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1. 发明授权

US06242207B1 Diagnostic compositions and devices utilizing same 失效
标题翻译：诊断组合物和利用其的装置
公开(公告)号：US06242207B1
公开(公告)日：2001-06-05
申请号：US09411237
申请日：1999-10-04
申请人： Joel S. Douglas , Karen R. Drexler , John M. Gleisner , John H. Priest
发明人： Joel S. Douglas , Karen R. Drexler , John M. Gleisner , John H. Priest
IPC分类号： C12Q126
CPC分类号： C12Q1/26 , C12Q1/28 , C12Q2326/00 , C12Q2326/32 , G01N33/52 , Y10S435/808 , Y10S435/814 , Y10S435/97
摘要： A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a peroxidase enzyme or a mixture thereof. The dry chemistry reagent matrix composition is useful in reagent test strips for determining the presence or concentration of an analyte in a fluid sample, such as blood.
摘要翻译：提供了含有基质材料和含有3-甲基-6（磺酸盐） - 苯并噻唑啉酮 - （2） - 腙（MBTH-S），N-乙基-N-（3-磺基丙基））苯胺，氧化酶或过氧化物酶或其混合物。干化学试剂基质组合物可用于试剂测试条，用于确定流体样品（如血液）中分析物的存在或浓度。

2. 发明授权

US06780651B2 Device for determination of an analyte in a body fluid 失效
标题翻译：用于测定体液中分析物的装置
公开(公告)号：US06780651B2
公开(公告)日：2004-08-24
申请号：US09875297
申请日：2001-06-07
申请人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner
发明人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner
IPC分类号： G01N33543
CPC分类号： G01N33/521 , B01L3/5023 , B01L2200/026 , B01L2200/0605 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N33/525 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A method of making strip for testing for the presence of an analyte generally comprises providing a support member which includes a spreading layer and a reagent layer, and a capillary in communication with the support layer and spreading layer for transporting a sample of body fluid thereto.
摘要翻译：制造用于测试分析物存在的条带的方法通常包括提供包括扩散层和试剂层的支撑构件，以及与支撑层连通的毛细管和用于将体液样品输送到其的扩散层。

3. 发明授权

US06271045B1 Device for determination of an analyte in a body fluid 失效
标题翻译：用于测定体液中分析物的装置
公开(公告)号：US06271045B1
公开(公告)日：2001-08-07
申请号：US09306994
申请日：1999-05-07
申请人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner
发明人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner
IPC分类号： G01N33543
CPC分类号： G01N33/521 , B01L3/5023 , B01L2200/026 , B01L2200/0605 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N33/525 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A strip for testing for the presence of an analyte generally comprises a support member which contains a spreading layer and a reagent layer, and a capillary tube in communication with the support layer and spreading layer for transporting a sample of body fluid thereto. A method of testing a fluid for the presence or concentration of an analyte is also provided which generally includes providing a test strip with a support member, a spreading layer, and a reagent layer on the spreading layer. A capillary tube is provided on the support member whereby a fluid containing an analyte to be tested is introduced into the tube and flows through the tube to the spreading layer and contacts the reagent layer.
摘要翻译：用于测试分析物存在的条带通常包括包含扩展层和试剂层的支撑构件和与支撑层连通的毛细管和用于将体液样品输送到其的扩散层。还提供了测试流体用于分析物的存在或浓度的方法，其通常包括在扩散层上提供具有支撑构件，扩散层和试剂层的测试条。毛细管设置在支撑构件上，由此将含有要测试的被分析物的流体引入到管中并流过管到扩散层并与试剂层接触。

4. 外观设计

USD403975S Test strip device 失效
公开(公告)号：USD403975S
公开(公告)日：1999-01-12
申请号：US72445
申请日：1997-06-17
申请人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner
设计人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner

5. 发明授权

US06750962B2 Optics alignment and calibration system 有权
标题翻译：光学对准和校准系统
公开(公告)号：US06750962B2
公开(公告)日：2004-06-15
申请号：US09828874
申请日：2001-04-10
申请人： Joel S. Douglas , Jeffrey N. Roe , John H. Priest , John M. Gleisner , Charles C. Raney , David A. Hasker , Ryszard Radwanski , John Ramirez
发明人： Joel S. Douglas , Jeffrey N. Roe , John H. Priest , John M. Gleisner , Charles C. Raney , David A. Hasker , Ryszard Radwanski , John Ramirez
IPC分类号： G01N110
CPC分类号： G01N21/8483
摘要： A multi-use assay system accurately docks a removable test strip supporting a reagent-analyte reaction with an optics system including an LED, photodetector, and lenses or light pipes for directing light to and from the test strip. Docking is achieved using alignment fixturing, whereby an optics block holder is relied upon to align the test strip and test pad with the various optical components. Signals from the photodetector indicative of test strip reaction progress are provided to a processor for measuring the analyte.
摘要翻译：多用分析系统将包含LED，光电检测器和透镜或光管的光学系统的支撑试剂 - 分析物反应的可移除测试条准确地对准，以将光导向和从测试条引导。使用对准夹具实现对接，由此依靠光学块保持器将测试条和测试垫与各种光学部件对准。来自光电检测器的指示测试条反应进程的信号被提供给用于测量分析物的处理器。

6. 发明授权

US5948695A Device for determination of an analyte in a body fluid 失效
标题翻译：用于测定体液中分析物的装置
公开(公告)号：US5948695A
公开(公告)日：1999-09-07
申请号：US874468
申请日：1997-06-17
申请人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner
发明人： Joel S. Douglas , Ryszard Radwanski , Brent G. Duchon , John H. Priest , David A. Hasker , John M. Gleisner
IPC分类号： G01N31/22 , B01L3/00 , G01N33/52 , G01N33/543
CPC分类号： G01N33/521 , B01L3/5023 , G01N33/525 , B01L2200/026 , B01L2200/0605 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A strip for testing for the presence of an analyte generally comprises a support member which contains a spreading layer and a reagent layer, and a capillary tube in communication with the support layer and spreading layer for transporting a sample of body fluid thereto. A method of testing a fluid for the presence or concentration of an analyte is also provided which generally includes providing a test strip with a support member, a spreading layer, and a reagent layer on the spreading layer. A capillary tube is provided on the support member whereby a fluid containing an analyte to be tested is introduced into the tube and flows through the tube to the spreading layer and contacts the reagent layer.
摘要翻译：用于测试分析物存在的条带通常包括包含扩展层和试剂层的支撑构件和与支撑层连通的毛细管和用于将体液样品输送到其的扩散层。还提供了测试流体用于分析物的存在或浓度的方法，其通常包括在扩散层上提供具有支撑构件，扩散层和试剂层的测试条。毛细管设置在支撑构件上，由此将含有要测试的被分析物的流体引入到管中并流过管到扩散层并与试剂层接触。

7. 发明授权

US06818180B2 Devices for testing for the presence and/or concentration of an analyte in a body fluid 失效
标题翻译：用于测试体液中分析物的存在和/或浓度的装置
公开(公告)号：US06818180B2
公开(公告)日：2004-11-16
申请号：US09879898
申请日：2001-06-14
申请人： Joel S. Douglas , Karen R. Drexler , James N. Wilson
发明人： Joel S. Douglas , Karen R. Drexler , James N. Wilson
IPC分类号： G01N3348
CPC分类号： G01N33/54366 , G01N33/521 , Y10S435/805
摘要： Devices and methods for utilizing dry chemistry dye indicator systems for body fluid analysis such as glucose level in whole blood are provided by incorporating a porous membrane with a skin side which enables separation of whole blood and visually reading the indicator without removing the red blood cell portion of the blood from the membrane. The devices also enable visual reading of the indicator by use of a membrane or matrix which provides separation of whole blood in a lateral flow of the blood through the matrix from the input area to a test area of the matrix. The devices also provide for microtitration of fluid samples in fixed volumetric openings containing indicator reagent. Another aspect of the device provides a determination of hematocrit level in whole blood in combination with indicator indication of analyte concentration which can be compensated for the hematocrit level. The devices provided are low cost.
摘要翻译：使用干化学染料指示剂系统用于体液分析的装置和方法，例如全血中的葡萄糖水平，通过掺入具有皮肤侧的多孔膜来提供，该多孔膜能够分离全血并在目视上读取指示剂而不去除红细胞部分的血液从膜。这些装置还使得能够通过使用膜或基质来使指示器可视化地读取，所述膜或基质将血液的横向流动中的全血分离通过矩阵从输入区域到基质的测试区域。该装置还提供含有指示剂试剂的固定体积开口中的液体样品的微量滴定。该装置的另一方面提供了全血中的血细胞比容水平的确定以及可补偿血细胞比容水平的分析物浓度的指示剂指示。所提供的设备成本低廉。

8. 发明授权

US6106780A Synchronized analyte testing system 有权
公开(公告)号：US6106780A
公开(公告)日：2000-08-22
申请号：US228814
申请日：1999-01-11
申请人： Joel S. Douglas , Karen R. Drexler , Jeffrey N. Roe
发明人： Joel S. Douglas , Karen R. Drexler , Jeffrey N. Roe
IPC分类号： G01N33/49 , A61B5/00 , C12Q1/54 , G01D3/02 , G01N21/01 , G01N21/78 , G01N21/86 , G01N27/28 , G01N27/327 , G01N31/22 , G01N33/48 , G01N33/487 , G01N33/52 , G01N33/66 , G01N35/00 , G01N37/00 , G01N21/00
CPC分类号： G01N33/528 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/150259 , A61B5/150305 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/15186 , A61B5/157 , A61B5/415 , C12Q1/54 , G01D3/022 , G01N21/8483 , G01N33/48757 , G01N33/48771 , G01N33/525 , G01N33/66 , A61B2560/0431 , A61B2562/0295 , A61B2562/085 , A61B5/150503 , G01N2035/00138 , Y10S435/808 , Y10S435/817
摘要： An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.

9. 发明授权

US6040151A Diagnostic compositions and devices utilizing same 失效
公开(公告)号：US6040151A
公开(公告)日：2000-03-21
申请号：US273532
申请日：1999-03-22
申请人： Joel S. Douglas , Karen R. Drexler
发明人： Joel S. Douglas , Karen R. Drexler
IPC分类号： C12Q1/26 , C12Q1/54 , G01N33/52 , C12Q1/28 , C12Q1/00
CPC分类号： C12Q1/26 , C12Q1/54 , G01N33/52 , C12Q2326/00 , C12Q2326/32 , Y10S435/808 , Y10S435/814 , Y10S435/97
摘要： A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.

10. 发明授权

US5989845A Diagnostic compositions and devices utilizing same 失效
标题翻译：诊断组合物和利用其的装置
公开(公告)号：US5989845A
公开(公告)日：1999-11-23
申请号：US151096
申请日：1998-09-10
申请人： Joel S. Douglas , Karen R. Drexler
发明人： Joel S. Douglas , Karen R. Drexler
IPC分类号： G01N33/573 , C12M1/40 , C12N11/08 , C12Q1/26 , C12Q1/28 , G01N33/52
CPC分类号： C12Q1/26 , C12Q1/28 , G01N33/52 , C12Q2326/00 , C12Q2326/32 , Y10S435/808 , Y10S435/814 , Y10S435/97
摘要： A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6-(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a peroxidase enzyme or a mixture thereof. The dry chemistry reagent matrix composition is useful in reagent test strips for determining the presence or concentration of an analyte in a fluid sample, such as blood.
摘要翻译：提供了含有基质材料和含有3-甲基-6-（磺酸盐） - 苯并噻唑啉酮 - （2） - 腙（MBTH-S），N-乙基-N-（3- 磺丙基）苯胺，氧化酶或过氧化物酶或其混合物。干化学试剂基质组合物可用于试剂测试条，用于确定流体样品（如血液）中分析物的存在或浓度。

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