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    • 4. 发明申请
    • NOVEL CELLULOSE ETHERS AND THEIR USE
    • 新颖的纤维素及其使用
    • US20130236512A1
    • 2013-09-12
    • US13825697
    • 2011-10-06
    • Roland AddenMeinolf BrackhagenMatthias KnarrJin Zhao
    • Roland AddenMeinolf BrackhagenMatthias KnarrJin Zhao
    • C08B11/02
    • C08B11/02A61J3/077A61K9/4816A61K9/4866A61K47/38C08B11/193C08L1/284
    • Cellulose ethers are described herein which are useful in capsules or in coatings for dosage forms. In these cellulose ethers the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.35 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.
    • 本文描述了纤维素醚,其可用于胶囊或用于剂型的包衣。 在这些纤维素醚中,醚取代基是甲基,羟基烷基和任选的不同于甲基的烷基,纤维素醚具有0.05至1.00的MS(羟基烷基),脱水葡萄糖单元的羟基被甲基取代,使得 [s23 / s26-0.2 * MS(羟烷基)]为0.35以下,其中s23为脱水葡萄糖单元的摩尔分数,其中脱水葡萄糖单元的2-和3-位上的两个羟基仅被甲基取代, 其中s26是脱水葡萄糖单元的摩尔分数,其中脱水葡萄糖单元的2-和6-位中的两个羟基仅被甲基取代。