专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080176941A1 Process For the Preparation of Polynuclear Ferric Hydroxide-Saccaride Complexes 有权
标题翻译：多核氢氧化铁 - Saccaride配合物的制备方法
公开(公告)号：US20080176941A1
公开(公告)日：2008-07-24
申请号：US11911449
申请日：2006-04-12
申请人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
发明人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
IPC分类号： A61K31/295
CPC分类号： C07H23/00
摘要： The invention discloses a process for preparing a polynuclear ferric hydroxide-saccharide complex, including: adding an aqueous solution of an alkaline substance drop-wise into an aqueous solution of iron salt at a temperature of 5-20° C. until pH 6-8, collecting the polynuclear ferric hydroxide from the reaction mixture by a conventional method; reacting the polynuclear ferric hydroxide with a saccharide in a solution of an alkaline substance for 10-40 hours at 106-125° C. under pH 10-12, resulting in a crude product having an isoelectric point of 4.4-5.3 and a weight average molecular weight of 20,000-100,000 Daltons, and then harvesting the polynuclear ferric hydroxide-saccharide complex from the crude product. The process can precisely control the molecular weight of the polynuclear ferric hydroxide-saccharide complex without an effect on the other characteristics of the product, for example its saccharide content or isoelectric point etc. Furthermore, it is very simple and readily applicable in industry.
摘要翻译：本发明公开了一种制备多核铁氢氧化物 - 糖复合物的方法，其包括：将碱性物质的水溶液滴加到铁盐水溶液中，温度为5-20℃直至pH6-8 ，通过常规方法从反应混合物中收集多核铁氢氧化物; 使多核铁氢氧化物与糖类在碱性物质的溶液中在106-125℃下在pH 10-12下反应10-40小时，得到等电点为4.4-5.3的粗产物，重均分子量分子量为20,000-100,000道尔顿，然后从粗产物中收获多核铁氢氧化物 - 糖复合物。该方法可以精确地控制多核铁氢氧化物 - 糖复合物的分子量，而不影响产品的其他特性，例如其糖含量或等电点等。此外，它非常简单且易于应用于工业中。

2. 发明授权

US08053470B2 Process for the preparation of polynuclear ferric hydroxide-saccaride complexes 有权
标题翻译：制备多核氢氧化铁 - 糖配合物的方法
公开(公告)号：US08053470B2
公开(公告)日：2011-11-08
申请号：US11911449
申请日：2006-04-12
申请人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
发明人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
IPC分类号： A61K31/295
CPC分类号： C07H23/00
摘要： The invention discloses a process for preparing a polynuclear ferric hydroxide-saccharide complex, including: adding an aqueous solution of an alkaline substance drop-wise into an aqueous solution of iron salt at a temperature of 5-20° C. until pH 6-8, collecting the polynuclear ferric hydroxide from the reaction mixture by a conventional method; reacting the polynuclear ferric hydroxide with a saccharide in a solution of an alkaline substance for 10-40 hours at 106-125° C. under pH 10-12, resulting in a crude product having an isoelectric point of 4.4-5.3 and a weight average molecular weight of 20,000-100,000 Daltons, and then harvesting the polynuclear ferric hydroxide-saccharide complex from the crude product. The process can precisely control the molecular weight of the polynuclear ferric hydroxide-saccharide complex without an effect on the other characteristics of the product, for example its saccharide content or isoelectric point etc. Furthermore, it is very simple and readily applicable in industry.
摘要翻译：本发明公开了一种制备多核铁氢氧化物 - 糖复合物的方法，其包括：将碱性物质的水溶液滴加到铁盐水溶液中，温度为5-20℃直至pH6-8 ，通过常规方法从反应混合物中收集多核铁氢氧化物; 使多核铁氢氧化物与糖类在碱性物质的溶液中在106-125℃下在pH 10-12下反应10-40小时，得到等电点为4.4-5.3的粗产物，重均分子量分子量为20,000-100,000道尔顿，然后从粗产物中收获多核铁氢氧化物 - 糖复合物。该方法可以精确地控制多核铁氢氧化物 - 糖复合物的分子量，而不影响产品的其他特性，例如其糖含量或等电点等。此外，它非常简单且易于应用于工业中。

3. 发明申请

US20090136549A1 TRANSDERMAL PATCH CONTAINING RASAGILINE FOR TREATMENT OR PROPHYLAXIS OF NERVOUS SYSTEM DISEASE AND ITS PREPARATION PROCESS 审中-公开
标题翻译：含有RASAGILINE用于治疗或预防神经系统疾病及其制备过程的透皮贴
公开(公告)号：US20090136549A1
公开(公告)日：2009-05-28
申请号：US12281875
申请日：2007-03-06
申请人： Jialiang Lin , Jinmai Xiao , Jie Deng
发明人： Jialiang Lin , Jinmai Xiao , Jie Deng
IPC分类号： A61K9/00 , A61K31/136 , A61P25/28
CPC分类号： A61K31/135 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7092
摘要： The present invention relates to a rasagiline transdermal patch for treatment or prophylaxis of nervous system diseases, in which the patch comprises an inert backing layer chemically inert to substrate ingredients, a substrate layer comprising rasagiline or a pharmaceutically acceptable salt thereof, and a protective layer to be peeled off before use. The substrate layer is an adhesive system comprising an organic polymer material as basis and an inorganic or organic material as filler, and a plurality of micro-reservoirs containing rasagiline. The substrate further comprises one or more substances for enhancing the transdermal absorption of rasagiline, in which the above organic polymer material in the substrate is used for the reservoir of rasagiline and as adhesive.
摘要翻译：本发明涉及一种用于治疗或预防神经系统疾病的雷沙吉兰透皮贴剂，其中贴片包括对底物成分具有化学惰性的惰性背衬层，包含雷沙吉兰或其药学上可接受的盐的底物层和保护层使用前剥离。基材层是以有机聚合物材料为基础和作为填料的无机或有机材料和含有雷沙吉兰的多个微储层的粘合剂体系。底物还包含一种或多种用于增强雷沙吉兰透皮吸收的物质，其中基质中的上述有机聚合物材料用于雷沙吉兰的储库和粘合剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式