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1. 发明授权

US06566063B1 Methods for determining metastatic potential of breast cancer cells by detecting GSEF gene product expression 失效
标题翻译：通过检测GSEF基因产物表达来确定乳腺癌细胞转移潜能的方法
公开(公告)号：US06566063B1
公开(公告)日：2003-05-20
申请号：US09570593
申请日：2000-05-12
申请人： Joerg Kaufmann , Hong Xin , Greg Harrowe
发明人： Joerg Kaufmann , Hong Xin , Greg Harrowe
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/136
摘要： The invention features methods for detection of metastatic and potentially metastatic cancerous cells by detection of expression of a gland-specific Ets transcription factor (GSEF) sequence, which encodes an Ets-domain containing protein. The invention also features methods and compositions for modulation of the polypeptide and/or gene activity for prophylactic and therapeutic purposes, such as inhibition of progression of a cell to a metastatic cancerous cell.
摘要翻译：本发明的特征在于通过检测编码含有Ets结构域的蛋白质的腺特异性Ets转录因子（GSEF）序列的表达来检测转移性和潜在转移性癌细胞的方法。本发明还涉及用于调节预防和治疗目的的多肽和/或基因活性的方法和组合物，例如抑制细胞向转移性癌细胞的进展。

2. 发明授权

US07867731B2 HX2004-6 polypeptide expressed in cancerous cells 有权
标题翻译： HX2004-6多肽在癌细胞中表达
公开(公告)号：US07867731B2
公开(公告)日：2011-01-11
申请号：US10977087
申请日：2004-10-28
申请人： Christoph Reinhard , Anne Bennett Jefferson , Vivien W. Chan , Joerg Kaufmann , Hong Xin , Giulia C. Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
发明人： Christoph Reinhard , Anne Bennett Jefferson , Vivien W. Chan , Joerg Kaufmann , Hong Xin , Giulia C. Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
IPC分类号： C12P21/00 , C12P21/02 , C12N15/09 , C07K14/00 , C07K14/435
CPC分类号： G01N33/5005 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/723 , C12N9/1205 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/5008 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

3. 发明申请

US20050130926A1 Gene products differentially expressed in cancerous cells and their methods of use V 有权
标题翻译：在癌细胞中差异表达的基因产物及其使用方法V
公开(公告)号：US20050130926A1
公开(公告)日：2005-06-16
申请号：US10977087
申请日：2004-10-28
申请人： Christoph Reinhard , Anne Jefferson , Vivien Chan , Joerg Kaufmann , Hong Xin , Giulia Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
发明人： Christoph Reinhard , Anne Jefferson , Vivien Chan , Joerg Kaufmann , Hong Xin , Giulia Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
IPC分类号： A61K38/00 , C07K14/47 , C07K14/72 , C12N9/12 , C12Q1/68 , G01N33/574 , G01N33/68 , A61K39/395 , A61K48/00 , C07H21/04 , C12N9/64
CPC分类号： G01N33/5005 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/723 , C12N9/1205 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/5008 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

4. 发明授权

US09416173B2 Peptide and conjugate vaccines for fungal infections 有权
标题翻译：用于真菌感染的肽和缀合疫苗
公开(公告)号：US09416173B2
公开(公告)日：2016-08-16
申请号：US14112561
申请日：2012-04-20
申请人： Hong Xin , Jim E. Cutler
发明人： Hong Xin , Jim E. Cutler
IPC分类号： A61K39/00 , C07K16/14 , C07K14/40 , C07K16/40 , A61K47/48
CPC分类号： C07K16/14 , A61K39/0002 , A61K47/6415 , A61K47/646 , A61K2039/505 , A61K2039/5158 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/6037 , C07K14/40 , C07K16/40 , C07K2319/00
摘要： Several new peptides have been developed that show effectiveness as vaccines against candidiasis and other fungal diseases. A new conjugate vaccine of a β-mannotriose linked to a fungal peptide linked to tetanus toxin has been shown to be effective as a vaccine with or without use of an adjuvant. In addition, a monoclonal antibody has been identified that offers protection from a Candida infection.
摘要翻译：已经开发了几种新的肽，其显示出作为针对念珠菌病和其它真菌疾病的疫苗的有效性。已经显示与连接到破伤风毒素的真菌肽连接的β-甘露三糖的新缀合疫苗作为具有或不使用佐剂的疫苗是有效的。此外，已经鉴定出提供针对念珠菌感染的保护的单克隆抗体。

5. 发明申请

US20080287309A1 Methods for Discovering Antibodies Specific to Cancer Cells and Antibodies Discovered Thereby 审中-公开
标题翻译：发现癌细胞和抗体特异性抗体的方法
公开(公告)号：US20080287309A1
公开(公告)日：2008-11-20
申请号：US11631911
申请日：2005-07-08
申请人： Katherine S. Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
发明人： Katherine S. Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
IPC分类号： C40B30/04 , A01N1/02 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： C07K14/4748 , A61K2039/5152 , C07K16/28 , C07K16/2842 , C07K16/2845 , C07K16/2848 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/55 , C07K2317/56 , C07K2317/565
摘要： This disclosure relates to methods for selecting antibodies having desirable characteristics from a population of diverse antibodies. More specifically, this disclosure provides methods for identifying antibodies which bind to cancer cells, but which do not bind to human red blood cells, white blood cells or normal tissue cells. Antibodies of the disclosure can be used for therapeutic and/or diagnostic purposes.
摘要翻译：本公开涉及从不同抗体群体中选择具有所需特征的抗体的方法。更具体地，本公开提供了用于鉴定结合癌细胞但不结合人红细胞，白细胞或正常组织细胞的抗体的方法。本公开的抗体可用于治疗和/或诊断目的。

6. 发明申请

US20080008719A1 Methods and compositions for the treatment of prostate cancer 审中-公开
标题翻译：用于治疗前列腺癌的方法和组合物
公开(公告)号：US20080008719A1
公开(公告)日：2008-01-10
申请号：US11789556
申请日：2007-04-24
申请人： Katherine Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
发明人： Katherine Bowdish , Hong Xin , Ferda Yantiri-Wernimont , Amara Siva
IPC分类号： A61K39/395 , A61P35/00 , C07K16/18
CPC分类号： C07K16/3069 , A61K39/39558 , C07K16/30 , C07K2317/55 , C07K2317/565 , C07K2317/77
摘要： The present application relates to methods and compositions for the treatment of cancer. In specific embodiments, the application relates to the use of antibodies capable of modulating CDCP1 as therapeutic agents for the treatment of cancer and as diagnostic agents for the detection of and/or prognosis of cancer.
摘要翻译：本申请涉及用于治疗癌症的方法和组合物。在具体实施方案中，本申请涉及能够调节CDCP1作为治疗癌症的治疗剂的抗体的使用以及用于癌症的检测和/或预后的诊断剂。

7. 发明授权

US07795407B2 Metastatic breast and colon cancer regulated genes 失效
标题翻译：转移性乳腺癌和结肠癌调节基因
公开(公告)号：US07795407B2
公开(公告)日：2010-09-14
申请号：US11657337
申请日：2007-01-24
申请人： Hong Xin , Klaus Giese
发明人： Hong Xin , Klaus Giese
IPC分类号： C12N15/11
CPC分类号： C12N9/6478 , A61K38/00 , C07K14/4748 , C07K2319/00 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N2500/00
摘要： Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs. Methods are provided for determining the risk of metastasis of a breast or colon tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS:1-18, or a substantial portion thereof. One of the gene sequences encodes a novel aspartyl protease termed CSP56, which can be used to provide reagents and methods for determining which tumors are likely to metastasize and for suppressing metastases of these tumors. Clinicians can use this information to predict which tumors will metastasize to other organs and to provide relevant therapies to appropriate patients.
摘要翻译：已经发现和分离了SEQ ID NO：1-18所示的基因序列，并发现与乳腺癌和结肠癌细胞向其他器官的转移性扩散显着相关。提供了用于确定乳腺或结肠肿瘤转移风险的方法，其涉及确定来自肿瘤的组织样品是否表达由SEQ ID NO：1-18所示基因编码的多肽，或其主要部分。其中一个基因序列编码一种称为CSP56的新型天冬氨酰蛋白，可用于提供用于确定哪些肿瘤可能转移并抑制这些肿瘤转移的试剂和方法。临床医生可以使用这些信息来预测哪些肿瘤会转移到其他器官，并为适当的患者提供相关的治疗。

8. 发明授权

US07598030B2 Antibodies against cancer produced using masked cancer cells as immunogen 失效
标题翻译：使用掩蔽的癌细胞作为免疫原产生抗癌的抗体
公开(公告)号：US07598030B2
公开(公告)日：2009-10-06
申请号：US11631910
申请日：2005-07-08
申请人： Katherine S. Bowdish , Hong Xin , Toshiaki Maruyama , Naveen Dakappagari
发明人： Katherine S. Bowdish , Hong Xin , Toshiaki Maruyama , Naveen Dakappagari
IPC分类号： G01N1/70 , G01N33/53 , G01N33/567
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/00 , C07K16/2896
摘要： This disclosure relates to methods for selecting antibodies having desirable characteristics from a population of diverse antibodies. More specifically, this disclosure provides methods for identifying antibodies which bind to cancer cells, but which do not bind to human red or white blood cells or normal tissue cells. Antibodies of the disclosure can be used for therapeutic and/or diagnostic purposes.
摘要翻译：本公开涉及从不同抗体群体中选择具有所需特征的抗体的方法。更具体地，本公开提供了用于鉴定结合癌细胞但不结合人红细胞或白细胞或正常组织细胞的抗体的方法。本公开的抗体可用于治疗和/或诊断目的。

9. 发明申请

US20140037641A1 Peptide and Conjugate Vaccines for Fungal Infections 有权
标题翻译：肽和共轭疫苗真菌感染
公开(公告)号：US20140037641A1
公开(公告)日：2014-02-06
申请号：US14112561
申请日：2012-04-20
申请人： Jim E. Cutler , Hong Xin , David R. Bundle , Sebastian Dziadek
发明人： Jim E. Cutler , Hong Xin , David R. Bundle , Sebastian Dziadek
IPC分类号： C07K16/14
CPC分类号： C07K16/14 , A61K39/0002 , A61K47/6415 , A61K47/646 , A61K2039/505 , A61K2039/5158 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/6037 , C07K14/40 , C07K16/40 , C07K2319/00
摘要： Several new peptides have been developed that show effectiveness as vaccines against candidiasis and other fungal diseases. A new conjugate vaccine of a β-mannotriose linked to a fungal peptide linked to tetanus toxin has been shown to be effective as a vaccine with or without use of an adjuvant. In addition, a monoclonal antibody has been identified that offers protection from a Candida infection.
摘要翻译：已经开发了几种新的肽，其显示出作为针对念珠菌病和其它真菌疾病的疫苗的有效性。已经显示与连接到破伤风毒素的真菌肽连接的β-甘露三糖的新缀合疫苗作为具有或不使用佐剂的疫苗是有效的。此外，已经鉴定出提供针对念珠菌感染的保护的单克隆抗体。

10. 发明授权

US08095477B2 Load fuzzy modeling device and method for power system 失效
标题翻译：电力系统负荷模糊建模装置及方法
公开(公告)号：US08095477B2
公开(公告)日：2012-01-10
申请号：US12327804
申请日：2008-12-03
申请人： Hua-Guang Zhang , Qiu-Ye Sun , Dong-Sheng Yang , Zhan-Shan Wang , Tie-Yan Zhang , Zhi-Shan Liang , Hong Xin , Wu-Qi Song , Yun-Shuang Wang
发明人： Hua-Guang Zhang , Qiu-Ye Sun , Dong-Sheng Yang , Zhan-Shan Wang , Tie-Yan Zhang , Zhi-Shan Liang , Hong Xin , Wu-Qi Song , Yun-Shuang Wang
IPC分类号： G06G7/00 , G06F15/18
CPC分类号： G06N7/04 , G05B13/0275 , G05B17/02
摘要： A load fuzzy modeling device for the power system based on the causality diagram, the composite cloud generator and the improved T-S fuzzy model, comprising: a hardware device, including: the sensors, a signal conditioning and filter module, an A/D conversion module, a causality conversion module, a DSP module, a memory module, a display and keyboard module connected with the DSP module, respectively and a communication module connected with the PC. The voltage and the current are respectively acquired from the system through a voltage transformer and a current transformer, and then are transmitted into the filter circuit for filtering, thus are amplified through a amplifier LM258P as the voltage within the range of −5V ˜+5V so as to input into the A/D conversion modules for sampling; the digital signal is simply processed by the causality conversion module according to certain analysis algorithm principle, and the processed signal is transmitted into the DSP to process, the final results thus displayed on the LCD screen and transmitted into the PC through the commutation module.
摘要翻译：一种基于因果关系图的电力系统的负荷模糊建模装置，复合云发电机和改进的TS模糊模型，包括：硬件设备，包括：传感器，信号调理和滤波模块，A / D转换模块分别与DSP模块连接的因果转换模块，DSP模块，存储器模块，显示器和键盘模块以及与PC连接的通信模块。电压和电流分别通过变压器和电流互感器从系统中获取，然后传输到滤波电路进行滤波，因此通过放大器LM258P放大到-5V〜+ 5V范围内的电压以便输入到A / D转换模块进行采样; 数字信号根据一定的分析算法原理由因果转换模块简单处理，并将处理后的信号传输到DSP进行处理，最终结果显示在LCD屏幕上，并通过换向模块传输到PC中。

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