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1. 发明申请

US20060263708A1 Imaging member 失效
公开(公告)号：US20060263708A1
公开(公告)日：2006-11-23
申请号：US11133979
申请日：2005-05-20
申请人： Jin Wu , Yuhua Tong , Jennifer Hwang , Liang-bih Lin , Andronique Ioannidis , Nancy Belknap , Timothy O'Brien , Anthony Uttaro
发明人： Jin Wu , Yuhua Tong , Jennifer Hwang , Liang-bih Lin , Andronique Ioannidis , Nancy Belknap , Timothy O'Brien , Anthony Uttaro
IPC分类号： G03G5/14
CPC分类号： G03G5/142 , G03G5/051 , G03G5/0514 , G03G5/0517 , G03G5/0525 , G03G5/144
摘要： Provided is an imaging member comprising a substrate, an undercoat layer (UCL), a charge generation layer, a charge transport layer, and an optional overcoat layer. The undercoat layer is formed from a single-phase UCL coating formulation comprising an organic titanate, a polymer containing active hydrogen, and an aminosilane. The UCL formulation has improved properties such as stability, processing convenience, and longer pot life etc. The UCL formulation can be used to manufacture an imaging member such as photoreceptor with improved properties such as stable, thick UCL coating, resistance to electrical failure, and PIDC independency on UCL thickness etc.

2. 发明申请

US20060177748A1 High-performance surface layer for photoreceptors 失效
标题翻译：用于光感受器的高性能表面层
公开(公告)号：US20060177748A1
公开(公告)日：2006-08-10
申请号：US11053856
申请日：2005-02-10
申请人： Jin Wu , Yuhua Tong , John Wilbert , Liang-bih Lin , Jennifer Hwang , Timothy O'Brien , Anthony Uttaro , Linda Ferrarese
发明人： Jin Wu , Yuhua Tong , John Wilbert , Liang-bih Lin , Jennifer Hwang , Timothy O'Brien , Anthony Uttaro , Linda Ferrarese
IPC分类号： G03G5/147 , G03G5/047
CPC分类号： G03G5/14773 , G03G5/0578 , G03G5/14708
摘要： An imaging member includes a substrate, a charge generating layer, and a charge transport layer, wherein an external of the imaging member includes a polyhedral oligomeric silsesquioxane modified silicone dispersed therein.
摘要翻译：成像构件包括基板，电荷产生层和电荷输送层，其中成像构件的外部包括分散在其中的多面体低聚倍半硅氧烷改性硅氧烷。

3. 发明申请

US20130008838A1 Autonomous Filter Element 审中-公开
公开(公告)号：US20130008838A1
公开(公告)日：2013-01-10
申请号：US13584023
申请日：2012-08-13
申请人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
发明人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
IPC分类号： B01D35/14
CPC分类号： B01D53/22 , B01D61/22 , B01D63/08 , B01D65/02 , B01D65/08 , B01D2311/103 , B01D2311/16 , B01D2313/22 , B01D2321/40 , G01F1/6888 , G01F1/69 , G01F15/125
摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

4. 发明申请

US20120318738A1 Autonomous Filter Element 审中-公开
标题翻译：自动过滤元件
公开(公告)号：US20120318738A1
公开(公告)日：2012-12-20
申请号：US13584032
申请日：2012-08-13
申请人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
发明人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
IPC分类号： B01D65/08 , B01D35/18 , G08B21/00 , B01D35/14
CPC分类号： B01D53/22 , B01D61/22 , B01D63/08 , B01D65/02 , B01D65/08 , B01D2311/103 , B01D2311/16 , B01D2313/22 , B01D2321/40 , G01F1/6888 , G01F1/69 , G01F15/125
摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.
摘要翻译：公开了一种自主的过滤装置和改善过滤器寿命和性能的方法。过滤器元件配备有适于测量一个或多个特性的一个或多个传感器。响应于测量的特性，滤波器元件内的控制逻辑能够确定适当的响应。例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。作为响应，控制逻辑可以启动旨在减轻阻塞的特定响应。然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。基于此，控制逻辑可以警告操作者必须更换过滤元件。或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。

5. 发明申请

US20120071521A1 CONCENTRATED, NON-FOAMING SOLUTION OF QUATERNARY AMMONIUM COMPOUNDS AND METHODS OF USE 失效
标题翻译：浓缩的季铵盐化合物的非泡沫溶液及其使用方法
公开(公告)号：US20120071521A1
公开(公告)日：2012-03-22
申请号：US13289794
申请日：2011-11-04
申请人： Cesar COMPADRE , Philip Breen , Hamid Salari , E. Kim Fifer , Danny L. Lattin , Michael Slavik , Yanbin Li , Timothy O'Brien , Amy L. Waldroup , Thomas F. Berg
发明人： Cesar COMPADRE , Philip Breen , Hamid Salari , E. Kim Fifer , Danny L. Lattin , Michael Slavik , Yanbin Li , Timothy O'Brien , Amy L. Waldroup , Thomas F. Berg
IPC分类号： A01N43/40 , A01P1/00 , A01N33/12
CPC分类号： A23L3/3526 , A01N33/12 , A01N43/40 , A23B4/20 , A23B4/30 , A23B7/154 , A23B7/158 , A23L3/3544 , Y02A50/486 , A01N31/02 , A01N25/30 , A01N25/02 , A01N2300/00
摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.
摘要翻译：公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。稀释的QAC溶液可用于食品，以防止食物中的微生物生长受到食源性微生物污染的广泛影响。还公开了使食品与稀释的QAC接触至少0.1秒的施用时间的方法。可以通过这种方法处理的食物是肉类和肉制品，海产品，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以被处理的食物，仍然保持其外观和质感。其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

6. 发明授权

US08124728B2 CA125 gene and its use for diagnostic and therapeutic interventions 有权
标题翻译： CA125基因及其在诊断和治疗干预中的应用
公开(公告)号：US08124728B2
公开(公告)日：2012-02-28
申请号：US10475117
申请日：2003-10-17
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07K14/00 , C07K14/435
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The CA125 gene has been cloned. The CA125 molecule comprises three major domains: an extracellular amino terminal domain; a large multiple repeat domain; and a carboxy terminal domain which includes a transmembrane anchor with a short cytoplasmic domain. Additionally, an amino terminal extension is present. The molecular structure is dominated by a repeat domain comprising more than sixty 156-amino-acid repeat units The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The structure has potential for use as a new gold standard for detecting the CA125 antigen, and can provide a basis for the development of a vaccine useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.
摘要翻译：已经克隆了CA125基因。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域; 一个大的多重重复域; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域。此外，存在氨基末端延伸。分子结构由包含多于六十六个156个氨基酸重复单元的重复结构域所支配。重复单元包含交互式二硫键桥接的C-封闭物和OC125和M11结合位点。 CA125分子在其羧基末端通过跨膜结构域和短的胞质尾部锚定。该结构有可能用作检测CA125抗原的新金标准，可为开发可用于治疗CA125升高的卵巢癌和其他癌症的疫苗提供依据。

7. 发明申请

US20100150877A1 Osteopontin for the Prediction and Treatment of Cardiovascular Diseases 有权
标题翻译：骨桥蛋白预测和治疗心血管疾病
公开(公告)号：US20100150877A1
公开(公告)日：2010-06-17
申请号：US12528610
申请日：2008-03-03
申请人： Timothy O'Brien , Frank Barry , Aaron Liew Yie Loong , Afshin Samali , Angela Duffy
发明人： Timothy O'Brien , Frank Barry , Aaron Liew Yie Loong , Afshin Samali , Angela Duffy
IPC分类号： A61K38/17 , C12N5/074 , C07K14/46 , C07H21/04 , A61K35/12 , A61K31/7088 , C12Q1/02 , C07K16/18 , A61P9/00
CPC分类号： A61K35/28 , A61K35/44
摘要： Osteopontin for the prediction and treatment of cardiovascular diseases The present invention relates to the use of endothelial progenitor cells (EPCs) and osteopontin for the treatment of cardiovascular diseases or complications. The invention also relates to the use of EPC osteopontin levels as a marker of the risk of the development of these cardiovascular complications. In particular, the invention provides compositions and methods based on osteopontin and the genes encoding osteopontin.
摘要翻译：用于预测和治疗心血管疾病的骨桥蛋白本发明涉及内皮祖细胞（EPCs）和骨桥蛋白用于治疗心血管疾病或并发症的用途。本发明还涉及使用EPC骨桥蛋白水平作为发展这些心血管并发症风险的标志物。特别地，本发明提供了基于骨桥蛋白和编码骨桥蛋白的基因的组合物和方法。

8. 发明申请

US20080028776A1 Enhanced Performance Dehumidifier 失效
标题翻译：增强性能除湿机
公开(公告)号：US20080028776A1
公开(公告)日：2008-02-07
申请号：US11872106
申请日：2007-10-15
申请人： Timothy O'Brien , Steve Dingle
发明人： Timothy O'Brien , Steve Dingle
IPC分类号： F24F3/14 , F25B39/02
CPC分类号： F24F3/153 , F24F1/04
摘要： A dehumidifier includes an air flow path with first, second and third segments in series from upstream to downstream and passing ambient air respectively to an evaporator coil then to a condenser coil and then discharging same. The air flow path has a fourth segment passing ambient air to the condenser coil in parallel with the noted second air flow path segment.
摘要翻译：除湿器包括具有从上游到下游串联的第一，第二和第三段的空气流动路径，并将环境空气分别传递到蒸发器线圈，然后到冷凝器盘管，然后将其排出。空气流动路径具有第四段，其将环境空气与所述第二气流通道段平行地传递到冷凝器盘管。

9. 发明申请

US20080027845A1 Closing Package for a Mortgage Loan 审中-公开
标题翻译：抵押贷款的封闭包
公开(公告)号：US20080027845A1
公开(公告)日：2008-01-31
申请号：US11870519
申请日：2007-10-11
申请人： Geoffery Dreyer , Mark Oman , Robert Caruso , Steven Bulmer , Eric Malchodi , Michael DeVito , Nancy Brennan , Michael Heid , Timothy O'Brien
发明人： Geoffery Dreyer , Mark Oman , Robert Caruso , Steven Bulmer , Eric Malchodi , Michael DeVito , Nancy Brennan , Michael Heid , Timothy O'Brien
IPC分类号： G06Q40/00 , G06Q90/00
CPC分类号： G06Q40/08 , G06Q40/00 , G06Q40/025
摘要： A method of refinancing a mortgage loan is provided. The method of refinancing a mortgage loan comprises pre-approving a customer for refinancing of a mortgage loan. This customer is sent a pre-screened offer. The offer comprises materials setting forth the terms of the refinanced mortgage loan, materials providing all required pre-acceptance disclosures, and instructions describing how the customer may accept the offer. Upon receiving an indication of acceptance of the offer from the customer, a closing package is sent to the customer to be executed by the customer. The execution of the closing package by the customer creates a refinancing loan agreement. Also provided is a closing package for a mortgage loan comprising closing documents and a format and instructions providing specific guidance to the customer for completion and execution of the closing documents.
摘要翻译：提供了贷款抵押贷款的方法。贷款抵押贷款的方法包括预先批准客户再融资抵押贷款。这个客户被发送了一个预先筛选的报价。该提议包括提供贷款抵押贷款条款的材料，提供所有必要的预接受披露的材料以及描述客户如何接受要约的说明。在收到客户接受要约的指示后，向客户发送关闭包以由客户执行。客户关闭包的执行创建了再融资贷款协议。还提供了一种用于抵押贷款的结算包，其中包括关闭文件以及为客户完成和执行关闭文件提供具体指导的格式和指令。

10. 发明申请

US20070082222A1 Corrosion and abrasion resistant decorative coating 审中-公开
标题翻译：耐腐蚀和耐磨装饰涂层
公开(公告)号：US20070082222A1
公开(公告)日：2007-04-12
申请号：US11401398
申请日：2006-04-10
申请人： James Sheek , Jarek Grembowicz , Inho Song , Timothy O'Brien
发明人： James Sheek , Jarek Grembowicz , Inho Song , Timothy O'Brien
IPC分类号： B32B15/01 , C25D5/24
CPC分类号： C23C14/0015 , C23C14/0084 , C23C14/06 , C23C14/165 , C23C28/021 , C23C28/023 , C23C30/00 , Y10S428/938 , Y10T428/12458 , Y10T428/12535 , Y10T428/12576 , Y10T428/12806 , Y10T428/12847 , Y10T428/12868 , Y10T428/12875 , Y10T428/12882 , Y10T428/12896 , Y10T428/12979 , Y10T442/2344
摘要： A new article of manufacture, for example a faucet or other article of hardware, has a specified decorative color, and is resistant to corrosion, abrasion and attack by chemicals. The article includes a substrate, one or more corrosion resistant layers applied to the substrate, a thin transition layer having a composition that varies systematically from a first composition to a second composition and in which the first composition has, at least in part, the function of corrosion protection, and in which the second composition determines the visible color or that portion of the substrate to which the transition layer is applied.
摘要翻译：一种新的制造方法，例如水龙头或其他五金制品，具有特定的装饰颜色，并且耐化学腐蚀，磨损和侵蚀。该制品包括基底，施加到基底上的一个或多个耐腐蚀层，具有从第一组合物到第二组合物系统地变化的组成的薄过渡层，并且其中第一组合物至少部分地具有功能的腐蚀保护，并且其中第二组合物确定可见颜色或施加过渡层的衬底的那部分。

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