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1. 发明申请

US20060019404A1 Quantitative assay with extended dynamic range 审中-公开
标题翻译：具有扩展动态范围的定量测定
公开(公告)号：US20060019404A1
公开(公告)日：2006-01-26
申请号：US11061096
申请日：2005-02-18
申请人： Joel Blatt , Michael Allen , Diem Le , Paul Patel , Patrick Sexton
发明人： Joel Blatt , Michael Allen , Diem Le , Paul Patel , Patrick Sexton
IPC分类号： G01N21/77
CPC分类号： G01N21/8483 , G01N21/78 , G01N33/689
摘要： An efficient design for an expanded dynamic range in a lateral flow one step assay for the detection of an analyte in a biological sample is disclosed. The device comprises a multiple strip design, each constructed of four zones; a sample receiving zone, a sample treatment zone, a labeling zone, and a capture zone. The sample containing analyte is accepted in the sample receiving zone in the form of blood, serum, plasma, or urine. It is then carried into the sample treatment zone where it is rendered compatible with the chemistries of the assay strip. The treated sample then flows into the labeling zone where it interacts with visible particles that are coupled to analyte specific binding proteins. The flow continues, carrying the labeled analyte into the capture zone where it is immobilized in specific regions with analyte specific binding proteins. Excess flow is absorbed in an absorbent zone that is in contact with the capture zone. A positive result is interpreted by detection of the visible particles in the specified regions of the capture zone.
摘要翻译：公开了用于在侧向流动中扩展的动态范围的有效设计，用于检测生物样品中的分析物的一步测定。该装置包括多个条带设计，每个由四个区域构成; 样品接收区，样品处理区，标记区和捕获区。含有分析物的样品在样品接收区域以血液，血清，血浆或尿液的形式被接受。然后将其运送到样品处理区域中，使其与测定条带的化学物质相容。然后将经处理的样品流入标记区域，在该区域与被分析物特异性结合蛋白偶联的可见颗粒相互作用。流动继续，将标记的分析物携带到捕获区中，在捕获区中将其固定在具有分析物特异性结合蛋白的特定区域中。在与捕获区接触的吸收区中吸收过量的流动。通过检测捕获区域的指定区域中的可见颗粒来解释正的结果。

2. 发明授权

US09326718B2 Blood glucose measurement for small blood volume 有权
标题翻译：血糖测量小血量
公开(公告)号：US09326718B2
公开(公告)日：2016-05-03
申请号：US12845512
申请日：2010-07-28
申请人： Wolfgang Petrich , Christian Vrancic , Daniel Wong , Paul Patel
发明人： Wolfgang Petrich , Christian Vrancic , Daniel Wong , Paul Patel
IPC分类号： A61B5/157 , B65D81/00 , A61B5/15 , A61B5/145
CPC分类号： A61B5/157 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150152 , A61B5/150358 , A61B5/150419 , A61B5/150427 , A61B5/150503 , A61B5/150816 , A61B5/150824 , A61B5/150954 , A61B5/15109 , A61B5/15113 , A61B5/15123
摘要： A system is proposed for detection of at least one analyte in a body fluid, in particular for detection of blood glucose. The system is designed to generate a sample of the body fluid and to transfer at least some of the sample to at least one test element, in particular a test panel. The system is designed such that a time period between the generation of the sample and the application to the test element is less than 1 second, preferably less than 500 ms.
摘要翻译：提出了用于检测体液中至少一种分析物的系统，特别是用于检测血糖。该系统设计成产生体液样品并将至少一些样品转移到至少一个测试元件，特别是测试面板。该系统被设计成使得样品生成和应用到测试元件之间的时间段小于1秒，优选小于500ms。

3. 发明申请

US20060079810A1 Integrated lancing test strip with capillary transfer sheet 失效
公开(公告)号：US20060079810A1
公开(公告)日：2006-04-13
申请号：US10961640
申请日：2004-10-08
申请人： Paul Patel , Edward Perez
发明人： Paul Patel , Edward Perez
IPC分类号： A61B5/00
CPC分类号： A61B5/14532
摘要： An integrated bodily fluid sampling device includes a lancet, a test strip attached to the lancet, and a flexible sheet extending from the test strip. The lancet and the flexible sheet form a gap sized to draw bodily fluid onto the test strip via capillary action. Further, a sampling end portion of the flexible sheet is shaped to enhance capillary action of the sheet. In one form, a removable film covers the lancet and forms a seal with the flexible sheet such that the seal surrounds a lancet tip. In another form, an insulating layer covers a portion of the lancet to prevent electrical interference between the lancet and an electrical testing system on the test strip and ensure an accurate analysis of the bodily fluid.

4. 发明申请

US20060030788A1 Apparatus and method for extracting bodily fluid utilizing a flat lancet 审中-公开
标题翻译：使用扁平刺血针提取体液的装置和方法
公开(公告)号：US20060030788A1
公开(公告)日：2006-02-09
申请号：US10911252
申请日：2004-08-04
申请人： Daniel Wong , Charles Raney , Paul Patel , Steven Roe
发明人： Daniel Wong , Charles Raney , Paul Patel , Steven Roe
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150106 , A61B5/150175 , A61B5/150213 , A61B5/150282 , A61B5/150358 , A61B5/150458 , A61B5/150465 , A61B5/150503 , A61B5/15113 , A61B5/1519 , A61B5/157
摘要： A bodily fluid sampling device is operable to rupture the skin surface at normal and oblique angles utilizing a flat lancet of specified thickness and at least one cutting surface inclined less than eighty degrees (80°) from the longitudinal axis of the flat lancet. The flat lancet thickness and cutting surface geometry minimize pain while maximizing the amount of emerged bodily fluid. The device limits the depth to which the flat lancet penetrates the skin to further minimize pain and may urge the bodily fluid from the rupture site. The bodily fluid emerging from the rupture site is transported to a test device that tests the bodily fluid for particular properties and characteristics.
摘要翻译：身体液体采样装置可操作以使用特定厚度的扁平的柳叶刀和从平胸针的纵轴倾斜小于八十度（80°）的至少一个切割表面以正常和倾斜的角度破裂皮肤表面。扁平的柳叶刀厚度和切割表面几何形状使疼痛减到最小，同时使出现的体液量达到最大。该装置限制了平刺血针穿透皮肤的深度，以进一步减少疼痛，并可以从破裂部位推动体液。从破裂部位出现的体液被运送到测试体液，以测试体液的特性和特性。

5. 发明授权

US07758518B2 Devices and methods for expression of bodily fluids from an incision 有权
标题翻译：用于从切口表达体液的装置和方法
公开(公告)号：US07758518B2
公开(公告)日：2010-07-20
申请号：US12353666
申请日：2009-01-14
申请人： Edward Perez , Charles C. Raney , Paul Patel
发明人： Edward Perez , Charles C. Raney , Paul Patel
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194
摘要： Systems and methods for the expression of bodily fluid from an incision in the skin include devices which bear against the skin in a manner to retain the fluid adjacent the incision site and urge the fluid inwardly toward the incision. Systems utilize a constricting member, a bi-stable expression member, or a pressing member. The present invention further encompasses combinations of the foregoing expression systems with each other, as well as with other expression devices known in the art. Moreover, the invention includes the combination of the expression systems with incising, sampling and/or testing systems, particularly in a single, integrated device. The present invention also contemplates the associated methods for expressing bodily fluid from an incision, including in combination with methods for incising, sampling and/or testing of the bodily fluid.
摘要翻译：用于从皮肤切口表达体液的系统和方法包括以保持与切口部位相邻的流体并将流体向内朝向切口推动的方式抵靠皮肤的装置。系统利用收缩构件，双稳态表达构件或按压构件。本发明还包括上述表达系统彼此的组合，以及本领域已知的其它表达装置。此外，本发明包括表达系统与切割，采样和/或测试系统的组合，特别是在单个集成设备中。本发明还考虑了用于从切口表达体液的相关方法，包括结合用于切开，取样和/或测试体液的方法。

6. 发明申请

US20090192409A1 RAPID BLOOD EXPRESSION AND SAMPLING 有权
标题翻译：快速血液表达和采样
公开(公告)号：US20090192409A1
公开(公告)日：2009-07-30
申请号：US12020766
申请日：2008-01-28
申请人： Daniel Wong , Paul Patel
发明人： Daniel Wong , Paul Patel
IPC分类号： A61B5/157 , A61B5/151
CPC分类号： A61B5/157 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150152 , A61B5/150358 , A61B5/150419 , A61B5/150427 , A61B5/150503 , A61B5/150816 , A61B5/150824 , A61B5/150954 , A61B5/15109 , A61B5/15113 , A61B5/15123
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid, the device further comprising a fluid receiving means remotely spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially. The collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0.5 seconds. The fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from the collection zone is automatically or manually transported to the fluid receiving means to contact the fluid with the test zone.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件，所述装置还包括与收集区远离间隔开的流体接收装置，使得收集区中的体液不会最初接触流体接收装置。收集区在小于0.5秒的非常短的时间段内占据非常小体积的体液约10至500nl。流体接收装置可以具有用于进行分析反应的测试区域。来自收集区的流体样品被自动或手动地输送到流体接收装置以使流体与测试区接触。

7. 发明授权

US06923192B2 Stackable process chambers 有权
标题翻译：可堆叠处理室
公开(公告)号：US06923192B2
公开(公告)日：2005-08-02
申请号：US10171429
申请日：2002-06-12
申请人： Chad M. Hosack , Paul Patel , Raoul Standt
发明人： Chad M. Hosack , Paul Patel , Raoul Standt
IPC分类号： B08B3/02 , B08B3/12 , H01L21/00 , H01L21/304 , B08B7/04
CPC分类号： H01L21/67051 , H01L21/67034 , Y10S134/902
摘要： A substrate processing system has a first substrate cleaner and a second substrate cleaner. The first substrate cleaner comprises a forward portion and a rear portion. The forward portion includes a rotatable substrate support. The rear portion is vertically thicker than the forward portion. The rear portion includes a device for rotating the support. The second substrate cleaner includes the elements included in the first substrate cleaner. The second substrate cleaner is stacked above the first substrate cleaner with the forward portions being vertically aligned and the rear portions being vertically aligned. A space is formed between the forward portions to permit access to the forward portion of the first substrate cleaner and to permit ample gas flow into the area between the forward portions of the first and the second substrate cleaners.
摘要翻译：衬底处理系统具有第一衬底清洁器和第二衬底清洁器。第一衬底清洁器包括前部和后部。前部包括可旋转的基板支撑件。后部比前部部分垂直厚。后部包括用于旋转支撑件的装置。第二基板清洁器包括包括在第一基板清洁器中的元件。第二基板清洁器堆叠在第一基板清洁器的上方，其中前部垂直对齐并且后部垂直对准。在前部之间形成空间，以允许进入第一基板清洁器的前部并且允许充足的气体流入第一和第二基板清洁器的前部之间的区域。

8. 发明授权

US09538941B2 Devices and methods for expression of bodily fluids from an incision 有权
标题翻译：用于从切口表达体液的装置和方法
公开(公告)号：US09538941B2
公开(公告)日：2017-01-10
申请号：US12797854
申请日：2010-06-10
申请人： Edward Perez , Charles C. Raney , Paul Patel
发明人： Edward Perez , Charles C. Raney , Paul Patel
IPC分类号： A61B5/145 , A61B5/15 , A61B5/151
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194
摘要： Systems and methods for the expression of bodily fluid from an incision in the skin include devices which bear against the skin in a manner to retain the fluid adjacent the incision site and urge the fluid inwardly toward the incision. Systems utilize a constricting member, a bi-stable expression member, or a pressing member. The present invention further encompasses combinations of the foregoing expression systems with each other, as well as with other expression devices known in the art. Moreover, the invention includes the combination of the expression systems with incising, sampling and/or testing systems, particularly in a single, integrated device. The present invention also contemplates the associated methods for expressing bodily fluid from an incision, including in combination with methods for incising, sampling and/or testing of the bodily fluid.
摘要翻译：用于从皮肤切口表达体液的系统和方法包括以保持与切口部位相邻的流体并将流体向内朝向切口推动的方式抵靠皮肤的装置。系统利用收缩构件，双稳态表达构件或按压构件。本发明还包括上述表达系统彼此的组合，以及本领域已知的其它表达装置。此外，本发明包括表达系统与切割，采样和/或测试系统的组合，特别是在单个集成设备中。本发明还考虑了用于从切口表达体液的相关方法，包括结合用于切开，取样和/或测试体液的方法。

9. 发明授权

US06928751B2 Megasonic cleaner and dryer system 有权
标题翻译：超声波清洗机和烘干机系统
公开(公告)号：US06928751B2
公开(公告)日：2005-08-16
申请号：US10171430
申请日：2002-06-12
申请人： Chad M. Hosack , Jeffrey M. Lauerhaas , Mario E. Bran , Raoul Standt , Paul Patel , Yi Wu , Geert Doumen , Paul Mertens
发明人： Chad M. Hosack , Jeffrey M. Lauerhaas , Mario E. Bran , Raoul Standt , Paul Patel , Yi Wu , Geert Doumen , Paul Mertens
IPC分类号： B08B3/02 , B08B3/12 , H01L21/00 , H01L21/304 , F26B17/00
CPC分类号： H01L21/67051 , H01L21/67034 , Y10S134/902
摘要： An apparatus includes a rotatable chuck for supporting a substrate and a splash guard. The splash guard surrounds the chuck and surrounds a substrate mounted on the chuck. The splash guard has a portion that deflects fluid being flung off the substrate by centrifugal action in a manner so as to not splash back onto the substrate. The splash guard is moveable between a process position in which the upper annular edge of the splash guard extends above the chuck and a substrate on the chuck, and a load/unload position in which the splash guard is tilted so that one side of the upper annular edge is below an upper edge of the chuck. The movement of the splash guard facilitates loading and unloading of a substrate.
摘要翻译：一种装置包括用于支撑衬底和防溅罩的可旋转卡盘。防溅罩围绕卡盘并围绕安装在卡盘上的基板。防溅罩具有通过离心作用将流体从基板上偏离的部分，以便不会溅回到基板上。防溅罩可以在其中防溅罩的上部环形边缘在卡盘上方延伸到卡盘上的基板和加载/卸载位置之间移动，在该位置，防溅罩倾斜使得防护罩的上侧环形边缘在卡盘的上边缘下方。防溅罩的运动有助于衬底的装载和卸载。

10. 发明申请

US20080065130A1 ELASTOMERIC TOROIDAL RING FOR BLOOD EXPRESSION 审中-公开
标题翻译：用于血液表达的弹性圆形环
公开(公告)号：US20080065130A1
公开(公告)日：2008-03-13
申请号：US11466202
申请日：2006-08-22
申请人： Paul Patel , Daniel Wong
发明人： Paul Patel , Daniel Wong
IPC分类号： A61B17/32
CPC分类号： A61B5/15117 , A61B5/150022 , A61B5/150068 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150511 , A61B5/15107
摘要： An expression device includes an expressing cap that defines a lancet opening. The expression cap has a skin contacting surface that is generally flat and positioned to face tissue during expression of body fluid. The expression cap includes an elastomeric ring extending around the lancet opening from the skin contacting surface. The elastomeric ring is made from elastomeric material. The expression cap has a beveled surface between the lancet opening and the elastomeric ring to enhance expression of the body fluid when the expression cap is pressed around an incision site. It was discovered that when the beveled was angled at about 20°, expression of the body fluid was significantly enhanced.
摘要翻译：表达装置包括限定刺血针开口的表达帽。表达帽具有通常平坦的皮肤接触表面，并且在体液表达期间定位成面对组织。表情帽包括从皮肤接触表面围绕刺血针开口延伸的弹性体环。弹性体环由弹性材料制成。表达帽在刺血针开口和弹性体环之间具有倾斜的表面，以在表达帽被压在切口部位周围时增强体液的表达。发现当斜面角度约为20°时，体液的表达显着增强。

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