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1. 发明申请

US20120157713A1 METHOD FOR PREPARATION OF 4,4'-DINITRODIPHENYLAMINE AND 4,4'-BIS(ALKYLAMINO)DIPHENYLAMINE WITH THE BASE CATALYST COMPLEX 有权
标题翻译： 4,4'-二氨基苯胺和4,4'-双（双（甲基）氨基）二苯胺与基础催化剂复合物的制备方法
公开(公告)号：US20120157713A1
公开(公告)日：2012-06-21
申请号：US13162610
申请日：2011-06-17
申请人： Jin-Eok Kim , Seoung-IL Kim , Han Jin Kwag , Sang hee Park
发明人： Jin-Eok Kim , Seoung-IL Kim , Han Jin Kwag , Sang hee Park
IPC分类号： C07C209/36 , C07C209/78
CPC分类号： C07C201/12 , C07C209/36 , C07C211/56
摘要： Provided is a method for preparing 4,4′-dinitrodiphenylamine (4,4′-DNDPA) in high yield via the NASH reaction using a mixture of a bis-quaternary ammonium base and a base catalyst for the reaction of urea with nitrobenzene, and a method of preparing 4,4′-bis(alkylamino)diphenylamine (4,4′BAADA) in high yield and purity by hydrogenating the resulting 4,4′-DNDPA with a ketone in the presence of hydrogen and hydrogenation catalyst. The catalyst complex used in the present invention allows easy recovery, provides superior alkaline stability and is capable of reducing production cost.
摘要翻译：提供了通过使用二季铵碱和碱催化剂的混合物通过NASH反应以高产率制备4,4'-二硝基二苯胺（4,4'-DNDPA）的方法，用于尿素与硝基苯的反应，以及通过在氢气和氢化催化剂存在下用酮氢化所得的4,4'-DNDPA，以高产率和纯度制备4,4'-双（烷基氨基）二苯胺（4,4'BAADA）的方法。本发明中使用的催化剂配合物容易回收，提供优异的碱稳定性，能够降低生产成本。

2. 发明授权

US08759587B2 Method for preparation of 4,4′-dinitrodiphenylamine and 4,4′-bis(alkylamino)diphenylamine by using 4-nitroaniline 有权
标题翻译：通过使用4-硝基苯胺制备4,4'-二硝基二苯胺和4,4'-双（烷基氨基）二苯胺的方法
公开(公告)号：US08759587B2
公开(公告)日：2014-06-24
申请号：US13162618
申请日：2011-06-17
申请人： Jin-Eok Kim , Seoung-Il Kim , Han Jin Kwag , Sang hee Park
发明人： Jin-Eok Kim , Seoung-Il Kim , Han Jin Kwag , Sang hee Park
IPC分类号： C07C209/00
CPC分类号： C07C209/36 , C07C201/12 , C07C211/55 , C07C211/56
摘要： Provided is a method of preparing 4,4′-dinitrodiphenylamine (4,4′-DNDPA) in high yield by reacting 4-nitroaniline with excess nitrobenzene via the NASH reaction, and a method of preparing 4,4′-bis(alkylamino)diphenylamine (4,4′BAADA) in high yield and purity by hydrogenating the resulting 4,4′-DNDPA with a ketone compound in the presence of hydrogen and hydrogenation catalyst. The disclosed process is simple, allows selective preparation of 4,4′-DNDPA without byproducts, and thus allows preparation of 4,4′-BAADA in high yield without a complicated purification procedure.
摘要翻译：提供了通过使NASH反应使4-硝基苯胺与过量硝基苯反应而以高产率制备4,4'-二硝基二苯胺（4,4'-DNDPA）的方法，以及制备4,4'-二（烷基氨基）二苯胺（4,4'BAADA）以高产率和纯度通过在氢气和氢化催化剂存在下用酮化合物氢化所得4,4'- DNDPA。所公开的方法简单，允许选择性制备4,4'- DNDPA而不产生副产物，因此允许以高产率制备4,4'-BAADA而无需复杂的纯化程序。

3. 发明授权

US08835687B2 Method for preparation of 4,4′-dinitrodiphenylamine and 4,4′-bis(alkylamino)diphenylamine with the base catalyst complex 有权
标题翻译： 4,4'-二硝基二苯胺和4,4'-双（烷基氨基）二苯胺与碱催化剂络合物的制备方法
公开(公告)号：US08835687B2
公开(公告)日：2014-09-16
申请号：US13162610
申请日：2011-06-17
申请人： Jin-Eok Kim , Seoung-IL Kim , Han Jin Kwag , Sang hee Park
发明人： Jin-Eok Kim , Seoung-IL Kim , Han Jin Kwag , Sang hee Park
IPC分类号： C07C209/00 , C07C209/36 , C07C201/12
CPC分类号： C07C201/12 , C07C209/36 , C07C211/56
摘要： Provided is a method for preparing 4,4′-dinitrodiphenylamine (4,4′-DNDPA) in high yield via the NASH reaction using a mixture of a bis-quaternary ammonium base and a base catalyst for the reaction of urea with nitrobenzene, and a method of preparing 4,4′-bis(alkylamino)diphenylamine (4,4′BAADA) in high yield and purity by hydrogenating the resulting 4,4′-DNDPA with a ketone in the presence of hydrogen and hydrogenation catalyst. The catalyst complex used in the present invention allows easy recovery, provides superior alkaline stability and is capable of reducing production cost.
摘要翻译：提供了通过使用二季铵碱和碱催化剂的混合物通过NASH反应以高产率制备4,4'-二硝基二苯胺（4,4'-DNDPA）的方法，用于尿素与硝基苯的反应，以及通过在氢气和氢化催化剂存在下用酮氢化所得的4,4'-DNDPA，以高产率和纯度制备4,4'-双（烷基氨基）二苯胺（4,4'BAADA）的方法。本发明中使用的催化剂配合物容易回收，提供优异的碱稳定性，能够降低生产成本。

4. 发明申请

US20120157714A1 METHOD FOR PREPARATION OF 4,4'-DINITRODIPHENYLAMINE AND 4,4'-BIS(ALKYLAMINO)DIPHENYLAMINE BY USING 4-NITROANILINE 有权
标题翻译：通过使用4-硝基苯胺制备4,4'-二氨基苯胺和4,4'-双（亚氨基）二苯胺的方法
公开(公告)号：US20120157714A1
公开(公告)日：2012-06-21
申请号：US13162618
申请日：2011-06-17
申请人： Jin-Eok Kim , Seoung-IL Kim , Han Jin Kwag , Sang hee Park
发明人： Jin-Eok Kim , Seoung-IL Kim , Han Jin Kwag , Sang hee Park
IPC分类号： C07C209/02 , C07C209/36
CPC分类号： C07C209/36 , C07C201/12 , C07C211/55 , C07C211/56
摘要： Provided is a method of preparing 4,4′-dinitrodiphenylamine (4,4′-DNDPA) in high yield by reacting 4-nitroaniline with excess nitrobenzene via the NASH reaction, and a method of preparing 4,4′-bis(alkylamino)diphenylamine (4,4′BAADA) in high yield and purity by hydrogenating the resulting 4,4′-DNDPA with a ketone compound in the presence of hydrogen and hydrogenation catalyst. The disclosed process is simple, allows selective preparation of 4,4′-DNDPA without byproducts, and thus allows preparation of 4,4′-BAADA in high yield without a complicated purification procedure.
摘要翻译：提供了通过使NASH反应使4-硝基苯胺与过量硝基苯反应而以高产率制备4,4'-二硝基二苯胺（4,4'-DNDPA）的方法，以及制备4,4'-二（烷基氨基）二苯胺（4,4'BAADA）以高产率和纯度通过在氢气和氢化催化剂存在下用酮化合物氢化所得4,4'- DNDPA。所公开的方法简单，允许选择性制备4,4'- DNDPA而不产生副产物，因此允许以高产率制备4,4'-BAADA而无需复杂的纯化程序。

5. 发明授权

US08283477B2 Method for preparing N-substituted maleimides 有权
标题翻译：制备N-取代马来酰亚胺的方法
公开(公告)号：US08283477B2
公开(公告)日：2012-10-09
申请号：US12999420
申请日：2009-06-24
申请人： Jin-Eok Kim , Seung-il Kim , Han-Jin Kwag
发明人： Jin-Eok Kim , Seung-il Kim , Han-Jin Kwag
IPC分类号： A61K31/4015 , A61K31/402 , C07D207/40
CPC分类号： C07D207/448
摘要： The present invention relates to a method of preparing N-substituted maleimide in high purity and high yield, wherein, unlike a conventional method of preparing N-substituted maleimide after preparing N-substituted maleamic acid, an organic solvent, an acid catalyst, a dehydration co-catalyst and a stabilizer are added into a reactor without separately preparing N-substituted maleamic acid, and then a primary amine is added into the reactor to form an amine salt, maleic anhydride is added into the reactor, and the resulting mixture is subjected to a dehydration-cyclization reaction, wherein water produced during the reaction is azeotropically distilled with the organic solvent so as to effectively suppress formation of a maleimide polymer. Particularly, the invention simplifies the process, has high yield, minimizes side reactions, eliminates the introduction of expensive raw materials and the complicated treatment of the reaction solution and significantly shortens the time over which the raw materials and maleic anhydride are added.
摘要翻译：本发明涉及以高纯度和高收率制备N-取代马来酰亚胺的方法，其中与制备N-取代马来酰胺酸，有机溶剂，酸催化剂，脱水剂的常规制备N-取代马来酰亚胺的方法不同助催化剂和稳定剂加入到反应器中，而无需单独制备N-取代的马来酰胺酸，然后将伯胺加入到反应器中以形成胺盐，将马来酸酐加入到反应器中，并将所得混合物进行脱水 - 环化反应，其中在反应期间产生的水与有机溶剂共沸蒸馏，以有效抑制马来酰亚胺聚合物的形成。特别地，本发明简化了方法，具有高产率，最小化副反应，消除了昂贵原料的引入和复杂的反应溶液处理，并显着缩短了添加原料和马来酸酐的时间。

6. 发明申请

US20110124882A1 Method for Preparing N-Substituted Maleimides 有权
标题翻译： N-取代的马来酰亚胺的制备方法
公开(公告)号：US20110124882A1
公开(公告)日：2011-05-26
申请号：US12999420
申请日：2009-06-24
申请人： Jin-Eok Kim , Seung-il Kim , Han-Jin Kwag
发明人： Jin-Eok Kim , Seung-il Kim , Han-Jin Kwag
IPC分类号： C07D207/448
CPC分类号： C07D207/448
摘要： The present invention relates to a method of preparing N-substituted maleimide in high purity and high yield, wherein, unlike a conventional method of preparing N-substituted maleimide after preparing N-substituted maleamic acid, an organic solvent, an acid catalyst, a dehydration co-catalyst and a stabilizer are added into a reactor without separately preparing N-substituted maleamic acid, and then a primary amine is added into the reactor to form an amine salt, maleic anhydride is added into the reactor, and the resulting mixture is subjected to a dehydration-cyclization reaction, wherein water produced during the reaction is azeotropically distilled with the organic solvent so as to effectively suppress formation of a maleimide polymer. Particularly, the invention simplifies the process, has high yield, minimizes side reactions, eliminates the introduction of expensive raw materials and the complicated treatment of the reaction solution and significantly shortens the time over which the raw materials and maleic anhydride are added.
摘要翻译：本发明涉及以高纯度和高收率制备N-取代马来酰亚胺的方法，其中与制备N-取代马来酰胺酸，有机溶剂，酸催化剂，脱水剂的常规制备N-取代马来酰亚胺的方法不同助催化剂和稳定剂加入到反应器中，而无需单独制备N-取代的马来酰胺酸，然后将伯胺加入到反应器中以形成胺盐，将马来酸酐加入到反应器中，并将所得混合物进行脱水 - 环化反应，其中在反应期间产生的水与有机溶剂共沸蒸馏，以有效抑制马来酰亚胺聚合物的形成。特别地，本发明简化了方法，具有高产率，最小化副反应，消除了昂贵原料的引入和复杂的反应溶液处理，并显着缩短了添加原料和马来酸酐的时间。

7. 发明授权

US06198001B1 Manufacturing method for 4-nitrosoaniline from urea and nitrobenzene 有权
标题翻译：尿素和硝基苯制备4-亚硝基苯胺的制备方法
公开(公告)号：US06198001B1
公开(公告)日：2001-03-06
申请号：US09525834
申请日：2000-03-15
申请人： Young J. Joo , Jin-Eok Kim , Jeong-Im Won , Kum-Ui Hwang
发明人： Young J. Joo , Jin-Eok Kim , Jeong-Im Won , Kum-Ui Hwang
IPC分类号： C07C1542
CPC分类号： C07C209/00 , C07C211/52
摘要： A method for preparing 4-nitrosoaniline, including reacting urea and nitrobenzene in a polar organic solvent in the presence of a base at a temperature of room temperature to 150° C. The method uses a relatively cheap urea and nitrobenzene as the raw materials, and also a relatively cheap base, thereby decreasing the manufacturing cost. Urea used as an amine donor is excellent in a reactivity to nitrobenzene, and a reaction intermediate is unstable as compared with 4-(4-nitrophenyl)benzamide to easily decompose into 4-nitroaniline and 4-nitrosoaniline. This allows a reaction time and a process time to be shortened. Moreover, the method is advantageous in that waste hazardous to the environment is not produced as a byproduct.
摘要翻译：一种制备4-亚硝基苯胺的方法，包括在极性有机溶剂中，在碱存在下，在室温至150℃的温度下使脲和硝基苯反应。该方法使用较便宜的尿素和硝基苯作为原料，也是一个相对便宜的基数，从而降低制造成本。作为胺供体的尿素与硝基苯的反应性优异，与4-（4-硝基苯基）苯甲酰胺相比，反应中间体不容易分解成4-硝基苯胺和4-亚硝基苯胺。这允许缩短反应时间和处理时间。此外，该方法的优点在于，作为副产物不会产生对环境有害的废物。

8. 发明授权

US5770774A Method for preparing 2-methyl-1,4-naphthoquinone (vitamin K.sub.3) 失效
标题翻译： 2-甲基-1,4-萘醌（维生素K3）的制备方法
公开(公告)号：US5770774A
公开(公告)日：1998-06-23
申请号：US758921
申请日：1996-12-02
申请人： Young J. Joo , Jin-Eok Kim , Jeong-Im Won , Kum-Ui Hwang
发明人： Young J. Joo , Jin-Eok Kim , Jeong-Im Won , Kum-Ui Hwang
IPC分类号： C07C45/69 , C07C46/02 , C07C46/00
CPC分类号： C07C45/69 , C07C46/02
摘要： A method for preparing 2-methyl-1,4-naphthoquinone (vitamin K.sub.3), in which 2-methyl-1,4-benzoquinone and 1,3-butadienes are subjected to a �2+4! Diels-Alder reaction and subsequently to oxidative dehydrogenation, using dimethylsulfoxide as both a dehydrogenating agent and a solvent in the presence of at least one Lewis acid or a Broensted acid, in a single pot, shows high selectivity and yield.
摘要翻译：制备2-甲基-1,4-萘醌（维生素K3）的方法，其中2-甲基-1,4-苯醌和1,3-丁二烯进行[2 + 4]狄尔斯 - 阿尔德反应，随后在单釜中，在至少一种路易斯酸或布朗斯台德酸存在下，使用二甲基亚砜作为脱氢剂和溶剂进行氧化脱氢，显示出高选择性和收率。

9. 发明授权

US07528285B2 Method for preparing thiomethylphenols 有权
标题翻译：硫甲基苯酚的制备方法
公开(公告)号：US07528285B2
公开(公告)日：2009-05-05
申请号：US11746833
申请日：2007-05-10
申请人： Hyung-Jae Lee , Jin-Eok Kim
发明人： Hyung-Jae Lee , Jin-Eok Kim
IPC分类号： C07C331/00
CPC分类号： C07C319/14 , C07C323/16
摘要： The present invention relates to a process for preparing thiomethylphenol derivatives, and particularly to a simple process of preparing thiophenol derivatives by performing a reaction of a phenol derivative, a mercaptan derivative and paraformaldehyde in a solvent in the presence of a given amount of heterocyclic amine base and acids, thereby capable of maintaining a mild reaction condition and providing thiomethylphenol derivatives with an improved discoloration by purification using acids.
摘要翻译：本发明涉及一种制备硫代甲基苯酚衍生物的方法，特别涉及通过在给定量的杂环胺基存在下，在溶剂中进行苯酚衍生物，硫醇衍生物和多聚甲醛的反应来制备苯硫酚衍生物的简单方法从而能够保持温和的反应条件并通过使用酸的纯化提供硫醇化苯甲酸衍生物和改进的变色。

10. 发明授权

US06552229B1 Method for preparing 4-nitroso-substituted aromatic amine 有权
标题翻译：制备4-亚硝基取代芳香胺的方法
公开(公告)号：US06552229B1
公开(公告)日：2003-04-22
申请号：US10209263
申请日：2002-07-31
申请人： Young-J Joo , Jin-Eok Kim , Jeong-Im Won
发明人： Young-J Joo , Jin-Eok Kim , Jeong-Im Won
IPC分类号： C07C20900
CPC分类号： C07C209/00 , C07C213/02 , C07C231/08 , C07C211/52 , C07C217/84 , C07C233/66
摘要： Disclosed is a method for preparing a 4-nitroso-substituted aromatic amine that includes contacting an amide compound with a nitroaromatic compound in the presence of a base and a solvent to directly prepare 4-nitroso-substituted aromatic amine as a main product and 4-nitro-substituted aromatic amine as a by-product without producing 4-nitroso- or 4-nitro-substituted amide as an intermediate.
摘要翻译：公开了一种制备4-亚硝基取代的芳族胺的方法，其包括在碱和溶剂的存在下使酰胺化合物与硝基芳族化合物接触，以直接制备4-亚硝基取代的芳族胺作为主要产物和4- 硝基取代的芳族胺作为副产物而不产生4-亚硝基或4-硝基取代的酰胺作为中间体。

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