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1. 发明授权

US5220921A Nonmagnetic tactile stimulator and biomagnetometer utilizing the stimulator 失效
标题翻译：非特异性手术刺激器和生物传感器利用刺激器
公开(公告)号：US5220921A
公开(公告)日：1993-06-22
申请号：US783109
申请日：1991-10-25
申请人： Johathan R. Ferris , K. Randy Brimhall , Frank W. Vanesky , D. Scott Buchanan , Laurence Warden
发明人： Johathan R. Ferris , K. Randy Brimhall , Frank W. Vanesky , D. Scott Buchanan , Laurence Warden
IPC分类号： A61B5/05 , A61B5/04 , A61B5/0476
CPC分类号： A61B5/04009
摘要： An apparatus for making bioelectromagnetic measurements of the human body includes an apparatus for measuring the bioelectromagnetic reaction of a living body to a tactile stimulation and a tactile stimulator that controllably applies a tactile stimulation to the body without creating a magnetic or electrical field that is detected directly by the apparatus for measuring the bioelectromagnetic reaction. The tactile stimulator includes a pressure chamber closed on one side by a movable body such as a piston or flexible membrane, a conduit that transmits pneumatic pressure to the pressure chamber, and apparatus for applying pneumatic pressure to the conduit. The measuring apparatus, such as a biomagnetometer, may be located within a shielded room, and in this case the pressure chamber and movable body are preferably located within the shielded room, the apparatus for applying pneumatic pressure is located outside the room, and the conduit passes from the exterior to the interior of the room.

2. 发明授权

US5494033A Biomagnetometer with sealed vacuum enclosure and solid conduction cooling 失效
标题翻译：具有密封真空外壳和固体传导冷却的生物计量仪
公开(公告)号：US5494033A
公开(公告)日：1996-02-27
申请号：US80876
申请日：1993-06-21
申请人： D. Scott Buchanan , Laurence Warden , Scott W. Riley , Richard T. Johnson , K. Randy Brimhall , Keith A. Esser
发明人： D. Scott Buchanan , Laurence Warden , Scott W. Riley , Richard T. Johnson , K. Randy Brimhall , Keith A. Esser
IPC分类号： A61B5/04 , G01R33/035 , A61B5/05
CPC分类号： A61B5/04005 , G01R33/0358 , A61B5/0046
摘要： A biomagnetometer includes a magnetic field sensor including a magnetic field pickup coil and a detector of small electrical currents flowing within the pickup coil. A vacuum-tight enclosure surrounds the sensor. The enclosure has a concavely upwardly curved first wall, with the magnetic field pickup coil located adjacent to the first wall. A vented reservoir of liquefied gas is located within the enclosure, and a solid thermal conductor extends from the sensor. There is a vacuum-tight thermal feedthrough by which the solid thermal conductor passes between the interior and the exterior of the enclosure. Electronic circuitry for filtering and amplifying the signals of the detector is also provided. Such a biomagnetometer is placed below the body of a reclining subject, and a second portion of the biomagnetometer can be placed above the body. In one form, the enclosures are shaped to form a cavity that receives the head of the subject therein, to achieve full head coverage of the pickup coils in the biomagnetometer.
摘要翻译：生物计量仪包括磁场传感器，其包括磁场拾取线圈和在拾取线圈内流动的小电流的检测器。真空密封的外壳围绕传感器。外壳具有凹入向上弯曲的第一壁，磁场拾取线圈位于第一壁附近。液化气体排放的储存器位于外壳内，固体导热体从传感器延伸出来。存在真空密封的馈热通道，固体热导体通过其进入外壳的内部和外部之间。还提供了用于滤波和放大检测器的信号的电子电路。这样的生物计量器放置在倾斜对象的身体下方，并且生物计量器的第二部分可以放置在身体上方。在一种形式中，外壳被成形为形成容纳主体的头部的空腔，以实现生物计量器中的拾取线圈的全头覆盖。

3. 发明申请

US20120134029A1 OPHTHALMIC DIAGNOSTIC INSTRUMENT 有权
标题翻译：眼科诊断仪
公开(公告)号：US20120134029A1
公开(公告)日：2012-05-31
申请号：US13360515
申请日：2012-01-27
申请人： Laurence Warden , Andreas W. Dreher , Gary D. Mills , Shui T. Lai , William G. Foote , David G. Sandler , Keith J. Dillon
发明人： Laurence Warden , Andreas W. Dreher , Gary D. Mills , Shui T. Lai , William G. Foote , David G. Sandler , Keith J. Dillon
IPC分类号： G02B3/00
CPC分类号： A61B3/0025 , A61B3/0075 , A61B3/1015
摘要： An eye simulation system for testing wavefront sensor systems, the eye stimulation system comprising a housing having a chamber with an opening for allowing light to enter said chamber, a fluid located in the chamber, said fluid having a known index of refraction, a lens positioned relative to said housing such that light entering the opening of the chamber passes through said lens, and a rotatable imaging surface positioned in said chamber such that light passing through said lens propagates through said fluid and is incident on said rotatable imaging surface.
摘要翻译：一种用于测试波前传感器系统的眼睛模拟系统，所述眼睛刺激系统包括壳体，所述壳体具有用于允许光进入所述腔室的开口的腔室，位于所述腔室中的流体，所述流体具有已知的折射率，相对于所述壳体，使得进入室的开口的光穿过所述透镜，以及可旋转的成像表面，其定位在所述室中，使得穿过所述透镜的光传播通过所述流体并入射在所述可旋转成像表面上。

4. 发明申请

US20100081579A1 SAMPLE DEVICE PRESERVATION 审中-公开
标题翻译：样品设备保存
公开(公告)号：US20100081579A1
公开(公告)日：2010-04-01
申请号：US12469163
申请日：2009-05-20
申请人： Paul BUSHWAY , Laurence Warden , Todd Peterson , David E. Kohne , Juan Yguerabide
发明人： Paul BUSHWAY , Laurence Warden , Todd Peterson , David E. Kohne , Juan Yguerabide
IPC分类号： C40B30/00 , B05D3/00 , G01N21/75 , C40B40/00 , C08L29/04 , C08L75/04 , C08L33/00 , G01J1/10
CPC分类号： G01N33/54393 , Y10T436/108331 , Y10T436/25
摘要： A method for preserving a sample is described. A method for preserving a sample device such as microarrays, slides and membranes is described. The preservation is achieved by applying a coating composition to a sample or sample device, and curing the coating composition. Candidate coating materials for forming the coating compositions are described. Preferably, the coating composition is an optically clear, solidifying solution. Also described are preservation kits which provide materials and instructions for the preservation of sample devices. Calibration devices are also described.
摘要翻译：描述了用于保存样品的方法。描述了用于保存样品装置如微阵列，载玻片和膜的方法。通过将涂料组合物施用于样品或样品装置并固化涂料组合物来实现保存。描述了用于形成涂料组合物的候选涂料。优选地，涂料组合物是光学透明的固化溶液。还描述了保存试剂盒，其提供用于保存样品装置的材料和说明书。还描述了校准装置。

5. 发明申请

US20090015831A1 METHODS FOR PROVIDING EXTENDED DYNAMIC RANGE IN ANALYTE ASSAYS 审中-公开
标题翻译：在分析测定中提供扩展动态范围的方法
公开(公告)号：US20090015831A1
公开(公告)日：2009-01-15
申请号：US12045626
申请日：2008-03-10
申请人： Juan Yguerabide , Evangelina Yguerabide , Laurence Warden , Todd Peterson
发明人： Juan Yguerabide , Evangelina Yguerabide , Laurence Warden , Todd Peterson
IPC分类号： G01N21/47
CPC分类号： G01N15/1468 , C12Q1/6816 , G01N21/47 , G01N2021/6439 , C12Q2565/501 , C12Q2563/137
摘要： Methods for enhancing the dynamic range for specific detection of one or more analytes in assays using scattered-light detectable particle labels. The methods involve utilizing variations in detection technique and/or signal processing to extend the dynamic range to either or both of lower and higher concentrations.
摘要翻译：在使用散射光可检测的颗粒标签的测定中增强特异性检测一种或多种分析物的动态范围的方法。所述方法涉及利用检测技术和/或信号处理中的变化来将动态范围扩展到较低和较高浓度中的一个或两者。

6. 发明申请

US20080180635A1 LENSOMETERS AND WAVEFRONT SENSORS AND METHODS OF MEASURING ABERRATION 有权
标题翻译：透镜和波形传感器和测量方法
公开(公告)号：US20080180635A1
公开(公告)日：2008-07-31
申请号：US12019614
申请日：2008-01-24
申请人： Laurence Warden , John Ferro , Andreas W. Dreher , William G. Foote
发明人： Laurence Warden , John Ferro , Andreas W. Dreher , William G. Foote
IPC分类号： A61B3/103 , G01M11/02
CPC分类号： A61B3/1015 , G01J9/00 , G01M11/0235
摘要： Wavefront measuring systems and methods are disclosed which may be employed, for example, in detecting phase aberrations in a spectacle lens and in an eye. Various embodiments include disposing a modulation pattern in the path of a return beam from the spectacle lens or the eye, and imaging a diffraction pattern at a self-imaging plane relative to the modulation pattern with a detector. The diffraction pattern is analyzed and the results are used to produce a representation of the wavefront phase characteristics that describe aberrations in the lens or eye being measured. Illumination and processing techniques for improving the measurement results are disclosed. Various embodiments comprise systems adaptable to both measure aberrations in lenses in spectacles as well as in a patient's eyes.
摘要翻译：公开了波前测量系统和方法，其可以用于例如检测眼镜片和眼睛中的相位差。各种实施例包括将调制图案设置在来自眼镜镜片或眼睛的返回光束的路径中，以及使用检测器相对于调制图案在自成像平面上成像衍射图案。分析衍射图案，并且使用结果来产生描述被测量的透镜或眼睛中的像差的波前相位特征的表示。公开了用于改善测量结果的照明和处理技术。各种实施例包括适于测量眼镜中的眼镜以及患者眼睛中的像差的系统。

7. 发明授权

US07188950B2 Eyeglass dispensing method 有权
标题翻译：眼镜分配方法
公开(公告)号：US07188950B2
公开(公告)日：2007-03-13
申请号：US10936131
申请日：2004-09-07
申请人： Andreas W. Dreher , Jagdish M. Jethmalani , Laurence Warden , Shui T. Lai
发明人： Andreas W. Dreher , Jagdish M. Jethmalani , Laurence Warden , Shui T. Lai
IPC分类号： G02C7/02
CPC分类号： G02C13/003 , B24B13/00
摘要： A method of making corrective eyeglasses is disclosed. One embodiment is a method of making corrective eyeglasses. The method includes obtaining vision parameters of a patient's eyes, obtaining an eyeglass frame comprising at least one mounted optical element, and programming the optical element to define a pattern of refraction that is associated with the vision parameters.
摘要翻译：公开了制造矫正眼镜的方法。一个实施例是制造矫正眼镜的方法。该方法包括获得患者眼睛的视觉参数，获得包括至少一个安装的光学元件的眼镜框架，以及编程光学元件以限定与视觉参数相关联的折射模式。

8. 发明申请

US20050225725A1 Ophthalmic diagnostic instrument 有权
标题翻译：眼科诊断仪
公开(公告)号：US20050225725A1
公开(公告)日：2005-10-13
申请号：US10971769
申请日：2004-10-22
申请人： Laurence Warden , Andreas Dreher , Gary Mills , Shui Lai , William Foote , David Sandler
发明人： Laurence Warden , Andreas Dreher , Gary Mills , Shui Lai , William Foote , David Sandler
IPC分类号： A61B3/10 , A61B3/103
CPC分类号： A61B3/0025 , A61B3/0075 , A61B3/1015
摘要： Diagnostic instruments, systems and methods for performing measurements on eyes are disclosed. In one embodiment of the instrument, a left ocular is disposed in a portion of a left visual path for the left eye, the left ocular positioned to permit the left eye to view a target, a right ocular is disposed in a portion of a right visual path for the right eye, the right ocular positioned to permit the right eye to view a target. The instrument can also include a wavefront sensor disposed on a translation stage, the wavefront sensor having an optical path to an imaging sensor, the translation stage being movable to position the optical path of the wavefront sensor in alignment with the portion of the left visual path in a first state and in alignment with the portion of the right visual path in a second state. One or more light sources are optionally provided for propagating light along a least part of the left and right visual paths to illuminate the left and right eyes.
摘要翻译：公开了用于对眼睛进行测量的诊断仪器，系统和方法。在仪器的一个实施例中，左眼设置在用于左眼的左视觉路径的一部分中，左眼定位成允许左眼观看目标，右眼设置在右侧的一部分右眼的视觉路径，右眼位于允许右眼观察目标。仪器还可以包括设置在平移台上的波前传感器，波前传感器具有到成像传感器的光路，平移台可移动以将波前传感器的光路定位成与左视觉路径的一部分对准处于第一状态并且在第二状态下与右视觉路径的部分对准。可选地提供一个或多个光源用于沿着左右视觉路径的至少一部分传播光以照亮左眼和右眼。

9. 发明授权

US06714299B2 Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes 失效
公开(公告)号：US06714299B2
公开(公告)日：2004-03-30
申请号：US09906580
申请日：2001-07-13
申请人： Todd Peterson , Laurence Warden , Juan Yguerabide , Evangelina Yguerabide
发明人： Todd Peterson , Laurence Warden , Juan Yguerabide , Evangelina Yguerabide
IPC分类号： G01N2100
CPC分类号： G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/025 , G01N2015/0288 , G01N2015/0693 , G01N2015/1486
摘要： The use of light scattering particles in the design, manufacturing, and quality control of microscale devices and process, and the analysis of solid substrate and porous substrate characteristics is described.

10. 发明授权

US5444373A Biomagnetometer with selectable pickup coil array 失效
标题翻译：具有可选择的拾音线圈阵列的生物测量仪
公开(公告)号：US5444373A
公开(公告)日：1995-08-22
申请号：US248533
申请日：1994-05-23
申请人： Richard T. Johnson , Laurence Warden
发明人： Richard T. Johnson , Laurence Warden
IPC分类号： A61B5/05 , A61B5/04 , G01R33/035 , G08C15/06 , H04J3/00
CPC分类号： G01R33/0354 , A61B5/04008
摘要： A biomagnetometer comprises an array of biomagnetic sensors, the array comprising a first plurality of magnetic field pickup coils, and a second plurality of detectors, each of which receives a pickup coil output from a pickup coil. There is a third plurality of signal processors, each of which receives an output from a detector, the third plurality of signal processors being fewer in number than the first plurality of pickup coils. The biomagnetometer further includes a selector that selects a subset of pickup coils, equal in number to the third plurality of signal processors, from the first plurality of pickup coils for signal processing by the signal processors. This biomagnetometer permits the placement of a very large array of relatively inexpensive pickup coils adjacent to a subject, and then processing information from subsets of that large array selected to optimize the gathering of data, while maintaining the cost of the signal processing electronics at a more economical level.
摘要翻译：生物测量计包括生物磁传感器阵列，该阵列包括第一多个磁场拾取线圈，以及第二多个检测器，每个检测器接收从拾取线圈输出的拾取线圈。存在第三多个信号处理器，每个信号处理器接收来自检测器的输出，第三多个信号处理器的数量少于第一多个拾取线圈。生物仪表还包括选择器，其从第一组多个拾取线圈中选择数量相等于第三多个信号处理器的拾取线圈的子集，用于由信号处理器进行信号处理。该生物计量器允许将相当便宜的拾取线圈的非常大的阵列放置在与受试者相邻的位置，然后从所选大阵列的子集中处理信息以优化数据采集，同时将信号处理电子设备的成本维持在更多经济水平。

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