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    • 1. 发明授权
    • miRNAs as therapeutic targets in cancer
    • miRNA作为癌症治疗靶点
    • US08927207B2
    • 2015-01-06
    • US12996249
    • 2009-06-05
    • Jingfang JuBo SongYuan Wang
    • Jingfang JuBo SongYuan Wang
    • C12Q1/68C12N15/113
    • C12N15/1137A61K31/7088A61K45/06C12N15/113C12N15/1135C12N2310/113C12N2310/14C12N2320/31C12Q1/6886C12Q2600/136C12Q2600/178
    • MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
    • 微RNA(miRNA)是一类非编码小RNA分子,通过与其靶mRNA的3'非翻译区(UTR)相互作用,在转录后水平调节基因表达。 本发明涉及miR-192和miR-215的应用。 这两种miRNA通过p53-miRNA电路影响细胞增殖,并与二氢叶酸还原酶(DHFR)和胸苷酸合酶(TS)相互作用。 特别地,这些miRNA的上调减少细胞增殖。 本发明涉及这一发现。 例如,抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。 此外,测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。 因此,本发明涉及与miR-192和miR-215的表达的鉴定,表征和调节相关的组合物和方法。
    • 3. 发明申请
    • MIRNAS AS THERAPEUTIC TARGETS IN CANCER
    • MIRNAS作为癌症中的治疗目标
    • US20110166201A1
    • 2011-07-07
    • US12996249
    • 2009-06-05
    • Jingfang JuBo SongYuan Wang
    • Jingfang JuBo SongYuan Wang
    • A61K31/7052C12N5/00C12Q1/68C07H21/00A61P35/00
    • C12N15/1137A61K31/7088A61K45/06C12N15/113C12N15/1135C12N2310/113C12N2310/14C12N2320/31C12Q1/6886C12Q2600/136C12Q2600/178
    • MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
    • 微RNA(miRNA)是一类非编码小RNA分子,通过与其靶mRNA的3'非翻译区(UTR)相互作用,在转录后水平调节基因表达。 本发明涉及miR-192和miR-215的应用。 这两种miRNA通过p53-miRNA电路影响细胞增殖,并与二氢叶酸还原酶(DHFR)和胸苷酸合酶(TS)相互作用。 特别地,这些miRNA的上调减少细胞增殖。 本发明涉及这一发现。 例如,抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。 此外,测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。 因此,本发明涉及与miR-192和miR-215的表达的鉴定,表征和调节相关的组合物和方法。