , Alan Sloma , Janice G. Pero , Randolph T. Hatch , Theron Hermann , Thomas Erdenberger
IPC分类号： C12P2500
CPC分类号： C12P25/00 , C12N15/52
摘要： Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
摘要翻译：用于过量产生核黄素的载体和重组细菌，其中过量产生核黄素生物合成蛋白的核酸被引入宿主生物体的染色体，例如。在多个站点和每个站点的多个副本。使用具有至少五个基因的rib操纵子来制备这样的重组细菌。

3. 发明授权

US5925538A Bacterial strains which overproduce riboflavin 失效
公开(公告)号：US5925538A
公开(公告)日：1999-07-20
申请号：US138775
申请日：1998-08-24
申请人： John B. Perkins , Alan Sloma , Janice G. Pero , Randolph T. Hatch , Theron Hermann , Thomas Erdenberger
发明人： John B. Perkins , Alan Sloma , Janice G. Pero , Randolph T. Hatch , Theron Hermann , Thomas Erdenberger
IPC分类号： C12N1/21 , C12N15/31 , C12N15/52 , C12P25/00 , C12N15/32
CPC分类号： C12P25/00 , C12N15/52
摘要： Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.

4. 发明申请

US20140349385A1 SINGLE-USE MIXING AND BIOREACTOR SYSTEMS 有权
标题翻译：单一混合和生物反应器系统
公开(公告)号：US20140349385A1
公开(公告)日：2014-11-27
申请号：US14345256
申请日：2012-09-13
申请人： Thomas Erdenberger , Richard L. Damren , Coln R. Tuohey , Michael Fisher , Parrish M. Galliher , Jonathan A. Kenney
发明人： Thomas Erdenberger , Richard L. Damren , Coln R. Tuohey , Michael Fisher , Parrish M. Galliher , Jonathan A. Kenney
IPC分类号： B01F13/08 , C12M1/00 , C12M1/06
CPC分类号： B01F13/0818 , B01F3/04106 , B01F3/04531 , B01F7/0025 , B01F7/00633 , B01F7/162 , B01F13/0872 , B01F15/00714 , B01F15/0085 , B01F2003/04673 , B01F2015/0011 , B01F2215/0073 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are “receiver-less” retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.
摘要翻译：公开了用于柔性容器反应容器的磁力搅拌混合系统。在本发明的一个方面中，叶轮磁体和外部驱动磁体之间的磁耦合的取向被改变，使得联接器既不是严格的轴向也不是严格的径向。还公开了“无接收器”保持器构造，由此一次性容器不需要具有限定杯或柱以接合可旋转搅拌器的刚性基座。

5. 发明授权

US11142737B2 Continuous recovery harvest bag 有权
公开(公告)号：US11142737B2
公开(公告)日：2021-10-12
申请号：US13402074
申请日：2012-02-22
申请人： Colin Tuohey , Thomas Erdenberger , Richard Damren , Michael Fisher , John Swibes
发明人： Colin Tuohey , Thomas Erdenberger , Richard Damren , Michael Fisher , John Swibes
IPC分类号： C12M1/12 , C12M1/00
摘要： Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.

6. 发明授权

US09969965B2 Linearly scalable single use bioreactor system 有权
公开(公告)号：US09969965B2
公开(公告)日：2018-05-15
申请号：US13978726
申请日：2012-01-11
申请人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
发明人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
IPC分类号： C12M1/00 , C12N1/06 , C12M1/06
CPC分类号： C12M23/28 , C12M23/02 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50-5000 L systems.

7. 发明授权

US09499781B2 Disposable bioreactor condenser bag and filter heater 有权
标题翻译：一次性生物反应器冷凝器袋和过滤器加热器
公开(公告)号：US09499781B2
公开(公告)日：2016-11-22
申请号：US13434345
申请日：2012-03-29
申请人： Richard Damren , Colin Touhey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
发明人： Richard Damren , Colin Touhey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
IPC分类号： F25B21/02 , F25D17/06 , F25B5/00 , C12M1/00 , B01D5/00
CPC分类号： C12M29/26 , B01D5/0042 , B01D5/0093 , B01D46/4263 , B01D53/265 , C12M23/28 , C12M29/04 , C12M41/12
摘要： Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, forming a dry gas stream for entering or leaving the bioreactor.
摘要翻译：本文公开了一种用于冷凝进入生物反应器或离开生物反应器的湿气流中的水分的系统和方法，形成用于进入或离开生物反应器的干燥气流。

8. 发明申请

US20130288346A1 LINEARLY SCALABLE SINGLE USE BIOREACTOR SYSTEM 有权
标题翻译：线性可扩展单一使用生物反应器系统
公开(公告)号：US20130288346A1
公开(公告)日：2013-10-31
申请号：US13978726
申请日：2012-01-11
申请人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
发明人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
IPC分类号： C12M1/00
CPC分类号： C12M23/28 , C12M23/02 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10 L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50-5000 L systems.
摘要翻译：公开了一种一次性生物反应器袋设计，其在叶轮尖端处提供基本上等效的最大剪切速率，并且在每单位工作体积和生物培养处理所需的rpm的功率范围内的平均或体积剪切速率。袋子设计的剪切轮廓的均匀性在用作缩小或放大平台时提供了独特的优势。还公开了一种线性可伸缩的一次性生物反应器系统，用于进行可扩展的生物制造过程，该系统包括两个不同体积的单次使用的生物反应器袋，其中工作体积H的高度比H / D 到罐的直径D或袋的直径D等于约1.5，并且每个袋中的体积剪切基本上是恒定的。所披露的小规模系统从剪切/可扩展性/性能基础以及从验证和监管的角度来模拟更大规模的系统。总之，所公开的10L生物反应器系统通过使用相同或基本上模拟相同的容器几何形状，气体喷射系统，叶轮形状和类型，柔性袋/部件的聚合物组成，过程控制系统和剪切速率为较大的50-5000 L系统。

9. 发明申请

US20120238011A1 CONTINUOUS RECOVERY HARVEST BAG 审中-公开
标题翻译：连续收回收获袋
公开(公告)号：US20120238011A1
公开(公告)日：2012-09-20
申请号：US13402074
申请日：2012-02-22
申请人： Colin Tuohey , Thomas Erdenberger , Richard Damren , Michael Fisher , John Swibes
发明人： Colin Tuohey , Thomas Erdenberger , Richard Damren , Michael Fisher , John Swibes
IPC分类号： C12M1/12
摘要： Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.
摘要翻译：本文公开了一种单次使用的连续回收，流通收获容器和相应的收获培养基的方法，同时将微载体珠粒留在容器中或将微载体珠粒和培养基流回生物反应器。

10. 发明授权

US09550157B2 Single-use mixing and bioreactor systems 有权
标题翻译：一次性混合和生物反应器系统
公开(公告)号：US09550157B2
公开(公告)日：2017-01-24
申请号：US14345256
申请日：2012-09-13
申请人： Thomas Erdenberger , Richard L. Damren , Colin R. Tuohey , Michael Fisher , Parrish M. Galliher , Jonathan A. Kenney
发明人： Thomas Erdenberger , Richard L. Damren , Colin R. Tuohey , Michael Fisher , Parrish M. Galliher , Jonathan A. Kenney
IPC分类号： B01F13/08 , B01F7/00 , B01F7/16 , B01F15/00 , B01F3/04 , C12M1/06 , C12M1/00
CPC分类号： B01F13/0818 , B01F3/04106 , B01F3/04531 , B01F7/0025 , B01F7/00633 , B01F7/162 , B01F13/0872 , B01F15/00714 , B01F15/0085 , B01F2003/04673 , B01F2015/0011 , B01F2215/0073 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are “receiver-less” retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.
摘要翻译：公开了用于柔性容器反应容器的磁力搅拌混合系统。在本发明的一个方面中，叶轮磁体和外部驱动磁体之间的磁耦合的取向被改变，使得联接器既不是严格的轴向也不是严格的径向。还公开了“无接收器”保持器构造，由此一次性容器不需要具有限定杯或柱以接合可旋转搅拌器的刚性基座。

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