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1. 发明申请

US20080176941A1 Process For the Preparation of Polynuclear Ferric Hydroxide-Saccaride Complexes 有权
标题翻译：多核氢氧化铁 - Saccaride配合物的制备方法
公开(公告)号：US20080176941A1
公开(公告)日：2008-07-24
申请号：US11911449
申请日：2006-04-12
申请人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
发明人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
IPC分类号： A61K31/295
CPC分类号： C07H23/00
摘要： The invention discloses a process for preparing a polynuclear ferric hydroxide-saccharide complex, including: adding an aqueous solution of an alkaline substance drop-wise into an aqueous solution of iron salt at a temperature of 5-20° C. until pH 6-8, collecting the polynuclear ferric hydroxide from the reaction mixture by a conventional method; reacting the polynuclear ferric hydroxide with a saccharide in a solution of an alkaline substance for 10-40 hours at 106-125° C. under pH 10-12, resulting in a crude product having an isoelectric point of 4.4-5.3 and a weight average molecular weight of 20,000-100,000 Daltons, and then harvesting the polynuclear ferric hydroxide-saccharide complex from the crude product. The process can precisely control the molecular weight of the polynuclear ferric hydroxide-saccharide complex without an effect on the other characteristics of the product, for example its saccharide content or isoelectric point etc. Furthermore, it is very simple and readily applicable in industry.
摘要翻译：本发明公开了一种制备多核铁氢氧化物 - 糖复合物的方法，其包括：将碱性物质的水溶液滴加到铁盐水溶液中，温度为5-20℃直至pH6-8 ，通过常规方法从反应混合物中收集多核铁氢氧化物; 使多核铁氢氧化物与糖类在碱性物质的溶液中在106-125℃下在pH 10-12下反应10-40小时，得到等电点为4.4-5.3的粗产物，重均分子量分子量为20,000-100,000道尔顿，然后从粗产物中收获多核铁氢氧化物 - 糖复合物。该方法可以精确地控制多核铁氢氧化物 - 糖复合物的分子量，而不影响产品的其他特性，例如其糖含量或等电点等。此外，它非常简单且易于应用于工业中。

2. 发明授权

US08053470B2 Process for the preparation of polynuclear ferric hydroxide-saccaride complexes 有权
标题翻译：制备多核氢氧化铁 - 糖配合物的方法
公开(公告)号：US08053470B2
公开(公告)日：2011-11-08
申请号：US11911449
申请日：2006-04-12
申请人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
发明人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
IPC分类号： A61K31/295
CPC分类号： C07H23/00
摘要： The invention discloses a process for preparing a polynuclear ferric hydroxide-saccharide complex, including: adding an aqueous solution of an alkaline substance drop-wise into an aqueous solution of iron salt at a temperature of 5-20° C. until pH 6-8, collecting the polynuclear ferric hydroxide from the reaction mixture by a conventional method; reacting the polynuclear ferric hydroxide with a saccharide in a solution of an alkaline substance for 10-40 hours at 106-125° C. under pH 10-12, resulting in a crude product having an isoelectric point of 4.4-5.3 and a weight average molecular weight of 20,000-100,000 Daltons, and then harvesting the polynuclear ferric hydroxide-saccharide complex from the crude product. The process can precisely control the molecular weight of the polynuclear ferric hydroxide-saccharide complex without an effect on the other characteristics of the product, for example its saccharide content or isoelectric point etc. Furthermore, it is very simple and readily applicable in industry.
摘要翻译：本发明公开了一种制备多核铁氢氧化物 - 糖复合物的方法，其包括：将碱性物质的水溶液滴加到铁盐水溶液中，温度为5-20℃直至pH6-8 ，通过常规方法从反应混合物中收集多核铁氢氧化物; 使多核铁氢氧化物与糖类在碱性物质的溶液中在106-125℃下在pH 10-12下反应10-40小时，得到等电点为4.4-5.3的粗产物，重均分子量分子量为20,000-100,000道尔顿，然后从粗产物中收获多核铁氢氧化物 - 糖复合物。该方法可以精确地控制多核铁氢氧化物 - 糖复合物的分子量，而不影响产品的其他特性，例如其糖含量或等电点等。此外，它非常简单且易于应用于工业中。

3. 发明申请

US20090136549A1 TRANSDERMAL PATCH CONTAINING RASAGILINE FOR TREATMENT OR PROPHYLAXIS OF NERVOUS SYSTEM DISEASE AND ITS PREPARATION PROCESS 审中-公开
标题翻译：含有RASAGILINE用于治疗或预防神经系统疾病及其制备过程的透皮贴
公开(公告)号：US20090136549A1
公开(公告)日：2009-05-28
申请号：US12281875
申请日：2007-03-06
申请人： Jialiang Lin , Jinmai Xiao , Jie Deng
发明人： Jialiang Lin , Jinmai Xiao , Jie Deng
IPC分类号： A61K9/00 , A61K31/136 , A61P25/28
CPC分类号： A61K31/135 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7092
摘要： The present invention relates to a rasagiline transdermal patch for treatment or prophylaxis of nervous system diseases, in which the patch comprises an inert backing layer chemically inert to substrate ingredients, a substrate layer comprising rasagiline or a pharmaceutically acceptable salt thereof, and a protective layer to be peeled off before use. The substrate layer is an adhesive system comprising an organic polymer material as basis and an inorganic or organic material as filler, and a plurality of micro-reservoirs containing rasagiline. The substrate further comprises one or more substances for enhancing the transdermal absorption of rasagiline, in which the above organic polymer material in the substrate is used for the reservoir of rasagiline and as adhesive.
摘要翻译：本发明涉及一种用于治疗或预防神经系统疾病的雷沙吉兰透皮贴剂，其中贴片包括对底物成分具有化学惰性的惰性背衬层，包含雷沙吉兰或其药学上可接受的盐的底物层和保护层使用前剥离。基材层是以有机聚合物材料为基础和作为填料的无机或有机材料和含有雷沙吉兰的多个微储层的粘合剂体系。底物还包含一种或多种用于增强雷沙吉兰透皮吸收的物质，其中基质中的上述有机聚合物材料用于雷沙吉兰的储库和粘合剂。

4. 发明授权

US08686140B2 Method of purifying a salt, sodium salt and disodium salt of pemetrexed 有权
标题翻译：培美曲塞的盐，钠盐和二钠盐的纯化方法
公开(公告)号：US08686140B2
公开(公告)日：2014-04-01
申请号：US12739576
申请日：2008-10-21
申请人： Jie Luo , Meng Lin , Bo Lin , Wenrun Ye , Yongmei Qin , Jie Deng
发明人： Jie Luo , Meng Lin , Bo Lin , Wenrun Ye , Yongmei Qin , Jie Deng
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.
摘要翻译：通过盐析纯化具有式（III）结构的培美曲塞盐的方法，其中如果M3 +为H +，则M1 +和M2 +各自独立地为H +，Li +，Na +或K +，条件是它们都不是 H +; 如果M3 +为Li +，Na +或K +，则M1 +和M2 +各自独立为Li +，Na +或K +。

5. 发明授权

US08563721B2 Morphinan derivatives and preparation methods thereof 失效
标题翻译：吗啡喃衍生物及其制备方法
公开(公告)号：US08563721B2
公开(公告)日：2013-10-22
申请号：US13000200
申请日：2009-06-19
申请人： Huafu Sun , Jie Luo , Wenrun Ye , Jie Deng , Bo Lin , Chunyan Dan , Bin Fan
发明人： Huafu Sun , Jie Luo , Wenrun Ye , Jie Deng , Bo Lin , Chunyan Dan , Bin Fan
IPC分类号： C07F7/02 , C07D489/08
CPC分类号： C07D489/08 , C07D489/09
摘要： The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.
摘要翻译：本发明涉及吗啡喃衍生物及其制备方法，尤其涉及缩酮羟基保护的吗啡喃衍生物化合物及其制备方法，以及通过使用缩酮羟基保护的化合物作为中间体制备相应的烷基化吗啡喃衍生物的方法，更具体地涉及作为制备甲基纳曲酮的中间体的甲基纳曲酮的缩酮羟基保护的化合物和通过所述中间体制备甲基纳曲酮的方法。

6. 发明申请

US20120267719A1 Method and Apparatus for use in Improving Linearity of MOSFETS using an Accumulated Charge Sink-Harmonic Wrinkle Reduction 有权
标题翻译：用于改善MOSFETs线性度的方法和装置，使用累积电荷沉降式抗皱消除
公开(公告)号：US20120267719A1
公开(公告)日：2012-10-25
申请号：US13277108
申请日：2011-10-19
申请人： Christopher N. Brindle , Jie Deng , Alper Genc , Chieh-Kai Yang
发明人： Christopher N. Brindle , Jie Deng , Alper Genc , Chieh-Kai Yang
IPC分类号： H01L29/78
CPC分类号： H01L29/7841 , H01L29/0688 , H01L29/36 , H01L29/78609 , H01L29/78615 , H01L29/78681 , H01L29/78684 , H03K2217/0018 , H03K2217/0054
摘要： A method and apparatus for use in improving linearity sensitivity of MOSFET devices having an accumulated charge sink (ACS) are disclosed. The method and apparatus are adapted to address degradation in second- and third-order intermodulation harmonic distortion at a desired range of operating voltage in devices employing an accumulated charge sink.
摘要翻译：公开了一种用于提高具有累积电荷吸收（ACS）的MOSFET器件的线性灵敏度的方法和装置。该方法和装置适于解决在采用累积电荷宿的装置中在期望工作电压范围内的二阶和三阶互调谐波失真的劣化。

7. 发明申请

US20120214877A1 STABLE RASAGILINE COMPOSITION 有权
标题翻译：稳定的RASAGILINE组合物
公开(公告)号：US20120214877A1
公开(公告)日：2012-08-23
申请号：US13504178
申请日：2010-10-28
申请人： Jialiang Lin , Jie Deng , Hao Chen , Tao Zhang
发明人： Jialiang Lin , Jie Deng , Hao Chen , Tao Zhang
IPC分类号： A61K31/135 , A61P25/14 , A61P25/28 , A61P25/16
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/06 , A61K9/7061 , A61K9/7069 , A61K31/355 , A61K31/375 , A61K47/10 , A61K47/22 , A61K2300/00
摘要： The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and an antioxidant used as a stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film, spray and solution, etc. The composition can be used to prevent or treat mental disorders.
摘要翻译：本发明提供雷沙吉兰的稳定组合物，其包含有效剂量的雷沙吉兰或其药学上可接受的盐和用作稳定剂的抗氧化剂。组合物的剂型是药学上常见的透皮 - 药物递送剂型和粘膜粘附递送剂型，例如贴剂，凝胶，软膏，霜剂，粘膜，膜，喷雾剂和溶液等。该组合物可用于预防或治疗精神错乱。

8. 发明申请

US20110082680A1 COMPACT MODEL FOR DEVICE/CIRCUIT/CHIP LEAKAGE CURRENT (IDDQ) CALCULATION INCLUDING PROCESS INDUCED UPLIFT FACTORS 失效
标题翻译：用于器件/电路/芯片泄漏电流（IDDQ）的紧凑型模型包括工艺引起的升级因素
公开(公告)号：US20110082680A1
公开(公告)日：2011-04-07
申请号：US12574440
申请日：2009-10-06
申请人： Paul Chang , Jie Deng , Terrence B. Hook , Sim Y. Loo , Anda C. Mocuta , Jae-Eun Park , Kern Rim , Xiaojun Yu
发明人： Paul Chang , Jie Deng , Terrence B. Hook , Sim Y. Loo , Anda C. Mocuta , Jae-Eun Park , Kern Rim , Xiaojun Yu
IPC分类号： G06F17/50 , G06F17/18 , G01R31/26
CPC分类号： G06F17/5081 , G01R31/2848 , G01R31/3008 , G06F17/5009 , G06F17/5022 , G06F17/5036
摘要： A system, method and computer program product for implementing a quiescent current leakage specific model into semiconductor device design and circuit design flows. The leakage model covers all device geometries with wide temperature and voltage ranges and, without the need for stacking factor calculations nor spread sheet based IDDQ calculations. The leakage model for IDDQ calculation incorporates further parasitic and proximity effects. The leakage model implements leakage calculations at different levels of testing, e.g., from a single device to a full chip design, and are integrated within one single model. The leakage model implements leakage calculations at different levels of testing with the leverage of a single switch setting. The implementation is via a hardware definition language code or object oriented code that can be compiled and operated using a netlist of interest, e.g., for conducting a performance analysis.
摘要翻译：一种用于将静态电流泄漏特定模型实现为半导体器件设计和电路设计流程的系统，方法和计算机程序产品。泄漏模型涵盖宽温度和电压范围的所有器件几何，并且不需要堆叠因子计算，也不需要基于平板的IDDQ计算。 IDDQ计算的泄漏模型包含进一步的寄生和邻近效应。泄漏模型在不同的测试水平下实施泄漏计算，例如从单个设备到全芯片设计，并且集成在一个单一的模型中。泄漏模型通过单个开关设置的杠杆来实现不同测试级别的泄漏计算。该实现是通过硬件定义语言代码或面向对象的代码，其可以使用感兴趣的网表来编译和操作，例如用于进行性能分析。

9. 发明申请

US20100306687A1 SYSTEM AND METHOD FOR AVATAR MANAGEMENT 审中-公开
标题翻译： AVATAR管理系统与方法
公开(公告)号：US20100306687A1
公开(公告)日：2010-12-02
申请号：US12856367
申请日：2010-08-13
申请人： Jie Deng
发明人： Jie Deng
IPC分类号： G06F15/16 , G06F3/048
CPC分类号： H04L67/38
摘要： The present invention provides a system for avatar management, including at least one client and a server, the client is adapted to assemble an avatar according to operation of a user, generate avatar information corresponding to the avatar, transmit the avatar information to the server via a network requesting the server to update the avatar of the user; the server is adapted to parse the avatar information to obtain the corresponding avatar, generate a snapshot based on the avatar, store and manage the avatar information and corresponding snapshot; the server further informs at least one client to update the avatar of the user; and the at least one client updates the avatar of the user according to the snapshot. The present invention also provides a method for avatar management. The present invention can save bandwidth of the server, speed snapshot generation, improve security and accuracy of snapshot generation, and increase system efficiency.
摘要翻译：本发明提供了一种用于化身管理的系统，包括至少一个客户端和服务器，该客户机适于根据用户的操作来组装化身，生成与该化身相对应的化身信息，并将该化身信息通过请求服务器更新用户的化身的网络; 服务器适于解析化身信息以获得相应的化身，基于头像生成快照，存储和管理化身信息和对应的快照; 服务器还通知至少一个客户端来更新用户的化身; 并且所述至少一个客户端根据所述快照更新所述用户的化身。本发明还提供了一种用于化身管理的方法。本发明可以节省服务器的带宽，快速生成快照，提高快照生成的安全性和准确性，提高系统效率。

10. 发明授权

US08626480B2 Compact model for device/circuit/chip leakage current (IDDQ) calculation including process induced uplift factors 失效
标题翻译：紧凑型器件/电路/芯片泄漏电流（IDDQ）计算，包括工艺引起的隆起因素
公开(公告)号：US08626480B2
公开(公告)日：2014-01-07
申请号：US12574440
申请日：2009-10-06
申请人： Paul Chang , Jie Deng , Terrence B. Hook , Sim Y. Loo , Anda C. Mocuta , Jae-Eun Park , Kern Rim , Xiaojun Yu
发明人： Paul Chang , Jie Deng , Terrence B. Hook , Sim Y. Loo , Anda C. Mocuta , Jae-Eun Park , Kern Rim , Xiaojun Yu
IPC分类号： G06F17/50
CPC分类号： G06F17/5081 , G01R31/2848 , G01R31/3008 , G06F17/5009 , G06F17/5022 , G06F17/5036
摘要： A system, method and computer program product for implementing a quiescent current leakage specific model into semiconductor device design and circuit design flows. The leakage model covers all device geometries with wide temperature and voltage ranges and, without the need for stacking factor calculations nor spread sheet based IDDQ calculations. The leakage model for IDDQ calculation incorporates further parasitic and proximity effects. The leakage model implements leakage calculations at different levels of testing, e.g., from a single device to a full chip design, and are integrated within one single model. The leakage model implements leakage calculations at different levels of testing with the leverage of a single switch setting. The implementation is via a hardware definition language code or object oriented code that can be compiled and operated using a netlist of interest, e.g., for conducting a performance analysis.
摘要翻译：一种用于将静态电流泄漏特定模型实现为半导体器件设计和电路设计流程的系统，方法和计算机程序产品。泄漏模型涵盖宽温度和电压范围的所有器件几何，并且不需要堆叠因子计算，也不需要基于平板的IDDQ计算。 IDDQ计算的泄漏模型包含进一步的寄生和邻近效应。泄漏模型在不同的测试水平下实施泄漏计算，例如从单个设备到全芯片设计，并且集成在一个单一的模型中。泄漏模型通过单个开关设置的杠杆来实现不同测试级别的泄漏计算。该实现是通过硬件定义语言代码或面向对象的代码，其可以使用感兴趣的网表来编译和操作，例如用于进行性能分析。

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